Guided differentiation of embryonic stem cells into Pdx1-expressing regional-specific definitive endoderm

Stem Cells

Volumn 26, Issue 4, 2008, Pages 874-885

  Shiraki, Nobuaki ^a   Yoshida, Tetsu ^a   Araki, Kimi ^a   Umezawa, Akihiro ^b   Higuchi, Yuichiro ^a   Goto, Hideo ^a   Kume, Kazuhiko ^a   Kume, Shoen ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

Author keywords

Embryonic stem cells; Endoderm induction; Growth factors; In vitro differentiation; Pancreatic differentiation

Indexed keywords

ACTIVIN; BONE MORPHOGENETIC PROTEIN; FIBROBLAST GROWTH FACTOR; TRANSCRIPTION FACTOR PDX 1; HOMEODOMAIN PROTEIN; INSULIN PROMOTER FACTOR 1; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; ENDODERM; MESODERM; MONOLAYER CULTURE; MOUSE; NONHUMAN; PANCREAS; PANCREAS DUCT; PANCREAS ISLET; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; COMPARATIVE STUDY; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; MALE; METHODOLOGY; MOUSE MUTANT; PHYSIOLOGY; STEM CELL TRANSPLANTATION; TRANSGENIC MOUSE;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; CELLS, CULTURED; EMBRYONIC STEM CELLS; ENDODERM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEODOMAIN PROTEINS; MALE; MICE; MICE, SCID; MICE, TRANSGENIC; STEM CELL TRANSPLANTATION; TRANS-ACTIVATORS;

EID: 48949112425     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2007-0608     Document Type: Article

References (49)

1. Lawson KA, Meneses JJ, Pedersen RA. Cell fate and cell lineage in the endoderm of the presomite mouse embryo, studied with an intracellular tracer. Dev Biol 1986;115:325-339.
2. Lowe LA, Yamada S, Kuehn MR. Genetic dissection of nodal function in patterning the mouse embryo. Development 2001;128:1831-1843.
3. Ciruna BG, Schwartz L, Harpal K et al. Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function: A role for FGFR1 in morphogenetic movement through the primitive streak. Development 1997;124:2829-2841.
4. Hori Y, Rulifson IC, Tsai BC et al. Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells. Proc Natl Acad Sci U S A 2002;99:16105-16110.
5. Lumelsky N, Blondel O, Laeng P et al. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 2001;292:1389 -1394.
6. Rajagopal J, Anderson WJ, Kume S et al. Insulin staining of ES cell progeny from insulin uptake. Science 2003;299:363.
7. Kubo A, Shinozaki K, Shannon JM et al. Development of definitive endoderm from embryonic stem cells in culture. Development 2004;131:1651-1662.
8. Tada S, Era T, Furusawa C et al. Characterization of mesendoderm: A diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture. Development 2005;132:4363-4374.
9. Yasunaga M, Tada S, Torikai-Nishikawa S et al. Induction and monitoring of definitive and visceral endoderm differentiation of mouse ES cells. Nat Biotechnol 2005;23:1542-1550.
10. Gadue P, Huber TL, Paddison PJ et al. Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells. Proc Natl Acad Sci U S A 2006;103:16806-16811.
11. D'Amour KA, Agulnick AD, Eliazer S et al. Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol 2005;23:1534-1541.
12. McLean AB, D'Amour KA, Jones KL et al. Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. STEM CELLS 2007;25:29-38.
13. D'Amour KA, Bang AG, Eliazer S et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 2006;24:1392-1401.
14. Offield MF, Jetton TL, Labosky PA et al. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 1996;122:983-995.
15. Gu G, Wells JM, Dombkowski D et al. Global expression analysis of gene regulatory pathways during endocrine pancreatic development. Development 2004;131:165-179.
16. Larsson SH, Charlieu JP, Miyagawa K et al. Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing. Cell 1995;81:391-401.
17. Ogawa M, Nishikawa S, Ikuta K et al. B cell ontogeny in murine embryo studied by a culture system with the monolayer of a stromal cell clone, ST2: B cell progenitor develops first in the embryonal body rather than in the yolk sac. EMBO J 1988;7:1337-1343.
18. Kodama H, Nose M, Niida S et al. Involvement of the c-kit receptor in the adhesion of hematopoietic stem cells to stromal cells. Exp Hematol 1994;22:979-984.
19. Kodama H, Hagiwara H, Sudo H et al. MC3T3-G2/PA6 preadipocytes support in vitro proliferation of hemopoietic stem cells through a mechanism different from that of interleukin 3. J Cell Physiol 1986;129:20-26.
20. Shiraki N, Lai CJ, Hishikari Y et al. TGF-beta signaling potentiates differentiation of embryonic stem cells to Pdx-1 expressing endodermal cells. Genes Cells 2005;10:503-516.
21. Wells JM, Melton DA. Early mouse endoderm is patterned by soluble factors from adjacent germ layers. Development 2000;127:1563-1572.
22. Nakano T, Kodama H, Honjo T. Generation of lymphohematopoietic cells from embryonic stem cells in culture. Science 1994;265:1098-1101.
23. Kawasaki H, Mizuseki K, Nishikawa S et al. Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity. Neuron 2000;28:31-40.
24. Sugiki T, Uyama T, Toyoda M et al. Hyaline cartilage formation and enchondral ossification modeled with KUM5 and OP9 chondroblasts. J Cell Biochem 2007;100:1240-1254.
25. Gu G, Dubauskaite J, Melton DA. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 2002;129:2447-2457.
26. Kim SK, Hebrok M, Melton DA. Notochord to endoderm signaling is required for pancreas development. Development 1997;124:4243-4252.
27. Hebrok M, Kim SK, Melton DA. Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev 1998;12:1705-1713.
28. Stafford D, White RJ, Kinkel MD et al. Retinoids signal directly to zebrafish endoderm to specify insulin-expressing beta-cells. Development 2006;133:949-956.
29. Inman GJ, Nicolas FJ, Callahan JF et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol 2002;62:65-74.
30. Vallier L, Reynolds D, Pedersen RA. Nodal inhibits differentiation of human embryonic stem cells along the neuroectodermal default pathway. Dev Biol 2004;275:403-421.
31. Ying QL, Nichols J, Chambers I et al. BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 2003;115:281-292.
32. Goswami M, Uzgare AR, Sater AK. Regulation of MAP kinase by the BMP-4/TAK1 pathway in Xenopus ectoderm. Dev Biol 2001;236:259-270.
33. Moritoh Y, Yamato E, Yasui Y et al. Analysis of insulin-producing cells during in vitro differentiation from feeder-free embryonic stem cells. Diabetes 2003;52:1163-1168.
34. Nishi M, Chan SJ, Nagamatsu S et al. Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone. Proc Natl Acad Sci U S A 1989;86:5738-5742.
35. Sakura H, Ammala C, Smith PA et al. Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle. FEBS Lett 1995;377:338-344.
36. Kunath T, Saba-El-Leil MK, Almousailleakh M et al. FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Development 2007;134:2895-2902.
37. Camus A, Perea-Gomez A, Moreau A et al. Absence of Nodal signaling promotes precocious neural differentiation in the mouse embryo. Dev Biol 2006;295:743-755.
38. Aouadi M, Bost F, Caron L et al. p38 mitogen-activated protein kinase activity commits embryonic stem cells to either neurogenesis or cardiomyogenesis. STEM CELLS 2006;24:1399-1406.
39. Ogawa K, Saito A, Matsui H et al. Activin-Nodal signaling is involved in propagation of mouse embryonic stem cells. J Cell Sci 2007;120:55-65.
40. Brennan J, Lu CC, Norris DP et al. Nodal signalling in the epiblast patterns the early mouse embryo. Nature 2001;411:965-969.
41. Lu CC, Robertson EJ. Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning. Dev Biol 2004;273:149-159.
42. Candia AF, Watabe T, Hawley SH et al. Cellular interpretation of multiple TGF-beta signals: Intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads. Development 1997;124:4467-4480.
43. Winnier G, Blessing M, Labosky PA et al. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev 1995;9:2105-2116.
44. Zhao M, Zhao Z, Koh JT et al. Combinatorial gene therapy for bone regeneration: Cooperative interactions between adenovirus vectors expressing bone morphogenetic proteins 2, 4, and 7. J Cell Biochem 2005;95:1-16.
45. Bao YL, Tsuchida K, Liu B et al. Synergistic activity of activin A and basic fibroblast growth factor on tyrosine hydroxylase expression through Smad3 and ERK1/ERK2 MAPK signaling pathways. J Endocrinol 2005;184:493-504.
46. Chen Y, Pan FC, Brandes N et al. Retinoic acid signaling is essential for pancreas development and promotes endocrine at the expense of exocrine cell differentiation in Xenopus. Dev Biol 2004;271:144-160.
47. Molotkov A, Molotkova N, Duester G. Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development. Dev Dyn 2005;232:950-957.
48. Micallef SJ, Janes ME, Knezevic K et al. Retinoic acid induces Pdx1-positive endoderm in differentiating mouse embryonic stem cells. Diabetes 2005;54:301-305.
49. Ryan EA, Lakey JR, Paty BW et al. Successful islet transplantation: Continued insulin reserve provides long-term glycemic control. Diabetes 2002;51:2148-2157.