The effect of social factors on the anxiolytic efficacy of buspirone in male rats, male mice, and men

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 27, Issue 8, 2003, Pages 1187-1199

  Majercsik, Eszter ^a   Haller, József ^b   Leveleki, Csilla ^b   Baranyi, Johanna ^b   Halász, József ^b   Rodgers, Robert John ^c  

^a Department of Gastroenterology   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Anxiety; Anxiolytic; Buspirone; Human; Individual housing; Men; Mouse; Rat; Serotonine; Social support

Indexed keywords

BUSPIRONE;

AGED; ANXIETY DISORDER; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; EXPLORATORY BEHAVIOR; HAMILTON SCALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MAZE TEST; MOUSE; NONHUMAN; RAT; SOCIAL ASPECT; SOCIAL ISOLATION; SOCIAL SUPPORT; SPECIES DIFFERENCE; TREATMENT OUTCOME;

EID: 0345059099     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2003.09.013     Document Type: Conference Paper

References (50)

1. Barrett J.E., Vanover K.E. 5-HT receptors as targets for the development of novel anxiolytic drugs: models, mechanisms and future directions. Psychopharmacology. 112:1993;1-12.
2. Bickerdike M.J., Wright I.K., Marsden C.A. Social isolation attenuates rat forebrain 5-HT release induced by KCI stimulation and exposure to a novel environment. Behav. Pharmacol. 4:1993;231-236.
3. Bohus B., Koolhaas J.M., Korte S.M., Bouws G.A., Eisenga W., Smit J. Behavioral physiology of serotonergic and steroid-like anxiolytics as antistress drugs. Neurosci. Biobehav. Rev. 14:1990;529-534.
4. Brain P.F. What does individual housing mean to a mouse? Life Sci. 16:1975;187-200.
5. Caldwell R.A., Pearson J.L., Chin R.J. Stress moderating effects: social support in the context of gender and locus of control. Pers. Soc. Psychol. Bull. 13:1987;5-17.
6. 1A receptor antagonism on plus-maze behaviour in mice: II. WAY 100635 SDZ 216-525 and NAN-190. Pharmacol. Biochem. Behav. 58:1997;593-603.
7. Cao B.J., Rodgers R.J. Comparative behavioural profiles of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine (1-PP) in the murine elevated plus-maze. Neuropharmacology. 36:1997;1089-1097.
8. Cheeta S., Irvine E., File S.E. Social isolation modifies nicotine's effects in animal tests of anxiety. Br. J. Pharmacol. 132:2001;1389-1395.
9. Cole J.C., Rodgers R.J. An ethological analysis of the effects of chlordiazepoxide and bretazenil (Ro 16-6028) in the murine elevated-plus maze. Behav. Pharmacol. 4:1993;573-580.
10. Cole J.C., Rodgers R.J. Ethological evaluation of the effects of acute and chronic buspirone treatment in the murine elevated plus-maze test: comparison with haloperidol. Psychopharmacology. 114:1994;196-288.
11. Collinson N., Dawson G.R. On the elevated plus-maze the anxiolytic-like effects of the 5-HT(1A) agonist, 8-OH-DPAT, but not the anxiogenic-like effects of the 5-HT(1A) partial agonist, buspirone, are blocked by the 5-HT1A antagonist WAY 100635. Psychopharmacology. 132:1997;35-43.
12. Delle Chiaie R., Pancheri P., Casacchia M., Stratta P., Kotzalidis G.D., Zibellini M. Assessment of the efficacy of buspirone in patients affected by generalized anxiety disorder, shifting to buspirone from prior treatment with lorazepam: a placebo-controlled, double-blind study. J. Clin. Psychopharmacol. 15:1995;12-19.
13. Downing R.W., Rickels K. The impact of favorable and unfavorable life events on psychotropic drug response. Psychopharmacology. 78:1982;97-100.
14. Ferrari P.F., Palanza P., Parmigiani S., Rodgers R.J. Interindividual variability in Swiss male mice: relationship between social factors., aggression and anxiety. Physiol. Behav. 63:1998;821-827.
15. 2C receptor responsiveness occurs on rearing rats in social isolation. Psychopharmacology. 123:1996;346-352.
16. Gao B., Cutler M.G. Buspirone increases social investigation in pair-housed male mice; comparison with the effects of chlordiazepoxide. Neuropharmacology. 32:1993;429-437.
17. Goldberg H.L., Finnerty R. Comparison of buspirone in two separate studies. J. Clin. Psychiatry. 43:1982;87-91.
18. Griebel G., Rodgers R.J., Perrault G., Sanger D.J. Risk assessment behavior: evaluation of utility in the study of 5-HT-related drugs in the elevated plus-maze test. Pharmacol. Biochem. Behav. 57:1997;817-827.
19. Haller J. The link between stress and the efficacy of anxiolytics. A new avenue of research. Physiol. Behav. 73:2001;337-342.
20. Haller J., Halász J., Makara G.B. Housing conditions and the anxiolytic efficacy of buspirone. The relationship between main and side effects. Behav. Pharmacol. 11:2000;403-412.
21. Haller J., Leveleki Cs., Halász J., Baranyi J. The effect of glucocorticoids on the anxiolytic efficacy of buspirone. Psychopharmacology. 157:2001;388-394.
22. Hogg S. A review of the validity and variability of the elevated plus-maze as an animal model of anxiety. Pharmacol. Biochem. Behav. 54:1996;21-30.
23. Johnston A.L., File S.E. 5-HT and anxiety: promises and pitfalls. Pharmacol. Biochem. Behav. 24:1986;1467-1470.
24. Kempf E., Puglisi-Allegra S., Cabib S., Schleef C., Mandel P. Serotonin levels and turnover in different brain areas of isolated aggressive or non-aggressive strains of mice. Prog. Neuro-Psychopharmacol. Biol. Psychiatry. 8:1984;365-371.
25. Krsiak M., Sulcova A. Differential effects of six structurally related benzodiazepines on some ethological measures of timidity, aggression and locomotion in mice. Psychopharmacology. 101:1990;396-402.
26. 3 Antagonists and Benzodiazepines. Their Comparative Behavioural Pharmacology. 1991;343-363 Wiley, Chichester.
27. Lader M., Scotto J.C. A multicentre double-blind comparison of hydroxyzine, buspirone and placebo in patients with generalized anxiety disorder. Psychopharmacology. 139:1998;402-406.
28. La Greca A.M., Lopez N. Social anxiety among adolescents: linkages with peer relations and friendships. J. Abnorm. Child Psychol. 26:1998;83-94.
29. Manzaneque J.M., Brain P.F., Navarro J.F. Effect of low doses of clozapine on behaviour of isolated and group-housed male mice in the elevated plus-maze test. Prog. Neuro-Psychopharmacol. 26:2002;349-355.
30. McNaughton N., Panickar K.S., Logan B. The pituitary-adrenal axis and the different behavioral effects of buspirone and chlordiazepoxide. Pharmacol. Biochem. Behav. 54:1996;51-56.
31. Motta V., Maisonnette S., Morato S., Castrechini P., Brandao M.L. Effects of blockade of 5-HT2 receptors and activation of 5-HT1A receptors on the exploratory activity of rats in the elevated plus-maze. Psychopharmacology. 107:1992;135-139.
32. Pecknold J.C., Familamiri P., Chang H., Wilson R., Alarcia J., McClure D.J. Buspirone: anxiolytic? Prog. Neuro-Psychopharmacol. Biol. Psychiatry. 9:1985;639-642.
33. Pecknold J.C., Matas M., Howarth B.G., Ross C., Swinson R., Vezeau C., Ungar W. Evaluation of buspirone as an antianxiety agent: buspirone and diazepam versus placebo. Can. J. Psychiatry. 34:1989;766-771.
34. Rickels K., Weisman K., Norstad N., Singer M., Stoltz D., Brown A., Danton J. Buspirone and diazepam in anxiety: a controlled study. J. Clin. Psychiatry. 43:1982;81-86.
35. Rilke O., Freier D., Jahkel M., Oehler J. Dynamic alterations of serotonergic metabolism and receptors during social isolation of low- and high-active mice. Pharmacol. Biochem. Behav. 59:1998;891-896.
36. Rodgers R.J. Animal models of 'anxiety': where next? Behav. Pharmacol. 8:1997;477-496.
37. Rodgers R.J., Cole J.C. The elevated plus-maze: pharmacology, methodology and ethology. Cooper S.J., Hendrie C.A. Ethology and Psychopharmacology. 1994;8-44 Wiley, Chichester.
38. Rodgers R.J., Johnson N.J. Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze test of anxiety. Pharmacol. Biochem. Behav. 52:1995;297-303.
39. 1A receptor antagonists. Palomo T., Beninger R.J., Archer T. Interactive Monoaminergic Disorders. 1999;47-63 Editorial Synthesis, Madrid.
40. Rodgers R.J., Cole J.C., Davies A. Anti-anxiety and behavioural suppressant actions of the novel 5-HT1A receptor agonist, flesinoxan. Pharmacol. Biochem. Behav. 48:1994;959-963.
41. Rodgers R.J., Nikulina E.M., Cole J.C. Dopamine D1 and D2 receptor ligands modulate the behaviour of mice in the elevated plus-maze. Pharmacol. Biochem. Behav. 49:1994;985-995.
42. Rodgers R.J., Cutler M.G., Jackson J.E. Behavioral effects of subchronic buspirone, odansetron and tianeptine: II. The elevated plus-maze. Pharmacol. Biochem. Behav. 56:1997;295-303.
43. Sramek J.J., Zarotsky V., Cutler N.R. Generalised anxiety disorder: treatment options. Drugs. 62:2002;1635-1648.
44. Steinberg J.R. Anxiety in elderly patients. A comparison of azapirones and benzodiazepines. Drugs Aging. 5:1994;335-345.
45. Strand M., Hetta J., Rosen A., Sorensen S., Malmstrom R., Fabian C., Marits K., Vetterskog K., Liljestrand A.G., Hegen C. A double-blind, controlled trial in primary care patients with generalized anxiety: a comparison between buspirone and oxazepam. J. Clin. Psychiatry. 51:1990;40-45. (Suppl.).
46. Tate L.A. Life satisfaction and death anxiety in aged women. Int. J. Aging Hum. Dev. 15:1982;299-306.
47. Treit D., Menard J., Royan C. Anxiogenic stimuli in the elevated plus-maze. Pharmacol. Biochem. Behav. 44:1993;463-469.
48. Weiss, S.M., 1995. Pharmacological and behavioural examination of the defensive reactions of laboratory mice to the calls of the Tawny Owl (Strix aluco). PhD thesis, University of Leeds.
49. Wright I.K., Ismail H., Upton N., Marsden C.A. Effect of isolation rearing on 5-HT agonist induced responses in the rat. Psychopharmacology. 105:1991;259-263.
50. Wurthmann C., Klieser E., Lehmann E., Krauth J. Single-subject experiments to determine individually differential effects of anxiolytics in generalized anxiety disorder. Neuropsychobiology. 33:1996;196-201.