An efficient synthesis of ABT-263, a novel inhibitor of antiapoptotic Bcl-2 proteins

Synthesis

Volumn , Issue 15, 2008, Pages 2398-2404

  Wang, Guangjun ^a,b,c   Zhang, Hushan ^b   Zhou, Jing ^b   Ha, Chengyong ^a   Pei, Duanqing ^b   Ding, Ke ^b  

^a GUANGZHOU INSTITUTE OF CHEMISTRY   (China)

^b GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

ABT 263; Anticancer drugs; Bcl 2 family protein inhibitor; Sulfonamides; Synthesis

Indexed keywords

BENZENE; CHEMOTHERAPY; DRUG DELIVERY; DRUG DOSAGE; FLUORINE;

ABT-263; ANTIAPOPTOTIC; ANTICANCER DRUGS; BCL-2 FAMILY PROTEIN INHIBITOR; BENZOIC ACID; EFFICIENT SYNTHESIS; KEY INTERMEDIATES; MANNICH REACTIONS; NEW PROCESSES; NUCLEOPHILIC FLUORINATION; SULFONAMIDES; SYNTHESIS; THREE-COMPONENT; TRIFLUORO METHYL;

CHEMICAL REACTIONS;

1 NITRO 2 [(TRIFLUOROMETHYL)SULFONYL]BENZENE; 4 [4 [[2 (4 CHLOROPHENYL) 5,5 DIMETHYLCYCLOHEX 1 ENYL]METHYL]PIPERAZIN 1 YL]BENZOIC ACID; 4 FLUORO 3 [(TRIFLUOROMETHYL)SULFONYL]BENZENESULFONAMIDE; BENZENE DERIVATIVE; PROTEIN ABT 263; PROTEIN BCL 2; PROTEIN INHIBITOR;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORINATION; MANNICH REACTION; OXIDATION; PROCESS DEVELOPMENT;

EID: 49649106694     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1067129     Document Type: Article

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