Electrophysiological characterization of 14-benzoyltalatisamine, a selective blocker of the delayed rectifier K+ channel found in virtual screening

European Journal of Pharmacology

Volumn 531, Issue 1-3, 2006, Pages 47-53

  Song, Ming Ke ^a,b   Liu, Hong ^a   Jiang, Hua Liang ^a   Yue, Jian Min ^a   Hu, Guo Yuan ^a  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

14 Benzoyltalatisamine; Channel blocker; Delayed rectifier K+ channel; Drug discovery; Tetraethylammonium; Virtual screening

Indexed keywords

14 BENZOYLTALATISAMINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; TETRYLAMMONIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; ELECTRIC CURRENT; ELECTROPHYSIOLOGY; HIPPOCAMPUS; HYPERPOLARIZATION; IC 50; KINETICS; MOLECULAR INTERACTION; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; STEADY STATE; VOLTAGE CLAMP;

ACONITINE; ANIMALS; DELAYED RECTIFIER POTASSIUM CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; MEMBRANE POTENTIALS; MOLECULAR STRUCTURE; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; PYRAMIDAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; TETRAETHYLAMMONIUM; TIME FACTORS;

EID: 32044433281     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.12.029     Document Type: Article

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