-
1
-
-
0033559265
-
Conserved bipartite motifs in yeast eIF5 and eIF2Bepsilon, GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2
-
Asano, K., T. Krishnamoorthy, L. Phan, G. D. Pavitt, and A. G. Hinnebusch. 1999. Conserved bipartite motifs in yeast eIF5 and eIF2Bepsilon, GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2. EMBO J. 18:1673-1688.
-
(1999)
EMBO J.
, vol.18
, pp. 1673-1688
-
-
Asano, K.1
Krishnamoorthy, T.2
Phan, L.3
Pavitt, G.D.4
Hinnebusch, A.G.5
-
2
-
-
0001598487
-
Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase
-
Berlanga, J. J., J. Santoyo, and C. De Haro. 1999. Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase. Eur. J. Biochem. 265:754-762.
-
(1999)
Eur. J. Biochem.
, vol.265
, pp. 754-762
-
-
Berlanga, J.J.1
Santoyo, J.2
De Haro, C.3
-
3
-
-
0021668558
-
A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance
-
Boeke, J. D., F. LaCroute, and G. R. Fink. 1984. A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance. Mol. Gen. Genet. 197:345-346.
-
(1984)
Mol. Gen. Genet.
, vol.197
, pp. 345-346
-
-
Boeke, J.D.1
Lacroute, F.2
Fink, G.R.3
-
4
-
-
0027732538
-
Proteins regulating Ras and its relatives
-
Boguski, M. S., and F. McCormick. 1993. Proteins regulating Ras and its relatives. Nature 366:643-654.
-
(1993)
Nature
, vol.366
, pp. 643-654
-
-
Boguski, M.S.1
McCormick, F.2
-
5
-
-
0027411601
-
Evidence that GCD6 and GCD7, translational regulators of GCN4 are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae
-
Bushman, J. L., A. I. Asuru, R. L. Matts, and A. G. Hinnebusch. 1993. Evidence that GCD6 and GCD7, translational regulators of GCN4 are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae. Mol. Cell. Biol. 13:1920-1932.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 1920-1932
-
-
Bushman, J.L.1
Asuru, A.I.2
Matts, R.L.3
Hinnebusch, A.G.4
-
6
-
-
0027261221
-
Guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae: Interactions between the essential subunits GCD2, GCD6, and GCD7 and the regulatory subunit GCN3
-
Bushman, J. L., M. Foiani, A. M. Cigan, C. J. Paddon, and A. G. Hinnebusch. 1993. Guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae: interactions between the essential subunits GCD2, GCD6, and GCD7 and the regulatory subunit GCN3. Mol. Cell. Biol. 13:4618-4631.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 4618-4631
-
-
Bushman, J.L.1
Foiani, M.2
Cigan, A.M.3
Paddon, C.J.4
Hinnebusch, A.G.5
-
7
-
-
0000615498
-
Plasmid vectors carrying the replication origin of filamentous single-stranded phages
-
Cesareni, G., and J. A. H. Murray. 1987. Plasmid vectors carrying the replication origin of filamentous single-stranded phages. Genetic Eng. 9:135-154.
-
(1987)
Genetic Eng.
, vol.9
, pp. 135-154
-
-
Cesareni, G.1
Murray, J.A.H.2
-
8
-
-
0033179296
-
GEFs: Structural basis for their activation of small GTP-binding proteins
-
Cherfils, J., and P. Chardin. 1999. GEFs: structural basis for their activation of small GTP-binding proteins. Trends Biochem. Sci. 24:306-311.
-
(1999)
Trends Biochem. Sci.
, vol.24
, pp. 306-311
-
-
Cherfils, J.1
Chardin, P.2
-
9
-
-
0026512939
-
Multifunctional yeast high-copy-number shuttle vectors
-
Christianson, T. W., R. S. Sikorski, M. Dante, J. H. Shero, and P. Hieter. 1992. Multifunctional yeast high-copy-number shuttle vectors. Gene 110: 119-122.
-
(1992)
Gene
, vol.110
, pp. 119-122
-
-
Christianson, T.W.1
Sikorski, R.S.2
Dante, M.3
Shero, J.H.4
Hieter, P.5
-
10
-
-
0025853453
-
Complex formation by positive and negative translational regulators of GCN4
-
Cigan, A. M., M. Foiani, E. M. Hannig, and A. G. Hinnebusch. 1991. Complex formation by positive and negative translational regulators of GCN4. Mol. Cell. Biol. 11:3217-3228.
-
(1991)
Mol. Cell. Biol.
, vol.11
, pp. 3217-3228
-
-
Cigan, A.M.1
Foiani, M.2
Hannig, E.M.3
Hinnebusch, A.G.4
-
11
-
-
0013112952
-
Yeast translation initiation suppressor sui2 encodes the alpha subunit of eukaryotic initiation factor 2 and snares sequence identity with the human alpha subunit
-
Cigan, A. M., E. K. Pabich, L. Feng, and T. F. Donahue. 1989. Yeast translation initiation suppressor sui2 encodes the alpha subunit of eukaryotic initiation factor 2 and snares sequence identity with the human alpha subunit. Proc. Natl. Acad. Sci. USA 86:2784-2788.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 2784-2788
-
-
Cigan, A.M.1
Pabich, E.K.2
Feng, L.3
Donahue, T.F.4
-
12
-
-
0002352428
-
Protein kinases that phosphorylate eIF2 and eIF2B, and their role in eukaryotic cell translational control
-
J. W. B. Hershey, M. B. Mathews, and N. Sonenberg (ed.), Cold Spring Harbor Laboratory Press. Cold Spring Harbor, N.Y.
-
Clemens, M. J. 1996, Protein kinases that phosphorylate eIF2 and eIF2B, and their role in eukaryotic cell translational control, p. 139-172. In J. W. B. Hershey, M. B. Mathews, and N. Sonenberg (ed.), Translational control. Cold Spring Harbor Laboratory Press. Cold Spring Harbor, N.Y.
-
(1996)
Translational Control
, pp. 139-172
-
-
Clemens, M.J.1
-
13
-
-
0031982348
-
Identification of GCD14 and GCD15, novel genes required for translational repression of GCN4 mRNA in saccharomyces cerevisiae
-
Cuesta, R., A. G. Hinnebusch, and M. Tamame. 1998. Identification of GCD14 and GCD15, novel genes required for translational repression of GCN4 mRNA in Saccharomyces cerevisiae. Genetics 148:1007-1020.
-
(1998)
Genetics
, vol.148
, pp. 1007-1020
-
-
Cuesta, R.1
Hinnebusch, A.G.2
Tamame, M.3
-
14
-
-
0033213918
-
Translation initiation: Adept at adapting
-
Dever, T. E. 1999. Translation initiation: adept at adapting. Trends Biochem. Sci. 24:398-403.
-
(1999)
Trends Biochem. Sci.
, vol.24
, pp. 398-403
-
-
Dever, T.E.1
-
15
-
-
0026556814
-
Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast
-
Dever, T. E., L. Feng, R. C. Wek, A. M. Cigan, T. F. Donahue, and A. G. Hinnebusch. 1992. Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast. Cell 68:585-596.
-
(1992)
Cell
, vol.68
, pp. 585-596
-
-
Dever, T.E.1
Feng, L.2
Wek, R.C.3
Cigan, A.M.4
Donahue, T.F.5
Hinnebusch, A.G.6
-
17
-
-
0029858531
-
Ligand interactions with eukaryotic translation initiation factor 2: Role of the γ-subunit
-
Erickson, F. L., and E. M. Hannig. 1996. Ligand interactions with eukaryotic translation initiation factor 2: role of the γ-subunit. EMBO J. 15:6311-6320.
-
(1996)
EMBO J.
, vol.15
, pp. 6311-6320
-
-
Erickson, F.L.1
Hannig, E.M.2
-
18
-
-
0030924304
-
Subunit assembly and guanine nucleotide exchange activity of eukaryotic initiation factor-2B expressed in Sf9 cells
-
Fabian, J. R., S. R. Kimball, N. K. Heinzinger, and L. S. Jefferson. 1997. Subunit assembly and guanine nucleotide exchange activity of eukaryotic initiation factor-2B expressed in Sf9 cells. J. Biol. Chem. 272:12359-12365.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 12359-12365
-
-
Fabian, J.R.1
Kimball, S.R.2
Heinzinger, N.K.3
Jefferson, L.S.4
-
19
-
-
0025869164
-
GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces cerevisiae
-
Foiani, M., A. M. Cigan, C. J. Paddon, S. Harashima, and A. G. Hinnebusch. 1991. GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces cerevisiae. Mol. Cell. Biol. 11:3203-3216.
-
(1991)
Mol. Cell. Biol.
, vol.11
, pp. 3203-3216
-
-
Foiani, M.1
Cigan, A.M.2
Paddon, C.J.3
Harashima, S.4
Hinnebusch, A.G.5
-
20
-
-
0003666097
-
-
Academic Press, Inc., San Diego, Calif
-
Guthrie, C., and G. R. Fink (ed.). 1991. Methods in enzymology, vol. 194. Guide to yeast genetics and molecular biology. Academic Press, Inc., San Diego, Calif.
-
(1991)
Methods in Enzymology, Vol. 194. Guide to Yeast Genetics and Molecular Biology
, vol.194
-
-
Guthrie, C.1
Fink, G.R.2
-
21
-
-
0028365073
-
Cdc25p, the guanine nucleotide exchange factor for the ras proteins of Saccharomyces cerevisiae, promotes exchange by stabilizing Ras in a nucleotide-free state
-
Haney, S. A., and J. A. Broach. 1994. Cdc25p, the guanine nucleotide exchange factor for the ras proteins of Saccharomyces cerevisiae, promotes exchange by stabilizing Ras in a nucleotide-free state. J. Biol. Chem. 269: 16541-16548.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 16541-16548
-
-
Haney, S.A.1
Broach, J.A.2
-
22
-
-
0022817680
-
Multiple GCD genes required for repression of GCN4, a transcriptional activator of amino acid biosynthetic genes in Saccharomyces cerevisiae
-
Harashima, S., and A. G. Hinnebusch. 1986. Multiple GCD genes required for repression of GCN4, a transcriptional activator of amino acid biosynthetic genes in Saccharomyces cerevisiae. Mol. Cell. Biol. 6:3990-3998.
-
(1986)
Mol. Cell. Biol.
, vol.6
, pp. 3990-3998
-
-
Harashima, S.1
Hinnebusch, A.G.2
-
23
-
-
0033590451
-
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
-
Harding, H. P., Y. Zhang, and D. Ron. 1999. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397:271-274.
-
(1999)
Nature
, vol.397
, pp. 271-274
-
-
Harding, H.P.1
Zhang, Y.2
Ron, D.3
-
24
-
-
0030803256
-
Translational regulation of yeast GCN4. A window on factors that control initiator-tRNA binding to the ribosome
-
Hinnebusch, A. G. 1997. Translational regulation of yeast GCN4. A window on factors that control initiator-tRNA binding to the ribosome. J. Biol. Chem. 272:21661-21664.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 21661-21664
-
-
Hinnebusch, A.G.1
-
25
-
-
0022238094
-
A study of the kinetic mechanism of elongation factor Ts
-
Huang, Y. W., and D. L. Miller. 1985. A study of the kinetic mechanism of elongation factor Ts. J. Biol. Chem. 260:11498-11502.
-
(1985)
J. Biol. Chem.
, vol.260
, pp. 11498-11502
-
-
Huang, Y.W.1
Miller, D.L.2
-
26
-
-
0020529962
-
Transformation of intact yeast cells treated with alkali cations
-
Ito, H., Y. Fukada, K. Murata, and A. Kimura. 1983. Transformation of intact yeast cells treated with alkali cations. J. Bacteriol. 153:163-168.
-
(1983)
J. Bacteriol.
, vol.153
, pp. 163-168
-
-
Ito, H.1
Fukada, Y.2
Murata, K.3
Kimura, A.4
-
27
-
-
0028801195
-
The kinetic mechanism of Ran-nucleotide exchange catalysed by RCC1
-
Klebe, C., H. Prinz, A. Wittinghofer, and R. S. Goody. 1995. The kinetic mechanism of Ran-nucleotide exchange catalysed by RCC1. Biochemistry 34:12543-12552.
-
(1995)
Biochemistry
, vol.34
, pp. 12543-12552
-
-
Klebe, C.1
Prinz, H.2
Wittinghofer, A.3
Goody, R.S.4
-
28
-
-
0029144599
-
Multidomain organization of eukaryotic guanine nucleotide exchange translation initiation factor eIF-2B subunits revealed by analysis of conserved sequence motifs
-
Koonin, E. V. 1995. Multidomain organization of eukaryotic guanine nucleotide exchange translation initiation factor eIF-2B subunits revealed by analysis of conserved sequence motifs. Protein Sci. 4:1608-1617.
-
(1995)
Protein Sci.
, vol.4
, pp. 1608-1617
-
-
Koonin, E.V.1
-
29
-
-
0014949207
-
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
-
Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
-
(1970)
Nature
, vol.227
, pp. 680-685
-
-
Laemmli, U.K.1
-
30
-
-
1842287951
-
Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2α kinase GCN2
-
Marton, M. J., C. R. Vazquez de Aldana, H. Qiu, K. Chakraburtty, and A. G. Hinnebusch. 1997. Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2α kinase GCN2. Mol. Cell. Biol. 17:4474-4489.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 4474-4489
-
-
Marton, M.J.1
Vazquez De Aldana, C.R.2
Qiu, H.3
Chakraburtty, K.4
Hinnebusch, A.G.5
-
31
-
-
0026718508
-
Mechanism and regulation of eukaryotic protein synthesis
-
Merrick, W. C. 1992. Mechanism and regulation of eukaryotic protein synthesis. Microbiol. Rev. 56:291-315.
-
(1992)
Microbiol. Rev.
, vol.56
, pp. 291-315
-
-
Merrick, W.C.1
-
32
-
-
0031853386
-
Isolation of the gene encoding the Drosophila melanogaster homolog of the Saccharomyces cerevisiae GCN2 eIF-2α kinase
-
Olsen, D. E., B. Jordan, D. Chen, R. C. Wek, and D. R. Cavener. 1998. Isolation of the gene encoding the Drosophila melanogaster homolog of the Saccharomyces cerevisiae GCN2 eIF-2α kinase. Genetics 149:1495-1509.
-
(1998)
Genetics
, vol.149
, pp. 1495-1509
-
-
Olsen, D.E.1
Jordan, B.2
Chen, D.3
Wek, R.C.4
Cavener, D.R.5
-
33
-
-
0032519585
-
IF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange
-
Pavitt, G. D., K. V. Ramaiah, S. R. Kimball, and A. G. Hinnebusch, 1998. eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange. Genes Dev. 12:514-526.
-
(1998)
Genes Dev.
, vol.12
, pp. 514-526
-
-
Pavitt, G.D.1
Ramaiah, K.V.2
Kimball, S.R.3
Hinnebusch, A.G.4
-
34
-
-
0031020341
-
Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2
-
Pavitt, G. D., W. Yang, and A. G. Hinnebusch. 1997. Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2. Mol. Cell. Biol. 17: 1298-1313.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 1298-1313
-
-
Pavitt, G.D.1
Yang, W.2
Hinnebusch, A.G.3
-
35
-
-
0029811357
-
Cloning of cDNA for the gamma-subunit of mammalian translation initiation factor 2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2
-
Price, N. T., S. R. Kimball, L. S. Jefferson, and C. G. Proud. 1996. Cloning of cDNA for the gamma-subunit of mammalian translation initiation factor 2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. Biochem. J. 318:631-636.
-
(1996)
Biochem. J.
, vol.318
, pp. 631-636
-
-
Price, N.T.1
Kimball, S.R.2
Jefferson, L.S.3
Proud, C.G.4
-
36
-
-
0028844306
-
A left-handed parallel β helix in the structure of UDP-N-acetylglucosamine acyltransferase
-
Raetz, C. R. H., and S. L. Roderick. 1995. A left-handed parallel β helix in the structure of UDP-N-acetylglucosamine acyltransferase. Science 270:997-1000.
-
(1995)
Science
, vol.270
, pp. 997-1000
-
-
Raetz, C.R.H.1
Roderick, S.L.2
-
37
-
-
0021821218
-
Kinetics and thermodynamics of the interaction of elongation factor tu with elongation factor Ts, guanine nucleotides, and aminoacyl-tRNA
-
Romero, G., V. Chau, and R. L. Biltonen. 1985. Kinetics and thermodynamics of the interaction of elongation factor Tu with elongation factor Ts, guanine nucleotides, and aminoacyl-tRNA. J. Biol. Chem. 260:6167-6174.
-
(1985)
J. Biol. Chem.
, vol.260
, pp. 6167-6174
-
-
Romero, G.1
Chau, V.2
Biltonen, R.L.3
-
38
-
-
0023878562
-
The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2
-
Rowlands, A. G., R. Panniers, and E. C. Henshaw. 1988. The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2. J. Biol. Chem. 263:5526-5533.
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 5526-5533
-
-
Rowlands, A.G.1
Panniers, R.2
Henshaw, E.C.3
-
39
-
-
0004136246
-
-
Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
-
Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
-
(1989)
Molecular Cloning: a Laboratory Manual, 2nd Ed.
-
-
Sambrook, J.1
Fritsch, E.F.2
Maniatis, T.3
-
40
-
-
0031755020
-
Identification and characterization of pancreatic eukaryotic initiation factor 2 α-subunit kinase, PEK, involved in translational control
-
Shi, Y., K. M. Vattem, R. Sood, J. An, J. Liang, L. Stramm, and R. C. Wek. 1998. Identification and characterization of pancreatic eukaryotic initiation factor 2 α-subunit kinase, PEK, involved in translational control. Mol. Cell. Biol. 18:7499-7509.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 7499-7509
-
-
Shi, Y.1
Vattem, K.M.2
Sood, R.3
An, J.4
Liang, J.5
Stramm, L.6
Wek, R.C.7
-
41
-
-
0032538347
-
Invasion of the nucleotide snatchers: Structural insights into the mechanism of G protein GEFs
-
Sprang, S. R., and D. E. Coleman. 1998. Invasion of the nucleotide snatchers: structural insights into the mechanism of G protein GEFs. Cell 95:155-158.
-
(1998)
Cell
, vol.95
, pp. 155-158
-
-
Sprang, S.R.1
Coleman, D.E.2
-
42
-
-
0002351439
-
Binding of initiator methionyl-tRNA to ribosomes
-
J. W. B. Hershey, M. B. Mathews, and N. Sonenberg (ed.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
-
Trachsel, H. 1996. Binding of initiator methionyl-tRNA to ribosomes, p. 113-138. In J. W. B. Hershey, M. B. Mathews, and N. Sonenberg (ed.), Translational control. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
-
(1996)
Translational Control
, pp. 113-138
-
-
Trachsel, H.1
-
43
-
-
0029805459
-
Identification of a regulatory sub-complex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2
-
Yang, W., and A. G. Hinnebusch. 1996. Identification of a regulatory sub-complex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2. Mol. Cell. Biol. 16:6603-6616.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 6603-6616
-
-
Yang, W.1
Hinnebusch, A.G.2
|