Characterization of a new Kv1.3 channel-specific blocker, J123, from the scorpion Buthus martensii Karsch

Peptides

Volumn 29, Issue 9, 2008, Pages 1514-1520

  Shijin, Yin ^a   Hong, Yi ^a   Yibao, Ma ^a   Zongyun, Chen ^a   Han, Song ^a   Yingliang, Wu ^a   Zhijian, Cao ^a   Wenxin, Li ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

Autoimmune diseases; Buthus martensii Karsch; Kv1.3 channel; Peptide J123; Pharmacological profile

Indexed keywords

PEPTIDE J123; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KV1.3; SCORPION VENOM; UNCLASSIFIED DRUG;

ARTICLE; AUTOIMMUNE DISEASE; DNA LIBRARY; DRUG POTENCY; ELECTROPHYSIOLOGY; EXPRESSION VECTOR; IC 50; MOLECULAR DOCKING; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN PURIFICATION; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; HUMANS; KIDNEY; KV1.3 POTASSIUM CHANNEL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; SCORPION VENOMS; SCORPIONS; SEQUENCE ALIGNMENT;

MESOBUTHUS MARTENSII; SCORPIONES;

EID: 49149104658     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2008.04.021     Document Type: Article

References (33)

1. Azam P., Sankaranarayanan A., Homerick D., Griffey S., and Wulff H. Targeting effector memory T cells with the small molecule Kv1.3 blocker PAP-1 suppresses allergic contact dermatitis. J Invest Dermatol 127 (2007) 1419-1429
2. + channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation. J Immunol 166 (2001) 936-944
3. Beeton C., and Chandy K.G. Potassium channels, memory T cells, and multiple sclerosis. Neuroscientist 11 (2005) 550-562
4. Beeton C., Pennington M.W., Wulff H., Singh S., Nugent D., Crossley G., et al. Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases. Mol Pharmacol 67 (2005) 1369-1381
5. Beeton C., Wulff H., Standifer N.E., Azam P., Mullen K.M., Pennington M.W., et al. Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proc Natl Acad Sci USA 103 (2006) 17414-17419
6. Chen R., Li L., and Weng Z. ZDOCK: an initial-stage protein-docking algorithm. Proteins 52 (2003) 80-87
7. + channel: a computational approach based on experimental distance restraints extracted from thermodynamic mutant cycles. Biophys J 83 (2002) 2595-2609
8. Garber K. Peptide leads new class of chronic pain drugs. Nat Biotechnol 23 (2005) 399
9. + channels as targets for specific immunomodulation. Trends Pharmacol Sci 25 (2004) 280-289
10. + channel: peptide and channel residues mediating molecular recognition. Neuron 12 (1994) 1377-1388
11. Gross A., and MacKinnon R. Agitoxin footprinting the shaker potassium channel pore. Neuron 16 (1996) 399-406
12. + channel pore through mutant cycles with a peptide inhibitor. Science 268 (1995) 307-310
13. Lewis R.J., and Garcia M.L. Therapeutic potential of venom peptides. Nat Rev Drug Discov 2 (2003) 790-802
14. Lu Z., Klem A.M., and Ramu Y. Ion conduction pore is conserved among potassium channels. Nature 413 (2001) 809-813
15. MacKinnon R., Cohen S.L., Kuo A., Lee A., and Chait B.T. Structural conservation in prokaryotic and eukaryotic potassium channels. Science 280 (1998) 106-109
16. +-channel blocker from scorpion venom. Biochem Biophys Res Commun 360 (2007) 728-734
17. + channel blockers: novel tools to inhibit T cell activation leading to specific immunosuppression. Curr Pharm Des 12 (2006) 2199-2220
18. Peng F., Zeng X.C., He X.H., Pu J., Li W.X., Zhu Z.H., et al. Molecular cloning and functional expression of a gene encoding an antiarrhythmia peptide derived from the scorpion toxin. Eur J Biochem 269 (2002) 4468-4475
19. + channels and scorpion toxins. Trends Pharmacol Sci 24 (2003) 222-227
20. +-channels. Toxicon 43 (2004) 865-875
21. + channel. Nature 422 (2003) 180-185
22. Schwede T., Kopp J., Guex N., Peitsch M.C., and SWISS-MODEL:. An automated protein homology-modeling server. Nucleic Acids Res 31 (2003) 3381-3385
23. + channel, SkCa2. J Biol Chem 276 (2001) 43145-43151
24. Visan V., Fajloun Z., Sabatier J.M., and Grissmer S. Mapping of maurotoxin binding sites on hKv1.2, hKv1.3, and hIKCa1 channels. Mol Pharmacol 66 (2004) 1103-1112
25. Wiehe K., Pierce B., Mintseris J., Tong W.W., Anderson R., Chen R., et al. ZDOCK and RDOCK performance in CAPRI rounds 3, 4, and 5. Proteins 60 (2005) 207-213
26. (+) channel toxin (LmKTx8) derived from scorpion Lychas mucronatus. Peptides 28 (2007) 2306-2312
27. Wu Y., Cao Z., Yi H., Jiang D., Mao X., Liu H., et al. Simulation of the interaction between ScyTx and small conductance calcium-activated potassium channel by docking and MM-PBSA. Biophys J 87 (2004) 105-112
28. (+) channel in effector memory T cells as new target for MS. J Clin Invest 111 (2003) 1703-1713
29. Wulff H., and Pennington M. Targeting effector memory T-cells with Kv1.3 blockers. Curr Opin Drug Discov Dev 10 (2007) 438-445
30. (+) Channel with Its Specific BeKm-1 Peptide: Insights into the Selectivity of Molecular Recognition. J Proteome Res 6 (2007) 611-620
31. Yi H., Qiu S., Cao Z., Wu Y., and Li W. Molecular basis of inhibitory peptide maurotoxin recognizing Kv1.2 channel explored by ZDOCK and molecular dynamic simulations. Proteins 70 (2008) 844-854
32. Zeng X.C., Luo F., and Li W.X. Molecular dissection of venom from Chinese scorpion Mesobuthus martensii: identification and characterization of four novel disulfide-bridged venom peptides. Peptides 27 (2006) 1745-1754
33. Zhijian C., Feng L., Yingliang W., Xin M., and Wenxin L. Genetic mechanisms of scorpion venom peptide diversification. Toxicon 47 (2006) 348-355