BIBN4096BS antagonizes human α-calcitonin gene related peptide-induced headache and extracerebral artery dilatation

Clinical Pharmacology and Therapeutics

Volumn 77, Issue 3, 2005, Pages 202-213

  Petersen, Kenneth A ^a,b   Lassen, Lisbeth H ^c   Birk, Steffen ^c   Lesko, Lynna ^c   Olesen, Jes ^c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CALCITONIN GENE RELATED PEPTIDE; OLCEGEPANT;

ADULT; ARTERY DIAMETER; ARTERY DILATATION; ARTICLE; BLOOD FLOW VELOCITY; BRAIN BLOOD FLOW; CEREBRAL ARTERY DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFECT; DRUG HALF LIFE; DRUG INDUCED DISEASE; DRUG MECHANISM; END TIDAL CARBON DIOXIDE TENSION; FEMALE; HEADACHE; HEMODYNAMICS; HUMAN; KIDNEY CLEARANCE; MALE; MIDDLE CEREBRAL ARTERY; PAIN ASSESSMENT; PRIORITY JOURNAL; RADIAL ARTERY; RANDOMIZED CONTROLLED TRIAL; TEMPORAL ARTERY;

ADULT; CALCITONIN GENE-RELATED PEPTIDE; CEREBRAL ARTERIES; CEREBROVASCULAR CIRCULATION; CROSS-OVER STUDIES; FEMALE; HEADACHE; HEART RATE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; PIPERAZINES; QUINAZOLINES; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; REFERENCE VALUES; TOMOGRAPHY SCANNERS, X-RAY COMPUTED; ULTRASONOGRAPHY, DOPPLER, TRANSCRANIAL; VASODILATION;

EID: 13944253331     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clpt.2004.10.001     Document Type: Article

References (51)

1. R. Uddman, L. Edvinsson, E. Ekblad, R. Hakanson, F. Sundler Calcitonin gene-related peptide (CGRP): perivascular distribution and vasodilatory effects Regul Pept 15 1986 1 23
2. S. Schifter Circulating concentrations of calcitonin gene-related peptide (CGRP) in normal man determined with a new, highly sensitive radioimmunoassay Peptides 12 1991 365 369
3. S.D. Brain, T.J. Williams, J.R. Tippins, H.R. Morris, I. MacIntyre Calcitonin gene-related peptide is a potent vasodilator Nature 313 1985 54 56
4. I. Jansen, A. Mortensen, L. Edvinsson Characterization of calcitonin gene-related peptide receptors in human cerebral vessels Vasomotor responses and cAMP accumulation Ann N Y Acad Sci 657 1992 435 440
5. P.J. Goadsby, L. Edvinsson, R. Ekman Vasoactive peptide release in the extracerebral circulation of humans during migraine headache Ann Neurol 28 1990 183 187
6. L.H. Lassen, P.A. Haderslev, V.B. Jacobsen, H.K. Iversen, B. Sperling, J. Olesen CGRP may play a causative role in migraine Cephalalgia 22 2002 54 61
7. J. Olesen, H.C. Diener, I.W. Husstedt, P.J. Goadsby, D. Hall, U. Meier, S. Pollentier Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine N Engl J Med 350 2004 1104 1110
8. M. Schindler, H.N. Doods Binding properties of the novel, non-peptide CGRP receptor antagonist radioligand [(3)H]BIBN4096BS Eur J Pharmacol 442 2002 187 193
9. R. Verheggen, K. Bumann, A.J. Kaumann BIBN4096BS is a potent competitive antagonist of the relaxant effects of alpha-CGRP on human temporal artery: comparison with CGRP(8-37) Br J Pharmacol 136 2002 120 126
10. Good Clinical Practice: consolidated guideline (E6) step 4 adopted 1996. Available from: URL: http://www.ich.org.
11. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain Headache Classification Committee of the International Headache Society Cephalalgia 8 1988 1 96
12. I. Kanno, N.A. Lassen Two methods for calculating regional cerebral blood flow from emission computed tomography of inert gas concentrations J Comput Assist Tomogr 3 1979 71 76
13. L.L. Thomsen, H.K. Iversen Experimental and biological variation of three-dimensional transcranial Doppler measurements J Appl Physiol 75 1993 2805 2810
14. T.H. Nielsen, H.K. Iversen, P. Tfelt-Hansen Determination of the luminal diameter of the radial artery in man by high frequency ultrasound: a methodological study Ultrasound Med Biol 16 1990 787 791
15. V.P. Shah, K.K. Midha, S. Dighe, I.J. McGilveray, J.P. Skelly, A. Yacobi Analytical methods validation: bioavailability, bioequivalence and pharmacokinetic studies Conference report. Eur J Drug Metab Pharmacokinet 16 1991 249 255
16. A. Dahl, D. Russell, R. Nyberg-Hansen, K. Rootwelt Effect of nitroglycerin on cerebral circulation measured by transcranial Doppler and SPECT Stroke 20 1989 1733 1736
17. W. Sorteberg Cerebral artery velocity and cerebral blood flow D.W. Newell R. Aaslid Transcranial Doppler 1992 Raven Press New York 57 66
18. A. Dahl, D. Russell, R. Nyberg-Hansen, K. Rootwelt A comparison of regional cerebral blood flow and middle cerebral artery blood flow velocities: simultaneous measurements in healthy subjects J Cereb Blood Flow Metab 12 1992 1049 1054
19. M. Iovino, U. Feifel, C.L. Yong, J.M. Wolters, G. Wallenstein Safety, tolerability and pharmacokinetics of BIBN 4096 BS, the first selective small molecule calcitonin gene-related peptide receptor antagonist, following single intravenous administration in healthy volunteers Cephalalgia 24 2004 645 656
20. L. Edvinsson, R. Ekman, I. Jansen, A. Ottosson, R. Uddman Peptide-containing nerve fibers in human cerebral arteries: immunocytochemistry, radioimmunoassay, and in vitro pharmacology Ann Neurol 21 1987 431 437
21. K. Petersen, L.H. Lassen, S. Birk, J. Olesen The novel CGRP-antagonist BIBN4096BS does not affect the cerebral hemodynamics in healthy volunteers [abstract] Cephalalgia 23 2003 729
22. M. Ashina, L. Bendtsen, R. Jensen, S. Schifter, J. Olesen Evidence for increased plasma levels of calcitonin gene-related peptide in migraine outside of attacks Pain 86 2000 133 138
23. A.D. Struthers, M.J. Brown, D.W. Macdonald, J.L. Beacham, J.C. Stevenson, H.R. Morris Human calcitonin gene related peptide: a potent endogenous vasodilator in man Clin Sci 70 1986 389 393
24. C.W. Howden, C. Logue, K. Gavin, L. Collie, P.C. Rubin Haemodynamic effects of intravenous human calcitonin-gene-related peptide in man Clin Sci (Lond) 74 1988 413 418
25. C. Kruuse, L.L. Thomsen, T.B. Jacobsen, J. Olesen The phosphodiesterase 5 inhibitor sildenafil has no effect on cerebral blood flow or blood velocity, but nevertheless induces headache in healthy subjects J Cereb Blood Flow Metab 22 2002 1124 1131
26. C. Kruuse, L.L. Thomsen, S. Birk, J. Olesen Migraine can be induced by sildenafil without changes in middle cerebral artery diameter Brain 126 2003 241 247
27. L. Thomsen Investigations into the role of nitric oxide and the large intracranial arteries in migraine headache Cephalalgia 17 1997 873 895
28. L. Edvinsson, D.N. Krause Cerebral blood flow and metabolism 2nd ed 2002 Lippincott Williams & Wilkins Philadelphia
29. S. Vorstrup Tomographic cerebral blood flow measurements in patients with ischemic cerebrovascular disease and evaluation of the vasodilator capacity by the acetazolamide test Acta Neurol Scand Suppl 114 1988 1 48
30. S. Vorstrup, L. Henriksen, O.B. Paulson Effect of acetazolamide on cerebral blood flow and cerebral metabolic rate for oxygen J Clin Invest 74 1984 1634 1639
31. T.J. Carroll, V. Teneggi, M. Jobin, L. Squassante, V. Treyer, T.F. Hany Absolute quantification of cerebral blood flow with magnetic resonance, reproducibility of the method, and comparison with H2(15)O positron emission tomography J Cereb Blood Flow Metab 22 2002 1149 1156
32. L.L. Thomsen, M. Ahlgren, H.K. Iversen, J. Olesen Middle cerebral artery blood velocity increases during experimental pressure pain in the head J. Olesen M.A. Moskowitz Experimental headache models 1995 Raven Press New York 337 339
33. M.K. Baskaya, Y. Suzuki, M. Anzai, Y. Seki, K. Saito, M. Takayasu Effects of adrenomedullin, calcitonin gene-related peptide, and amylin on cerebral circulation in dogs J Cereb Blood Flow Metab 15 1995 827 834
34. Y. Suzuki, S. Satoh, I. Ikegaki, T. Okada, M. Shibuya, K. Sugita Effects of neuropeptide Y and calcitonin gene-related peptide on local cerebral blood flow in rat striatum J Cereb Blood Flow Metab 9 1989 268 270
35. D.T. Beattie, D.K. McNeil, H.E. Connor The influence of neurokinins and calcitonin gene-related peptide on cerebral blood flow in anaesthetized guinea-pigs Neuropeptides 24 1993 343 349
36. K.W. Hong, K.M. Pyo, W.S. Lee, S.S. Yu, B.Y. Rhim Pharmacological evidence that calcitonin gene-related peptide is implicated in cerebral autoregulation Am J Physiol 266 1994 H11 H16
37. R. Macfarlane, M.A. Moskowitz, E. Tasdemiroglu, E.P. Wei, H.A. Kontos Postischemic cerebral blood flow and neuroeffector mechanisms Blood Vessels 28 1991 46 51
38. M. Wahl, L. Schilling, A.A. Parsons, A. Kaumann Involvement of calcitonin gene-related peptide (CGRP) and nitric oxide (NO) in the pial artery dilatation elicited by cortical spreading depression Brain Res 637 1994 204 210
39. J. Stanley, J. Martin, H. Richards, M. Lovick, M. Barron, J. Pickard Effects of calcitonin gene related peptide on cerebral blood flow in healthy volunteers [abstract] J Cereb Blood Flow Metab 11 Suppl 2 1991 s273
40. Naylor AR, Miller JD, Edwards CR, Merrick MV, Sellar RJ, O'Shaughnessy D, et al. Effect of calcitonin gene-related peptide on middle cerebral artery velocities [abstract]. J Cereb Blood Flow Metab 1989;9.
41. R. Juul, S. Aakhus, K. Bjornstad, S.E. Gisvold, A.O. Brubakk, L. Edvinsson Calcitonin gene-related peptide (human alpha-CGRP) counteracts vasoconstriction in human subarachnoid haemorrhage Neurosci Lett 170 1994 67 70
42. A.R. Naylor, I.J. Robertson, C.R. Edwards, M.V. Merrick, R.J. Sellar, D. O'Shaughnessy Cerebral vasospasm following subarachnoid hemorrhage: effect of calcitonin gene-related peptide on middle cerebral artery velocities using transcranial Doppler sonography Surg Neurol 36 1991 278 280
43. F.G. Johnston, B.A. Bell, I.J. Robertson, J.D. Miller, C. Haliburn, D. O'Shaughnessy Effect of calcitonin-gene-related peptide on postoperative neurological deficits after subarachnoid haemorrhage Lancet 335 1990 869 872
44. P. Salmon, D. Fitzgerald, R. Lambe, A. Darragh, D. O'Shaughnessy, A. Riddell A single rising intravenous dose tolerance and pharmacodynamic study of human calcitonin gene related peptide (CGRP) in healthy male volunteers [abstract] Clin Pharmacol Ther 45 1989 170
45. D.R. Poyner, P.M. Sexton, I. Marshall, D.M. Smith, R. Quirion, W. Born International Union of Pharmacology XXXII The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol Rev 54 2002 233 246
46. L. Edvinsson, L. Cantera, I. Jansen-Olesen, R. Uddman Expression of calcitonin gene-related peptide1 receptor mRNA in human trigeminal ganglia and cerebral arteries Neurosci Lett 229 1997 209 211
47. H. Doods, G. Hallermayer, D. Wu, M. Entzeroth, K. Rudolf, W. Engel Pharmacological profile of BIBN 4096BS, the first selective small molecule CGRP antagonist Br J Pharmacol 129 2000 420 423
48. D. Wu, W. Eberlein, K. Rudolf, W. Engel, G. Hallermayer, H. Doods Characterisation of calcitonin gene-related peptide receptors in rat atrium and vas deferens: evidence for a [Cys(Et)(2, 7)]hCGRP-preferring receptor Eur J Pharmacol 400 2000 313 319
49. L.M. McLatchie, N.J. Fraser, M.J. Main, A. Wise, J. Brown, N. Thompson RAMPs regulate the transport and ligand specificity of the calcitonin-receptor- like receptor Nature 393 1998 333 339
50. H. Doods, K. Rudolf, G. Hallermayer, W. Eberlein CGRP antagonistic properties of BIBN 4096BS in rats Cephalalgia 20 2000 414 420
51. L. Edvinsson, R. Alm, D. Shaw, R.Z. Rutledge, K.S. Koblan, J. Longmore Effect of the CGRP receptor antagonist BIBN4096BS in human cerebral, coronary and omental arteries and in SK-N-MC cells Eur J Pharmacol 434 2002 49 53