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Volumn 122, Issue 2, 1996, Pages 163-172

Homocysteine mediated endothelial cell toxicity and its amelioration

Author keywords

Allopurinol; DNA; Eicosanoids; Endothelial cells; Glutathione; Homocysteine; Radicals; Scavengers

Indexed keywords

3 AMINOBENZAMIDE; 4 BROMOPHENACYL BROMIDE; ALLOPURINOL; ASCORBIC ACID; DAZOXIBEN; DEHYDROARACHIDONIC ACID; FREE RADICAL; IBUPROFEN; ICOSANOID; MEPACRINE; SCAVENGER; SQ 30714; TRANYLCYPROMINE; UNCLASSIFIED DRUG;

EID: 0342624737     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/0021-9150(95)05730-7     Document Type: Article
Times cited : (155)

References (43)
  • 5
    • 0018858624 scopus 로고
    • Homocysteine-induced endothelial cell injury in vitro: A model for the study of vascular injury
    • Wall RT, Harlan JM, Harker LA, Striker GE. Homocysteine-induced endothelial cell injury in vitro: a model for the study of vascular injury. Thromb Res 1980;18:113.
    • (1980) Thromb Res , vol.18 , pp. 113
    • Wall, R.T.1    Harlan, J.M.2    Harker, L.A.3    Striker, G.E.4
  • 6
    • 0022591979 scopus 로고
    • The pathogenesis of atherosclerosis: An update
    • Ross R. The pathogenesis of atherosclerosis: an update. New Engl J Med 1986;314:488.
    • (1986) New Engl J Med , vol.314 , pp. 488
    • Ross, R.1
  • 7
    • 0014434483 scopus 로고
    • Activation of Hageman factor by L-homocystine
    • Ratnoff OD. Activation of Hageman factor by L-homocystine. Science 1968;162:1007.
    • (1968) Science , vol.162 , pp. 1007
    • Ratnoff, O.D.1
  • 8
    • 0022472013 scopus 로고
    • Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator
    • Rodgers GM, Kane WH. Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator. J Clin Invest 1986;77:1909.
    • (1986) J Clin Invest , vol.77 , pp. 1909
    • Rodgers, G.M.1    Kane, W.H.2
  • 9
    • 0026345948 scopus 로고
    • Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine
    • Lentz SR, Sadler JE. Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine. J Clin Invest 1991;88:1906.
    • (1991) J Clin Invest , vol.88 , pp. 1906
    • Lentz, S.R.1    Sadler, J.E.2
  • 10
    • 0027503504 scopus 로고
    • Arterial endothelial barrier dysfunction: Actions. of homocysteine and the hypoxanthinexanthine oxidase free radical generating system
    • Berman RS, Martin W. Arterial endothelial barrier dysfunction: actions. of homocysteine and the hypoxanthinexanthine oxidase free radical generating system. Br J Pharmacol 1993;108:920.
    • (1993) Br J Pharmacol , vol.108 , pp. 920
    • Berman, R.S.1    Martin, W.2
  • 11
    • 0027250615 scopus 로고
    • Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells
    • Fryer RH, Wilson BD, Gubler DB, Fitzgerald LA, Rodgers GM. Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells. Arterioscler Thromb 1993;13:1327.
    • (1993) Arterioscler Thromb , vol.13 , pp. 1327
    • Fryer, R.H.1    Wilson, B.D.2    Gubler, D.B.3    Fitzgerald, L.A.4    Rodgers, G.M.5
  • 12
    • 0027288252 scopus 로고
    • Homocysteine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor
    • Hajjar KA. Homocysteine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor. J Clin Invest 1993;91:2873.
    • (1993) J Clin Invest , vol.91 , pp. 2873
    • Hajjar, K.A.1
  • 13
    • 0027472128 scopus 로고
    • Homocysteine inhibits von Willebrand factor processing and secretion by preventing transport from the endoplasmic reticulum
    • Lentz SR, Sadler JE. Homocysteine inhibits von Willebrand Factor processing and secretion by preventing transport from the endoplasmic reticulum. Blood 1993;81:683.
    • (1993) Blood , vol.81 , pp. 683
    • Lentz, S.R.1    Sadler, J.E.2
  • 14
    • 0027319970 scopus 로고
    • Homocysteine, a thrombogenic agent, suppresses anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells
    • Nishinaga M, Ozawa T, Shimada K. Homocysteine, a thrombogenic agent, suppresses anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells. J Clin Invest 1993;92:1381.
    • (1993) J Clin Invest , vol.92 , pp. 1381
    • Nishinaga, M.1    Ozawa, T.2    Shimada, K.3
  • 15
    • 0022552919 scopus 로고
    • Endothelial cell injury due to copper-catalysed hydrogen peroxide generation from homocysteine
    • Starkebaum G, Harlan JM. Endothelial cell injury due to copper-catalysed hydrogen peroxide generation from homocysteine. J Clin Invest 1986;77:1370.
    • (1986) J Clin Invest , vol.77 , pp. 1370
    • Starkebaum, G.1    Harlan, J.M.2
  • 16
    • 0017324380 scopus 로고
    • Hydrogen peroxide lowers ATP levels in platelets without altering adenylate energy charge and platelet function
    • Holmsen H, Robkin L. Hydrogen peroxide lowers ATP levels in platelets without altering adenylate energy charge and platelet function. J Biol Chem 1977;252:752.
    • (1977) J Biol Chem , vol.252 , pp. 752
    • Holmsen, H.1    Robkin, L.2
  • 17
    • 0022348883 scopus 로고
    • Alterations in adenosine triphosphate and energy charge in cultured endothelial and P388D cells after oxidant injury
    • Spragg RG, Hinshaw DB, Hyslop PA, Schraufstatter IU, Cochrane CG. Alterations in adenosine triphosphate and energy charge in cultured endothelial and P388D cells after oxidant injury. J Clin Invest. 1985;76:1471.
    • (1985) J Clin Invest. , vol.76 , pp. 1471
    • Spragg, R.G.1    Hinshaw, D.B.2    Hyslop, P.A.3    Schraufstatter, I.U.4    Cochrane, C.G.5
  • 18
    • 0023874677 scopus 로고
    • Mechanisms of oxidant-mediated cell injury. The glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide
    • Hyslop PA, Hinshaw DB, Halsey Jr WA, Schraufstatter IU, Sauerheber RD, Spragg RG, Jackson JH, Cochrane CG. Mechanisms of oxidant-mediated cell injury. The glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide. J Biol Chem 1988;263:1665.
    • (1988) J Biol Chem , vol.263 , pp. 1665
    • Hyslop, P.A.1    Hinshaw, D.B.2    Halsey W.A., Jr.3    Schraufstatter, I.U.4    Sauerheber, R.D.5    Spragg, R.G.6    Jackson, J.H.7    Cochrane, C.G.8
  • 19
    • 0025732677 scopus 로고
    • Lipid peroxidation, protein thiol oxidation and DNA damage in hydrogen peroxide induced injury to endothelial cells: Role of activation of poly(ADP-ribose) polymerase
    • Kirkland JB, Lipid peroxidation, protein thiol oxidation and DNA damage in hydrogen peroxide induced injury to endothelial cells: role of activation of poly(ADP-ribose) polymerase. Biochim Biophys Acta 1991;1092:319.
    • (1991) Biochim Biophys Acta , vol.1092 , pp. 319
    • Kirkland, J.B.1
  • 20
    • 0022553195 scopus 로고
    • Oxidant injury of cells. DNA strand breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide
    • Schraufstatter IU, Hinshaw DB, Hyslop PA, Spragg RG, Cochrane CG. Oxidant injury of cells. DNA strand breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide. J Clin invest 1986;77:1312.
    • (1986) J Clin Invest , vol.77 , pp. 1312
    • Schraufstatter, I.U.1    Hinshaw, D.B.2    Hyslop, P.A.3    Spragg, R.G.4    Cochrane, C.G.5
  • 22
    • 0025063154 scopus 로고
    • Homocysteine uptake by human umbilical vein endothelial cells in culture
    • Ewadh MJA, Tudball N. Rose FA. Homocysteine uptake by human umbilical vein endothelial cells in culture. Biochim Biophys Acta 1990;1054:263.
    • (1990) Biochim Biophys Acta , vol.1054 , pp. 263
    • Ewadh, M.J.A.1    Tudball, N.2    Rose, F.A.3
  • 23
    • 0015901215 scopus 로고
    • Antihemophilic factor antigen. Localisation in endothelial cells by immunofluorescent microscopy
    • Hoyer LM, de Pos Santos RP, Hover JR. Antihemophilic factor antigen. Localisation in endothelial cells by immunofluorescent microscopy. J Clin Invest 1973;52:2737.
    • (1973) J Clin Invest , vol.52 , pp. 2737
    • Hoyer, L.M.1    De Pos Santos, R.P.2    Hover, J.R.3
  • 24
    • 0028329986 scopus 로고
    • Lipid peroxidation and homocysteine induced toxicity
    • Jones BG, Rose FA, Tudball N. Lipid peroxidation and homocysteine induced toxicity. Atherosclerosis 1994;105:165.
    • (1994) Atherosclerosis , vol.105 , pp. 165
    • Jones, B.G.1    Rose, F.A.2    Tudball, N.3
  • 25
    • 0015888084 scopus 로고
    • An improved cycling assay for nicotinamide adenine dinucelotide
    • Bernofsky C, Swan M. An improved cycling assay for nicotinamide adenine dinucelotide. Anal Biochem 1973;53:452.
    • (1973) Anal Biochem , vol.53 , pp. 452
    • Bernofsky, C.1    Swan, M.2
  • 26
    • 0015598569 scopus 로고
    • Radiation induced strand breakage in DNA from mammalian cells. Strand separation in alkaline solution
    • Ahnstrom G, Erixson K. Radiation induced strand breakage in DNA from mammalian cells. Strand separation in alkaline solution. Int J Radiat Biol 1973;23:285.
    • (1973) Int J Radiat Biol , vol.23 , pp. 285
    • Ahnstrom, G.1    Erixson, K.2
  • 27
    • 0017800374 scopus 로고
    • Microtubule dynamics and glutathione metabolism in phagocytozing human polymorphonuclear leukocytes
    • Burchill BR, Oliver JM, Pearson CB, Leonbach ED, Berlin RD. Microtubule dynamics and glutathione metabolism in phagocytozing human polymorphonuclear leukocytes. J Cell Biol 1978;76:439.
    • (1978) J Cell Biol , vol.76 , pp. 439
    • Burchill, B.R.1    Oliver, J.M.2    Pearson, C.B.3    Leonbach, E.D.4    Berlin, R.D.5
  • 28
    • 0014481378 scopus 로고
    • Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues
    • Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 1969;27:502.
    • (1969) Anal Biochem , vol.27 , pp. 502
    • Tietze, F.1
  • 30
    • 0013969948 scopus 로고
    • Preparation of L-homocysteine from L-homocysteine thiolactone
    • Duerre JA, Miller CH. Preparation of L-homocysteine from L-homocysteine thiolactone. Anal Biochem 1966;17:310.
    • (1966) Anal Biochem , vol.17 , pp. 310
    • Duerre, J.A.1    Miller, C.H.2
  • 31
    • 0021960720 scopus 로고
    • Enhancement of intracellular glutathione protects endothelial cells against oxidant damage
    • Tsan MF, Danis EH, Del Vecchio PJ, Rosano CL. Enhancement of intracellular glutathione protects endothelial cells against oxidant damage. Biochem Biophys Res Commun 1985;127:270.
    • (1985) Biochem Biophys Res Commun , vol.127 , pp. 270
    • Tsan, M.F.1    Danis, E.H.2    Del Vecchio, P.J.3    Rosano, C.L.4
  • 32
    • 0023003551 scopus 로고
    • Antioxidant defense mechanisms of endothelial cells: Glutathione redox cycle versus catalase
    • Suttorp N, Toepfer W, Roka L. Antioxidant defense mechanisms of endothelial cells: glutathione redox cycle versus catalase. Am J Physiol 1986;251:C671.
    • (1986) Am J Physiol , vol.251
    • Suttorp, N.1    Toepfer, W.2    Roka, L.3
  • 33
    • 0024376458 scopus 로고
    • Single-strand cleavage of DNA by Cu(II) and thiols: A powerful chemical DNA-cleaving system
    • Reed CJ, Douglas KT. Single-strand cleavage of DNA by Cu(II) and thiols: a powerful chemical DNA-cleaving system. Biochem Biophys Res Commun 1989;162:1111.
    • (1989) Biochem Biophys Res Commun , vol.162 , pp. 1111
    • Reed, C.J.1    Douglas, K.T.2
  • 34
    • 0025023597 scopus 로고
    • Disruption of thymidylate synthesis and glycine-serine interconversion by L-methionine and L-homocystine in Raji cells
    • Fell D, Selhub J. Disruption of thymidylate synthesis and glycine-serine interconversion by L-methionine and L-homocystine in Raji cells. Biochim Biophys Acta 1990;1033:80.
    • (1990) Biochim Biophys Acta , vol.1033 , pp. 80
    • Fell, D.1    Selhub, J.2
  • 35
    • 0026637964 scopus 로고
    • Role of cellular superoxide dismutase against reactive oxygen metabolite injury in cultured bovine aortic endothelial cells
    • Hiraishi H, Terano A, Razandi M, Sugimoto T. Harada T, Ivey KJ. Role of cellular superoxide dismutase against reactive oxygen metabolite injury in cultured bovine aortic endothelial cells. J Biol Chem 1992;267:14812.
    • (1992) J Biol Chem , vol.267 , pp. 14812
    • Hiraishi, H.1    Terano, A.2    Razandi, M.3    Sugimoto, T.4    Harada, T.5    Ivey, K.J.6
  • 36
    • 0023257674 scopus 로고
    • Formation and reduction of glutathione-protein mixed disulfides during oxidative stress. A study with isolated hepatocytes and menadione (2-methyl-1,4-naphthoquinone)
    • Bellamo G, Mirabelli F, DiMonte D, Richelmi P, Thor H, Orrenius C, Orrenius S. Formation and reduction of glutathione-protein mixed disulfides during oxidative stress. A study with isolated hepatocytes and menadione (2-methyl-1,4-naphthoquinone). Biochem Pharmacol 1987;36:1313.
    • (1987) Biochem Pharmacol , vol.36 , pp. 1313
    • Bellamo, G.1    Mirabelli, F.2    DiMonte, D.3    Richelmi, P.4    Thor, H.5    Orrenius, C.6    Orrenius, S.7
  • 37
    • 0021324531 scopus 로고
    • Glutathione redox cycle protects cultured endothelial cells against lysis by extracellularly generated hydrogen peroxide
    • Harlan JM, Levine JD, Callahan KS, Schwartz BR. Glutathione redox cycle protects cultured endothelial cells against lysis by extracellularly generated hydrogen peroxide. J Clin Invest 1984;73:706.
    • (1984) J Clin Invest , vol.73 , pp. 706
    • Harlan, J.M.1    Levine, J.D.2    Callahan, K.S.3    Schwartz, B.R.4
  • 38
    • 0023178426 scopus 로고
    • Vitamin E protection against chemical-induced cell injury. 1. Maintenance of cellular protein thiols as a cytoprotective mechanism
    • Pascoe GA, Olafsdottir K, Reed DJ. Vitamin E protection against chemical-induced cell injury. 1. Maintenance of cellular protein thiols as a cytoprotective mechanism. Arch Biochem Biophys 1987;256:150.
    • (1987) Arch Biochem Biophys , vol.256 , pp. 150
    • Pascoe, G.A.1    Olafsdottir, K.2    Reed, D.J.3
  • 43
    • 0023277174 scopus 로고
    • Oxygen-derived radicals: A link between reperfusion injury and inflammation
    • McCord JM. Oxygen-derived radicals: a link between reperfusion injury and inflammation. Fed Proc 1987;46:2402.
    • (1987) Fed Proc , vol.46 , pp. 2402
    • McCord, J.M.1


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