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Volumn 23, Issue 8, 2008, Pages 2450-2453

Hepcidin: A new tool in the management of anaemia in patients with chronic kidney disease?

Author keywords

Chronic kidney disease; Erythropoietin; Hepcidin; Inflammation; Iron

Indexed keywords

HEMOGLOBIN; HEPCIDIN; IRON; RECOMBINANT ERYTHROPOIETIN;

EID: 48749125607     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfn267     Document Type: Review
Times cited : (73)

References (38)
  • 1
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    • Pigeon C, Ilyin G, Courselaud B et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 2001; 276: 7811-7819
    • (2001) J Biol Chem , vol.276 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3
  • 2
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    • Park CH, Valore EV, Waring AJ et al. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001; 276: 7806-7810
    • (2001) J Biol Chem , vol.276 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3
  • 3
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E, Tuttle MS, Powelson J et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004; 306: 2090-2093
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3
  • 4
    • 37549059612 scopus 로고    scopus 로고
    • Regulation of iron acquisition and storage: Consequences for iron-linked disorders
    • De Domenico I, Mc Vey Ward D, Kaplan J. Regulation of iron acquisition and storage: consequences for iron-linked disorders. Nat Rev Mol Cell Biol 2008; 9: 72-81
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 72-81
    • De Domenico, I.1    Mc Vey Ward, D.2    Kaplan, J.3
  • 5
    • 33645509481 scopus 로고    scopus 로고
    • Hepcidin inhibits in vitro erythroid colony formation at reduced erythropoietin concentrations
    • Dallalio G, Law E, Means RT Jr. Hepcidin inhibits in vitro erythroid colony formation at reduced erythropoietin concentrations. Blood 2006; 107: 2702-2704
    • (2006) Blood , vol.107 , pp. 2702-2704
    • Dallalio, G.1    Law, E.2    Means Jr., R.T.3
  • 7
    • 0036791486 scopus 로고    scopus 로고
    • The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia and inflammation
    • Nicolas G, Chauvet C, Viatte L et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia and inflammation. J Clin Invest 2002; 110: 1037-1044
    • (2002) J Clin Invest , vol.110 , pp. 1037-1044
    • Nicolas, G.1    Chauvet, C.2    Viatte, L.3
  • 8
    • 33845245942 scopus 로고    scopus 로고
    • Suppression of hepcidin during anemia requires erythropoietic activity
    • Pak M, Lopez MA, Gabayan V et al. Suppression of hepcidin during anemia requires erythropoietic activity. Blood 2006; 108: 3730-3735
    • (2006) Blood , vol.108 , pp. 3730-3735
    • Pak, M.1    Lopez, M.A.2    Gabayan, V.3
  • 9
    • 34548594676 scopus 로고    scopus 로고
    • Hepcidin and its role in regulating systemic iron metabolism
    • Ganz T. Hepcidin and its role in regulating systemic iron metabolism. Hematol Am Soc Hematol Educ Program 2006; 507: 29-35
    • (2006) Hematol Am Soc Hematol Educ Program , vol.507 , pp. 29-35
    • Ganz, T.1
  • 10
    • 38549136843 scopus 로고    scopus 로고
    • Hepcidin: From discovery to differential diagnosis
    • Kemna EHJM, Tjalsma H, Willems JL et al. Hepcidin: from discovery to differential diagnosis. Haematologica 2008; 93: 90-97
    • (2008) Haematologica , vol.93 , pp. 90-97
    • Kemna, E.H.J.M.1    Tjalsma, H.2    Willems, J.L.3
  • 11
    • 34447120059 scopus 로고    scopus 로고
    • Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)
    • Peyssonnaux C, Zinkernagel AS, Schuepbach RA et al. Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J Clin Invest 2007; 117: 1926-1932
    • (2007) J Clin Invest , vol.117 , pp. 1926-1932
    • Peyssonnaux, C.1    Zinkernagel, A.S.2    Schuepbach, R.A.3
  • 12
    • 38349194098 scopus 로고    scopus 로고
    • Furin mediated release of soluble hemojuvelin: A new link between hypoxia and iron homeostasis
    • Silvestri L, Pagani A, Camaschella C. Furin mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis. Blood 2008; 111: 924-931
    • (2008) Blood , vol.111 , pp. 924-931
    • Silvestri, L.1    Pagani, A.2    Camaschella, C.3
  • 13
    • 33745742487 scopus 로고    scopus 로고
    • Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis
    • Vokurka M, Krijt J, Sulc K et al. Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis. Physiol Res 2006; 55: 667-674
    • (2006) Physiol Res , vol.55 , pp. 667-674
    • Vokurka, M.1    Krijt, J.2    Sulc, K.3
  • 14
    • 41949132519 scopus 로고    scopus 로고
    • Regulation of hepcidin: Insights from biochemical analysis on human serum samples
    • Kemna EHJM, Kartikasari AER, van Tits LHJ et al. Regulation of hepcidin: insights from biochemical analysis on human serum samples. Blood Cells Mol Dis 2007; 40: 339-346
    • (2007) Blood Cells Mol Dis , vol.40 , pp. 339-346
    • Kemna, E.H.J.M.1    Kartikasari, A.E.R.2    van Tits, L.H.J.3
  • 15
    • 0037362778 scopus 로고    scopus 로고
    • Soluble transferrin receptor for evaluation of erythropoiesis and iron status
    • Beguin Y. Soluble transferrin receptor for evaluation of erythropoiesis and iron status. Clin Chim Acta 2003; 329: 9-22
    • (2003) Clin Chim Acta , vol.329 , pp. 9-22
    • Beguin, Y.1
  • 16
    • 34948904750 scopus 로고    scopus 로고
    • High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin
    • Tanno T, Bhanu NV, Oneal PA et al. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med 2007; 13: 1096-1101
    • (2007) Nat Med , vol.13 , pp. 1096-1101
    • Tanno, T.1    Bhanu, N.V.2    Oneal, P.A.3
  • 17
    • 23944502314 scopus 로고    scopus 로고
    • Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS
    • Kemna E, Pickkers P, Nemeth E et al. Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood 2005; 106: 1864-1846
    • (2005) Blood , vol.106 , pp. 1864-1846
    • Kemna, E.1    Pickkers, P.2    Nemeth, E.3
  • 18
    • 10844222807 scopus 로고    scopus 로고
    • Serum pro-hepcidin: Measuring active hepcidin or non-functional precursor?
    • Brookes MJ, Sharma NK, Tselepis C et al. Serum pro-hepcidin: measuring active hepcidin or non-functional precursor? Gut 2005; 54: 169-170
    • (2005) Gut , vol.54 , pp. 169-170
    • Brookes, M.J.1    Sharma, N.K.2    Tselepis, C.3
  • 19
    • 34047261779 scopus 로고    scopus 로고
    • Serum prohepcidin concentration: No association with iron absorption in healthy men, and no relationship with iron status in men carrying HFE mutations, hereditary haemochromatosis patients undergoing phlebotomy treatment, or pregnant woman
    • Roe MA, Spinks C, Heath AL et al. Serum prohepcidin concentration: no association with iron absorption in healthy men, and no relationship with iron status in men carrying HFE mutations, hereditary haemochromatosis patients undergoing phlebotomy treatment, or pregnant woman. Br J Nutr 2007; 97: 544-549
    • (2007) Br J Nutr , vol.97 , pp. 544-549
    • Roe, M.A.1    Spinks, C.2    Heath, A.L.3
  • 20
    • 36549034762 scopus 로고    scopus 로고
    • Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin
    • Valore EV, Ganz T. Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin. Blood Cells Mol Dis 2008; 40: 132-138
    • (2008) Blood Cells Mol Dis , vol.40 , pp. 132-138
    • Valore, E.V.1    Ganz, T.2
  • 21
    • 23044463685 scopus 로고    scopus 로고
    • Primary iron overload with inappropriate hepcidin expression in V162del ferroportin disease
    • Zoller H, McFarlane I, Theurl I et al. Primary iron overload with inappropriate hepcidin expression in V162del ferroportin disease. Hepatology 2005; 42: 466-472
    • (2005) Hepatology , vol.42 , pp. 466-472
    • Zoller, H.1    McFarlane, I.2    Theurl, I.3
  • 22
    • 2342422913 scopus 로고    scopus 로고
    • Pro-hepcidin: Expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia
    • Kulaksiz H, Gehrke SG, Janetzko A et al. Pro-hepcidin: expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia. Gut 2004; 53: 735-743
    • (2004) Gut , vol.53 , pp. 735-743
    • Kulaksiz, H.1    Gehrke, S.G.2    Janetzko, A.3
  • 23
    • 2342569721 scopus 로고    scopus 로고
    • Prohepcidin accumulates in renal insufficiency
    • Taes YE, Wuyts B, Boelaert JR et al. Prohepcidin accumulates in renal insufficiency. Clin Chem Lab Med 2004; 42: 387-389
    • (2004) Clin Chem Lab Med , vol.42 , pp. 387-389
    • Taes, Y.E.1    Wuyts, B.2    Boelaert, J.R.3
  • 24
    • 33750584843 scopus 로고    scopus 로고
    • Hepcidin, iron status, and renal function in chronic renal failure, kidney transplantation and hemodialysis
    • Malyszko J, Malyszko JS, Pawlak K et al. Hepcidin, iron status, and renal function in chronic renal failure, kidney transplantation and hemodialysis. Am J Hematol 2006; 81: 832-837
    • (2006) Am J Hematol , vol.81 , pp. 832-837
    • Malyszko, J.1    Malyszko, J.S.2    Pawlak, K.3
  • 25
    • 0038662619 scopus 로고    scopus 로고
    • Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
    • Nemeth E, Valore EV, Territo M et al. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003; 101: 2461-2463
    • (2003) Blood , vol.101 , pp. 2461-2463
    • Nemeth, E.1    Valore, E.V.2    Territo, M.3
  • 26
    • 27144475517 scopus 로고    scopus 로고
    • Novel urine hepcidin assay by mass spectrometry
    • Kemna E, Tjalsma H, Laarakkers C et al. Novel urine hepcidin assay by mass spectrometry. Blood 2005; 106: 3268-3270
    • (2005) Blood , vol.106 , pp. 3268-3270
    • Kemna, E.1    Tjalsma, H.2    Laarakkers, C.3
  • 27
    • 34147197662 scopus 로고    scopus 로고
    • Mass spectrometry-based hepcidin measurements in serum and urine: Analytical aspects and clinical implications
    • Kemna EHJM, Tjalsma H, Podust VN et al. Mass spectrometry-based hepcidin measurements in serum and urine: analytical aspects and clinical implications. Clin Chem 2007; 53: 620-628
    • (2007) Clin Chem , vol.53 , pp. 620-628
    • Kemna, E.H.J.M.1    Tjalsma, H.2    Podust, V.N.3
  • 28
    • 33747167627 scopus 로고    scopus 로고
    • Detection of serum hepcidin in renal failure and inflammation by using ProteinChip system
    • Tomosugi N, Kawabata H, Wakatabe R et al. Detection of serum hepcidin in renal failure and inflammation by using ProteinChip system. Blood 2006; 108: 1381-1387
    • (2006) Blood , vol.108 , pp. 1381-1387
    • Tomosugi, N.1    Kawabata, H.2    Wakatabe, R.3
  • 29
    • 34547940326 scopus 로고    scopus 로고
    • Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry
    • Murphy AT, Witcher DR, Luan P et al. Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry. Blood 2007; 110: 1048-1054
    • (2007) Blood , vol.110 , pp. 1048-1054
    • Murphy, A.T.1    Witcher, D.R.2    Luan, P.3
  • 30
    • 37649012006 scopus 로고    scopus 로고
    • Simple and sensitive quantification of bioactive peptides in biological matrices using liquid chromatography/ selected reaction monitoring mass spectrometry coupled with trichloroacetic acid clean-up
    • Murao N, Ishigai M, Yasuno H et al. Simple and sensitive quantification of bioactive peptides in biological matrices using liquid chromatography/ selected reaction monitoring mass spectrometry coupled with trichloroacetic acid clean-up. Rapid Commun Mass Spectrom 2007; 21: 4033-4038
    • (2007) Rapid Commun Mass Spectrom , vol.21 , pp. 4033-4038
    • Murao, N.1    Ishigai, M.2    Yasuno, H.3
  • 31
    • 14844291392 scopus 로고    scopus 로고
    • The iron-regulatory peptide hormone hepcidin: Expression and cellular localization in the mammalian kidney
    • Kulaksiz H, Theilig F, Bachmann S et al. The iron-regulatory peptide hormone hepcidin: expression and cellular localization in the mammalian kidney. J Endocrinol 2005; 184: 361-370
    • (2005) J Endocrinol , vol.184 , pp. 361-370
    • Kulaksiz, H.1    Theilig, F.2    Bachmann, S.3
  • 32
    • 29244487098 scopus 로고    scopus 로고
    • Kaysen GA, Müller HG, Ding J et al. Challenging the validity of the EPO index. Am J Kidney Dis 2006; 47: 166.e1-166.e13
    • Kaysen GA, Müller HG, Ding J et al. Challenging the validity of the EPO index. Am J Kidney Dis 2006; 47: 166.e1-166.e13
  • 33
    • 7444256054 scopus 로고    scopus 로고
    • Epoetin requirements predict mortality in hemodialysis patients
    • Zhang Y, Thamer M, Stefanik K et al. Epoetin requirements predict mortality in hemodialysis patients. Am J Kidney Dis 2004; 44: 866-876
    • (2004) Am J Kidney Dis , vol.44 , pp. 866-876
    • Zhang, Y.1    Thamer, M.2    Stefanik, K.3
  • 34
    • 0032572913 scopus 로고    scopus 로고
    • The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin
    • Besarab A, Bolton WK, Browne JK et al. The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin. N Engl J Med 1998; 339: 584-590
    • (1998) N Engl J Med , vol.339 , pp. 584-590
    • Besarab, A.1    Bolton, W.K.2    Browne, J.K.3
  • 35
    • 33750983605 scopus 로고    scopus 로고
    • (CHOIR Investigators). Correction of anemia with epoetin alfa in chronic kidney disease
    • Singh AK, Szczech L, Tang KL et al. (CHOIR Investigators). Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med 2006; 355: 2085-2098
    • (2006) N Engl J Med , vol.355 , pp. 2085-2098
    • Singh, A.K.1    Szczech, L.2    Tang, K.L.3
  • 36
    • 33751002326 scopus 로고    scopus 로고
    • (CREATE Investigators). Normalization of hemoglobin level in patients with chronic kidney disease and anemia
    • Drüeke TB, Locatelli F, Clyne N et al. (CREATE Investigators). Normalization of hemoglobin level in patients with chronic kidney disease and anemia. N Engl J Med 2006; 355: 2071-2084
    • (2006) N Engl J Med , vol.355 , pp. 2071-2084
    • Drüeke, T.B.1    Locatelli, F.2    Clyne, N.3
  • 37
    • 34249304479 scopus 로고    scopus 로고
    • Predictors of the response to treatment in anemic hemodialysis patients with high serum ferritin and low transferrin saturation
    • DRIVE Study Group
    • Singh AK, Coyne DW, Shapiro W et al. (DRIVE Study Group). Predictors of the response to treatment in anemic hemodialysis patients with high serum ferritin and low transferrin saturation. Kidney Int 2007; 71: 1163-1171
    • (2007) Kidney Int , vol.71 , pp. 1163-1171
    • Singh, A.K.1    Coyne, D.W.2    Shapiro, W.3
  • 38
    • 36249027662 scopus 로고    scopus 로고
    • Association of prohepcidin and hepcidin-25 with erythropoietin response and ferritin in hemodialysis patients
    • Kato A, Tsuji T, Luo J et al. Association of prohepcidin and hepcidin-25 with erythropoietin response and ferritin in hemodialysis patients. Am J Nephrol 2008; 28: 115-121
    • (2008) Am J Nephrol , vol.28 , pp. 115-121
    • Kato, A.1    Tsuji, T.2    Luo, J.3


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