Dextran cross-linked gelatin microspheres as a drug delivery system

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 47, Issue 2, 1999, Pages 153-160

  Cortesi, Rita ^a,b   Esposito, Elisabetta ^a   Osti, Maria ^a   Squarzoni, Giacomo ^a   Menegatti, Enea ^a   Davis, Stanley Spencer ^b   Nastruzzi, Claudio ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Cross linking; Dextran; Drug delivery; Gelatin; Microspheres

Indexed keywords

ANTINEOPLASTIC AGENT; DEXTRAN; DEXTRAN 70; DRUG CARRIER; GELATIN; MICROSPHERE;

ARTICLE; DISSOLUTION; DRUG DELIVERY SYSTEM; DRUG RELEASE; KINETICS; SCANNING ELECTRON MICROSCOPY;

DEXTRANS; DRUG DELIVERY SYSTEMS; GELATIN; MICROSPHERES;

EID: 0032967431     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(98)00076-9     Document Type: Article

References (20)

1. R. Arshady, Albumin microspheres and microcapsules: methodology of manufacturing techniques, J. Control. Rel. 14 (1990) 111-131.
2. C. Nastruzzi, C. Pastesini, R. Cortesi, E. Esposito, R. Gambari, E. Menegatti, Production and in vitro evaluation of gelatin microspheres containing an antitumor tetra-amidine, J. Microencaps. 11 (1994) 249-260.
3. K.C. Lee, Y.J. Lee, W.B. Kim, C.Y. Cha, Monoclonal antibody-based targeting of methotrexate-loaded microspheres, Int. J. Pharm. 59 (1990) 27-33.
4. D.A. Pecosky, J.R. Robinsonn, Bioadhesive polymers and drug delivery, in: P.J Tarcha (Ed.), Polymers for Controlled Drug Delivery, CRC Press, Boca Raton, 1991, pp. 99-125.
5. K. Tomihata, K. Burczak, K. Shiraki, Y. Ikada, Cross-linking and biodegradation of native and denaturated collagen, in: S.W. Shalaby, Y. Ikada, R. Langer, J. Williams (Eds.), Polymers of Biological and Biomedical Significance, American Chemical Society Press, Washington, 1994, pp. 275-286.
6. G.A. Digenis, B.G. Thomas, V.P. Shah, Cross-linking of gelatin capsules and its relevance to their in vitro-in vivo performance, J. Pharm. Sci. 83 (1994) 915-921.
7. E. Esposito, R. Cortesi, C. Nastruzzi, Gelatin microspheres: influence of preparation parameters and thermal treatment on chemico-physical and biopharmaceutical properties, Biomaterials 17 (1996) 2009-2020.
8. L. Ruys, J. Vermeersh, E. Schacht, E. Goethals, Polymer drug combinations. VII. Polymethacrylates and modified polysaccharides with potential antiarrhythmic activity, Acta Pharm. Technol. 29 (1983) 105-112.
9. E. Schacht, J.C. Vandichel, A. Lemahieu, N. De Rooze, R. Vansteenkiste, The use of gelatin and alginate for the immobilization of bioactive agents, in: D.R. Karsa, R.A. Stephenson (Eds.), Encapsulation and Drug Release, Royal Society of Chemistry Press, London, 1993, pp. 18-34.
10. C. Nastruzzi, G. Feriotto, D.A. Spandidos, R. Ferroni, M. Guarneri, R. Barbieri, R. Gambari, Inhibition of in vitro tumor cell growth by aromatic polyamidines exhibiting antsiproteinase activity, Clin. Exp. Metastas. 7 (1989) 25-39.
11. D. Smith, B. Gazzard, Treatment and prophylaxis of pneumocistis carinli pneumonia in AIDS patient, Drugs 42 (1991) 628-639.
12. R. Gambari, C. Nastruzzi, DNA-binding activity and biological effects of aromatic polyamidines, Biochem. Pharm. 47 (1994) 599-610.
13. C. Nastruzzi, E. Menegatti, C. Pastesini, R. Cortesi, E. Esposito, M. Spano, R. Biagini, E. Cordelli, G. Feriotto, R. Gambari, DNA binding activity and inhibition of DNA-protein interactions: differential effects of tetra-p-amidinophenoxyneopentane and its 2′-bromo derivative, Biochem. Pharmacol. 44 (1992) 1985-1994.
14. A. Bartolazzi, R. Barbieri, C. Nastruzzi, P.G. Natali, R. Gambari, Antitumor activity of the proteinase inhibitor tetra-p-amidinophenoxyneopentane in a nude mouse model of human melanoma, In vivo 3 (1989) 383-388.
15. R. Ferroni, E. Menegatti, M. Guarneri, U. Taddeo, M. Bolognesi, P. Ascenzi, G. Amiconi, Aromatic tetra-amidines: synthesis of haloderivatives and their antiproteolytic activity, Il Farmaco 39 (1984) 901-909.
16. D. Bruneel, E. Schacht, Chemical modification of pullulan: 1. Periodate oxidation, Polymer 34 (1993) 2628-2632.
17. C. Nastruzzi, E. Esposito, R. Cortesi, R. Gambari, E. Menegatti, Kinetics of bromocriptine release from microspheres: comparative analysis between different in vitro models, J. Microencaps. 11 (1994) 565-574.
18. T. Hakata, H. Sato, Y. Watanabe, M. Matsumoto, Effect of formaldehyde on the physicochemical properties of soft gelatin capsule shells, Chem. Pharm. Bull. 42 (1994) 1138-1142.
19. S.S. Davis, L. Illum, Microspheres as drug carriers, in: F.H.D. Roedink, A.M. Kroon (Eds.), Drug Carrier Systems, Wiley, UK, 1989, pp. 131-153.
20. C. Nastruzzi, C. Pastesini, R. Cortesi, E. Esposito, R. Gambari, E. Menegatti, Production and in vitro evaluation of gelatin microspheres containing an antitumour tetra-amidine, J. Microencaps. 11 (1994) 249-260.