Selective IκB kinase expression in airway epithelium generates neutrophilic lung inflammation

Journal of Immunology

Volumn 170, Issue 2, 2003, Pages 1091-1098

  Sadikot, Ruxana T ^a   Han, Wei ^a   Everhart, M Brett ^a   Zoia, Ornella ^a   Peebles, R Stokes ^a   Jansen, E Duco ^a   Yull, Fiona E ^a   Christman, John W ^a   Blackwell, Timothy S ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; COMPLEMENTARY DNA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; MACROPHAGE INFLAMMATORY PROTEIN 2; MESSENGER RNA;

AIRWAY; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOLOGY; INFLAMMATION; LUNG DISEASE; LUNG LAVAGE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM;

EID: 0037438457     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.2.1091     Document Type: Article

References (36)

1. Blackwell, T. S., and J. W. Christman. 1997. The role of nuclear factor-κB in cytokine gene regulation. Am. J. Respir. Mol. Biol. 17:3.
2. Christman, J. W., R. T. Sadikot, and T. S, Blackwell. 2000. The role of nuclear factor κB in pulmonary diseases. Chest 117:1482.
3. Schmitz, M. L., and P. A. Baeuerle. 1991. The p65 subunit is responsible for the strong transcription activating potential of NF-κB. EMBO J. 10:3805.
4. Verma, I. M., J. K. Stevenson, E. M. Schwarz, A. D. Van, and S. Miyamoto. 1995. Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev. 9:2723.
5. Beg, A. A., and A. S. Baldwin, Jr. 1993. The IκB proteins: multifunctional regulators of Rel/NF-κB transcription factors. Genes Dev. 7:2064.
6. Baldwin, A. S. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649.
7. Karin, M. 1999. How NF-κB is activated: the role of the IκB kinase (IKK) complex. Oncogene 18:6867.
8. Regnier, C. H., H. Y. Song, X. Gao, D. V. Goedell, Z. Cao, and M. Rothe. 1997. Identification and characterization of an IκB kinase. Cell 90:373.
9. Zandi, E., and M. Karin, 1999. Bridging the gap: composition, regulation and physiological function of the IκB kinase complex, Mol. Cell. Biol. 19:4547.
10. Zandi, E., D. M. Rothwarf, M. Delhase, M. Hayakawa, and M. Karin. 1997. The IκB kinase complex (IKK) contains two kinase subunits IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. Cell 91:243.
11. Yamaoka, S., G. Courtois, C. Bessia, S. T. Whiteside, R. Weil, F. Agou, H. E. Kirk, R. J. Kay, and A. Israel. 1998. Complementation cloning of NEMO, a component of the IκB kinase complex essential for NF-κB activation. Cell 93:1231.
12. Mercurio, F., H. Zhu, B. W. Murray, A. Shevchenko, B. L. Bennett, J. W. Li, D. B. Young, M. Barbosa, M. Mann, A. Manning, and A. Rao. 1997. IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation. Science 278:860.
13. Woronicz, J. D., G. Xiong, Z. Cao, M. Rothe, and D. V. Goeddel, 1997. IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK. Science 278:866.
14. Chen, G., P. Cao, and D. V. Goeddel. 2002. TNF-induced recruitment and activation of the IKK complex requires Cdc37 and Hsp90. Mol. Cell 9:401.
15. Li, Q., D. Van Antwerp, F. Mercurio, K-F, Lee, and I. M. Verma. 1999. Severe liver degeneration in mice lacking the IκB kinase 2 gene. Science 284:321.
16. Israel, A. 2000. The IKK complex: an integrator of all signals that activate NF-κB. Trends Cell Biol. 10:129.
17. O'Connell, M. A., B. L. Bennett, F. Mercurio, A. M. Manning, and N. Machman. 1998. Role of IKK1 and IKK2 in lipopolysaccharide signaling in human monocytic cells. J. Biol. Chem. 273:30410.
18. Yamamoto, Y., M. J. Yin, and R. B. Gaynor. 2000. IκB kinase α (IKKα) regulation of IKKβ kinase activity. Mol. Cell. Biol. 20:3655.
19. O'Mahony, A. O., X. Lin, R. Gelezius, and W. C. Greene, 2000. Activation of the heterodimeric IκB kinase a (IKKα)-IKKβ complex is directional: IKKα regulates IKKβ under both basal and stimulated conditions. Mol. Cell. Biol. 20:1170.
20. Hu, Y., V. Baud, T. Oga, K. Kim, K. Yoshida, and M. Karin, 2001. IKKα controls formation of epidermis independently of NF-κB. Nature 410:710.
21. Venkatakrishnan, A., G. King, A. A. Stecenko, T. R. Blackwell, K. L. Brigham, J. W. Christman, and T. S. Blackwell. 2000. Exaggerated activation of NF-κB and altered IκB-β processing in cystic fibrosis bronchial epithelial cells. Am. J. Respir. Cell Mol. Biol. 23:396.
22. DiMango, E., H. J. Zar, R. Bryan, and A. Prince. 1995. Diverse Pseudomonas aeruginosa gene products stimulate respiratory epithelial cells to produce interleukin-8. J. Clin. Invest. 96:2204.
23. Melotti, P., A. Tamanini, R. Rolfini, A. Pavirani, and G. Cabrini, G. 2001. Activation of NF-κB mediates ICAM-1 induction in respiratory cells exposed to an adenovirus-derived vector. Gene Ther. 8:1436.
24. Blackwell, T. S., F. E. Yull, C. L. Chen, A. Venkatakrishnan, T. R. Blackwell, D. J. Hicks, L. H. Lancaster, J. W. Christman, and L. D. Kerr. 2000. NF-κB activation and cytokine production in a transgenic mouse model of endotoxin-induced lung inflammation. Am. J. Respir. Crit. Care Med. 162:1095.
25. Sadikot, R. T., E. D. Jansen, T. R. Blackwell, O. Zoia, F. Yull, J. W. Christman, J., and T. S. Blackwell. 2001. High dose dexamethasone accentuates NF-κB activation in endotoxin treated mice. Am. J. Respir. Crit. Care Med. 164:873.
26. Sadikot, R. T., J. P. Debelak, D. E. Jansen, L. J. Wudel, D. S. Morris, J. W. Christman, T. S. Blackwell, and W. C. Chapman. 2002. Hepatic cryo-ablation-induced multisystem injury: bioluminescent detection of NF-κB activation is a transgenic mouse model. J. Gastrointest. Surg. 6:264.
27. Bradford, M. 1976. A rapid and sensitive method for quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248.
28. Blackwell, T. S., T. R. Blackwell, and J. W. Christman. 1997. Impaired activation of NF-κB in endotoxin-tolerant rats is associated with down-regulation of chemokine gene expression and inhibition of neutrophilic lung inflammation. J. Immunol. 159:5934.
29. Crystal, R. G., N. G. McElvaney, M. A. Rosenfeld, C. Chu, A. Mastrangeli, A. Hay, S. L. Brody, H. A. Jaffe, N. T. Eissa, and C. Danel. 1994. Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis. Nat. Genet. 8:42.
30. McCoy, R. D., B. L. Davidson, B. J. Roessler, G. B. Huffnagle, S. L. Janich, T. J. Laing, and R. H. Simon. 1995. Pulmonary inflammation induced by incomplete or inactivated adenoviral particles. Hum. Gene Ther. 6:1553.
31. Thorne, P. S., P. B. McCray, T. S. Howe, and M. A. O'Neill. 1999. Early-onset inflammatory responses in vivo to adenoviral vectors in the presence or absence of lipopolysaccharide-induced inflammation. Am. J. Respir. Cell Mol. Biol. 20:1155.
32. Tak, P. P., D. M. Gerlag, K. R. Aupperle, van de Geest, M. Overbecek, B. L. Bennett, D. L. Boyle, A. M. Manning, and G. S. Firestein. 2001. Inhibitor of nuclear factor κB kinase β is a key regulator of synovial inflammation. Arthritis Rheum. 44:1897.
33. Chen, X., B. Ji, B. Han, S. A. Ernst, D. Simeone, and C. D. Logsdon. 2002. NF-κB activation in pancreas induces pancreatic and systemic inflammatory response. Gastroenterology 122:448.
34. Park, G. Y., S. Le, K. H. Park, C. T. Le, Y. W. Kim, S. K. Han, Y. S. Shim, and C. G. Yoo. 2001. Anti-inflammatory effect of adenovirus-mediated IκBα overexpression in respiratory epithelial cells. Eur. Respir. J. 18:801.
35. Griesenbach, U., P. Scheid, E. Hillery, R. de Martin, L. Huang, D. M. Geddes, and E. W. Alton. 2000. Anti-inflammatory gene therapy directed at the lung epithelium. Gene Ther. 7:306.
36. Delhase, M., M. Hayakawa, Y. Chen, and M. Karin. 1999. Positive and negative regulation of IκB kinase activity through IKKβ subunit phosphorylation. Science 284:309.