Ion permeation properties of a cloned human 5-HT3 receptor transiently expressed in HEK 293 cells

Amino Acids

Volumn 17, Issue 3, 1999, Pages 243-255

  Mochizuki, S ^a   Miyake, A ^a   Furuichi, K ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Amino acids; Ion channel; Ion permeability; Serotonin receptor; Serotonin 3 receptor

Indexed keywords

CALCIUM ION; LITHIUM ION; MAGNESIUM ION; POTASSIUM ION; RUBIDIUM ION; SEROTONIN 3 RECEPTOR; SODIUM ION;

ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DNA TRANSFECTION; HUMAN; HUMAN CELL; ION TRANSPORT; MEMBRANE CONDUCTANCE; MEMBRANE PERMEABILITY; MOLECULAR CLONING; PATCH CLAMP; POTASSIUM TRANSPORT; PRIORITY JOURNAL; SODIUM TRANSPORT;

EID: 0033490980     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01366923     Document Type: Article

References (36)

1. Alhaider AA (1997) Effect of systemically administered SR 57227A on the tail-flick latency in mice. Pharmacologist 39: 108
2. Anderson CR, Stevens CF (1973) Voltage-clamp analysis of acetylcholine produced endplate current fluctuations at the frog neuromuscular junction. J Physiol 235: 655-691
3. Ascher P, Nowak L (1988) The role of divalent cations in the N-methyl-D-aspartate responses of mouse central neurones in culture. J Physiol 399: 247-266
4. S receptor subunit. Mol Pharmacol 48: 1054-1062
5. 3A). J Physiol 507: 653-665
6. 3 receptor antagonists as anti-emetics. Trends Pharmacol Sci 12: 46-48
7. 3 receptors in three isolated preparations derived from guinea-pig tissues. Br J Pharmacol 101: 591-598
8. Chen C, Okayama H (1987) High efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 7: 2745-2752
9. 3 receptors are membrane ion channels. Nature 339: 706-709
10. 3 receptor stably expressed in HEK293 cells. Br J Pharmacol 114: 1211-1221
11. 3 receptor antagonists: a critical update on therapeutic potential. Trends Pharmacol Sci 14: 265-270
12. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch 391: 85-100
13. Higashi H, Nishi S (1982) 5-Hydroxytryptamine receptors of visceral primary afferent neurones on rabbit nodose ganglia. J Physiol 323: 543-567
14. Hill B (1992) Ion channels of excitable membranes, 2nd edn. Sinauer Associates Inc., Sunderland, pp 288-290
15. Hodgkin AL (1951) The ionic basis of electrical activity in nerve and muscle. Biol Rev 26: 339-409
16. 3 receptor A subunit. Eur J Pharmacol 245: 187-192
17. Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PPA (1994) International union of pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol Rev 46: 157-203
18. Hussy N, Lukas W, Jones KA (1994) Functional properties of a cloned 5-hydroxytryptamine ionotropic receptor subunit: comparsion with native mouse receptors. J Physiol 481: 311-323
19. Ireland SJ, Tyers MB (1987) Pharmacological characterization of 5-hydroxytryptamine-induced depolarization of the rat isolated vagus nerve. Br J Pharmacol 90: 229-238
20. 3 receptor subunit. NeuroReport 5: 121-124
21. Kamato T, Ito H, Nagakura Y, Nishida A, Yuki H, Yamano M, Miyata K (1993) Mechanisms of cisplatin-and m-chlorophenylbiguanide-induced emesis in ferrets. Eur J Pharmacol 238: 369-376
22. 3 receptors in clonal cell lines studied by patch-clamp techniques. Br J Pharmacol 97: 27-40
23. 3 receptor, a serotonin-galed ion channel. Science 254: 432-437
24. Marshall J, Molloy R, Moss GWJ, Howe JR, Hughes TE (1995) The jellyfish green fluorescent protein: a new tool for studying ion channel expression and function. Neuron 14: 211-215
25. 3 receptor: heterogeneity in distribution and function among species. Mol Pharmacol 48: 407-416
26. 3 receptor-induced currents in N1E-115 neuroblastoma cells. Eur J Pharmacol 151: 491-495
27. 3 receptors. Trends Pharmacol Sci 13: 391-397
28. 3 receptors of rabbit nodose ganglion neurones in culture. Br J Pharmacol 110: 665-676
29. 3 receptor agonist, in rodents. J Neural Transm 102: 83-90
30. Reuter H, Stevens CF (1980) Ion conductance and ion selectivity of potassium channels in snail neurons. J Membr Biol 57: 103-118
31. Robinson RA, Stokes RH (1959) Electrolyte solutions, 2nd edn. Butterworths, London, pp 230-237
32. 3 receptor gene and functional expression of two splice variants. Mol Brain Res 26: 233-241
33. 3 receptors mediated rapid responses in cultured hippocampus and a clonal cell line. Neuron 1: 615-621
34. 3 receptor. Brain Res 533: 46-52
35. Yang J (1990) Ion permeation through 5-hydroxytryptamine-gated channels in neuroblastoma N18 cells. J Gen Physiol 96: 1177-1198
36. 3 receptor channels in dissociated rat superior cervical ganglion neurons. J Physiol 448: 237-256