Effects of chronic citalopram treatment on 5-HT1A and 5-HT2A receptors in group- and isolation-housed mice

European Journal of Pharmacology

Volumn 593, Issue 1-3, 2008, Pages 49-61

  Günther, Lydia ^a   Liebscher, Sabine ^a   Jähkel, Monika ^a   Oehler, Jochen ^a  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

Author keywords

5 HT1A receptor; 5 HT2A receptor; Citalopram; Social isolation; SSRI

Indexed keywords

CITALOPRAM; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL HOUSING; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DRUG BINDING; FOREBRAIN; MALE; MOUSE; NEUROBIOLOGY; NONHUMAN; POSTSYNAPTIC MEMBRANE; PRIORITY JOURNAL; SOCIAL ISOLATION;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANALYSIS OF VARIANCE; ANIMALS; ANTIDEPRESSIVE AGENTS; AUTORADIOGRAPHY; BRAIN; BRAIN CHEMISTRY; CITALOPRAM; DATA INTERPRETATION, STATISTICAL; KETANSERIN; MALE; MICE; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT2A; SEROTONIN ANTAGONISTS; SOCIAL ENVIRONMENT; SOCIAL ISOLATION;

EID: 49749106227     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.07.011     Document Type: Article

References (91)

1. Abumaria N., Rygula R., Hiemke C., Fuchs E., Havemann-Reinecke U., Ruther E., and Flügge G. Effect of chronic citalopram on serotonin-related and stress-regulated genes in the dorsal raphe nucleus of the rat. Eur. Neuropsychopharmacol. 17 (2007) 417-429
2. Amargos-Bosch M., Bortolozzi A., Puig M.V., Serrats J., Adell A., Celada P., Toth M., Mengod G., and Artigas F. Co-expression and in vivo interaction of serotonin1A and serotonin2A receptors in pyramidal neurons of prefrontal cortex. Cereb. Cortex 14 (2004) 281-299
3. Aznavour N., Rbah L., Leger L., Buda C., Sastre J.P., Imhof A., Charnay Y., and Zimmer L. A comparison of in vivo and in vitro neuroimaging of 5-HT 1A receptor binding sites in the cat brain. J. Chem. Neuroanat. 31 (2006) 226-232
4. Aznavour N., Rbah L., Riad M., Reilhac A., Costes N., Descarries L., and Zimmer L. A PET imaging study of 5-HT(1A) receptors in cat brain after acute and chronic fluoxetine treatment. NeuroImage 33 (2006) 834-842
5. Barr L.C., Heninger G.R., Goodman W., Charney D.S., and Price L.H. Effects of fluoxetine administration on mood response to tryptophan depletion in healthy subjects. Biol. Psychiatry 41 (1997) 949-954
6. Beck S.G., Birnstiel S., Choi K.C., and Pouliot W.A. Fluoxetine selectively alters 5-hydroxytryptamine1A and gamma-aminobutyric acidB receptor-mediated hyperpolarization in area CA1, but not area CA3, hippocampal pyramidal cells. J. Pharmacol. Exp. Ther. 281 (1997) 115-122
7. Berggard C., Damberg M., and Oreland L. Brainstem levels of transcription factor AP-2 in rat are changed after treatment with phenelzine, but not with citalopram. BMC Pharmacol. 5 (2005) 1 10.1186/1471-2210-5-1
8. Bhagwagar Z., Rabiner E.A., Sargent P.A., Grasby P.M., and Cowen P.J. Persistent reduction in brain serotonin1A receptor binding in recovered depressed men measured by positron emission tomography with [11C]WAY-100635. Mol. Psychiatry 9 (2004) 386-392
9. Bobula B., Tokarski K., Zahorodna A., and Hess G. Adaptive changes in the reactivity of 5-HT1A and 5-HT2 receptors induced in rat frontal cortex by repeated imipramine and citalopram. Naunyn-Schmiedebergs Arch. Pharmacol. 367 (2003) 444-450
10. Bonaventure P., Nepomuceno D., Kwok A., Chai W., Langlois X., Hen R., Stark K., Carruthers N., and Lovenberg T.W. Reconsideration of 5-hydroxytryptamine (5-HT)(7) receptor distribution using [(3)H]5-carboxamidotryptamine and [(3)H]8-hydroxy-2-(di-n-propylamino)tetraline: analysis in brain of 5-HT(1A) knockout and 5-HT(1A/1B) double-knockout mice. J. Pharmacol. Exp. Ther. 302 (2002) 240-248
11. Bonne O., Krausz Y., Aharon Y., Gelfin Y., Chisin R., and Lerer B. Clinical doses of fluoxetine and cerebral blood flow in healthy volunteers. Psychopharmacology (Berl). 143 (1999) 24-28
12. Boothman L.J., Mitchell S.N., and Sharp T. Investigation of the SSRI augmentation properties of 5-HT(2) receptor antagonists using in vivo microdialysis. Neuropharmacology 50 (2006) 726-732
13. Brain P. What does individual housing mean to a mouse?. Life Sci. 16 (1975) 187-200
14. Brenes Saenz J.C., Villagra O.R., and Fornaguera Trias J. Factor analysis of Forced Swimming test, Sucrose Preference test and Open Field test on enriched, social and isolated reared rats. Behav. Brain Res. 169 (2006) 57-65
15. Ceci A., Fodritto F., and Borsini F. Repeated treatment with fluoxetine decreases the number of spontaneously active cells per track in frontal cortex. Eur. J. Pharmacol. 271 (1994) 231-234
16. Ceglia I., Acconcia S., Fracasso C., Colovic M., Caccia S., and Invernizzi R.W. Effects of chronic treatment with escitalopram or citalopram on extracellular 5-HT in the prefrontal cortex of rats: role of 5-HT1A receptors. Br. J. Pharmacol. 142 (2004) 469-478
17. Czachura J.F., and Rasmussen K. Effects of acute and chronic administration of fluoxetine on the activity of serotonergic neurons in the dorsal raphe nucleus of the rat. Naunyn-Schmiedebergs Arch. Pharmacol. 362 (2000) 266-275
18. Einon D.F., Humphreys A.P., Chivers S.M., Field S., and Naylor V. Isolation has permanent effects upon the behavior of the rat, but not the mouse, gerbil, or guinea pig. Dev. Psychobiol. 14 (1981) 343-355
19. El Mansari M., Sanchez C., Chouvet G., Renaud B., and Haddjeri N. Effects of acute and long-term administration of escitalopram and citalopram on serotonin neurotransmission: an in vivo electrophysiological study in rat brain. Neuropsychopharmacology 30 (2005) 1269-1277
20. Elena Castro M., Diaz A., del Olmo E., and Pazos A. Chronic fluoxetine induces opposite changes in G protein coupling at pre and postsynaptic 5-HT1A receptors in rat brain. Neuropharmacology 44 (2003) 93-101
21. Franklin K.B.J., and Paxinos G. The Mouse Brain in Stereotaxic Coordinates (1997), Academic Press, San Diego, CA
22. Fredricson Overo K. Kinetics of citalopram in test animals; drug exposure in safety studies. Prog. Neuropsychopharmacol. Biol. Psychiatry 6 (1982) 297-309
23. Gariepy J.L., Rodriguiz R.M., and Jones B.C. Handling, genetic and housing effects on the mouse stress system, dopamine function, and behavior. Pharmacol. Biochem. Behav. 73 (2002) 7-17
24. Garoflos E., Stamatakis A., Mantelas A., Philippidis H., and Stylianopoulou F. Cellular mechanisms underlying an effect of "early handling" on pCREB and BDNF in the neonatal rat hippocampus. Brain Res. 1052 (2005) 187-195
25. Garrick N.A., and Murphy D.L. Species differences in the deamination of dopamine and other substrates for monoamine oxidase in brain. Psychopharmacology (Berl). 72 (1980) 27-33
26. Gartside S.E., Leitch M.M., and Young A.H. Altered glucocorticoid rhythm attenuates the ability of a chronic SSRI to elevate forebrain 5-HT: implications for the treatment of depression. Neuropsychopharmacology 28 (2003) 1572-1578
27. Gelfin Y., Gorfine M., and Lerer B. Effect of clinical doses of fluoxetine on psychological variables in healthy volunteers. Am. J. Psychiatry 155 (1998) 290-292
28. Haddjeri N., Blier P., and de Montigny C. Long-term antidepressant treatments result in a tonic activation of forebrain 5-HT1A receptors. J. Neurosci. 18 (1998) 10150-10156
29. Hall F.S. Social deprivation of neonatal, adolescent, and adult rats has distinct neurochemical and behavioral consequences. Crit. Rev. Neurobiol. 12 (1998) 129-162
30. Hall F.S., Wilkinson L.S., Humby T., Inglis W., Kendall D.A., Marsden C.A., and Robbins T.W. Isolation rearing in rats: pre- and postsynaptic changes in striatal dopaminergic systems. Pharmacol. Biochem. Behav. 59 (1998) 859-872
31. Hendrie C.A., Pickles A.R., Duxon M.S., Riley G., and Hagan J.J. Effects of fluoxetine on social behaviour and plasma corticosteroid levels in female Mongolian gerbils. Behav. Pharmacol. 14 (2003) 545-550
32. Hensler J.G. Differential regulation of 5-HT1A receptor-G protein interactions in brain following chronic antidepressant administration. Neuropsychopharmacology 26 (2002) 565-573
33. Hensler J.G., Kovachich G.B., and Frazer A. A quantitative autoradiographic study of serotonin1A receptor regulation. Effect of 5,7-dihydroxytryptamine and antidepressant treatments. Neuropsychopharmacology 4 (1991) 131-144
34. Hervas I., Vilaro M.T., Romero L., Scorza M.C., Mengod G., and Artigas F. Desensitization of 5-HT(1A) autoreceptors by a low chronic fluoxetine dose effect of the concurrent administration of WAY-100635. Neuropsychopharmacology 24 (2001) 11-20
35. Hrdina P.D., and Vu T.B. Chronic fluoxetine treatment upregulates 5-HT uptake sites and 5-HT2 receptors in rat brain: an autoradiographic study. Synapse 14 (1993) 324-331
36. Hyttel J. Citalopram-pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity. Prog. Neuropsychopharmacol. Biol. Psychiatry 6 (1982) 277-295
37. Ishiwata H., Shiga T., and Okado N. Selective serotonin reuptake inhibitor treatment of early postnatal mice reverses their prenatal stress-induced brain dysfunction. Neuroscience 133 (2005) 893-901
38. Jähkel M., Schiller L., and Oehler J. Effects of citalopram-selective serotonin reuptake inhibitor-on behaviour in isolated and grouped mice. In: Elsner N., and Kreutzberg G.W. (Eds). Göttingen Neurobiology Report, Proceedings of the 4th Meeting of the German Neuroscience Society (2001), Thieme, Göttingen 860
39. Jerussi T.P., and Hyde J.F. Circling behavior in mice and rats: possible relationship to isolation-induced aggression. Experientia 41 (1985) 329-331
40. Jongsma M.E., Bosker F.J., Cremers T.I., Westerink B.H., and den Boer J.A. The effect of chronic selective serotonin reuptake inhibitor treatment on serotonin 1B receptor sensitivity and HPA axis activity. Prog. Neuropsychopharmacol. Biol. Psychiatry 29 (2005) 738-744
41. Klimek V., Zak-Knapik J., and Mackowiak M. Effects of repeated treatment with fluoxetine and citalopram, 5-HT uptake inhibitors, on 5-HT1A and 5-HT2 receptors in the rat brain. J. Psychiatry Neurosci. 19 (1994) 63-67
42. Konstandi M., Johnson E., Lang M.A., Malamas M., and Marselos M. Noradrenaline, dopamine, serotonin: different effects of psychological stress on brain biogenic amines in mice and rats. Pharmacol. Res. 41 (2000) 341-346
43. Koolhaas J.M., De Boer S.F., De Rutter A.J., Meerlo P., and Sgoifo A. Social stress in rats and mice. Acta Physiol. Scand. Suppl. 640 (1997) 69-72
44. Kreiss D.S., and Lucki I. Effects of acute and repeated administration of antidepressant drugs on extracellular levels of 5-hydroxytryptamine measured in vivo. J. Pharmacol. Exp. Ther. 274 (1995) 866-876
45. Kristiansen K., and Dahl S.G. Molecular modeling of serotonin, ketanserin, ritanserin and their 5-HT2C receptor interactions. Eur. J. Pharmacol. 306 (1996) 195-210
46. Leussis M.P., and Andersen S.L. Is adolescence a sensitive period for depression? Behavioral and neuroanatomical findings from a social stress model. Synapse 62 (2008) 22-30
47. Leysen J.E., Niemegeers C.J., Van Nueten J.M., and Laduron P.M. [3H]Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites. Binding properties, brain distribution, and functional role. Mol. Pharmacol. 21 (1982) 301-314
48. Li Q., Battaglia G., and Van de Kar L.D. Autoradiographic evidence for differential G-protein coupling of 5-HT1A receptors in rat brain: lack of effect of repeated injections of fluoxetine. Brain Res. 769 (1997) 141-151
49. Li Q., Muma N.A., Battaglia G., and Van de Kar L.D. A desensitization of hypothalamic 5-HT1A receptors by repeated injections of paroxetine: reduction in the levels of G(i) and G(o) proteins and neuroendocrine responses, but not in the density of 5-HT1A receptors. J. Pharmacol. Exp. Ther. 282 (1997) 1581-1590
50. Majercsik E., Haller J., Leveleki C., Baranyi J., Halasz J., and Rodgers R.J. The effect of social factors on the anxiolytic efficacy of buspirone in male rats, male mice, and men. Prog. Neuropsychopharmacol. Biol. Psychiatry 27 (2003) 1187-1199
51. Massou J.M., Trichard C., Attar-Levy D., Feline A., Corruble E., Beaufils B., and Martinot J.L. Frontal 5-HT2A receptors studied in depressive patients during chronic treatment by selective serotonin reuptake inhibitors. Psychopharmacology (Berl). 133 (1997) 99-101
52. Messa C., Colombo C., Moresco R.M., Gobbo C., Galli L., Lucignani G., Gilardi M.C., Rizzo G., Smeraldi E., Zanardi R., Artigas F., and Fazio F. 5-HT(2A) receptor binding is reduced in drug-naive and unchanged in SSRI-responder depressed patients compared to healthy controls: a PET study. Psychopharmacology (Berl). 167 (2003) 72-78
53. Meyer J.H., Kapur S., Eisfeld B., Brown G.M., Houle S., DaSilva J., Wilson A.A., Rafi-Tari S., Mayberg H.S., and Kennedy S.H. The effect of paroxetine on 5-HT(2A) receptors in depression: an [(18)F]setoperone PET imaging study. Am. J. Psychiatry 158 (2001) 78-85
54. Mokrosz M.J., Chojnacka-Wójcik E., Tatarczynska E., Klodzinska A., Filip M., Boksa J., Charakchieva-Minol S., and Mokrosz J.L. 1-(2-Methoxyphenyl)-4-[(4-succinimido)butyl]-piperazine (MM-77): a new, potent, postsynaptic antagonist of 5-HT1A receptors. Med. Chem. Res. 4 (1994) 161-169
55. Montgomery S.A., and Djarv L. The antidepressant efficacy of citalopram. Int. Clin. Psychopharmacol. 11 Suppl 1 (1996) 29-33
56. Newman M.E., Shapira B., and Lerer B. Regulation of 5-hydroxytryptamine1A receptor function in rat hippocampus by short- and long-term administration of 5-hydroxytryptamine1A agonist and antidepressants. J. Pharmacol. Exp. Ther. 260 (1992) 16-20
57. Oehler J., Schiller L., and Jähkel M. Effects of citalopram-selective serotonin reuptake inhibitor-on 5-HT metabolism in isolated and grouped mice. In: Elsner N., and Kreutzberg G.W. (Eds). Göttingen Neurobiology Report, Proceedings of the 4th Meeting of the German Neuroscience Society (2001), Thieme, Göttingen 861
58. Olivier B., Mos J., van der Heyden J., and Hartog J. Serotonergic modulation of social interactions in isolated male mice. Psychopharmacology (Berl). 97 (1989) 154-156
59. Parsey R.V., Oquendo M.A., Ogden R.T., Olvet D.M., Simpson N., Huang Y.Y., Van Heertum R.L., Arango V., and Mann J.J. Altered serotonin 1A binding in major depression: a [carbonyl-C-11]WAY100635 positron emission tomography study. Biol. Psychiatry 59 (2006) 106-113
60. Patris M., Bouchard J.M., Bougerol T., Charbonnier J.F., Chevalier J.F., Clerc G., Cyran C., Van Amerongen P., Lemming O., and Hopfner Petersen H.E. Citalopram versus fluoxetine: a double-blind, controlled, multicentre, phase III trial in patients with unipolar major depression treated in general practice. Int. Clin. Psychopharmacol. 11 (1996) 129-136
61. Pejchal T., Foley M.A., Kosofsky B.E., and Waeber C. Chronic fluoxetine treatment selectively uncouples raphe 5-HT(1A) receptors as measured by [(35)S]-GTP gamma S autoradiography. Br. J. Pharmacol. 135 (2002) 1115-1122
62. Peroutka S.J., and Snyder S.H. Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding. Science 210 (1980) 88-90
63. Pinna G., Dong E., Matsumoto K., Costa E., and Guidotti A. In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 2035-2040
64. Porter R.J., Gallagher P., Watson S., and Young A.H. Corticosteroid-serotonin interactions in depression: a review of the human evidence. Psychopharmacology (Berl). 173 (2004) 1-17
65. Preece M.A., Dalley J.W., Theobald D.E., Robbins T.W., and Reynolds G.P. Region specific changes in forebrain 5-hydroxytryptamine1A and 5-hydroxytryptamine2A receptors in isolation-reared rats: an in vitro autoradiography study. Neuroscience 123 (2004) 725-732
66. Raap D.K., Garcia F., Muma N.A., Wolf W.A., Battaglia G., and van de Kar L.D. Sustained desensitization of hypothalamic 5-hydroxytryptamine1a receptors after discontinuation of fluoxetine: inhibited neuroendocrine responses to 8-hydroxy-2-(dipropylamino)tetralin in the absence of changes in Gi/o/z proteins. J. Pharmacol. Exp. Ther. 288 (1999) 561-567
67. Ramanathan M., Kumar S.N., and Suresh B. Evaluation of cognitive function of fluoxetine, sertraline and tianeptine in isolation and chronic unpredictable mild stress-induced depressive Wistar rats. Indian J. Exp. Biol. 41 (2003) 1269-1272
68. Riad M., Zimmer L., Rbah L., Watkins K.C., Hamon M., and Descarries L. Acute treatment with the antidepressant fluoxetine internalizes 5-HT1A autoreceptors and reduces the in vivo binding of the PET radioligand [18F]MPPF in the nucleus raphe dorsalis of rat. J. Neurosci. 24 (2004) 5420-5426
69. Rilke O., Freier D., Jähkel M., and Oehler J. Dynamic alterations of serotonergic metabolism and receptors during social isolation of low- and high-active mice. Pharmacol. Biochem. Behav. 59 (1998) 891-896
70. Rilke O., Will K., Jähkel M., and Oehler J. Behavioral and neurochemical effects of anpirtoline and citalopram in isolated and group housed mice. Prog. Neuropsychopharmacol. Biol. Psychiatry 25 (2001) 1125-1144
71. Rosa M.L., Silva R.C., Moura-de-Carvalho F.T., Brandao M.L., Guimaraes F.S., and Del Bel E.A. Routine post-weaning handling of rats prevents isolation rearing-induced deficit in prepulse inhibition. Braz. J. Med. Biol. Res. 38 (2005) 1691-1696
72. Rossi D.V., Valdez M., Gould G.G., and Hensler J.G. Chronic administration of venlafaxine fails to attenuate 5-HT1A receptor function at the level of receptor-G protein interaction. Int. J. Neuropsychopharmacol. 9 (2006) 393-406
73. Rutter J.J., Gundlah C., and Auerbach S.B. Increase in extracellular serotonin produced by uptake inhibitors is enhanced after chronic treatment with fluoxetine. Neurosci. Lett. 171 (1994) 183-186
74. Sanchez C., and Hyttel J. Isolation-induced aggression in mice: effects of 5-hydroxytryptamine uptake inhibitors and involvement of postsynaptic 5-HT1A receptors. Eur. J. Pharmacol. 264 (1994) 241-247
75. Sanchez C., Bergqvist P.B., Brennum L.T., Gupta S., Hogg S., Larsen A., and Wiborg O. Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities. Psychopharmacology (Berl). 167 (2003) 353-362
76. Sapena R., Morin D., Zini R., and Tillement J.P. Cyclic AMP and inositol phosphate accumulations in rat brain cortical slices following chronic citalopram or desipramine administration. Drugs Exp. Clin. Res. 20 (1994) 93-102
77. Sargent P.A., Kjaer K.H., Bench C.J., Rabiner E.A., Messa C., Meyer J., Gunn R.N., Grasby P.M., and Cowen P.J. Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment. Arch. Gen. Psychiatry 57 (2000) 174-180
78. Schiller L., Jähkel M., Kretzschmar M., Brust P., and Oehler J. Autoradiographic analyses of 5-HT1A and 5-HT2A receptors after social isolation in mice. Brain Res. 980 (2003) 169-178
79. Schiller L., Jähkel M., and Oehler J. The influence of sex and social isolation housing on pre- and postsynaptic 5-HT1A receptors. Brain Res. 1103 (2006) 76-87
80. Sharp J., Zammit T., Azar T., and Lawson D. Stress-like responses to common procedures in individually and group-housed female rats. Contemp. Top. Lab. Anim. Sci. 42 (2003) 9-18
81. Shen C., Li H., and Meller E. Repeated treatment with antidepressants differentially alters 5-HT1A agonist-stimulated [35S]GTP gamma S binding in rat brain regions. Neuropharmacology 42 (2002) 1031-1038
82. Subhash M.N., Srinivas B.N., Vinod K.Y., and Jagadeesh S. Modulation of 5-HT1A receptor mediated response by fluoxetine in rat brain. J. Neural Transm. 107 (2000) 377-387
83. Tadokoro C., Kiuchi Y., Yamazaki Y., Nara K., Oguchi K., and Kamijima K. Behavioral stimulation without alteration of beta and 5-HT receptors and adenylate cyclase activity in rat brain after chronic sertraline administration. Psychopharmacology (Berl). 130 (1997) 124-130
84. Taylor G.T. Fighting in juvenile rats and the ontogeny of agonisitc behavior. J. Comp. Physiol. Psychol. 94 (1980) 953-961
85. Tokarski K., and Bijak M. Antidepressant-induced adaptive changes in the effects of 5-HT, 5-HT1A and 5-HT4 agonists on the population spike recorded in hippocampal CA1 cells do not involve presynaptic effects on excitatory synaptic transmission. Pol. J. Pharmacol. 48 (1996) 565-573
86. van Praag H.M. Can stress cause depression?. Prog. Neuropsychopharmacol. Biol. Psychiatry 28 (2004) 891-907
87. Varrault A., Leviel V., and Bockaert J. 5-HT1A-sensitive adenylyl cyclase of rodent hippocampal neurons: effects of antidepressant treatments and chronic stimulation with agonists. J. Pharmacol. Exp. Ther. 257 (1991) 433-438
88. Wamsley J.K., Byerley W.F., McCabe R.T., McConnell E.J., Dawson T.M., and Grosser B.I. Receptor alterations associated with serotonergic agents: an autoradiographic analysis. J. Clin. Psychiatry 48 (1987) 19-25 Suppl
89. Welner S.A., De Montigny C., Desroches J., Desjardins P., and Suranyi-Cadotte B.E. Autoradiographic quantification of serotonin1A receptors in rat brain following antidepressant drug treatment. Synapse 4 (1989) 347-352
90. Wikell C., Apelqvist G., Carlsson B., Hjorth S., Bergqvist P.B., Kugelberg F.C., Ahlner J., and Bengtsson F. Pharmacokinetic and pharmacodynamic responses to chronic administration of the selective serotonin reuptake inhibitor citalopram in rats. Clin. Neuropharmacol. 22 (1999) 327-336
91. Zanardi R., Artigas F., Moresco R., Colombo C., Messa C., Gobbo C., Smeraldi E., and Fazio F. Increased 5-hydroxytryptamine-2 receptor binding in the frontal cortex of depressed patients responding to paroxetine treatment: a positron emission tomography scan study. J. Clin. Psychopharmacol. 21 (2001) 53-58