Relationships between structure and vascular activity in a series of benzylisoquinolines

British Journal of Pharmacology

Volumn 122, Issue 3, 1997, Pages 409-416

  Chulia, Susana ^a   Ivorra, Maria Dolores ^a   Martinez, Sonia ^a   Elorriaga, Martin ^a   Valiente, Miguel ^a   Noguera, Maria Antonia ^a   Lugnier, Claire ^b   Advenier, Charles ^c   D'Ocon, Pilar ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

1 adrenoceptor subtypes; Benzylisoquinolines; Phosphodiesterases; Rat aorta; Structure activity relationship

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1D ADRENERGIC RECEPTOR; BENZYLISOQUINOLINE DERIVATIVE; CAFFEINE; CALCIUM CHANNEL; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; DILTIAZEM; INOSITOL PHOSPHATE; ISOQUINOLINE; LAUDANOSINE; NITRENDIPINE; NORADRENALIN; PAPAVERINE; PHOSPHATIDYLINOSITIDE; POTASSIUM CHLORIDE; PRAZOSIN; TETRAHYDROPAPAVERINE; TETRAHYDROPAPAVEROLINE;

ANIMAL TISSUE; AORTA; ARTERY CONSTRICTION; ARTICLE; BINDING SITE; BLOOD VESSEL REACTIVITY; BRAIN CORTEX; CATTLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVITY; FEMALE; MALE; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; AORTA; DILTIAZEM; FEMALE; INOSITOL PHOSPHATES; ISOQUINOLINES; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; PAPAVERINE; PARASYMPATHOLYTICS; PRAZOSIN; RADIOLIGAND ASSAY; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030882744     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701410     Document Type: Article

References (28)

1. 1-adrenoceptor mediating contractions of rat aorta, vas deferens and spleen. Br. J. Pharmacol., 109, 80-87.
2. ANSELMI, E., FAYOS, G., BLASCO, R., CANDENAS, M.L., CORTES, D. & D'OCON, M.P. (1992). Selective inhibition of calcium entry induced by benzylisoquinolines in smooth muscle. J. Pharm. Pharmacol., 44, 337-343.
3. AOKI, H., NISHIMURA, J., KOBAYASHI, S. & KANAIDE, H. (1994). Relationship between cytosolic calcium concentration and force in the papaverine-induced relaxation of medial strips of pig coronary artery. Br. J. Pharmacol., 111, 489-496.
4. BERRIDGE, M.J., DOWNES, C.P. & HANLEY, M.R. (1982). Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands. Biochem. J. 206, 587-595.
5. 50) of an enzymatic reaction. Biochem. Pharmacol., 22, 3099-3108.
6. CHULIÁ, S., IVORRA, M.D., LUGNIER, C., VILA, E., NOGUERA, M.A. & D'OCON, P. (1994). Mechanism of the cardiovascular activity of laudanosine: comparison with papaverine and other benzylisoquinolines. Br. J Pharmacol., 113, 1377-1385.
7. CORTES, D., TORRERO, M.Y., D'OCON, M.P., CANDENAS, M.L., CAVE, A. & HADI, A.H.A. (1990). Norstephalagint et atherospermidine, deux aporphines d'Artabotrys maingayi relaxantes du muscle lisse. J. Nat. Prod., 53, 503-508.
8. D'OCON, M.P., BLASCO, R., CANDENAS, M.L. IVORRA, M.D., LOPEZ, S., VILLAVERDE, C., CASTEDO, L. & CORTES, D. (1991). Inhibition of calcium entry induced by cularines and isocrasifoline in uterine smooth muscle. Eur. J. Pharmacol., 196, 183-187.
9. FERRARI, M. (1974). Effects of papaverine on smooth muscle and their mechanisms. Pharmacol. Res. Commun., 6, 97-115.
10. FURCHGOTT, R.F. & ZAWADZKI, J.V. (1980). The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature, 288, 373-376.
11. 1-adrenoceptors. Meth. Find. Exp. Clin. Pharmacol., 18, Suppl. B, 157.
12. HIEBLE, J.P., BYLUND, D.B., CLARKE, D.E., EIKENBURG, D.C., LANGER, S.Z., LEFKOWITZ, R.J., MINNEMAN, K.P. & RUFFOLO, R.R. (1995). International union of pharmacology X. Recommendation to nomenclature of a-adrenoceptors: consensus update. Pharmacol. Rev., 47, 267-270.
13. IRVINE, R.F., ANGGARD, E.E., LETCHER, A.J. & DOWNES, C.P. (1985). Metabolism of inositol 1,4,5-triphosphate and inositol 1,3,4-triphosphate in rat parotid glands. Biochem. J., 229, 505-511.
14. IVORRA, M.D., LE BEC, A. & LUGNIER, C. (1992a). Characterization of membrane-bound cyclic nucleotide phosphodiesterases from bovine aortic smooth muscle. J. Cardiovasc. Pharmacol., 19, 532-540.
15. 1-adrenoceptor and benzothiazepine binding site at the calcium channel. Br. J. Pharmacol., 106, 387-394.
16. 1A-adrenoceptor mediating the contractile response of rat aorta to noradrenaline. Br J. Pharmacol., 115, 981-986.
17. KERAVIS, T.M., WELLS, J.N. & HARDMAN, J.G. (1980). Cyclic nucleotide phosphodiesterase activities from pig coronary arteries; lack of interconvertibility of major forms. Biochem. Biophys. Acta. 613, 116-129.
18. 1D-adrenoceptor antagonist isolated from Fissitigma glaucescens. Br. J. Pharmacol., 112, 1174-1180.
19. LACROIX, P., LINEE, P. & FOREST, M.C. (1991). Diproteverine (BRL 40015): a new type of calcium antagonist with potential antianginal properties. Eur. J. Pharmacol., 192, 317-327.
20. LINDGREN, S., RASCON, A., DEGERMAN, E., BELFRAGE, P., MANGIANELLO, V. & ANDERSSON, K.E. (1990). Identification of the cyclic GMP-inhibited low Km cyclic AMP phosphodiesterase in rat aortic smooth muscle. Eur. J. Pharmacol., 183, 806-812.
21. LUGNIER, C., DORE, J.C. & VIEL, C. (1994). Inhibition of cyclic nucleotide phosphodiesterases from bovine aorta by papaverine analogues: a multivariate approach. J. Med. Chem., 29, 723-734.
22. LUGNIER, C., SCHOEFFTER, P., LE BEC, A., STROUTHOU, E. & STOCLET, J.C. (1986). Selective inhibition of cyclic nucleotide phosphodiesterases of human, bovine and rat aorta. Biochem. Pharmacol., 35, 1743-1751.
23. 1A-adrenoceptor subtype. Br. J. Pharmacol., 119, 1563-1568.
24. MUNSON, P.J. & RODBARD, D. (1980). LIGAND: A versatile computerized approach for characterization of ligand-binding systems. Anal. Biochem., 107, 220-239.
25. NOGUERA, M.A. & D'OCON, P. (1992). Different and common intracellular calcium-stores mobilized by noradrenaline and caffeine in vascular smooth muscle. Naunyn-Schiemdeberg's Arch. Pharmacol., 343, 333-341.
26. 1B-adrenoceptor subtypes in rat brain cortical membranes. Eur. J. Pharmacol.-Mol. Pharmacol. Sec., 266, 301-308.
27. 3H]-nitrendipine binding sites. J. Cardiovasc. Pharmacol., 12, (Suppl4) S102-S103.
28. TASHIRO, N. & TOMITA, A. (1970). The effects of papaverine on the electrical and mechanical activity of the guinea-pig taenia coli. Br. J. Pharmacol., 39, 608-618.