Gelatin microspheres encapsulated with a nonpeptide angiogenic agent, ginsenoside Rg1, for intramyocardial injection in a rat model with infarcted myocardium

Journal of Controlled Release

Volumn 120, Issue 1-2, 2007, Pages 27-34

  Wei, Hao Ji ^a   Yang, Hang Hsing ^b   Chen, Chun Hung ^b   Lin, Wei Wen ^c   Chen, Sung Ching ^b   Lai, Po Hong ^b   Chang, Yen ^a   Sung, Hsing Wen ^a,b  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^c TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Angiogenesis; Gelatin microsphere; Ginsenoside Rg1; Intramuscular injection; Myocardial infarction

Indexed keywords

CROSSLINKING; DRUG PRODUCTS; ENCAPSULATION; PHYSIOLOGICAL MODELS; RATS; SWELLING;

ANGIOGENESIS; GELATIN MICROSPHERES; GINSENOSIDES; INTRAMUSCULAR INJECTION; MYOCARDIAL INFARCTION;

MICROSPHERES;

BASIC FIBROBLAST GROWTH FACTOR; GELATIN; GINSENOSIDE RG 1; MICROSPHERE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; HEART INFARCTION; HEART MUSCLE FIBROSIS; HISTOPATHOLOGY; MALE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RAT;

ANGIOGENESIS INDUCING AGENTS; ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; CHEMISTRY, PHARMACEUTICAL; CORONARY CIRCULATION; CROSS-LINKING REAGENTS; DISEASE MODELS, ANIMAL; DRUG CARRIERS; DRUG COMPOUNDING; ENDOTHELIAL CELLS; FEASIBILITY STUDIES; FIBROBLAST GROWTH FACTOR 2; FIBROSIS; GELATIN; GINSENOSIDES; HUMANS; INJECTIONS, INTRAMUSCULAR; IRIDOIDS; MALE; MICROSPHERES; MYOCARDIAL INFARCTION; NEOVASCULARIZATION, PHYSIOLOGIC; PARTICLE SIZE; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; TIME FACTORS; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 34249911703     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2007.04.005     Document Type: Article

References (50)

1. Sellke F.W., and Ruel M. Vascular growth factors and angiogenesis in cardiac surgery. Ann. Thorac. Surg. 75 (2003) 685-690
2. Bull D.A., Bailey S.H., Rentz J.J., Zebrack J.S., Lee M., Litwin S.E., and Kim S.W. Effect of Terplex/VEGF-165 gene therapy on left ventricular function and structure following myocardial infarction: VEGF gene therapy for myocardial infarction. J. Control. Release 93 (2003) 175-181
3. Richardson T.P., Peters M.C., Ennett A.B., and Mooney D.J. Polymeric system for dual growth factor delivery. Nat. Biotechnol. 19 (2001) 1029-1034
4. Young S., Wong M., Tabata Y., and Mikos A.G. Gelatin as a delivery vehicle for the controlled release of bioactive molecules. J. Control. Release 109 (2005) 256-274
5. Yan C., Li X., Chen X., Wang D., Zhong D., Tan T., and Kitano H. Anticancer gelatin microspheres with multiple function. Biomaterials 12 (1991) 640-644
6. Prisell P.T., Camber O., Hiselius J., and Norstedt G. Evaluation of hyaluronan as a vehicle for peptide growth factors. Int. J. Pharm. 85 (1992) 51-56
7. Shea L.D., Smiley E., Bonadio J., and Mooney D.J. DNA delivery from polymer matrices for tissue engineering. Nat. Biotechnol. 17 (1999) 551-554
8. Lee K.Y., Halberstadt C.R., Holder W.D., and Mooney D.J. Breast reconstruction. In: Lanza R.P., Langer R., and Vacanti J. (Eds). Principles of Tissue Engineering (2000), Academic Press, New York 409-423
9. Tabata Y., Hijikata S., and Ikada Y. Enhanced vascularization and tissue granulation by basic fibroblast growth factor impregnated in gelatin hydrogels. J. Control. Release 31 (1994) 189-199
10. Morisaki N., Watanabe S., Tezuka M., Zenibayashi M., Shiina R., Koyama N., Kanzaki T., and Saito Y. Mechanism of angiogenic effects of saponin from Ginseng Radix rubra in human umbilical vein endothelial cells. Br. J. Pharmacol. 115 (1995) 1188-1193
11. 1, one of the major active molecules from Panax ginseng, is a functional ligand of glucocorticoid receptor. Mol. Cell. Endocrinol. 133 (1997) 135-140
12. Liang H.C., Chen C.T., Chang Y., Huang Y.C., Chen S.C., and Sung H.W. Loading of a novel angiogenic agent, ginsenoside Rg1 in an acellular biological tissue for tissue regeneration. Tissue Eng. 11 (2005) 835-846
13. Liang H.C., Chang W.H., Lin K.J., and Sung H.W. Genipin-crosslinked gelatin microspheres as a drug carrier for intramuscular administration: In vitro and in vivo studies. J. Biomed. Mater. Res. A 65 (2003) 271-282
14. Ugwoke M.I., and Kinget R. Influence of processing variables on the properties of gelatin microspheres prepared by emulsification solvent extraction technique. J. Microencapsul 15 (1998) 273-281
15. Tanaka N., Takino S., and Utsumi I. A new oral gelatinized sustained-release dosage form. J. Pharm. Sci. 52 (1963) 664-667
16. In: Stryer L. (Ed). Biochemistry. 3rd ed. (1988), Freeman, New York 50-55
17. Yamashita S., Furubayashi T., Kataoka M., Sakane T., Sezaki H., and Tokuda H. Optimized conditions for prediction of intestinal drug permeability using Caco-2 cells. Eur. J. Pharm. Sci. 10 (2000) 195-204
18. Lin Y.H., Liang H.F., Chung C.K., Chen M.C., and Sung H.W. Physically crosslinked alginate/N,O-carboxymethyl chitosan hydrogels with calcium for oral delivery of protein drugs. Biomaterials 26 (2005) 2105-2113
19. Tabata Y. Tissue regeneration based on growth factor release. Tissue Eng. 9 (2003) S5-S15
20. Yu L.C., Chen S.C., Chang W.C., Huang Y.C., Lin K.M., Lai P.H., and Sung H.W. Stability of novel angiogenic agents, ginsenoside Rg1 and Re, isolated from Panax ginseng. Int. J. Pharm. 328 (2007) 168-176
21. Nie D., Lamberti M., Zacharek A., Li L., Szekeres K., Tang K., Chen Y.C., and Honn K.V. Thromboxane A2 regulation of endothelial cell migration, angiogenesis, and tumor metastasis. Biochem. Biophys. Res. Commun. 267 (2000) 245-251
22. Huang Y.C., Chen C.T., Chen S.C., Lai P.H., Liang H.C., Chang Y., Yu L.C., and Sung H.W. A natural compound (ginsenoside Re) isolated from Panax ginseng as a novel angiogenic agent for tissue regeneration. Pharm. Res. 22 (2005) 636-646
23. Morales D.E., McGowan K.A., Grant D.S., Maheshwari S., Bhartiya D., Cid M.C., Kleinman H.K., and Schnaper H.W. Estrogen promotes angiogenic activity in human umbilical vein endothelial cells in vitro and in a murine model. Circulation 91 (1995) 755-763
24. Wang H.S., Hwang L.L., Sue H.F., Lee K.M., and Chen C.T. A simple quantitative method for evaluation of angiogenesis activity. Assay Drug Dev. Technol. 2 (2004) 31-38
25. Nishina T., Nishimura K., Yuasa S., Miwa S., Sakakibara Y., Ikeda T., and Komeda M. A rat model of ischemic cardiomyopathy for investigating left ventricular volume reduction surgery. J. Card. Surg. 17 (2002) 155-162
26. Sakakibara Y., Nishimura K., Tambara K., Yamamoto M., Lu F., Tabata Y., and Komeda M. Prevascularization with gelatin microspheres containing basic fibroblast growth factor enhances the benefits of cardiomyocyte transplantation. J. Thorac. Cardiovasc. Surg. 124 (2002) 50-56
27. Iwakura A., Fujita M., Kataoka K., Tambara K., Sakakibara Y., Komeda M., and Tabata Y. Intramyocardial sustained delivery of basic fibroblast growth factor improves angiogenesis and ventricular function in a rat infarct model. Heart Vessels 18 (2003) 93-99
28. Orlic D., Kajstura J., Chimenti S., Limana F., Jakoniuk I., Quaini F., Nadal-Ginard B., Bodine D.M., Leri A., and Anversa P. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 10344-10349
29. Bader A., Schiling T., and Teebken O.E. Tissue engineering of heart valves-human endothelial cell seeding of detergent acellularized porcine valves. Eur. J. Cardiothorac. Surg. 14 (1998) 279-284
30. Courtman D.W., Errett B.F., and Wilson G.J. The role of crosslinking in modification of the immune response elicited against xenogenic vascular acellular matrice. J. Biomed. Mater. Res. 55 (2001) 576-586
31. Freedman S.B., and Isner J.M. Therapeutic angiogenesis for coronary artery disease. Ann. Intern. Med. 136 (2002) 54-71
32. Laham R. Angiogenesis (clinical trials). Can. J. Cardiol. 17 (2001) 29A-32A
33. Chen R.R., and Mooney D.J. Polymeric growth factor delivery strategies for tissue engineering. Pharm. Res. 20 (2003) 1103-1112
34. Esposito E., Cortesi R., and Nastruzzi C. Gelatin microspheres: influence of preparation parameters and thermal treatment on chemico-physical and biopharmaceutical properties. Biomaterials 17 (1996) 2009-2020
35. Akao T., Kobashi K., and Aburada M. Enzymatic studies on the animal and intestinal bacterial metabolism of geniposide. Biol. Pharm. Bull. 17 (1994) 1573-1576
36. Sung H.W., Huang R.N., Huang L.L., Tsai C.C., and Chiu C.T. Feasibility study of a natural crosslinking reagent for biological tissue fixation. J. Biomed. Mater. Res. 42 (1998) 560-567
37. Touyama R., Inoue K., Takeda Y., Yatsuzuka M., Ikumoto T., Moritome N., Shingu T., Yokoi T., and Inouye H. Studies on the blue pigments produced from genipin and methylamine. II. On the formation mechanisms of brownish-red intermediates leading to the blue pigment formation. Chem. Pharm. Bull. 42 (1994) 1571-1578
38. Liang H.C., Chang Y., Hsu C.K., Lee M.H., and Sung H.W. Effects of crosslinking degree of an acellular biological tissue on its tissue regeneration pattern. Biomaterials 25 (2004) 3541-3552
39. Nehls V., Schuchardt E., and Drenckhahn D. The effect of fibroblasts, vascular smooth muscle cells, and pericytes on sprout formation of endothelial cells in a fibrin gel angiogenesis system. Microvasc. Res. 48 (1994) 349-363
40. 1 derived from Panax notoginseng. J. Clin. Endocrinol. Metab. 87 (2002) 3691-3695
41. 1 and Re decrease cardiac contraction in adult rat ventricular myocytes: role of nitric oxide. Br. J. Pharmacol. 134 (2001) 1159-1165
42. Babaei S., and Stewart D.J. Overexpression of endothelial NO synthase induces angiogenesis in a co-culture model. Cardiovasc. Res. 55 (2002) 190-200
43. Sengupta S., Toh S.A., Sellers L.A., Skepper J.N., Koolwijk P., Leung H.W., Yeung H.W., Wong R.N., Sasisekharan R., and Fan T.P. Modulating angiogenesis: the yin and the yang in ginseng. Circulation 110 (2004) 1219-1225
44. Lai P.H., Chang Y., Chen S.C., Wang C.C., Liang H.C., Chang W.C., and Sung H.W. Acellular biological tissues containing inherent glycosaminoglycans for loading bFGF promote angiogenesis and tissue regeneration. Tissue Eng. 12 (2006) 2499-2508
45. Westal F.C., Rubin R., and Gospodarowicz D. Brain-derived fibroblast growth factor: a study of its inactivation. Life Sci. 33 (1983) 2425-2429
46. Vemuri S., Beylin I., Sluzky V., Stratton P., Eberlein G., and Wang Y.J. The stability of bFGF against thermal denaturation. J. Pharm. Pharmacol. 46 (1994) 481-486
47. Popovich D.G., and Kitts D.D. Structure-function relationship exists for ginsenosides in reducing proliferation and inducing apoptosis in the human leukemia (THP-1) cell line. Arch. Biochem. Biophys. 406 (2002) 1-8
48. Tongay S., Dag S., Senger R.T., and Ciraci S. Ab-initio electron transport calculations of carbon based string structures. Phys. Rev. Lett. 93 (2004) 136404
49. Kocher A.A., Schuster M.D., Szabolcs M.J., Takuma S., Burkhoff D., Wang J., Homma S., Edwards N.M., and Itescu S. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduce remodeling and improves cardiac function. Nat. Med. 7 (2001) 430-436
50. Kellar R.S., Shepherd B.R., Larson D.F., Naughton G.K., and Williams S.K. Cardiac patch constructed from human fibroblasts attenuates reduction in cardiac function after acute infarct. Tissue Eng. 11 (2005) 1678-1687