Discovery of talatisamine as a novel specific blocker for the delayed rectifier K+ channels in rat hippocampal neurons

Neuroscience

Volumn 155, Issue 2, 2008, Pages 469-475

  Song, M K ^a,b   Liu, H ^b   Jiang, H L ^b   Yue, J M ^b   Hu, G Y ^b   Chen, H Z ^a  

^a Shanghai Jiao Tong University Science and Education Plaza   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Aconitum alkaloids; channel blocker; delayed rectifier K+ channel; talatisamine; virtual screening

Indexed keywords

14 BENZOYLTALATISAMINE; ACONITUM EXTRACT; ALKALOID; DELAYED RECTIFIER POTASSIUM CHANNEL; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; PYROCHASMACONITIN; SONGORINE; TALATISAMINE; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL;

ACONITUM; ALLOSTERISM; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CHANNEL GATING; DRUG BINDING; DRUG IDENTIFICATION; DRUG POTENCY; DRUG STRUCTURE; HIPPOCAMPUS; HYPERPOLARIZATION; IC 50; NONHUMAN; POTASSIUM TRANSPORT; PRIORITY JOURNAL; RAT; STEADY STATE;

ACONITINE; ALKALOIDS; ANIMALS; CALCIUM CHANNELS; DELAYED RECTIFIER POTASSIUM CHANNELS; DRUGS, CHINESE HERBAL; HIPPOCAMPUS; ION CHANNEL GATING; KINETICS; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; PYRAMIDAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNELS;

EID: 49349086562     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2008.06.009     Document Type: Article

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