In vitro and in vivo suppression of cellular activity by guanidinoethyl disulfide released from hydrogel microspheres composed of partially oxidized hyaluronan and gelatin

Biomaterials

Volumn 29, Issue 31, 2008, Pages 4149-4156

  Weng, Lihui ^a   Ivanova, Natalia D ^a   Zakhaleva, Julia ^a   Chen, Weiliam ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

Cell infiltration; Gelatin; Guanidinoethyl disulfide; Hyaluronan; Microspheres

Indexed keywords

CHEMOTHERAPY; COLLOIDS; DRUG DELIVERY; DRUG DOSAGE; EMULSIFICATION; ENCAPSULATION; HYDROGELS; POLARIZATION; PROTEINS; THREE DIMENSIONAL;

AVERAGE DIAMETER; CELL INFILTRATION; CELLULAR ACTIVITIES; CROSS LINKERS; CROSSLINKED; CROSSLINKED GELATIN; GELATIN; GUANIDINOETHYL DISULFIDE; HYALURONAN; HYDROGEL MICROSPHERES; IN-VITRO; IN-VIVO; INVERSE CORRELATION; MODEL DRUGS; POROUS STRUCTURES; ROUGH SURFACES; TRANSCUTANEOUS; WATER-IN-OIL;

MICROSPHERES;

GELATIN; GUANIDINOETHYL DISULFIDE; HYALURONIC ACID; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVITY; CELL INFILTRATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS LINKING; DRUG EFFICACY; DRUG RELEASE; EMULSION; ENCAPSULATION; FREEZE DRYING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEL; MACROPHAGE; MALE; MOUSE; NONHUMAN; POROSITY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; VALIDATION PROCESS;

ANIMALS; CELL LINE; CELL SHAPE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; GELATIN; GUANIDINES; HYALURONIC ACID; HYDROGEL; MACROPHAGES; MICE; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; OXIDATION-REDUCTION; PARTICLE SIZE; SKIN;

EID: 49349103487     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2008.07.026     Document Type: Article

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