Identification and characterization of the unique guanine nucleotide exchange factor, SmgGDS, in vascular smooth muscle cells

Journal of Cellular Biochemistry

Volumn 104, Issue 5, 2008, Pages 1760-1770

  Thill, Rebecca ^a   Campbell, William B ^a   Williams, Carol L ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Guanine nucleotide exchange factors; Rap1GDS1; RhoA; Smg GDS; SmgGDS; Smooth muscle

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; COLLAGEN GEL; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MYOSIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMALL INTERFERING RNA;

ANIMAL CELL; AORTA MEDIA; ARTICLE; CELL SHAPE; CELL SPREADING; CELL STRAIN 3T3; CELL STRUCTURE; CORONARY ARTERY; DOWN REGULATION; GEL; IMMUNOFLUORESCENCE; MUSCLE FIBER CONTRACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; VASCULAR SMOOTH MUSCLE;

ANIMALS; CATTLE; CELL SHAPE; CELLS, CULTURED; DOWN-REGULATION; GENE SILENCING; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MODELS, BIOLOGICAL; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; MYOSIN LIGHT CHAINS; MYOSINS; PHOSPHORYLATION; PROTEIN PHOSPHATASE 1; RATS; RHOA GTP-BINDING PROTEIN; RNA, SMALL INTERFERING; TRANSFECTION;

BOVINAE; RATTUS;

EID: 50249171006     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21740     Document Type: Article

References (45)

1. Apolloni A, Prior IA, Lindsay M, Parton RG, Hancock JF. 2000. H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway. Mol Cell Biol 20:2475-2487.
2. Arber S, Barbayannis FA, Hanser H, Schneider C, Stanyon CA, Bernard 0, Caroni P. 1998. Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. Nature 393:805-809.
3. Bi D, Nishimura J, Niiro N, Hirano K, Kanaide H. 2005. Contractile properties of the cultured vascular smooth muscle cells: The crucial role played by RhoA in the regulation of contractility. Circ Res 96:890-897.
4. Bogdanov VY, Poon M, Taubman MB. 1998. Platelet-derived growth factor-specific regulation of the JE promoter in rat aortic smooth muscle cells. J Biol Chem 273:24932-24938.
5. Cadwallader KA, Paterson H, Macdonald SG, Hancock JF. 1994. N-terminally myristoylated ras proteins require palmitoylation or a polybasic domain for plasma membrane localization. Mol Cell Biol 14:4722-4730.
6. Chuang TH, Xu X, Quilliam LA, Bokoch GM. 1994. SmgGDS stabilizes nucleotide-bound and -free forms of the Rac1 GTP-binding protein and stimulates GTP/GDP exchange through a substituted enzyme mechanism. Biochem J 303(Pt 3):761-767.
7. Conway AM, James AB, O'Kane EM, Rakhit S, Morris BJ. 2004. Regulation of myosin light chain phosphorylation by RhoB in neuronal cells. Exp Cell Res 300:35-42.
8. Corteling RL, Brett SE, Yin H, Zheng XL, Walsh MP, Welsh DG. 2007. The functional consequence of RhoA knockdown by RNA interference in rat cerebral arteries. Am J Physiol Heart Circ Physiol 293:H440-H447.
9. Defawe OD, Kenagy RD, Choi C, et al. 2005. MMP-9 regulates both positively and negatively collagen gel contraction: A nonproteolytic function of MMP-9. Cardiovasc Res 66:402-409.
10. Esufali S, Bapat B. 2004. Cross-talk between Racl GTPase and dysregulated wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation. Oncogene 23:8260-8271.
11. Hilgers RH, Webb RC. 2005. Molecular aspects of arterial smooth muscle contraction: Focus on rho. Exp Biol Med (Maywood) 230:829-835.
12. Hughes SC, Fehon RG. 2007. Understanding ERM proteins - The awesome power of genetics finally brought to bear. Curr Opin Cell Biol 19:51-56.
13. Ito M, Nakano T, Erdodi F, Hartshorne DJ. 2004. Myosin phosphatase: Structure, regulation and function. Mol Cell Biochem 259:197-209.
14. Ivanov V, Roomi MW, Kalinovsky T, Niedzwiecki A, Rath M. 2005. Bioflavonoids effectively inhibit smooth muscle cell-mediated contraction of collagen matrix induced by angiotensin II. J Cardiovasc Pharmacol 46: 570-576.
15. Izawa T, Fukata Y, Kimura T, Iwamatsu A, Dohi K, Kaibuchi K. 2000. Elongation factor-1 alpha is a novel substrate of rho-associated kinase. Biochem Biophys Res Commun 278:72-78.
16. Kaibuchi K, Mizuno T, Fujioka H, et al. 1991. Molecular cloning of the cDNA for stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like small GTP-binding proteins) and characterization of stimulatory GDP/GTP exchange protein. Mol Cell Biol 11:2873-2880.
17. 2+ sensitization in rabbit smooth muscle. J Physiol 546:879-889.
18. Kozasa T, Jiang X, Hart MJ, et al. 1998. p115 RhoGEF, a GTPase activating protein for Galphal2 and Galphal3. Science 280:2109-2111.
19. Kuzuya M, Cheng XW, Sasaki T, Tamaya-Mori N, Iguchi A. 2004. Pitavastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, blocks vascular smooth muscle cell populated-collagen lattice contraction. J Cardiovasc Pharmacol 43:808-814.
20. Lai A, Frishman WH. 2005. Rho-kinase inhibition in the therapy of cardiovascular disease. Cardiol Rev 13:285-292.
21. Leung T, Chen XQ, Manser E, Lim L. 1996. The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Mol Cell Biol 16:5313-5327.
22. Li N, Zou AP, Ge ZD, Campbell WB, Li PL. 2000. Effect of nitric oxide on calcium-induced calcium release in coronary arterial smooth muscle. Gen Pharmacol 35: 37-45.
23. Li S, Moon JJ, Miao H, et al. 2003. Signal transduction in matrix contraction and the migration of vascular smooth muscle cells in three-dimensional matrix. J Vase Res 40: 378-388.
24. Maeda Y, Hirano K, Nishimura J, Sasaki T, Kanaide H. 2003. Rho-kinase inhibitor inhibits both myosin phos-phorylation-dependent and -independent enhancement of myofilament Ca2+ sensitivity in the bovine middle cerebral artery. Br J Pharmacol 140:871-880.
25. Matsui T, Maeda M, Doi Y, et al. 1998. Rho-kinase phosphorylates COOH-terminal threonines of ezrin/ radixin/moesin (ERM) proteins and regulates their head-to-tail association. J Cell Biol 140:647-657.
26. Ngo P, Ramalingam P, Phillips JA, Furuta GT. 2006. Collagen gel contraction assay. Methods Mol Biol 341: 103-109.
27. Nobe H, Nobe K, Fazal F, De Lanerolle P, Paul RJ. 2003. Rho kinase mediates serum-induced contraction in fibroblast fibers independent of myosin LC20 phosphorylation. Am J Physiol Cell Physiol 284:C599-C606.
28. Ogita H, Kunimoto S, Kamioka Y, Sawa H, Masuda M, Mochizuki N. 2003. EphA4-mediated rho activation via vsm-RhoGEF expressed specifically in vascular smooth muscle cells. Circ Res 93:23-31.
29. Ohashi K, Nagata K, Maekawa M, Ishizaki T, Narumiya S, Mizuno K. 2000. Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. J Biol Chem 275:3577-3582.
30. Ohtsu H, Mifune M, Frank GD, et al. 2005. Signal-crosstalk between Rho/ROCK and c-jun NH2-terminal kinase mediates migration of vascular smooth muscle cells stimulated by angiotensin II. Arterioscler Thromb Vasc Biol 25:1831-1836.
31. Orita S, Kaibuchi K, Kuroda S, Shimizu K, Nakanishi H, Takai Y. 1993. Comparison of kinetic properties between two mammalian ras p21 GDP/GTP exchange proteins, ras guanine nucleotide-releasing factor and smg GDP dissociation stimulation. J Biol Chem 268:25542-25546.
32. Pearce JD, Li J, Edwards MS, English WP, Geary RL. 2004. Differential effects of rho-kinase inhibition on artery wall mass and remodeling. J Vasc Surg 39:223-228.
33. Quilliam LA, Rebhun JF, Castro AF. 2002. A growing family of guanine nucleotide exchange factors is responsible for activation of ras-family GTPases. Prog Nucleic Acid Res Mol Biol 71:391-444.
34. Seasholtz TM. 2003. The RHOad less traveled: The myosin phosphorylation-independent path from rho kinase to cell contraction, focus on "rho kinase mediates seruminduced contraction in fibroblast fibers independent of myosin LC20 phosphorylation". Am J Physiol Cell Physiol 284:C596-C598.
35. Strassheim D, Porter RA, Phelps SH, Williams CL. 2000. Unique in vivo associations with SmgGDS and RhoGDI and different guanine nucleotide exchange activities exhibited by RhoA, dominant negative RhoA(asn-19), and activated RhoA(val-14). J Biol Chem 275:6699-6702.
36. ten Klooster JP, Jaffer ZM, Chernoff J, Hordijk PL. 2006. Targeting and activation of Rac1 are mediated by the exchange factor beta-pix. J Cell Biol 172:759-769.
37. Ueyama T, Eto M, Kami K, et al. 2005. Isoform-specific membrane targeting mechanism of rac during fc gamma R-mediated phagocytosis: Positive charge-dependent and independent targeting mechanism of rac to the phagosome. J Immunol 175:2381-2390.
38. van Hennik PB, ten Klooster JP, Halstead JR, et al. 2003. The C-terminal domain of Racl contains two motifs that control targeting and signaling specificity. J Biol Chem 278:39166-39175.
39. Wheeler AP, Ridley AJ. 2004. Why three rho proteins? RhoA, RhoB, RhoC, and cell motility. Exp Cell Res 301: 43-49.
40. Williams CL. 2003. The polybasic region of ras and rho family small GTPases: A regulator of protein interactions and membrane association and a site of nuclear localization signal sequences. Cell Signal 15:1071-1080.
41. Williams CL, Lennon VA, Pittelkow MR. 1989. Novel redistribution of myosin-containing filaments in cultured keratinocytes identified by a human monoclonal autoantibody. In Vitro Cell Dev Biol 25:397-401.
42. Yaku H, Sasaki T, Takai Y. 1994. The dbl oncogene product as a GDP/GTP exchange protein for the rho family: Its properties in comparison with those of smg GDS. Biochem Biophys Res Commun 198:811-817.
43. Yamamoto T, Kaibuchi K, Mizuno T, Hiroyoshi M, Shirataki H, Takai Y. 1990. Purification and, characterization from bovine brain cytosol of proteins that regulate the GDP/GTP exchange reaction of smg p21s, ras p21-like GTP-binding proteins. J Biol Chem 265:16626-16634.
44. Ying Z, Jin L, Palmer T, Webb RC. 2006. Angiotensin II up-regulates the leukemia-associated rho guanine nucleotide exchange factor (RhoGEF), a regulator of G protein signaling domain-containing RhoGEF, in vascular smooth muscle cells. Mol Pharmacol 69:932-940.
45. Yonemura S, Matsui T, Tsukita S, Tsukita S. 2002. Rho-dependent and -independent activation mechanisms of ezrin/radixin/moesin proteins: An essential role for polyphosphoinositides in vivo. J Cell Sci 115:2569-2580.