Clues to the mechanism of action of eIF2B, the guanine-nucleotide-exchange factor for translation initiation

Biochemical Society Transactions

Volumn 36, Issue 4, 2008, Pages 658-664

  Mohammad Qureshi, Sarah S ^a   Jennings, Martin D ^a   Pavitt, Graham D ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Childhood ataxia with central nervous system hypomyelination (CACH); Eukaryotic initiation factor 2B (eIF2B); G protein; Guanine nucleotide exchange factor (GEF); Leukoencephalopathy with vanishing white matter (VWM); Translation initiation

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR; ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR 1; ALANINE; ASPARTIC ACID; ELONGATION FACTOR TU; GLUTAMIC ACID; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; INITIATION FACTOR 2; INITIATION FACTOR 5; LEUCINE; MESSENGER RNA; METHIONINE TRANSFER RNA; SERINE; THREONINE; TRANSCRIPTION FACTOR GCN4; TRYPTOPHAN;

AMINO ACID SUBSTITUTION; GENE MUTATION; HUMAN; LEUKOENCEPHALOPATHY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING; PROTEIN STRUCTURE; PROTEIN SYNTHESIS REGULATION; REVIEW; RIBOSOME SUBUNIT; RNA TRANSLATION; TRANSLATION INITIATION; TRANSLATION REGULATION; YEAST;

CATALYSIS; EUKARYOTIC INITIATION FACTOR-2B; LIGANDS; MODELS, MOLECULAR; PEPTIDE CHAIN INITIATION, TRANSLATIONAL; PROTEIN BINDING;

EUKARYOTA;

EID: 49349090915     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0360658     Document Type: Review

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