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Volumn 7, Issue 3, 2008, Pages 126-136

Hyperhomocysteinemia and lower extremity wounds

Author keywords

Folic acid; Foot ulcer; Hyperhomocysteinemia; Leg ulcer; Venous insufficiency; Vitamin B12

Indexed keywords

HOMOCYSTEINE;

EID: 49749131184     PISSN: 15347346     EISSN: 15526941     Source Type: Journal    
DOI: 10.1177/1534734608322490     Document Type: Review
Times cited : (14)

References (108)
  • 1
    • 0029066299 scopus 로고
    • A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes
    • Boushey CJ, Beresford SA, Omenn GS, Motulsky AG A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA. 1995 ; 274 ; 1049-1057.
    • (1995) JAMA , vol.274 , pp. 1049-1057
    • Boushey, C.J.1    Beresford, S.A.2    Omenn, G.S.3    Motulsky, A.G.4
  • 2
    • 1842331509 scopus 로고    scopus 로고
    • Plasma homocysteine as a risk factor for vascular disease: The European Concerted Action Project
    • Graham IM, Daly LE, Refsum HM, et al. Plasma homocysteine as a risk factor for vascular disease: the European Concerted Action Project. JAMA. 1997 ; 277: 1775-1781.
    • (1997) JAMA , vol.277 , pp. 1775-1781
    • Graham, I.M.1    Le, D.2    Refsum, H.M.3
  • 3
    • 0037164375 scopus 로고    scopus 로고
    • Homocysteine and cardiovascular disease: Evidence of causality from a meta-analysis
    • Wald DS, Law M., Morris JK Homocysteine and cardiovascular disease: evidence of causality from a meta-analysis. BMJ. 2002 ; 325 ; 1202-1209.
    • (2002) BMJ , vol.325 , pp. 1202-1209
    • Wald, D.S.1    Law, M.2    Morris, J.K.3
  • 4
    • 0041695231 scopus 로고    scopus 로고
    • Emerging risk factors for atherosclerotic vascular disease: A critical review of the evidence
    • Hackam DG, Anand SS Emerging risk factors for atherosclerotic vascular disease: a critical review of the evidence. JAMA. 2003 ; 290: 932-940.
    • (2003) JAMA , vol.290 , pp. 932-940
    • Hackam, D.G.1    Anand, S.S.2
  • 5
    • 0014545138 scopus 로고
    • Vascular pathology of homocysteinemia: Implications for pathogenesis of atherosclerosis
    • McCully KS Vascular pathology of homocysteinemia: implications for pathogenesis of atherosclerosis. Am J Pathol. 1969 ; 56: 111-128.
    • (1969) Am J Pathol , vol.56 , pp. 111-128
    • McCully, K.S.1
  • 8
    • 0033818441 scopus 로고    scopus 로고
    • Pathways and regulation of homocysteine metabolism in mammals
    • Finklestein JD Pathways and regulation of homocysteine metabolism in mammals. Semin Thromb Hemost. 2000 ; 26: 219-225.
    • (2000) Semin Thromb Hemost , vol.26 , pp. 219-225
    • Finklestein, J.D.1
  • 9
    • 0032771346 scopus 로고    scopus 로고
    • Homocysteine metabolism
    • Selhub J. Homocysteine metabolism. Annu Rev Nutr. 1999 ; 19: 217-246.
    • (1999) Annu Rev Nutr , vol.19 , pp. 217-246
    • Selhub, J.1
  • 11
    • 33645666453 scopus 로고    scopus 로고
    • Homocysteine metabolism, hyperhomocysteinemia and vascular disease: An overview
    • Castro R., Rivera U., Blom HJ, et al. Homocysteine metabolism, hyperhomocysteinemia and vascular disease: an overview. J Inherit Metab Dis. 2006 ; 29: 3-20.
    • (2006) J Inherit Metab Dis , vol.29 , pp. 3-20
    • Castro, R.1    Rivera, U.2    Blom, H.J.3
  • 12
    • 0031747255 scopus 로고    scopus 로고
    • Hyperhomocysteinaemia in terms of steady-state kinetics
    • Refsum H., Guttormsen AB, Fiskerstrand T., Ueland PM Hyperhomocysteinaemia in terms of steady-state kinetics. Eur J Pediatr. 1998 ; 157: S45 - S49.
    • (1998) Eur J Pediatr , vol.157
    • Refsum, H.1    Ab, G.2    Fiskerstrand, T.3    Ueland, P.M.4
  • 13
    • 0032915831 scopus 로고    scopus 로고
    • Cystathionine beta-synthase mutations in homocystinuria
    • Kraus JP, Janosík M., Kozich V., et al. Cystathionine beta-synthase mutations in homocystinuria. Hum Mutat. 1999 ; 13: 362-375.
    • (1999) Hum Mutat , vol.13 , pp. 362-375
    • Kraus, J.P.1    Janosík, M.2    Kozich, V.3
  • 14
    • 0028487161 scopus 로고
    • Human methylenetetrahydrofolate reductase: Isolation of cDNA, mapping and mutation identification
    • Goyette P., Sumner JS, Milos R., et al. Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification. Nat Genet. 1994 ; 7: 195-200.
    • (1994) Nat Genet , vol.7 , pp. 195-200
    • Goyette, P.1    Sumner, J.S.2    Milos, R.3
  • 15
    • 0034435074 scopus 로고    scopus 로고
    • Genetic determinants of hyperhomocysteinaemia: The roles of cystathionine beta-synthase and 5,10-methylenetetrahydrofolate reductase
    • Blom HJ Genetic determinants of hyperhomocysteinaemia: the roles of cystathionine beta-synthase and 5,10-methylenetetrahydrofolate reductase. Eur J Pediatr. 2000 ; 159: S208 - S212.
    • (2000) Eur J Pediatr , vol.159
    • Blom, H.J.1
  • 16
    • 18444365916 scopus 로고    scopus 로고
    • Hyperhomocysteinemia due to methionine synthase deficiency, cblG: Structure of the MTR gene, genotype diversity, and recognition of a common mutation, P1173L
    • Watkins D., Ru M., Hwang HY, et al. Hyperhomocysteinemia due to methionine synthase deficiency, cblG: structure of the MTR gene, genotype diversity, and recognition of a common mutation, P1173L. Am J Hum Genet. 2002 ; 71: 143-153.
    • (2002) Am J Hum Genet , vol.71 , pp. 143-153
    • Watkins, D.1    Ru, M.2    Hwang, H.Y.3
  • 17
    • 0023696435 scopus 로고
    • Intermediate homocysteinemia: A thermolabile variant of methylenetetrahydrofolate reductase
    • Kang SS, Zhou J., Wong PW, Kowalisyn J., Strokosch G. Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase. Am J Hum Genet. 1988 ; 43: 414-421.
    • (1988) Am J Hum Genet , vol.43 , pp. 414-421
    • Kang, S.S.1    Zhou, J.2    Wong, P.W.3    Kowalisyn, J.4    Strokosch, G.5
  • 18
    • 0037163849 scopus 로고    scopus 로고
    • MTHFR 677C→T polymorphism and risk of coronary heart disease: A meta-analysis
    • Klerk M., Verhoef P., Clarke R., et al. MTHFR 677C→T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA. 2002 ; 288: 2023-2031.
    • (2002) JAMA , vol.288 , pp. 2023-2031
    • Klerk, M.1    Verhoef, P.2    Clarke, R.3
  • 19
    • 0027392610 scopus 로고
    • Vitamin B-12, vitamin B-6, and folate nutritional status in men with hyperhomocysteinemia
    • Ubbink JB, Vermaak WJ, van der Merwe A., Becker PJ Vitamin B-12, vitamin B-6, and folate nutritional status in men with hyperhomocysteinemia. Am J Clin Nutr. 1993 ; 57: 47-53.
    • (1993) Am J Clin Nutr , vol.57 , pp. 47-53
    • Ubbink, J.B.1    Vermaak, W.J.2    Van Der Merwe, A.3    Becker, P.J.4
  • 20
    • 0033533505 scopus 로고    scopus 로고
    • Serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey (1991-1994): Population reference ranges and contribution of vitamin status to high serum concentrations
    • Selhub J., Jacques PF, Rosenberg IH, et al. Serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey (1991-1994): population reference ranges and contribution of vitamin status to high serum concentrations. Ann Intern Med. 1999 ; 131: 331-339.
    • (1999) Ann Intern Med , vol.131 , pp. 331-339
    • Selhub, J.1    Jacques, P.F.2    Rosenberg, I.H.3
  • 21
    • 0036999173 scopus 로고    scopus 로고
    • Vitamins, homocysteine and cardiovascular risk
    • Graham IM, O'Callaghan P. Vitamins, homocysteine and cardiovascular risk. Cardiovasc Drugs Ther. 2002 ; 16: 383-389.
    • (2002) Cardiovasc Drugs Ther , vol.16 , pp. 383-389
    • Graham, I.M.1    O'Callaghan, P.2
  • 22
    • 0027382008 scopus 로고
    • Vitamin status and intake as primary determinants of homocysteinemia in an elderly population
    • Selhub J., Jacques PF, Wilson PWF, Rush D., Rosenberg IH Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA. 1993 ; 270: 2693-2698.
    • (1993) JAMA , vol.270 , pp. 2693-2698
    • Selhub, J.1    Jacques, P.F.2    Pwf, W.3    Rush, D.4    Rosenberg, I.H.5
  • 23
    • 0032984676 scopus 로고    scopus 로고
    • Hyperhomocysteinaemia in chronic renal disease
    • Bostom AG, Culleton BF Hyperhomocysteinaemia in chronic renal disease. J Am Soc Nephrol. 1999 ; 10: 891-900.
    • (1999) J Am Soc Nephrol , vol.10 , pp. 891-900
    • Bostom, A.G.1    Culleton, B.F.2
  • 24
    • 0033028279 scopus 로고    scopus 로고
    • Plasma total homocysteine and cysteine in relation to glomerular filtration rate in diabetes mellitus
    • Wollesen F., Brattström L., Refsum H., Ueland PM, Berglund L., Berne C. Plasma total homocysteine and cysteine in relation to glomerular filtration rate in diabetes mellitus. Kidney Int. 1999 ; 55: 1028-1035.
    • (1999) Kidney Int , vol.55 , pp. 1028-1035
    • Wollesen, F.1    Brattström, L.2    Refsum, H.3    Ueland, P.M.4    Berglund, L.5    Berne, C.6
  • 25
    • 0031934299 scopus 로고    scopus 로고
    • Plasma total homocysteine levels in hyperthyroid and hypothyroid patients
    • Nedrebø BG, Ericsson UB, Nygård O., et al. Plasma total homocysteine levels in hyperthyroid and hypothyroid patients. Metabolism. 1998 ; 47: 89-93.
    • (1998) Metabolism , vol.47 , pp. 89-93
    • Nedrebø, B.G.1    Ericsson, U.B.2    Nygård, O.3
  • 26
    • 0012355336 scopus 로고    scopus 로고
    • Diabetes mellitus and hyperhomocysteinemia
    • van Guldener C., Stehouwer CD Diabetes mellitus and hyperhomocysteinemia. Semin Vasc Med. 2002 ; 2: 87-95.
    • (2002) Semin Vasc Med , vol.2 , pp. 87-95
    • Van Guldener, C.1    Stehouwer, C.D.2
  • 27
    • 45549104666 scopus 로고    scopus 로고
    • 5,10-Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and the risk of acute lymphoblastic leukemia (ALL) in Filipino children
    • Alcasabas P., Ravindranath Y., Goyette G., et al. 5,10- Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and the risk of acute lymphoblastic leukemia (ALL) in Filipino children. Pediatr Blood Cancer. 2008 ; 51: 178-182.
    • (2008) Pediatr Blood Cancer , vol.51 , pp. 178-182
    • Alcasabas, P.1    Ravindranath, Y.2    Goyette, G.3
  • 28
    • 9144225352 scopus 로고    scopus 로고
    • Facts and recommendations about total homocysteine determinations: An expert opinion
    • Refsum H., Smith AD, Ueland PM, et al. Facts and recommendations about total homocysteine determinations: an expert opinion. Clin Chem. 2004 ; 50: 3-32.
    • (2004) Clin Chem , vol.50 , pp. 3-32
    • Refsum, H.1    Smith, A.D.2    Ueland, P.M.3
  • 29
    • 0027241856 scopus 로고
    • The pathogenesis of atherosclerosis: A perspective for the 1990s
    • Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993 ; 362: 801-809.
    • (1993) Nature , vol.362 , pp. 801-809
    • Ross, R.1
  • 30
    • 0017197285 scopus 로고
    • Homocysteine-induced arteriosclerosis. the role of endothelial cell injury and platelet response in its genesis
    • Harker LA, Ross R., Slichter SJ, Scott CR Homocysteine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis. J Clin Invest. 1976 ; 58: 731-741.
    • (1976) J Clin Invest. , vol.58 , pp. 731-741
    • Harker, L.A.1    Ross, R.2    Slichter, S.J.3    Scott, C.R.4
  • 31
    • 0018858624 scopus 로고
    • Homocysteine-induced endothelial cell injury in vitro: A model for the study of vascular injury
    • Wall RT, Harlan JM, Harker LA, Striker GE Homocysteine-induced endothelial cell injury in vitro: a model for the study of vascular injury. Thromb Res. 1980 ; 18: 113-121.
    • (1980) Thromb Res , vol.18 , pp. 113-121
    • Wall, R.T.1    Harlan, J.M.2    Harker, L.A.3    Striker, G.E.4
  • 32
    • 0342624737 scopus 로고    scopus 로고
    • Homocysteine mediated endothelial cell toxicity and its amelioration
    • Blundell G., Jones BG, Rose FA, Tudball N. Homocysteine mediated endothelial cell toxicity and its amelioration. Atherosclerosis. 1996 ; 122: 163-172.
    • (1996) Atherosclerosis , vol.122 , pp. 163-172
    • Blundell, G.1    Jones, B.G.2    Rose, F.A.3    Tudball, N.4
  • 33
    • 0031018333 scopus 로고    scopus 로고
    • Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans
    • Tawakol A., Omland T., Gerhard M., Wu JT, Creager MA Hyperhomocyst(e) inemia is associated with impaired endothelium-dependent vasodilation in humans. Circulation. 1997 ; 95: 1119-1121.
    • (1997) Circulation , vol.95 , pp. 1119-1121
    • Tawakol, A.1    Omland, T.2    Gerhard, M.3    Wu, J.T.4    Ma, C.5
  • 34
    • 0027755295 scopus 로고
    • Effects of homocysteine and related compounds on prostacyclin production by cultured human vascular endothelial cells
    • Wang J., Dudman NPB, Wilcken DE Effects of homocysteine and related compounds on prostacyclin production by cultured human vascular endothelial cells. Thromb Haemost. 1993 ; 70: 1047-1052.
    • (1993) Thromb Haemost , vol.70 , pp. 1047-1052
    • Wang, J.1    Npb, D.2    De, W.3
  • 35
    • 14044276314 scopus 로고    scopus 로고
    • Mechanisms of increased vascular oxidant stress in hyperhomocysteinemia and its impact on endothelial function
    • Weiss N. Mechanisms of increased vascular oxidant stress in hyperhomocysteinemia and its impact on endothelial function. Curr Drug Metab. 2005 ; 6: 27-36.
    • (2005) Curr Drug Metab , vol.6 , pp. 27-36
    • Weiss, N.1
  • 36
    • 0027531427 scopus 로고
    • Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen
    • Stamler JS, Osborne JA, Jaraki O., et al. Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. J Clin Invest. 1993 ; 91: 308-318.
    • (1993) J Clin Invest , vol.91 , pp. 308-318
    • Stamler, J.S.1    Osborne, J.A.2    Jaraki, O.3
  • 37
    • 1842411860 scopus 로고    scopus 로고
    • Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase
    • Upchurch GR Jr, Welch GN, Fabian AJ, et al. Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J Biol Chem. 1997 ; 272: 17012-17017.
    • (1997) J Biol Chem , vol.272 , pp. 17012-17017
    • Upchurch Jr., G.R.1    Welch, G.N.2    Fabian, A.J.3
  • 38
    • 0030188563 scopus 로고    scopus 로고
    • The oxidant stress of hyperhomocysteinemia
    • Loscalzo J. The oxidant stress of hyperhomocysteinemia. J Clin Invest. 1996 ; 98: 5-7.
    • (1996) J Clin Invest , vol.98 , pp. 5-7
    • Loscalzo, J.1
  • 39
    • 0023094333 scopus 로고
    • Oxidation of low-density lipoprotein by thiol compounds leads to its recognition by the acetyl LDL receptor
    • Parthasarathy S. Oxidation of low-density lipoprotein by thiol compounds leads to its recognition by the acetyl LDL receptor. Biochem Biophys Acta. 1987 ; 917: 337-340.
    • (1987) Biochem Biophys Acta , vol.917 , pp. 337-340
    • Parthasarathy, S.1
  • 40
    • 35448972133 scopus 로고    scopus 로고
    • Vascular oxidant stress and inflammation in hyperhomocysteinemia
    • Papatheodorou L., Weiss N. Vascular oxidant stress and inflammation in hyperhomocysteinemia. Antioxid Redox Signal. 2007 ; 9: 1941-1958.
    • (2007) Antioxid Redox Signal , vol.9 , pp. 1941-1958
    • Papatheodorou, L.1    Weiss, N.2
  • 41
    • 33746543557 scopus 로고    scopus 로고
    • Mitochondrial mechanism of microvascular endothelial cells apoptosis in hyperhomocysteinemia
    • Tyagi N., Ovechkin AV, Lominadze D., Moshal KS, Tyagi SC Mitochondrial mechanism of microvascular endothelial cells apoptosis in hyperhomocysteinemia. J Cell Biochem. 2006 ; 98: 1150-1162.
    • (2006) J Cell Biochem , vol.98 , pp. 1150-1162
    • Tyagi, N.1    Ovechkin, A.V.2    Lominadze, D.3    Moshal, K.S.4    Tyagi, S.C.5
  • 42
    • 0036350569 scopus 로고    scopus 로고
    • Homocysteine decreases endothelium-dependent vasorelaxation in porcine arteries
    • Chen C., Conklin BS, Ren Z., Zhong DS Homocysteine decreases endothelium-dependent vasorelaxation in porcine arteries. J Surg Res. 2002 ; 102: 22-30.
    • (2002) J Surg Res , vol.102 , pp. 22-30
    • Chen, C.1    Conklin, B.S.2    Ren, Z.3    Zhong, D.S.4
  • 43
    • 34047159358 scopus 로고    scopus 로고
    • Acute hyperhomocysteinemia induces microvascular and macrovascular endothelial dysfunction
    • Abahji TN, Nill L., Ide N., Keller C., Hoffmann U., Weiss N. Acute hyperhomocysteinemia induces microvascular and macrovascular endothelial dysfunction. Arch Med Res. 2007 ; 38: 411-416.
    • (2007) Arch Med Res , vol.38 , pp. 411-416
    • Abahji, T.N.1    Nill, L.2    Ide, N.3    Keller, C.4    Hoffmann, U.5    Weiss, N.6
  • 44
    • 38449095878 scopus 로고    scopus 로고
    • The role of vascular smooth muscle cells on the pathogenesis of atherosclerosis
    • Rudijanto A. The role of vascular smooth muscle cells on the pathogenesis of atherosclerosis. Acta Med Indones. 2007 ; 39: 86-93.
    • (2007) Acta Med Indones , vol.39 , pp. 86-93
    • Rudijanto, A.1
  • 45
    • 0028298171 scopus 로고
    • Promotion of vascular smooth muscle cell growth by homocysteine: A link to athersoclerosis
    • Tsai JC, Perrella MA, Yoshizumi M., et al. Promotion of vascular smooth muscle cell growth by homocysteine: a link to athersoclerosis. Proc Natl Acad Sci U S A. 1994 ; 91: 6369-6373.
    • (1994) Proc Natl Acad Sci U S a , vol.91 , pp. 6369-6373
    • Tsai, J.C.1    Ma, P.2    Yoshizumi, M.3
  • 46
    • 0032786116 scopus 로고    scopus 로고
    • Folic acid inhibits homocytsiene-induced proliferation of human arterial smooth muscle cells
    • Carmody BJ, Arora S., Avena R., Cosby K., Sidawy N. Folic acid inhibits homocytsiene-induced proliferation of human arterial smooth muscle cells. J Vasc Surg. 1999 ; 30: 1121-1128.
    • (1999) J Vasc Surg , vol.30 , pp. 1121-1128
    • Carmody, B.J.1    Arora, S.2    Avena, R.3    Cosby, K.4    Sidawy, N.5
  • 47
    • 0033980003 scopus 로고    scopus 로고
    • Effects of homocysteine on smooth muscle cell proliferation in both cell culture and artery perfusion culture models
    • Chen C., Halkos ME, Surowiec SM, Conklin BS, Lin PH, Lumsden AB Effects of homocysteine on smooth muscle cell proliferation in both cell culture and artery perfusion culture models. J Surg Res. 2000 ; 88: 26-33.
    • (2000) J Surg Res , vol.88 , pp. 26-33
    • Chen, C.1    Halkos, M.E.2    Surowiec, S.M.3    Conklin, B.S.4    Ph, L.5    Ab, L.6
  • 49
    • 29244484401 scopus 로고    scopus 로고
    • Homocysteine rapidly increases matrix metalloproteinase-2 expression and activity in cultured human vascular smooth muscle cells. Role of phosphatidyl inositol 3-kinase and mitogen activated protein kinase pathways
    • Doronzo G., Russo I., Mattiello L., Trovati M., Anfossi G. Homocysteine rapidly increases matrix metalloproteinase-2 expression and activity in cultured human vascular smooth muscle cells. Role of phosphatidyl inositol 3-kinase and mitogen activated protein kinase pathways. Thromb Haemost. 2005 ; 94: 1285-1293.
    • (2005) Thromb Haemost. , vol.94 , pp. 1285-1293
    • Doronzo, G.1    Russo, I.2    Mattiello, L.3    Trovati, M.4    Anfossi, G.5
  • 50
    • 17344368557 scopus 로고    scopus 로고
    • Homocysteine as a risk factor for vascular disease. Enhanced collagen production and accumulation by smooth muscle cells
    • Majors A., Ehrhart LA, Pezacka EH Homocysteine as a risk factor for vascular disease. Enhanced collagen production and accumulation by smooth muscle cells. Arterioscler Thromb Vasc Biol. 1997 ; 17: 2074-2081.
    • (1997) Arterioscler Thromb Vasc Biol. , vol.17 , pp. 2074-2081
    • Majors, A.1    Ehrhart, L.A.2    Pezacka, E.H.3
  • 51
    • 11144344917 scopus 로고    scopus 로고
    • Homocysteine and the production of collagens, proliferation and apoptosis in human arterial smooth muscle cells
    • Rasmussen LM, Hansen PR, Ledet T. Homocysteine and the production of collagens, proliferation and apoptosis in human arterial smooth muscle cells. APMIS. 2004 ; 112: 598-604.
    • (2004) APMIS , vol.112 , pp. 598-604
    • Rasmussen, L.M.1    Hansen, P.R.2    Ledet, T.3
  • 52
    • 0029921114 scopus 로고    scopus 로고
    • Hyperhomocysteinaemia as a risk factor for deep-vein thrombosis
    • den Heijer M., Koster T., Blom HJ, et al. Hyperhomocysteinaemia as a risk factor for deep-vein thrombosis. N Engl J Med. 1996 ; 334: 759-762.
    • (1996) N Engl J Med , vol.334 , pp. 759-762
    • Den Heijer, M.1    Koster, T.2    Blom, H.J.3
  • 53
    • 0030971062 scopus 로고    scopus 로고
    • Homocysteine and thrombotic disease
    • D'Angelo A., Selhub J. Homocysteine and thrombotic disease. Blood. 1997 ; 90: 1-11.
    • (1997) Blood , vol.90 , pp. 1-11
    • D'Angelo, A.1    Selhub, J.2
  • 54
    • 0020055946 scopus 로고
    • Effect of homocysteine and homocystine on platelet and vascular arachidonic acid metabolism
    • Graeber JE, Slott JH, Ulane RE, Schulman JD, Stuart MJ Effect of homocysteine and homocystine on platelet and vascular arachidonic acid metabolism. Pediatr Res. 1982 ; 16: 490-493.
    • (1982) Pediatr Res , vol.16 , pp. 490-493
    • Graeber, J.E.1    Slott, J.H.2    Ulane, R.E.3    Schulman, J.D.4    Stuart, M.J.5
  • 55
    • 0027247803 scopus 로고
    • Abnormally high thromboxane biosynthesis in homozygous homocystinuria. Evidence for platelet involvement and probucolsensitive mechanism
    • Di Minno G., Davì G., Margaglione M., et al. Abnormally high thromboxane biosynthesis in homozygous homocystinuria. Evidence for platelet involvement and probucolsensitive mechanism. J Clin Invest. 1993 ; 92: 1400-1408.
    • (1993) J Clin Invest. , vol.92 , pp. 1400-1408
    • Di Minno, G.1    Davì, G.2    Margaglione, M.3
  • 57
    • 0029928653 scopus 로고    scopus 로고
    • Pro-thrombotic effects of a folic acid deficient diet in rat platelets and macrophages related to elevated homocysteine and decreased n-3 polyunsaturated fatty acids
    • Durand P., Prost M., Blache D. Pro-thrombotic effects of a folic acid deficient diet in rat platelets and macrophages related to elevated homocysteine and decreased n-3 polyunsaturated fatty acids. Atherosclerosis. 1996 ; 121: 231-243.
    • (1996) Atherosclerosis , vol.121 , pp. 231-243
    • Durand, P.1    Prost, M.2    Blache, D.3
  • 58
    • 2942549553 scopus 로고    scopus 로고
    • Altered platelet reactivity in peripheral vascular disease complicated with elevated plasma homocysteine levels
    • Riba R., Nicolaou A., Troxler M., Homer-Vaniasinkam S., Naseem KM Altered platelet reactivity in peripheral vascular disease complicated with elevated plasma homocysteine levels. Atherosclerosis. 2004 ; 175: 69-75.
    • (2004) Atherosclerosis , vol.175 , pp. 69-75
    • Riba, R.1    Nicolaou, A.2    Troxler, M.3    Homer-Vaniasinkam, S.4    Naseem, K.M.5
  • 59
    • 0027250615 scopus 로고
    • Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells
    • Fryer RH, Wilson BD, Gubler DB, Fitzgerald LJ, Rodgers GM Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells. Arterioscler Thromb. 1993 ; 13: 1327-1333.
    • (1993) Arterioscler Thromb , vol.13 , pp. 1327-1333
    • Fryer, R.H.1    Wilson, B.D.2    Gubler, D.B.3    Fitzgerald, L.J.4    Rodgers, G.M.5
  • 60
    • 0027319970 scopus 로고
    • Omocysteine, a thrombogenic agent, suppresses anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells
    • Nishinaga M., Ozawa T., Shimada K. Omocysteine, a thrombogenic agent, suppresses anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells. J Clin Invest. 1993 ; 92: 1381-1386.
    • (1993) J Clin Invest , vol.92 , pp. 1381-1386
    • Nishinaga, M.1    Ozawa, T.2    Shimada, K.3
  • 61
    • 0014434483 scopus 로고
    • Activation of Hageman factor by L-homocystine
    • Ratnoff OD Activation of Hageman factor by L-homocystine. Science. 1968 ; 162: 1007-1009.
    • (1968) Science , vol.162 , pp. 1007-1009
    • Ratnoff, O.D.1
  • 62
    • 0022472013 scopus 로고
    • Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator
    • Rodgers GM, Kane WH Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator. J Clin Invest. 1986 ; 77: 1909-1016.
    • (1986) J Clin Invest , vol.77 , pp. 1909-1016
    • Rodgers, G.M.1    Kane, W.H.2
  • 63
    • 0025190042 scopus 로고
    • Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells
    • Rodgers GM, Conn MT Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells. Blood. 1990 ; 75: 895-901.
    • (1990) Blood , vol.75 , pp. 895-901
    • Rodgers, G.M.1    Conn, M.T.2
  • 64
    • 0026345948 scopus 로고
    • Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine
    • Lentz SR, Sadler JE Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine. J Clin Invest. 1991 ; 88: 1906-1914.
    • (1991) J Clin Invest , vol.88 , pp. 1906-1914
    • Lentz, S.R.1    Sadler, J.E.2
  • 65
    • 36148996511 scopus 로고    scopus 로고
    • Thrombin-thrombomodulin connects coagulation and fibrinolysis: More than an in vitro phenomenon
    • Binette TM, Taylor FB Jr, Peer G., Bajzar L. Thrombin-thrombomodulin connects coagulation and fibrinolysis: more than an in vitro phenomenon. Blood. 2007 ; 110: 3168-3175.
    • (2007) Blood , vol.110 , pp. 3168-3175
    • Binette, T.M.1    Taylor Jr., F.B.2    Peer, G.3    Bajzar, L.4
  • 66
    • 0027288252 scopus 로고
    • Homocysteine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor
    • Hajjar KA Homocysteine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor. J Clin Invest. 1993 ; 91: 2873-2879.
    • (1993) J Clin Invest , vol.91 , pp. 2873-2879
    • Hajjar, K.A.1
  • 67
    • 0036847628 scopus 로고    scopus 로고
    • Association between increased homocysteine levels and impaired fibrinolytic potential: Potential mechanism for cardiovascular risk
    • Tofler GH, D'Agostino RB, Jacques PF, et al. Association between increased homocysteine levels and impaired fibrinolytic potential: potential mechanism for cardiovascular risk. Thromb Haemost. 2002 ; 88: 799-804.
    • (2002) Thromb Haemost , vol.88 , pp. 799-804
    • Tofler, G.H.1    D'Agostino, R.B.2    Jacques, P.F.3
  • 68
    • 0141450396 scopus 로고    scopus 로고
    • Elevated plasma homocysteine leads to alterations in fibrin clot structure and stability: Implications for the mechanism of thrombosis in hyperhomocysteinemia
    • Sauls DL, Wolberg AS, Hoffman M. Elevated plasma homocysteine leads to alterations in fibrin clot structure and stability: implications for the mechanism of thrombosis in hyperhomocysteinemia. J Thromb Haemost. 2003 ; 1: 300-306.
    • (2003) J Thromb Haemost , vol.1 , pp. 300-306
    • Sauls, D.L.1    Wolberg, A.S.2    Hoffman, M.3
  • 69
    • 34247374843 scopus 로고    scopus 로고
    • Pro-thrombotic and pro-oxidant effects of diet-induced hyperhomocysteinemia
    • Sauls DL, Arnold EK, Bell CW, Allen JC, Hoffman M. Pro-thrombotic and pro-oxidant effects of diet-induced hyperhomocysteinemia. Thromb Res. 2007 ; 120: 117-126.
    • (2007) Thromb Res , vol.120 , pp. 117-126
    • Sauls, D.L.1    Arnold, E.K.2    Bell, C.W.3    Allen, J.C.4    Hoffman, M.5
  • 70
    • 33646774995 scopus 로고    scopus 로고
    • Rntoft TF. Folate deficiency induced hyperhomocysteinemia changes the expression of thrombosis-related genes
    • Ebbesen LS, Olesen SH, Kruhøffer M., Ingerslev J., rntoft TF. Folate deficiency induced hyperhomocysteinemia changes the expression of thrombosis-related genes. Blood Coagul Fibrinolysis. 2006 ; 17: 293-301.
    • (2006) Blood Coagul Fibrinolysis , vol.17 , pp. 293-301
    • Ebbesen, L.S.1    Sh, O.2    Kruhøffer, M.3    Ingerslev, J.4
  • 71
    • 20944441114 scopus 로고    scopus 로고
    • Venous ulcer: Epidemiology, physiopathology, diagnosis and treatment
    • Abbade LP, Lastoria S. Venous ulcer: epidemiology, physiopathology, diagnosis and treatment. Int J Dermatol. 2005 ; 44: 449-456.
    • (2005) Int J Dermatol , vol.44 , pp. 449-456
    • Abbade, L.P.1    Lastoria, S.2
  • 72
    • 34548045763 scopus 로고    scopus 로고
    • Prevalence of hyperhomocysteinemia in vascular disease: Comparative study of thrombotic venous disease vis-a-vis occlusive arterial disease
    • Bhargava S., Parakh R., Manocha A., Ali A., Srivastava LM Prevalence of hyperhomocysteinemia in vascular disease: comparative study of thrombotic venous disease vis-a-vis occlusive arterial disease. Vascular. 2007 ; 15: 149-153.
    • (2007) Vascular , vol.15 , pp. 149-153
    • Bhargava, S.1    Parakh, R.2    Manocha, A.3    Ali, A.4    Srivastava, L.M.5
  • 73
    • 0028853921 scopus 로고
    • Prevalence of moderate hyperhomocysteinemia in patients with early-onset venous and arterial occlusive disease
    • Fermo I., Vigano'D'Angelo S., Paroni R., Mazzola G., Calori G., D'Angelo A. Prevalence of moderate hyperhomocysteinemia in patients with early-onset venous and arterial occlusive disease. Ann Intern Med. 1995 ; 123: 747-753.
    • (1995) Ann Intern Med , vol.123 , pp. 747-753
    • Fermo, I.1    Vigano'D'Angelo, S.2    Paroni, R.3    Mazzola, G.4    Calori, G.5    D'Angelo, A.6
  • 74
    • 0345599881 scopus 로고    scopus 로고
    • Leg ulceration as a long-term complication of deep vein thrombosis
    • Walker N., Rodgers A., Birchall N., Norton R., MacMahon S. Leg ulceration as a long-term complication of deep vein thrombosis. J Vasc Surg. 2003 ; 38: 1331-1335.
    • (2003) J Vasc Surg , vol.38 , pp. 1331-1335
    • Walker, N.1    Rodgers, A.2    Birchall, N.3    Norton, R.4    MacMahon, S.5
  • 75
    • 0028864146 scopus 로고
    • Risk factors for chronic venous insufficiency: A dual case-control study
    • Scott TE, LaMorte WW, Gorin DR, Menzoian JO Risk factors for chronic venous insufficiency: a dual case-control study. J Vasc Surg. 1995 ; 22: 622-628.
    • (1995) J Vasc Surg , vol.22 , pp. 622-628
    • Scott, T.E.1    Lamorte, W.W.2    Gorin, D.R.3    Menzoian, J.O.4
  • 76
    • 84993736248 scopus 로고    scopus 로고
    • Hyperhomocysteinemia and venous thrombosis
    • Lee P., Prasad K. Hyperhomocysteinemia and venous thrombosis. Int J Low Extrem Wounds. 2002 ; 1: 4-12.
    • (2002) Int J Low Extrem Wounds , vol.1 , pp. 4-12
    • Lee, P.1    Prasad, K.2
  • 78
    • 0036241283 scopus 로고    scopus 로고
    • Recurrent leg ulcers in a young man with hyperhomocysteinemia, factor V Leiden and impaired fibrinolysis
    • Kolbach DN, Veraart JC, Hamulyák K., Spaapen LJ, Neumann HA Recurrent leg ulcers in a young man with hyperhomocysteinemia, factor V Leiden and impaired fibrinolysis. Acta Derm Venereol. 2002 ; 82: 52-54.
    • (2002) Acta Derm Venereol , vol.82 , pp. 52-54
    • Kolbach, D.N.1    Veraart, J.C.2    Hamulyák, K.3    Spaapen, L.J.4    Neumann, H.A.5
  • 79
    • 34347245278 scopus 로고    scopus 로고
    • Effect of homocysteine on nitric oxide production in coronary microvascular endothelial cells
    • Erol A., Cinar MG, Can C., Olukman M., Ulker S., Ko?ay. Effect of homocysteine on nitric oxide production in coronary microvascular endothelial cells. Endothelium. 2007 ; 14: 157-161.
    • (2007) Endothelium , vol.14 , pp. 157-161
    • Erol, A.1    Cinar, M.G.2    Can, C.3    Olukman, M.4    Ulker, S.5    Koay6
  • 81
    • 0036237064 scopus 로고    scopus 로고
    • Cutaneous necrosis revealing the coexistence of an antiphospholipid syndrome with acquired protein S deficiency, factor V Leiden and hyperhomocysteinemia
    • Combemale P., Amiral J., Estival JL, Dupin M., Chouvet B., Berruyer M. Cutaneous necrosis revealing the coexistence of an antiphospholipid syndrome with acquired protein S deficiency, factor V Leiden and hyperhomocysteinemia. Eur J Dermatol. 2002 ; 12: 278-282.
    • (2002) Eur J Dermatol , vol.12 , pp. 278-282
    • Combemale, P.1    Amiral, J.2    Estival, J.L.3    Dupin, M.4    Chouvet, B.5    Berruyer, M.6
  • 83
    • 0032999350 scopus 로고    scopus 로고
    • Predictors of early disease in the lower limbs
    • Dormandy J., Heeck L., Vig S. Predictors of early disease in the lower limbs. Semin Vasc Surg. 1999 ; 12: 109-117.
    • (1999) Semin Vasc Surg , vol.12 , pp. 109-117
    • Dormandy, J.1    Heeck, L.2    Vig, S.3
  • 84
    • 0024391453 scopus 로고
    • Prevalence of hyperhomocyst(e)inemia in patients with peripheral arterial occlusive disease
    • Malinow MR, Kang SS, Taylor LM, et al. Prevalence of hyperhomocyst(e) inemia in patients with peripheral arterial occlusive disease. Circulation. 1989 ; 79: 1180-1188.
    • (1989) Circulation , vol.79 , pp. 1180-1188
    • Malinow, M.R.1    Kang, S.S.2    Taylor, L.M.3
  • 85
    • 0026520124 scopus 로고
    • Hyperhomocyst(e)inaemia: An independent risk factor for intermittent claudication
    • Molgaard J., Malinow MR, Lassvik C., Holm AC, Upson B., Olsson G. Hyperhomocyst(e)inaemia: an independent risk factor for intermittent claudication. J Intern Med. 1992 ; 231: 273-279.
    • (1992) J Intern Med , vol.231 , pp. 273-279
    • Molgaard, J.1    Malinow, M.R.2    Lassvik, C.3    Holm, A.C.4    Upson, B.5    Olsson, G.6
  • 86
    • 0026036480 scopus 로고
    • The association of elevated plasma homocyst(e)ine with progression of symptomatic peripheral arterial disease
    • Taylor LM Jr, DeFrang RD, Harris EJ Jr, Porter JM The association of elevated plasma homocyst(e)ine with progression of symptomatic peripheral arterial disease. J Vasc Surg. 1991 ; 13: 128-136.
    • (1991) J Vasc Surg , vol.13 , pp. 128-136
    • Taylor Jr., L.M.1    Defrang, R.D.2    Harris Jr., E.J.3    Porter, J.M.4
  • 87
    • 36148974671 scopus 로고    scopus 로고
    • Homocysteine levels and peripheral arterial occlusive disease: A prospective cohort study and review of the literature
    • Asfar S., Safar HA Homocysteine levels and peripheral arterial occlusive disease: a prospective cohort study and review of the literature. J Cardiovasc Surg (Torino). 2007 ; 48: 601-605.
    • (2007) J Cardiovasc Surg (Torino) , vol.48 , pp. 601-605
    • Asfar, S.1    Safar, H.A.2
  • 89
    • 0027195080 scopus 로고
    • How can we best prolong life? Benefits of coronary risk factor reduction in non-diabetic and diabetic subjects
    • Yudkin JS How can we best prolong life? Benefits of coronary risk factor reduction in non-diabetic and diabetic subjects. BMJ. 1993 ; 306: 1313-1318.
    • (1993) BMJ , vol.306 , pp. 1313-1318
    • Yudkin, J.S.1
  • 90
    • 17744389242 scopus 로고    scopus 로고
    • Homocysteine concentrations and vascular complications in patients with type 2 diabetes
    • Rudy A., Kowalska I., Straczkowski M., Kinalska I. Homocysteine concentrations and vascular complications in patients with type 2 diabetes. Diabetes Metab. 2005 ; 31: 112-117.
    • (2005) Diabetes Metab , vol.31 , pp. 112-117
    • Rudy, A.1    Kowalska, I.2    Straczkowski, M.3    Kinalska, I.4
  • 91
    • 11844286368 scopus 로고    scopus 로고
    • Total homocysteine levels relation with chronic complications of diabetes, body composition, and other cardiovascular risk factors in a population of patients with diabetes mellitus type 2
    • de Luis DA, Fernandez N., Arranz ML, Aller R., Izaola O., Romero E. Total homocysteine levels relation with chronic complications of diabetes, body composition, and other cardiovascular risk factors in a population of patients with diabetes mellitus type 2. J Diabetes Complications. 2005 ; 19: 42-46.
    • (2005) J Diabetes Complications , vol.19 , pp. 42-46
    • De Luis, D.A.1    Fernandez, N.2    Arranz, M.L.3    Aller, R.4    Izaola, O.5    Romero, E.6
  • 92
    • 0036889421 scopus 로고    scopus 로고
    • Plasmatic homocysteine concentration and its relationship with complications associated to diabetes mellitus
    • Agulló-Ortuño MT, Albaladejo MD, Parra S., et al. Plasmatic homocysteine concentration and its relationship with complications associated to diabetes mellitus. Clin Chim Acta. 2002 ; 326: 105-112.
    • (2002) Clin Chim Acta , vol.326 , pp. 105-112
    • Agulló-Ortuño, M.T.1    Albaladejo, M.D.2    Parra, S.3
  • 93
    • 26944481612 scopus 로고    scopus 로고
    • Treatment of elevated homocysteine to restore normal wound healing: A possible relationship between homocysteine, nitric oxide, and wound repair
    • Boykin JV Jr, Baylis C., Allen SK, et al. Treatment of elevated homocysteine to restore normal wound healing: a possible relationship between homocysteine, nitric oxide, and wound repair. Adv Skin Wound Care. 2005 ; 18: 297-300.
    • (2005) Adv Skin Wound Care , vol.18 , pp. 297-300
    • Boykin Jr., J.V.1    Baylis, C.2    Allen, S.K.3
  • 94
    • 0033459381 scopus 로고    scopus 로고
    • Diabetes-impaired wound healing predicted by urinary nitrate assay: A preliminary, retrospective study
    • Boykin JV Jr, Shawler LG, Sommer VL, Crossland MC, Kalns JE Diabetes-impaired wound healing predicted by urinary nitrate assay: a preliminary, retrospective study. Wounds. 1999 ; 11: 62-69.
    • (1999) Wounds , vol.11 , pp. 62-69
    • Boykin Jr., J.V.1    Shawler, L.G.2    Sommer, V.L.3    Crossland, M.C.4    Kalns, J.E.5
  • 95
    • 0036338579 scopus 로고    scopus 로고
    • Regulation of eNOS in normal and diabetes-impaired skin repair: Implications for tissue regeneration
    • Stallmeyer B., Anhold M., Wetzler C., Kahlina K., Pfeilschifter J., Frank S. Regulation of eNOS in normal and diabetes-impaired skin repair: implications for tissue regeneration. Nitric Oxide. 2002 ; 6: 168-177.
    • (2002) Nitric Oxide , vol.6 , pp. 168-177
    • Stallmeyer, B.1    Anhold, M.2    Wetzler, C.3    Kahlina, K.4    Pfeilschifter, J.5    Frank, S.6
  • 96
    • 0031969785 scopus 로고    scopus 로고
    • Livedoid vasculopathy: What is it
    • Jorizzo JL Livedoid vasculopathy: what is it ? Arch Dermatol. 1998 ; 134: 491-493.
    • (1998) Arch Dermatol , vol.134 , pp. 491-493
    • Jorizzo, J.L.1
  • 97
    • 33751247618 scopus 로고    scopus 로고
    • Livedoid vasculopathy: What it is and how the patient should be evaluated and treated
    • Callen JP Livedoid vasculopathy: what it is and how the patient should be evaluated and treated. Arch Dermatol. 2006 ; 142: 1481-1482.
    • (2006) Arch Dermatol , vol.142 , pp. 1481-1482
    • Callen, J.P.1
  • 98
    • 0032966845 scopus 로고    scopus 로고
    • Homocysteinemia and livedoid vasculitis
    • Gibson GE, Li H., Pittelkow MR Homocysteinemia and livedoid vasculitis. J Am Acad Dermatol. 1999 ; 40 (2 Pt 1). 279-281.
    • (1999) J Am Acad Dermatol. , vol.40 , Issue.1-2 , pp. 279-281
    • Gibson, G.E.1    Li, H.2    Pittelkow, M.R.3
  • 99
    • 33751250798 scopus 로고    scopus 로고
    • Livedoid vasculopathy: Further evidence for procoagulant pathogenesis
    • Hairston BR, Davis MD, Pittelkow MR, Ahmed I. Livedoid vasculopathy: further evidence for procoagulant pathogenesis. Arch Dermatol. 2006 ; 142: 1413-1418.
    • (2006) Arch Dermatol , vol.142 , pp. 1413-1418
    • Hairston, B.R.1    Davis, M.D.2    Pittelkow, M.R.3    Ahmed, I.4
  • 100
    • 33748452084 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism associated with moderate hyperhomocysteinaemia in a patient with livedo vasculopathy: Treatment with vitamin supplementation and low molecular weight heparin
    • Rampf J., Sunderkötter C., Hirschfeld G., Scharffetter-Kochanek K., Weiss JM Methylenetetrahydrofolate reductase polymorphism associated with moderate hyperhomocysteinaemia in a patient with livedo vasculopathy: treatment with vitamin supplementation and low molecular weight heparin. Br J Dermatol. 2006 ; 155: 850-852.
    • (2006) Br J Dermatol , vol.155 , pp. 850-852
    • Rampf, J.1    Sunderkötter, C.2    Hirschfeld, G.3    Scharffetter-Kochanek, K.4    Weiss, J.M.5
  • 101
    • 48449098780 scopus 로고    scopus 로고
    • Livedoid vasculopathy associated with combined prothrombin G20210A and factor V (Leiden) heterozygosity and MTHFR C677T homozygosity [published online ahead of print March 23, 2008]
    • Irani-Hakime NA, Stephan F., Kreidy R., Jureidini I., Almawi WY Livedoid vasculopathy associated with combined prothrombin G20210A and factor V (Leiden) heterozygosity and MTHFR C677T homozygosity [published online ahead of print March 23, 2008]. J Thromb Thrombolysis. doi:10.1007/s11239-008-0214-1.
    • J Thromb Thrombolysis
    • Irani-Hakime, N.A.1    Stephan, F.2    Kreidy, R.3    Jureidini, I.4    Almawi, W.Y.5
  • 102
    • 33645564880 scopus 로고    scopus 로고
    • Livedoid vasculopathy. the role of hyperhomocysteinemia and its simple therapeutic consequences
    • Meiss F., Marsch WC, Fischer M. Livedoid vasculopathy. The role of hyperhomocysteinemia and its simple therapeutic consequences. Eur J Dermatol. 2006: 16: 159-162.
    • (2006) Eur J Dermatol. , vol.16 , pp. 159-162
    • Meiss, F.1    Marsch, W.C.2    Fischer, M.3
  • 103
    • 0032231635 scopus 로고    scopus 로고
    • Measurement and use of total plasma homocysteine
    • ASHG/ACMG statement. Measurement and use of total plasma homocysteine. Am J Hum Genet. 1998 ; 63: 1541-1543.
    • (1998) Am J Hum Genet , vol.63 , pp. 1541-1543
    • Statement, A.1
  • 104
    • 2242477014 scopus 로고    scopus 로고
    • ' Collabotation. Lowering blood homocysteine with folic acid supplementation: Meta-analysis of randomized trials
    • Homocysteine Lowering Trialists ' Collabotation. Lowering blood homocysteine with folic acid supplementation: meta-analysis of randomized trials. BMJ. 1998 ; 316: 894-898.
    • (1998) BMJ , vol.316 , pp. 894-898
    • Lowering Trialists, H.1
  • 105
    • 1342309318 scopus 로고    scopus 로고
    • Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: The Vitamin Intervention for Stroke Prevention (VISP) randomized control trial
    • Toole JF, Malinow MR, Chambless LE, et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized control trial. JAMA. 2004 ; 291: 565-575.
    • (2004) JAMA , vol.291 , pp. 565-575
    • Toole, J.F.1    Malinow, M.R.2    Le, C.3
  • 106
    • 33645796222 scopus 로고    scopus 로고
    • Homocysteine lowering and cardiovascular events after acute myocardial infarction
    • Bonaa KH, Njolstad I., Ueland PM, et al for Norvit. Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med. 2006 ; 354: 1578-1588.
    • (2006) N Engl J Med , vol.354 , pp. 1578-1588
    • Kh, B.1    Njolstad, I.2    Ueland, P.M.3    Norvit4
  • 107
    • 33645753544 scopus 로고    scopus 로고
    • Homocysteine lowering with folic acid and B vitamins in vascular disease
    • for the Heart Outcomes Prevention Evaluation (HOPE) 2.
    • Lonn E., Yusuf S., Arnold MJ, et al for the Heart Outcomes Prevention Evaluation (HOPE) 2. Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med. 2006 ; 354: 1567-1577.
    • (2006) N Engl J Med , vol.354 , pp. 1567-1577
    • Lonn, E.1    Yusuf, S.2    Arnold, M.J.3
  • 108
    • 31344459617 scopus 로고    scopus 로고
    • Homocysteine-lowering trials for prevention of cardiovascular events: A review of the design and power of the large randomized trials
    • Clarke R., Armitage J., Lewington S., et al for the B-Vitamin Treatment Trialists' Collaboration. Homocysteine-lowering trials for prevention of cardiovascular events: a review of the design and power of the large randomized trials. Am Heart J. 2006 ; 151: 282-287.
    • (2006) Am Heart J , vol.151 , pp. 282-287
    • Clarke, R.1    Armitage, J.2    Lewington, S.3    B-Vitamin Treatment Trialists'Collaboration, T.4


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