Routine post-weaning handling of rats prevents isolation rearing-induced deficit in prepulse inhibition

Brazilian Journal of Medical and Biological Research

Volumn 38, Issue 11, 2005, Pages 1691-1696

  Rosa, M L N M ^a   Silva, R C B ^a   Moura de Carvalho, F T ^a   Brandao M L ^a   Guimaraes F S ^a   Del Bel, E A ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Locomotor activity; Prepulse inhibition; Rat; Schizophrenia; Social isolation; Stress

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENTION DEFICIT DISORDER; CONTROLLED STUDY; MALE; NONHUMAN; PREPULSE INHIBITION; RAT; RAT STRAIN; REARING; SCHIZOPHRENIA; SOCIAL ISOLATION; STATISTICAL SIGNIFICANCE; WEANING;

ANIMALIA; RATTUS NORVEGICUS;

EID: 27944456087     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2005001100018     Document Type: Article

References (16)

1. Kim JW & Kirkpatrick B (1996). Social isolation in animal models of relevance to neuropsychiatric disorders. Biological Psychiatry, 40: 918-922.
2. Geyer MA, Wilkinson SL, Humby T et al. (1993). Isolation rearing of rats produces a deficit in prepulse inhibition of acoustic startle similar to that in schizophrenia. Biological Psychiatry, 34: 361-372.
3. Fulford AJ & Marsden CA (1998). Conditioned release of 5-hydroxytryptamine in vivo in the nucleus accumbens following isolation-rearing in the rat. Neuroscience, 83: 481-487.
4. Heidbreder CA, Weiss IC, Domeney AM et al. (2000). Behavioral, neurochemical and endocrinological characterization of the early social isolation syndrome. Neuroscience, 100: 749-768.
5. Swerdlow NR, Braff DL & Geyer MA (1999). Cross-species studies of sensorimotor gating of the startle reflex. Annals of the New York Academy of Sciences, 877: 202-216.
6. Varty GB & Higgins GA (1995). Examination of drug-induced and isolation-induced disruptions of prepulse inhibition as models to screen antipsychotic drugs. Psychopharmacology 122: 15-26.
7. Hall FS, Huang S & Fong G (1997). Effects of isolation-rearing on acoustic startle and prepulse inhibition in Wistar and Fawn Hooded rats. Annals of the New York Academy of Sciences, 821: 542-544.
8. Wilkinson LS, Killcross SS, Humby T et al. (1994). Social isolation in the rat produces developmentally specific deficits in prepulse inhibition of the acoustic startle response without disrupting latent inhibition. Neuropsychopharmacology, 10: 61-72.
9. Bakshi VP & Geyer MA (1999). Ontogeny of isolation rearing-induced deficits in sensorimotor gating in rats. Physiology and Behavior, 67: 385-392.
10. Varty GB, Braff DL & Geyer MA (1999). Is there a critical developmental 'window' for isolation rearing-induced changes in prepulse inhibition of the acoustic startle response? Behavioural Brain Research, 100: 177-183.
11. Weiss IC, Feldon J & Domeney AM (1999). Isolation rearing-induced disruption of prepulse inhibition: further evidence for fragility of the response. Behavioural Pharmacology, 10: 139-149.
12. Domeney A & Feldon J (1998). The disruption of prepulse inhibition by social isolation in the Wistar rat: how robust is the effect? Pharmacology, Biochemistry, and Behavior, 59: 883-890.
13. Holson RR, Scallet AC, Ali SF et al. (1991). "Isolation stress" revisited: Isolation-rearing effects depend on animal care methods. Physiology and Behavior, 49: 1107-1118.
14. Krebs-Thomson K, Giracello D, Solis A et al. (2001). Post-weaning handling attenuates isolation-rearing induced disruptions of prepulse inhibition in rats. Behavioural Brain Research, 120: 221-224.
15. Hall FS, Wilkinson LS, Humby T et al. (1998). Isolation rearing in rats: pre- and postsynaptic changes in striatal dopaminergic systems. Pharmacology, Biochemistry, and Behavior, 59: 859-872.
16. Gentsch C, Lichtsteiner M, Frischknecht HR et al. (1988). Isolation-induced locomotor hyperactivity and hypoalgesia in rats are prevented by handling and reversed by resocialization. Physiology and Behavior, 43: 13-16.