Effects of acute and chronic administration of fluoxetine on the activity of serotonergic neurons in the dorsal raphe nucleus of the rat

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 362, Issue 3, 2000, Pages 266-275

  Czachura, J F ^a   Rasmussen, K ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; FLUOXETINE; NORFLUOXETINE; SEROTONIN; SEROTONIN 1A AGONIST; SEROTONIN UPTAKE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; DOSE TIME EFFECT RELATION; DRUG ADMINISTRATION ROUTE; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG EFFECT; LONG TERM CARE; MALE; NONHUMAN; RAT; RECEPTOR DOWN REGULATION; SEROTONINERGIC TRANSMISSION;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; FLUOXETINE; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; MALE; NEURONS; PIPERAZINES; PYRIDINES; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN ANTAGONISTS; SEROTONIN UPTAKE INHIBITORS;

EID: 0033864136     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002100000290     Document Type: Article

References (42)

1. Feedback regulation of central monoaminergic neurons: Evidence from single-cell recording studies
2. Fluoxetine and norfluoxetine plasma concentrations in major depression: A multicenter study
3. Fluoxetine: Relationships among dose, response, adverse events, and plasma concentrations in the treatment of depression
4. Fluoxetine: A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in depressive illness
5. Effect of long-term administration of antidepressant treatments on serotonin release in brain regions involved in obsessive-compulsive disorder
6. Electrophysiological investigations on the effect of repeated zimelidine administration on serotonergic neurotransmission in the rat
7. 1(A) agonist gepirone: Electrophysiological studies in the rat brain
8. Effects of the two anti-depressant drugs mianserin and indalpine on the serotonergic system: Single-cell studies in the rat
9. Long-term 5-HT reuptake blockade, but not monoamine oxidase inhibition, decreases the function of terminal 5-HT autoreceptors: An electrophysiological study in the rat brain
10. Influence of dose and route of administration on the kinetics of fluoxetine and its metabolite norfluoxetine in the rat
11. The inhibitory effect of 8-OH-DPAT on the firing activity of dorsal raphe serotonergic neurons in rats is attenuated by lesion of the frontal cortex
12. Effects of a selective 5-HT reuptake blocker, citalopram, on the sensitivity of 5-HT autoreceptors: Electrophysiological studies in the rat brain
13. Further evidence that serotonin is a neurotransmitter involved in the control of prolactin secretion
14. The interaction of cocaine with serotonin dorsal raphe neurons: Single-unit extracellular recording studies
15. 1(A) control of dorsal raphe cell firing and 5-HT release
16. Electrophysiologically identified serotonin receptors in the rat CNS
17. Modification of serotonergic neuron properties by long-term treatment with serotonin reuptake blockers
18. 1(A) receptor agonist ipsapirone: Electrophysiological studies in the rat hippocampus and dorsal raphe
19. Electrophysiological, biochemical, neurohormonal and behavioral studies with WAY-100635. Potent, selective and silent 5-HT(1A) receptor antagonist
20. Basic advances in serotonin pharmacology
21. Uptake inhibitors increase extracellular serotonin concentration measured by brain microdialysis
22. Serotonin uptake inhibitors: Uses in clinical therapy and in laboratory research
23. Inhibition of serotonin reuptake
24. Serotonin uptake and serotonin up-take inhibition
25. Importance of duration of drug action in the antagonism of p-chloroamphetamine depletion of brain serotonin - Comparison of fluoxetine and chlorimipramine
26. Role of the medial prefrontal cortex in 5-HT(1A) receptor-induced inhibition of 5-HT neuronal activity in the rat
27. Lack of 5-HT(1A) autoreceptor desensitization following chronic citalopram treatment, as determined by in vivo microdialysis
28. Extracellular concentrations of serotonin in the dorsal hippocampus after acute and chronic treatment with citalopram
29. Central pre- and postsynaptic 5-HT(1A) receptors in rats treated chronically with a novel antidepressant, cericlamine
30. Early desensitization of somato-dendritic 5-HT(1A) autoreceptors in rats treated with fluoxetine or paroxetine
31. Chronic fluoxetine induces a gradual desensitization of 5-HT(1A) receptors: Reductions in hypothalamic and midbrain Gi and Go proteins and in neuroendocrine responses to a 5-HT(1A) agonist
32. Daily injections of fluoxetine induce dose-dependent desensitization of hypothalamic 5-HT(1A) receptors: Reductions in neuroendocrine responses to 8-OH-DPAT and in levels of G-z and G-i proteins
33. Sustained desensitization of hypothalamic 5-hydroxytryptamine-1A receptors after discontinuation of fluoxetine: Inhibited neuroendocrine responses to 8-hydroxy-2-(dipropylamino)tetralin in the absence of changes in G(i/o/z) proteins
34. Accumulation of fluoxetine and norfluoxetine in human brain during therapeutic administration
35. Serotonin uptake blockers inhibit the firing of presumed serotonergic dorsal raphe neurons in vitro
36. Reduction of in vivo striatal 5-hydroxytryptamine release by 8-OH-DPAT after inactivation of Gi/Go proteins in dorsal raphe nucleus
37. Electrophysiological characterization of the effect of long-term duloxetine administration on the rat serotonergic and noradrenergic systems
38. Systemic uptake inhibition decreases serotonin release via somatodendritic autoreceptor activation
39. Electrophysiological effects of fluoxetine and duloxetine in the dorsal raphe nucleus and hippocampus
40. Electrophysiological responses of serotonergic dorsal raphe neurons to 5-HT(1A) and 5-HT-1B agonists
41. Comparison of the effects of sertraline and its metabolite desmethylsertraline on blockade of central 5-HT reuptake in vivo
42. Autoradiographic quantification of serotonin-1A receptors in rat brain following antidepressant drug treatment