Rho-kinase inhibitor inhibits both myosin phosphorylation-dependent and -independent enhancement of myofilament Ca 2+ sensitivity in the bovine middle cerebral artery

British Journal of Pharmacology

Volumn 140, Issue 5, 2003, Pages 871-880

  Maeda, Yoshihisa ^a   Hirano, Katsuya ^a   Nishimura, Junji ^a   Sasaki, Tomio ^b   Kanaide, Hideo ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Ca 2+ sensitization; Cerebral artery; Myosin light chain; Myosin light chain kinase; Rho kinase; Thromboxane A 2

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CALCIUM ION; MYOSIN; MYOSIN LIGHT CHAIN; MYOSIN LIGHT CHAIN KINASE INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; POTASSIUM ION; RHO KINASE; RHO KINASE INHIBITOR; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL TISSUE; ARTICLE; CATTLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; MIDDLE CEREBRAL ARTERY; MYOFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SENSITIZATION; SMOOTH MUSCLE CONTRACTILITY; STEADY STATE;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; AMIDES; ANIMALS; CALCIUM; CATTLE; ENZYME INHIBITORS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICROFILAMENTS; MIDDLE CEREBRAL ARTERY; MYOSINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; VASOCONSTRICTION;

EID: 0344873148     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705487     Document Type: Article

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