The pharmacology of adrenomedullin receptors and their relationship to CGRP receptors

Journal of Molecular Neuroscience

Volumn 22, Issue 1-2, 2004, Pages 105-113

  Hay, Debbie L ^a,b,d   Conner, Alex C ^a   Howitt, Stephen C ^a   Smith, David M ^c   Poyner, David R ^a  

^a ASTON UNIVERSITY   (United Kingdom)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c ASTRAZENECA   (United Kingdom)

^d UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Adrenomedullin; Adrenomedullin22 52; Calcitonin receptor like receptor; CGRP; CGRP8 37; CL; RAMP2; RAMP3

Indexed keywords

ADRENOMEDULLIN; ADRENOMEDULLIN PEPTIDE[22-52]; ADRENOMEDULLIN RECEPTOR; ADRENOMEDULLIN RECEPTOR 1; ADRENOMEDULLIN RECEPTOR 2; BETA CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE 1; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CALCITONIN GENE RELATED PEPTIDE[8-37]; OLCEGEPANT; RECEPTOR ACTIVITY MODIFYING PROTEIN; RECEPTOR ACTIVITY MODIFYING PROTEIN 1; RECEPTOR ACTIVITY MODIFYING PROTEIN 2; RECEPTOR ACTIVITY MODIFYING PROTEIN 3; RECEPTOR BLOCKING AGENT; RECEPTOR PROTEIN; UNCLASSIFIED DRUG; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN RECEPTOR; CALCITONIN RECEPTOR LIKE RECEPTOR; CALCITONIN RECEPTOR-LIKE RECEPTOR; LIGAND; MEMBRANE PROTEIN; PEPTIDE; RECEPTOR; SIGNAL PEPTIDE;

CONFERENCE PAPER; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SPECIFICITY; HUMAN; NONHUMAN; RECEPTOR AFFINITY; RECEPTOR UPREGULATION; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; REVIEW;

ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MEMBRANE PROTEINS; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CALCITONIN; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; RECEPTORS, PEPTIDE;

EID: 3042739237     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:22:1-2:105     Document Type: Conference Paper

References (43)

1. Aiyar N., Disa J., Ao Z., Xu D., Surya A., Pillarisetti K., et al. (2002) Molecular cloning and pharmacological characterization of bovine calcitonin receptor-like receptor from bovine aortic endothelial cells. Biochem. Pharmacol. 63, 1949-1959.
2. Aiyar N., Disa J., Pullen M., and Nambi P. (2001) Receptor activity modifying proteins interaction with human and porcine calcitonin receptor-like receptor (CRLR) in HEK-293 cells. Mol. Cell. Biochem. 224, 123-133.
3. Aiyar N., Rand K., Elshourbagy N. A., Zeng Z. Z., Adamou J. E., Bergsma D. J., et al. (1996) A cDNA encoding the calcitonin-gene-related peptide type-1 receptor. J. Biol. Chem. 271, 11325-11329.
4. Aldecoa A., Gujer R., Fischer J., and Born W. (2000) Mammalian calcitonin receptor-like receptor / receptor modifying protein complexes define calcitonin gene-related peptide and adrenomedullin receptors in Drosophila Schneider 2 cells. FEBS Lett. 471, 156-160.
5. Buhlmann N., Leuthauser K., Muff R., Fischer J. A., and Born W. (1999) A receptor activity modifying protein (RAMP)2-dependent adrenomedullin receptor is a calcitonin gene-related peptide receptor when coexpressed with human RAMP1. Endocrinology 140, 2883-2890.
6. Caron K. M. and Smithies O. (2001) Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional adrenomedullin gene. Proc. Natl. Acad. Sci. 98, 615-619.
7. Chakravarty P., Suthar T. P., Coppock H. A., Nicholl C. G., Bloom S. R., Legon S., et al. (2000) CGRP and adrenomedullin binding correlates with transcript levels for calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) in rat tissues. Br. J. Pharmacol. 130, 189-195.
8. Champion H. C., Santiago J. A., Murphy W. A., Coy D. H., and Kadowitz P. J. (1997) Adrenomedullin-(22-52) antagonizes vasodilator responses to CGRP but not adrenomedullin in the cat. Am J Physiol 272, R234-R242.
9. Choksi T., Hay D. L., Legon L., Poyner D. R., Hagner S., Bloom S. R., et al. (2002) Comparison of the expression of calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) with CGRP and adrenomedullin binding in cell lines. Br. J. Pharmacol. 136, 784-792.
10. Coppock H .A., Owji A. A., Austin C., Upton P. D., Jackson M. L., Gardiner J. V., et al. (1999) Rat-2 fibroblasts express specific adrenomedullin receptors, but not calcitonin-gene-related-peptide receptors, which mediate increased intracellular cyclic AMP and inhibit mitogen-activated protein kinase activity. Biochem. J. 338, 15-22.
11. Dennis T., Fournier A., Cadieux A., Pomerleau F., Jolicoeur F. B., St Pierre S., et al. (1990) hCGRP8-37, a calcitonin gene-related peptide antagonist revealing calcitonin gene-related peptide receptor heterogeneity in brain and periphery. J. Pharmacol. Exp. Ther. 254, 123-128.
12. Doods H., Hallermayer G., Wu D., Entzeroth M., Rudolf K., Engel W., et al. (2000) Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist. Br. J. Pharmacol. 129, 420-423.
13. Dumont Y., Fournier A., St Pierre S., and Quirion R. (1997) A potent and selective CGRP2 agonist, [Cys(Et)2,7]hCGRP alpha: comparison in prototypical CGRP1 and CGRP2 in vitro bioassays. Can. J. Physiol. Pharmacol. 75, 671-676.
14. Eguchi S., Hirata Y., Iwasaki H., Sato K., Watanabe T. X., Inui T., et al. (1994) Structure-activity relationship of adrenomedullin, a novel vasodilatory peptide, in cultured rat vascular smooth muscle cells. Endocrinology 135, 2454-2458.
15. Elshourbagy N. A., Adamou J. E., Swift A. M., Disa J., Mao J., Ganguly, S., et al. (1998) Molecular cloning and characterization of the porcine calcitonin gene-related peptide receptor. Endocrinology 139, 1678-1683.
16. Evans B. N., Rosenblatt M. I., Mayer L. O., Oliver K. R., and Dickerson I. M. (2002) CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors. J. Biol. Chem. 275, 31438-31443.
17. Fraser N. J., Wise A., Brown J., McLachtie L. M., Main M. J., and Foord S. M. (1999) The amino terminus of receptor activity modifying proteins is a critical determinant of glycosylation state and ligand binding of calcitonin receptor-like receptor. Mol. Pharmacol. 55,1054-1059.
18. Hay D. L. and Smith D. M. (2001) Knockouts and transgenics confirm the importance of adrenomedullin in the vasculature. Trends Pharmacol. Sci. 22, 57-59.
19. Hinson J. P., Kapas S., and Smith D. M. (2000) Adrenomedullin, a multifunctional regulatory peptide. Endocr. Rev. 21, 138-167.
20. Husmann K., Sexton P. M., Fischer J. A., and Born W. (2000) Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid sequence, expression and function. Mol. Cell. Endocrinol. 162, 35-43.
21. Jansen-Olesen I., Mortensen A., and Edvinsson L. (1996) Calcitonin gene-related peptide is released from capsaicin-sensitive nerve fibres and induces vasodilatation of human cerebral arteries concomitant with activation of adenylyl cyclase. Cephalalgia, 16, 310-316.
22. Juaneda C., Dumont Y., and Quirion R. (2000) The molecular pharmacology of CGRP and related peptide receptor subtypes Trends Pharmacol. Sci. 21, 432-438.
23. Kuwasako K., Kitamura K., Ito K., Uemura T., Yanagita Y, Kato J., et al. (2001) The seven amino acids of human RAMP2 (86-92) and RAMP3 (59-65) are critical for agonist binding to human adrenomedullin receptors. J. Biol. Chem. 276, 49459-49465.
24. Kuwasako K., Kitamura K., Onitsuka H., Uemura T., Nagoshi Y., Kato J., et al. (2002) Rat RAMP domains involved in adrenomedullin binding specificity. FEBS Lett. 519, 113-116.
25. Kuwasako K., Kitamura K., Nagoshi Y., and Eto T. (2003) Identification of the human receptor activity-modifying protein 1 domains responsible for agonist binding specificity. J Biol Chem. 278, 22,623-22,630.
26. Mallee J. J., Salvatore C. A., LeBourdelles B., Oliver K. R., Longmore J., Koblan K., et al. (2002) RAMP1 determines the species selectivity of non-peptide CGRP receptor antagonists. J. Biol. Chem. 277, 14294-14298.
27. McLatchie L. M., Fraser N. J., Main M. J., Wise A., Brown J., Thompson N., et al. (1998) RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 393, 333-339.
28. Miller M. J., Martinez A., Unsworth E. J., Thiele C. J., Moody T. W., Elsasser T., et al. (1996) Adrenomedullin expression in human tumor cell lines: its potential role as an autocrine growth factor. J Biol Chem. 271, 23345-23351.
29. Nagae T., Mukoyama M., Sugawara A., Mori K., Yahata K., Kasahara M., et al. (2000) Rat receptor-activity-modifying proteins (RAMPs) for adrenomedullin / CGRP receptor: cloning and upregulation in obstructive nephropathy. Biochem. Biophys. Res. Commun. 270, 89-93.
30. Nagoshi Y., Kuwasako K., Ito K., Uemura T., Kato J., Kitamura K., et al. (2002) The calcitonin receptor-like receptor / receptor activity-modifying protein 1 heterodimer can functionas a calcitonin gene-related peptide-(8-37)-sensitive adrenomedullin receptor. Eur. J. Pharmacol. 450, 237-243.
31. Oliver K. R., Kane S. A., Salvatore C. A., Mallee J. J., Kinsey A. M., Koblan K. S., et al. (2001) Cloning, characterization and central nervous system distribution of receptor activity modifying proteins in the rat. Eur. J. Neuroscience 14, 618-628.
32. Ono, Y., Okano, I., Kojima, M., Okada, K., and Kangawa, K. (2000) Decreased gene expression of adrenomedullin receptor in mouse lungs during sepsis. Biochem. Biophys. Res. Commun. 271, 197-202.
33. Pinto A., Sekizawa K., Yamaya M., Ohrui T., Jia Y. X., and Sasaki H. (1996) Effects of adrenomedullin and calcitonin gene-related peptide on airway and pulmonary vascular smooth muscle in guinea-pigs. Br. J. Pharmacol. 119, 1477-1483.
34. Poyner D. R., Taylor G. M., Tomlinson A. E., Richardson A. G., and Smith D. M. (1999) Characterization of receptors for calcitonin gene-related peptide and adrenomedullin on the guinea-pig vas deferens. Br. J. Pharmacol. 126, 1276-1282.
35. Poyner D. R, Sexton P. M., Marshall I., Smith D. M., Quirion R., Born W., et al. (2002) International Union of Pharmacology. XXXII. The mammalian CGRP, adrenomedullin, amylin and calcitonin receptors. Pharm. Rev. 54, 233-246.
36. Prado M. A., Evans-Bain B., Oliver K. R., and Dickerson I. M. (2001) The role of the CGRP-receptor component protein (RCP) in adrenomedullin receptor signal transduction. Peptides 22,1773-1781.
37. Sexton P. M., Albiston A., Morfis M., and Tilakaratne N. (2001) Receptor activity modifying proteins. Cell Signal. 13, 73-83.
38. Shindo T., Kurihara Y., Nishimatsu H., Moriyama N., Kakoki M., Wang Y., et al. (2001) Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene. Circulation 104, 1964-1971.
39. Tomlinson A. E. and Poyner D. R. (1996) Multiple receptors for CGRP and amylin on guinea pig vas deferens and vas deferens. Br. J. Pharmacol. 117, 1362-1368.
40. Withers D. J., Coppock H. A., Seufferlein T., Smith D. M., Bloom S. R., and Rozengurt E. (1996) Adrenomedullin stimulates DNA synthesis and cell proliferation via elevation of cyclic AMP in Swiss 3T3 cells. FEBS Lett. 378, 83-87.
41. Wu D., Eberlein W., Rudolf K., Engel W., Hallermayer G., and Doods H. (2000) Characterisation of calcitonin gene-related peptide receptors in rat atrium and vas deferens: evidence for a [Cys(Et)(2, 7)] hCGRP-preferring receptor. Eur. J. Pharmacol. 400, 313-319.
42. Yoshimoto R., Mitsui-Saito M., Ozaki H., and Karaki H. (1998) Effects of adrenomedullin and calcitonin gene-related peptide on contractions of the rat aorta and porcine coronary artery. Br. J. Pharmacol. 123, 1645-1654.
43. Zimmermann U., Fischer J. A., and Muff R. (1995) Adrenomedullin and calcitonin gene-related peptide interact with the same receptor in cultured human neuroblastoma SK-N-MC cells. Peptides 16, 421-424.