TYK2 activity promotes ligand-induced IFNAR1 proteolysis

Biochemical Journal

Volumn 397, Issue 1, 2006, Pages 31-38

  Marijanovic, Zrinka ^a   Ragimbeau, Josiane ^a   Kumar, K G Suresh ^b   Fuchs, Serge Y ^b   Pellegrini, Sandra ^a  

^a INSTITUT PASTEUR   (France)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Degradation; Interferon receptor 1 subunit (IFNAR1); Internalization; Tyk2; Type I interferon (IFN); Ubiquitination

Indexed keywords

CATALYSIS; CHEMICAL REACTIONS; DEGRADATION; DIMERS; KINEMATICS; SIGNAL PROCESSING;

INTERFERON-Α RECEPTOR 1 SUBUNIT (IFNAR1); INTERNALIZATION; TYK2; TYPE I INTERFERON (IFN); UBIQUITINATION;

BIOLOGICAL MEMBRANES;

ALPHA INTERFERON; ALPHA INTERFERON RECEPTOR; ERYTHROPOIETIN; IODINE 125; JANUS KINASE; LIGAND; PROTEIN TYROSINE KINASE; SERINE; ALPHA BETA INTERFERON RECEPTOR; ERYTHROPOIETIN RECEPTOR; IFNAR1 PROTEIN, HUMAN; IFNAR2 PROTEIN, HUMAN; INTERFERON RECEPTOR; MEMBRANE PROTEIN; PROTEIN KINASE TYK2; RADIOACTIVE IODINE; TYK2 PROTEIN, HUMAN;

ARTICLE; CATALYSIS; CHIMERA; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; HALF LIFE TIME; HUMAN; HUMAN CELL; LIGAND BINDING; LYSOSOME; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN METABOLISM; SIGNAL TRANSDUCTION; UBIQUITINATION; BIOTINYLATION; CELL CULTURE; CYTOLOGY; FIBROSARCOMA; GENETIC TRANSFECTION; GENETICS; KIDNEY; METABOLISM; PHYSIOLOGY;

BIOTINYLATION; CATALYSIS; CHIMERA; FIBROSARCOMA; HALF-LIFE; HUMANS; INTERFERON-ALPHA; IODINE RADIOISOTOPES; KIDNEY; LIGANDS; MEMBRANE PROTEINS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RECEPTOR, INTERFERON ALPHA-BETA; RECEPTORS, ERYTHROPOIETIN; RECEPTORS, INTERFERON; SERINE; TRANSFECTION; TUMOR CELLS, CULTURED; TYK2 KINASE;

EID: 33745523440     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20060272     Document Type: Article

References (42)

1. Burke, P., Schooler, K. and Wiley, H. S. (2001) Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking. Mol. Biol. Cell. 12, 1897-1910
2. Le Roy, C. and Wrana, J. L. (2005) Clathrin- and non-clathrin-mediated endocytic regulation of cell signaling. Nat. Rev. Mol. Cell Biol. 6, 112-126
3. Marmor, M. D. and Yarden, Y. (2004) Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases. Oncogene. 23, 2057-2070
4. Boulay, J. L., O'Shea, J. J. and Paul, W. E. (2003) Molecular phylogeny within type I cytokines and their cognate receptors. Immunity 19, 159-163
5. Kotenko, S. V. and Pestka, S. (2000) Jak-Stat signal transduction pathway through the eyes of cytokine class II receptor complexes. Oncogene 19, 2557-2565
6. Kisseleva, T., Bhattacharya, S., Braunstein, J. and Schindler, C. W. (2002) Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene 285, 1-24
7. Yen, T. C. and Pellegrini, S. (1999) The Janus kinase family of protein tyrosine kinases and their role in signaling. Cell. Mol. Life. Sci. 55, 1523-1534
8. van Kerkhof, P., Govers, R., Alves dos Santos, C. M. and Strous, G. J. (2000) Endocytosis and degradation of the growth hormone receptor are proteasome-dependent. J. Biol. Chem. 275, 1575-1580
9. Govers, R., van Kerkhof, P., Schwartz, A. L. and Strous, G. J. (1997) Linkage of the ubiquitin-conjugating system and the endocytic pathway in ligand-induced internalization of the growth hormone receptor. EMBO J. 16, 4851-4858
10. Walrafen, P., Verdier, F., Kadri, Z., Chretien, S., Lacombe, C. and Mayeux, P. (2005) Both proteasomes and lysosomes degrade the activated erythropoietin receptor. Blood 105, 600-608
11. Lamaze, C., Dujeancourt, A., Baba, T., Lo, C. G., Benmerah, A. and Dautry-Varsat, A. (2001) Interleukin 2 receptors and detergent-resistant membrane domains define a clathrin-independent endocytic pathway. Mol. Cell. 7, 661-671
12. Subtil, A., Hemar, A. and Dautry-Varsat, A. (1994) Rapid endocytosis of interleukin 2 receptors when clathrin-coated pit endocytosis is inhibited. J. Cell. Sci. 107, 3461-3468
13. Hemar, A., Subtil, A., Lieb, M., Morelon, E., Hellio, R. and Dautry-Varsat, A. (1995) Endocytosis of interleukin 2 receptors in human T lymphocytes: distinct intracellular localization and fate of the receptor α, β, and gamma chains. J. Cell. Biol. 129, 55-64
14. Rocca, A., Lamaze, C., Subtil, A. and Dautry-Varsat, A. (2001) Involvement of the ubiquitin/proteasome system in sorting of the interleukin 2 receptor β chain to late endocytic compartments. Mol. Biol. Cell. 12, 1293-1301
15. Mogensen, K. E., Lewerenz, M., Reboul, J., Lutfalla, G. and Uze, G. (1999) The type I interferon receptor: structure, function, and evolution of a family business. J. Interferon Cytokine Res. 19, 1069-1098
16. Pestka, S., Krause, C. D. and Walter, M. R. (2004) Interferons, interferon-like cytokines, and their receptors. Immunol. Rev. 202, 8-32
17. Lamken, P., Lata, S., Gavutis, M. and Piehler, J. (2004) Ligand-induced assembling of the type I interferon receptor on supported lipid bilayers. J. Mol. Biol. 341, 303-318
18. Ling, L. E., Zafari, M., Reardon, D., Brickelmeier, M., Goelz, S. E. and Benjamin, C. O. (1995) Human type I interferon receptor, IFNAR, is a heavily glycosylated 120-130 KD membrane protein. J. Interferon Cytokine Res. 15, 55-61
19. Colamonici, O., Yan, H., Domanski, P., Handa, R., Smalley, D., Mullersman, J., Witte, M., Krishnan, K. and Krolewski, J. (1994) Direct binding to and tyrosine phosphorylation of the α subunit of the type I interferon receptor by p135tyk2 tyrosine kinase. Mol. Cell. Biol. 14, 8133-8142
20. Ragimbeau, J., Dondi, E., Alcover, A., Eid, P., Uze, G. and Pellegrini, S. (2003) The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression. EMBO J. 22, 537-547
21. Pellegrini, S., John, J., Shearer, M., Kerr, I. M. and Stark, G. R. (1989) Use of a selectable marker regulated by α interferon to obtain mutations in the signaling pathway. Mol. Cell. Biol. 9, 4605-4612
22. Gauzzi, M. C., Velazquez, L., McKendry, R., Mogensen, K. E., Fellous, M. and Pellegrini, S. (1996) Interferon-α-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase. J. Biol. Chem. 271, 20494-20500
23. Ragimbeau, J., Dondi, E., Vasserot, A., Romero, P., Uze, G. and Pellegrini, S. (2001) The receptor interaction region of Tyk2 contains a motif required for its nuclear localization. J. Biol. Chem. 276, 30812-30818
24. Gauzzi, M. C., Barbieri, G., Richter, M. F., Uze, G., Ling, L., Fellous, M. and Pellegrini, S. (1997) The amino-terminal region of Tyk2 sustains the level of interferon α receptor 1, a component of the interferon α/β receptor. Proc. Natl. Acad. Sci. U.S.A. 94, 11839-11844
25. Kumar, K. G., Krolewski, J. J. and Fuchs, S. Y. (2004) Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor. J. Biol. Chem. 279, 46614-46620
26. Hammond, D. E., Carter, S., McCullough, J., Urbe, S., Vande Woude, G. and Clague, M. J. (2003) Endosomal dynamics of Met determine signaling output. Mol. Biol. Cell. 14, 1346-1354
27. Goldman, L. A., Zafari, M., Cutrone, E. C., Dang, A., Brickelmeier, M., Runkel, L., Benjamin, C. D., Ling, L. E. and Langer, J. A. (1999) Characterization of artihuman IFNAR-1 monoclonal antibodies: epitope localization and functional analysis. J. Interferon Cytokine Res. 19, 15-26
28. Neumann, D., Wikstrom, L., Watowich, S. S. and Lodish, H. F. (1993) Intermediates in degradation of the erythropoietin receptor accumulate and are degraded in lysosomes. J. Biol. Chem. 268, 13639-13649
29. Li, X., Leung, S., Kerr, I. M. and Stark, G. R. (1997) Functional subdomains of STAT2 required for preassociation with the α interferon receptor and for signaling. Mol. Cell. Biol. 17, 2048-2056
30. Kumar, K. G., Tang, W., Ravindranath, A. K., Clark, W. A., Croze, E. and Fuchs, S. Y. (2003) SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-α receptor. EMBO J. 22, 5480-5490
31. Royer, Y., Staerk, J., Costuleanu, M., Courtoy, P. J. and Constantinescu, S. N. (2005) Janus kinases affect thrombopoietin receptor cell surface localization and stability. J. Biol. Chem. 280, 27251-27261
32. Radtke, S., Hermanns, H. M., Haan, C., Schmitz-Van De Leur, H., Gascan, H., Heinrich, P. C. and Behrmann, I. (2002) Novel rale of Janus kinase 1 in the regulation of oncostatin M receptor surface expression. J. Biol. Chem. 277, 11297-11305
33. Huang, L. J., Constantinescu, S. N. and Lodish, H. F. (2001) The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor. Mol. Cell. 8, 1327-1338
34. Beckman, D. L., Lin, L. L., Quinones, M. E. and Longmore, G. D. (1999) Activation of the erythropoietin receptor is not required for internalization of bound erythropoietin. Blood 94, 2667-2675
35. Alves dos Santos, C. M., ten Broeke, T. and Strous, G. J. (2001) Growth hormone receptor ubiquitination, endocytosis, and degradation are independent of signal transduction via Janus kinase 2. J. Biol. Chem. 276, 32635-32641
36. Thiel, S., Behrmann, I., Dittrich, E., Muys, L., Tavernier, J., Wijdenes, J., Heinrich, P. C. and Graeve, L. (1998) Internalization of the interleukin 6 signal transducer gp130 does not require activation of the Jak/STAT pathway. Biochem. J. 330, 47-54
37. Friedrich, K., Kammer, W., Erhardt, I., Brandlein, S., Arnold, S. and Sebald, W. (1999) The two subunits of the interleukin-4 receptor mediate independent and distinct patterns of ligand endocytosis. Eur. J. Biochem. 265, 457-465
38. Li, Y., Kumar, K. G., Tang, W., Spiegelman, V. S. and Fuchs, S. Y. (2004) Negative regulation of prolactin receptor stability and signaling mediated by SCF(β-TrCP) E3 ubiquitin ligase. Mol. Cell. Biol. 24, 4038-4048
39. Sigismund, S., Woelk, T., Puri, C., Maspero, E., Tacchetti, C., Transidico, P., Di Fiore, P. P. and Polo, S. (2005) Clathrin-independent endocytosis of ubiquitinated cargos. Proc. Natl. Acad. Si. U.S.A. 102, 2760-2765
40. Holler, D. and Dikic, I. (2004) Receptor endocytosis via ubiquitin-dependent and -independent pathways. Biochem. Pharmacol. 67, 1013-1017
41. Katzmann, D. J., Odorizzi, G. and Emr, S. D. (2002) Receptor downregulation and multivesicular-body sorting. Nat. Rev. Mol. Cell. Biol. 3, 893-905
42. Saleh, A. Z., Fang, A. T., Arch, A. E., Neupane, D., El Fiky, A. and Krolewski, J. J. (2004) Regulated proteolysis of the IFNaR2 subunit of the interferon-α receptor. Oncogene 23, 7076-7086