-
1
-
-
34250785643
-
Selective toxicity of aristolochic acids I and II
-
Shibutani S, Dong H, Suzuki N, Ueda S, Miller F, Grollman AP. Selective toxicity of aristolochic acids I and II. Drug Metab Dispos 2007, 35, 1217-1222.
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 1217-1222
-
-
Shibutani, S.1
Dong, H.2
Suzuki, N.3
Ueda, S.4
Miller, F.5
Grollman, A.P.6
-
2
-
-
37849189626
-
Epithelial-mesenchymal transition and its implications for the development of renal tubulointerstitial fibrosis
-
Rastaldi MP. Epithelial-mesenchymal transition and its implications for the development of renal tubulointerstitial fibrosis. J Nephrol 2006, 19, 407-412.
-
(2006)
J Nephrol
, vol.19
, pp. 407-412
-
-
Rastaldi, M.P.1
-
3
-
-
0025222517
-
The transforming growth factor-β family
-
Massague J. The transforming growth factor-β family. Annu Rev Cell Biol 1990, 6, 597-641.
-
(1990)
Annu Rev Cell Biol
, vol.6
, pp. 597-641
-
-
Massague, J.1
-
4
-
-
0034785496
-
Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis
-
Yang J, Liu Y. Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am. J. Pathol 2001, 159, 1465-1475.
-
(2001)
Am. J. Pathol
, vol.159
, pp. 1465-1475
-
-
Yang, J.1
Liu, Y.2
-
5
-
-
0036088906
-
Renal fibrosis: Extracellular matrix microenvironment regulates migratory behavior of activated tubular epithelial cells
-
Zeisberg M, Maeshima Y, Mosterman B, Kalluri R. Renal fibrosis: Extracellular matrix microenvironment regulates migratory behavior of activated tubular epithelial cells. Am J Pathol 2002, 160, 2001-2008.
-
(2002)
Am J Pathol
, vol.160
, pp. 2001-2008
-
-
Zeisberg, M.1
Maeshima, Y.2
Mosterman, B.3
Kalluri, R.4
-
6
-
-
0036189844
-
Regulation of cell proliferation by Smad proteins
-
Ten Dijke P, Goumans MJ, Itoh F, Itoh S. Regulation of cell proliferation by Smad proteins. J Cell Physiol 2002, 191, 1-16.
-
(2002)
J Cell Physiol
, vol.191
, pp. 1-16
-
-
Ten Dijke, P.1
Goumans, M.J.2
Itoh, F.3
Itoh, S.4
-
7
-
-
0030611757
-
Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signaling
-
Nakao A, Afrakhte MA, Moren A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin NE, Heldin CH, Dijke PT. Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signaling. Nature 1997, 389, 631-635.
-
(1997)
Nature
, vol.389
, pp. 631-635
-
-
Nakao, A.1
Afrakhte, M.A.2
Moren, A.3
Nakayama, T.4
Christian, J.L.5
Heuchel, R.6
Itoh, S.7
Kawabata, M.8
Heldin, N.E.9
Heldin, C.H.10
Dijke, P.T.11
-
8
-
-
11144324910
-
Both SP1 and Smad participate in mediating TGF-β1-induced HGF receptor expression in renal epithelial cells
-
Zhang X, Yang J, Li Y, Liu Y. Both SP1 and Smad participate in mediating TGF-β1-induced HGF receptor expression in renal epithelial cells. Am J Physiol Renal Physiol 2005, 288, 16-26.
-
(2005)
Am J Physiol Renal Physiol
, vol.288
, pp. 16-26
-
-
Zhang, X.1
Yang, J.2
Li, Y.3
Liu, Y.4
-
9
-
-
2442672575
-
Augmented cytoplasmic Smad4 induces acceleration of TGF-β1 signaling in renal tubulointerstitial cells of hereditary nephrotic ICGN mice with chronic renal fibrosis; possible role for myofibroblastic differentiation
-
Goto Y, Manabe N, Uchio-Yamada, K, Yamaguchi-Yamada M, Inoue N, Yamamoto Y, Ogura A, Nagano N, Miyamoto H. Augmented cytoplasmic Smad4 induces acceleration of TGF-β1 signaling in renal tubulointerstitial cells of hereditary nephrotic ICGN mice with chronic renal fibrosis; possible role for myofibroblastic differentiation. Cell Tissue Res 2004, 315, 209-221.
-
(2004)
Cell Tissue Res
, vol.315
, pp. 209-221
-
-
Goto, Y.1
Manabe, N.2
Uchio-Yamada, K.3
Yamaguchi-Yamada, M.4
Inoue, N.5
Yamamoto, Y.6
Ogura, A.7
Nagano, N.8
Miyamoto, H.9
-
10
-
-
0037186459
-
Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5)
-
Callahan JF, Burgess JL, Fornwald JA, Gaster LM, Harling JD, Harrington FP, Heer J, Kwon C, Lehr R, Mathur A, Olson BA, Weinstock J, Laping NJ. Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5). J Med Chem 2002, 45, 999-1001.
-
(2002)
J Med Chem
, vol.45
, pp. 999-1001
-
-
Callahan, J.F.1
Burgess, J.L.2
Fornwald, J.A.3
Gaster, L.M.4
Harling, J.D.5
Harrington, F.P.6
Heer, J.7
Kwon, C.8
Lehr, R.9
Mathur, A.10
Olson, B.A.11
Weinstock, J.12
Laping, N.J.13
-
11
-
-
0036082554
-
Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542
-
Laping NJ, Grygielko E, Mathur A, Butter S, Bomberger J, Tweed C, Martin W, Fornwald J, Lehr R, Harling J, Gaster L, Callahan JF, Olson BA. Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542. Mol Pharmacol 2002, 62, 58-64.
-
(2002)
Mol Pharmacol
, vol.62
, pp. 58-64
-
-
Laping, N.J.1
Grygielko, E.2
Mathur, A.3
Butter, S.4
Bomberger, J.5
Tweed, C.6
Martin, W.7
Fornwald, J.8
Lehr, R.9
Harling, J.10
Gaster, L.11
Callahan, J.F.12
Olson, B.A.13
-
12
-
-
0034612231
-
Transforming growth factor β-inducible independent binding of SMAD to the Smad7 promoter
-
Denissova NG, Pouponnot C, Long J, He D, Liu F. Transforming growth factor β-inducible independent binding of SMAD to the Smad7 promoter. PNAS 2000, 97, 6397-6402.
-
(2000)
PNAS
, vol.97
, pp. 6397-6402
-
-
Denissova, N.G.1
Pouponnot, C.2
Long, J.3
He, D.4
Liu, F.5
-
13
-
-
0347363474
-
TGF-β receptor kinase inhibitor enhances growth and integrity of embryonic stem cellderived endothelial cells
-
Watabe T, Nishihara A, Mishima K, Yamashita J, Shimizu K, Miyazawa K, Nishikawa S, Miyazono K. TGF-β receptor kinase inhibitor enhances growth and integrity of embryonic stem cellderived endothelial cells. J Cell Biol 2003, 163, 1303-1311.
-
(2003)
J Cell Biol
, vol.163
, pp. 1303-1311
-
-
Watabe, T.1
Nishihara, A.2
Mishima, K.3
Yamashita, J.4
Shimizu, K.5
Miyazawa, K.6
Nishikawa, S.7
Miyazono, K.8
-
14
-
-
0029091682
-
Identification and characterization of a fibroblast maker: FSP1
-
Strutz F, Okada H, Lo CW, Danoff T, Carone RL, Tomaszewski JE, Neilson EG. Identification and characterization of a fibroblast maker: FSP1. J Cell 1995, 1320, 393-405.
-
(1995)
J Cell
, vol.1320
, pp. 393-405
-
-
Strutz, F.1
Okada, H.2
Lo, C.W.3
Danoff, T.4
Carone, R.L.5
Tomaszewski, J.E.6
Neilson, E.G.7
-
15
-
-
0031682715
-
Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats
-
Ng YY, Huang TP, Yang WC, Chen ZP, Yang AH, Mu W, Nikolic-Paterson DJ, Atkins RC, Lan HY. Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats. Kidney Int 1998, 54, 864-876.
-
(1998)
Kidney Int
, vol.54
, pp. 864-876
-
-
Ng, Y.Y.1
Huang, T.P.2
Yang, W.C.3
Chen, Z.P.4
Yang, A.H.5
Mu, W.6
Nikolic-Paterson, D.J.7
Atkins, R.C.8
Lan, H.Y.9
-
16
-
-
0031059573
-
Polarity of stimulation and secretion of transforming growth factor-β1 by cultured proximal tubular cells
-
Phillips AO, Steadman R, Morrisey, K, Williams JD. Polarity of stimulation and secretion of transforming growth factor-β1 by cultured proximal tubular cells. Am J Pathol 1997, 150, 1101-1111.
-
(1997)
Am J Pathol
, vol.150
, pp. 1101-1111
-
-
Phillips, A.O.1
Steadman, R.2
Morrisey, K.3
Williams, J.D.4
-
17
-
-
0036233040
-
Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation
-
Strutz F, Zeisberg M, Ziyadeh FN, Yang CQ, Kalluri R, Müller GA, Neilson EG. Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation. Kidney Int 2002, 61, 1714-1728.
-
(2002)
Kidney Int
, vol.61
, pp. 1714-1728
-
-
Strutz, F.1
Zeisberg, M.2
Ziyadeh, F.N.3
Yang, C.Q.4
Kalluri, R.5
Müller, G.A.6
Neilson, E.G.7
-
18
-
-
0034085245
-
Aristolochic acid Iinduced apoptosis in LLC-PK1 cells and amelioration of the apoptotic damage by calcium antagonist
-
Gao RT, Zheng FL, Liu YX, Zheng DX, Li XM, Bo YH, Liu Y. Aristolochic acid Iinduced apoptosis in LLC-PK1 cells and amelioration of the apoptotic damage by calcium antagonist. Chinese Med J 2000, 113, 418-424.
-
(2000)
Chinese Med J
, vol.113
, pp. 418-424
-
-
Gao, R.T.1
Zheng, F.L.2
Liu, Y.X.3
Zheng, D.X.4
Li, X.M.5
Bo, Y.H.6
Liu, Y.7
-
19
-
-
0038364209
-
Localization and phenotypical characterization of collagen-producing cells in TGF-β1-induced renal interstitial fibrosis
-
Chai Q, Krag S, Chai S. Localization and phenotypical characterization of collagen-producing cells in TGF-β1-induced renal interstitial fibrosis. Histochem Cell Biol 2003, 119, 267-280.
-
(2003)
Histochem Cell Biol
, vol.119
, pp. 267-280
-
-
Chai, Q.1
Krag, S.2
Chai, S.3
-
20
-
-
0037229290
-
Tubular epithelial-myofibroblast transdifferentiation mechanisms in proximal tubule cells
-
Lan HY. Tubular epithelial-myofibroblast transdifferentiation mechanisms in proximal tubule cells. Curr Opin Nephrol Hypertens 2003, 12, 25-29.
-
(2003)
Curr Opin Nephrol Hypertens
, vol.12
, pp. 25-29
-
-
Lan, H.Y.1
-
21
-
-
0030975645
-
TGF-beta in kidney fibrosis: A target for gene therapy
-
Border WA, Noble NA. TGF-beta in kidney fibrosis: A target for gene therapy. Kidney Int 1997, 51, 1388-1396.
-
(1997)
Kidney Int
, vol.51
, pp. 1388-1396
-
-
Border, W.A.1
Noble, N.A.2
-
22
-
-
0031438047
-
TGF-beta signalling from cell membrane to nucleus through SMAD proteins
-
Heldin, CH, Miyazono K, ten Dijke P. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 1997, 390, 465-471.
-
(1997)
Nature
, vol.390
, pp. 465-471
-
-
Heldin, C.H.1
Miyazono, K.2
ten Dijke, P.3
-
23
-
-
33846011104
-
Regulation of Smad activity
-
Lan X. Regulation of Smad activity. Biochim Biophys Acta 2006, 1759, 503-513.
-
(2006)
Biochim Biophys Acta
, vol.1759
, pp. 503-513
-
-
Lan, X.1
-
24
-
-
0034574298
-
How cells read TGF-beta signals
-
Massague J. How cells read TGF-beta signals. Nat Rev Mol Cell Biol 2000, 1, 169-178.
-
(2000)
Nat Rev Mol Cell Biol
, vol.1
, pp. 169-178
-
-
Massague, J.1
-
25
-
-
0037204990
-
Signal transduction by the TGF-beta superfamily
-
Attisano L, Wrana JL. Signal transduction by the TGF-beta superfamily. Science 2002, 296, 1646-1647.
-
(2002)
Science
, vol.296
, pp. 1646-1647
-
-
Attisano, L.1
Wrana, J.L.2
-
26
-
-
0034646674
-
Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor beta
-
Gersdorff G, Susztak K, Rezvani F, Bitzer M, Liang D, Böttinger EP. Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor beta. J Biol Chem 2000, 275, 11320-11326.
-
(2000)
J Biol Chem
, vol.275
, pp. 11320-11326
-
-
Gersdorff, G.1
Susztak, K.2
Rezvani, F.3
Bitzer, M.4
Liang, D.5
Böttinger, E.P.6
-
27
-
-
2542609844
-
-
Flanders KC. Smad3 as a mediator of the fibrotic response. Int J Exp Pathol 2004, 85, 47-64.
-
Flanders KC. Smad3 as a mediator of the fibrotic response. Int J Exp Pathol 2004, 85, 47-64.
-
-
-
-
28
-
-
0035827581
-
Functional characterization of transforming growth factor beta signaling in smad2- and smad3-deficient fibroblasts
-
Piek E, Ju WJ, Heyer J, Escalante-Alcalde D, Stewart CL, Weinstein M, Deng CX, Kucherlapati R, Böttinger EP, Roberts AB. Functional characterization of transforming growth factor beta signaling in smad2- and smad3-deficient fibroblasts. J Biol Chem 2001, 276, 19945-19953.
-
(2001)
J Biol Chem
, vol.276
, pp. 19945-19953
-
-
Piek, E.1
Ju, W.J.2
Heyer, J.3
Escalante-Alcalde, D.4
Stewart, C.L.5
Weinstein, M.6
Deng, C.X.7
Kucherlapati, R.8
Böttinger, E.P.9
Roberts, A.B.10
-
29
-
-
0037186459
-
Identification of novel inhibitors of the transforming growth factor β 1 (TGF-β 1) type I receptor (ALK5)
-
Callahan JF, Burgess JL, Fornwald JA, Gaster LM, Harling JD, Harrington FP, Heer J, Kwon C, Lehr R, Mathur A, Olson BA, Weinstock J, Laping NJ. Identification of novel inhibitors of the transforming growth factor β 1 (TGF-β 1) type I receptor (ALK5). J Med Chem 2002, 45, 999-1001.
-
(2002)
J Med Chem
, vol.45
, pp. 999-1001
-
-
Callahan, J.F.1
Burgess, J.L.2
Fornwald, J.A.3
Gaster, L.M.4
Harling, J.D.5
Harrington, F.P.6
Heer, J.7
Kwon, C.8
Lehr, R.9
Mathur, A.10
Olson, B.A.11
Weinstock, J.12
Laping, N.J.13
-
30
-
-
0036085920
-
SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
-
Inman GJ, Nicolas FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS.SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol. Pharmacol 2002, 62, 65-74.
-
(2002)
Mol. Pharmacol
, vol.62
, pp. 65-74
-
-
Inman, G.J.1
Nicolas, F.J.2
Callahan, J.F.3
Harling, J.D.4
Gaster, L.M.5
Reith, A.D.6
Laping, N.J.7
Hill, C.S.8
-
31
-
-
20244383986
-
Progressive transforming growth factorβ1-induced lung fibrosis is blocked by an orally active ALK5 kinase inhibitor
-
Bonniaud P, Margetts PJ, Kolb M, Schroeder JA, Kapoun AM, Damm D, Murphy A, Chakravarty S, Dugar S, Higgins L, Protter AA, Gauldie J. Progressive transforming growth factorβ1-induced lung fibrosis is blocked by an orally active ALK5 kinase inhibitor. Am J Respir Crit Care Med 2005, 171, 889-898.
-
(2005)
Am J Respir Crit Care Med
, vol.171
, pp. 889-898
-
-
Bonniaud, P.1
Margetts, P.J.2
Kolb, M.3
Schroeder, J.A.4
Kapoun, A.M.5
Damm, D.6
Murphy, A.7
Chakravarty, S.8
Dugar, S.9
Higgins, L.10
Protter, A.A.11
Gauldie, J.12
-
32
-
-
19944421105
-
Inhibition of TGF-β signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis
-
de Gouville AC, Boullay V, Krysa G, Pilot J, Brusq JM, Loriolle F, Gauthier JM, Papworth SA, Laroze A, Gellibert F, Huet S. Inhibition of TGF-β signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis. Br. J. Pharmacol 2005, 145, 166-177.
-
(2005)
Br. J. Pharmacol
, vol.145
, pp. 166-177
-
-
de Gouville, A.C.1
Boullay, V.2
Krysa, G.3
Pilot, J.4
Brusq, J.M.5
Loriolle, F.6
Gauthier, J.M.7
Papworth, S.A.8
Laroze, A.9
Gellibert, F.10
Huet, S.11
-
33
-
-
0031587828
-
The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGF beta signaling
-
Hayashi H, Abdollah S, Qiu Y, Cai J, Xu YY, Grinnell BW, Richardson MA, Topper JN, Gimbrone MA Jr, Wrana JL, Falb D. The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGF beta signaling. Cell 1997, 89, 1165-1173.
-
(1997)
Cell
, vol.89
, pp. 1165-1173
-
-
Hayashi, H.1
Abdollah, S.2
Qiu, Y.3
Cai, J.4
Xu, Y.Y.5
Grinnell, B.W.6
Richardson, M.A.7
Topper, J.N.8
Gimbrone Jr, M.A.9
Wrana, J.L.10
Falb, D.11
-
34
-
-
0034517389
-
Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta for degradation
-
Kavsak P, Rasmussen PK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta for degradation. Mol Cell 2000, 6, 1365-1375.
-
(2000)
Mol Cell
, vol.6
, pp. 1365-1375
-
-
Kavsak, P.1
Rasmussen, P.K.2
Causing, C.G.3
Bonni, S.4
Zhu, H.5
Thomsen, G.H.6
Wrana, J.L.7
-
35
-
-
0031964859
-
Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
-
Hata A, Lagna G, Massagué J, Hemmati-Brivanlou A. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev 1998, 12, 186-197.
-
(1998)
Genes Dev
, vol.12
, pp. 186-197
-
-
Hata, A.1
Lagna, G.2
Massagué, J.3
Hemmati-Brivanlou, A.4
-
36
-
-
0036014928
-
Smad7 Inhibits Fibrotic Effect of TGF-β on Renal Tubular Epithelial Cells by Blocking Smad2 Activation
-
Li JH, Zhu HJ, Huang XR, Lai KN, Johnson RJ, Lan HY. Smad7 Inhibits Fibrotic Effect of TGF-β on Renal Tubular Epithelial Cells by Blocking Smad2 Activation. J Am Soc Nephrol 2002, 13, 1464-1472.
-
(2002)
J Am Soc Nephrol
, vol.13
, pp. 1464-1472
-
-
Li, J.H.1
Zhu, H.J.2
Huang, X.R.3
Lai, K.N.4
Johnson, R.J.5
Lan, H.Y.6
-
37
-
-
14844286953
-
Ultraviolet irradiation induces Smad7 via induction of transcription factor AP-1 in human skin fibroblasts
-
Quan TH, He TY, Voorhees JJ, Fisher GJ. Ultraviolet irradiation induces Smad7 via induction of transcription factor AP-1 in human skin fibroblasts. J Biol Chem 2005, 9, 8079-8085.
-
(2005)
J Biol Chem
, vol.9
, pp. 8079-8085
-
-
Quan, T.H.1
He, T.Y.2
Voorhees, J.J.3
Fisher, G.J.4
|