Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 2, 2005, Pages 443-448

  Kashiwada, Yoshiki ^a   Aoshima, Akihiro ^a   Ikeshiro, Yasumasa ^a   Chen, Yuh Pan ^b   Furukawa, Hiroshi ^c   Itoigawa, Masataka ^d   Fujioka, Toshihiro ^e   Mihashi, Kunihide ^e   Cosentino, L Mark ^f   Morris Natschke, Susan L ^g   Lee, Kuo Hsiung ^g  

^a NIIGATA UNIVERSITY OF PHARMACY AND APPLIED LIFE SCIENCES   (Japan)

^b Brion Research Institute of Taiwan   (Taiwan)

^c MEIJO UNIVERSITY   (Japan)

^d TOKAI GAKUEN UNIVERSITY   (Japan)

^e FUKUOKA UNIVERSITY   (Japan)

^f BBI Biotech Research Laboratories   (United States)

^g UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Anti HIV; Benzylisoquinoline alkaloid; Flavonoid; Nelumbo nucifera

Indexed keywords

ALKALOID DERIVATIVE; COCLAURINE; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; ISOLIENSININE; LIENSININE; N BENZYL 1 (4' CHLOROBENZYL) 6 METHOXY 7 BENZYLOXY 1,2,3,4 TETRAHYDROISOQUINOLINE; N BENZYL 1 (4' FLUOROBENZYL) 6 METHOXY 7 BENZYLOXY 1,2,3,4 TETRAHYDROISOQUINOLINE; NEGFERINE; NORCOCLAURINE; NUCIFERINE; QUERCETIN 3 O BETA DEXTRO GLUCURONIDE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ISOLATION; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HUMAN CELL; NELUMBO; NELUMBO NUCIFERA; NONHUMAN; PLANT LEAF; STRUCTURE ACTIVITY RELATION;

ALKALOIDS; ANIMALS; ANTI-HIV AGENTS; CELL LINE; HIV-1; ISOQUINOLINES; MOLECULAR STRUCTURE; NELUMBO; PLANT LEAVES; QUERCETIN; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES;

NELUMBO; NELUMBO NUCIFERA;

EID: 20844441926     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.10.020     Document Type: Article

References (14)

1. Chinese Materia Medica, Jiangsu New Medical College, Ed., Shanghai People's Pub. House: Shanghai, 1977; p 1810
2. Y. Sekine, and A. Brossi J. Nat. Prod. 53 1990 53
3. L.J. Haymes, and K.L. Stuart J. Chem. Soc., Chem. Commun. 1965 141
4. B. Möhle, W. Heller, and E. Wellmann Phytochemistry 24 1985 465
5. H. Koshiyama, H. Ohkuma, H. Kawaguchi, H.Y. Hsu, and Y.P. Chen Chem. Pharm. Bull. 18 1970 2564
6. J.E. Leet, V. Fajardo, A.J. Freyer, and M. Shamma J. Nat. Prod. 46 1983 908
7. L.M. Lausen, J.K. Nielsen, and H. Sørensen Phytochemistry 21 1982 1029
8. J.B. Harbone T.J. Marbry The Flavonoids 1982 Chapman and Hall London p 19
9. M. Tomita, Y. Watanabe, and H. Furukawa Yakugaku Zasshi 81 1961 1644
10. M. Tomita, Y. Watanabe, and H. Furukawa Yakugaku Zasshi 81 1961 1202
11. M. Tomita, H. Furukawa, T.H. Yang, and T.J. Liu Chem. Pharm. Bull. 13 1965 39
12. H. Furukawa Yakugaku Zasshi 88 1965 335
13. T. Kametani, K. Sakurai, S. Kano, and H. Iida Yakugaku Zasshi 87 1967 822
14. Y. Kashiwada, T. Nagao, A. Hashimoto, Y. Ikeshiro, H. Okabe, L.M. Cosentino, and K.H. Lee J. Nat. Prod. 63 2000 1619