The CB1 endocannabinoid system modulates adipocyte insulin sensitivity

Obesity

Volumn 16, Issue 8, 2008, Pages 1727-1734

  Motaghedi, Roja ^a   McGraw, Timothy E ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 ARACHIDONOYLGLYCEROL; 2-ARACHIDONYLGLYCEROL; ACYLGLYCEROL; ARACHIDONIC ACID DERIVATIVE; CANNABINOID 1 RECEPTOR; ENDOCANNABINOID; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR; PERTUSSIS TOXIN; PIPERIDINE DERIVATIVE; PROTEIN KINASE B; PYRAZOLE DERIVATIVE; RIMONABANT; SLC2A4 PROTEIN, MOUSE;

ADIPOCYTE; ANIMAL; ARTICLE; CELL MEMBRANE; CELL STRAIN 3T3; CYTOLOGY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; INSULIN RESISTANCE; METABOLISM; MOUSE; PHYSIOLOGY;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; ARACHIDONIC ACIDS; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCANNABINOIDS; GLUCOSE TRANSPORTER TYPE 4; GLYCERIDES; INSULIN; INSULIN RESISTANCE; MICE; PERTUSSIS TOXIN; PIPERIDINES; PROTO-ONCOGENE PROTEINS C-AKT; PYRAZOLES; RECEPTOR, CANNABINOID, CB1; RECEPTOR, INSULIN;

EID: 48749100198     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2008.309     Document Type: Article

References (42)

1. Srinivasan SR, Myers L, Berenson GS. Predictability of childhood adiposity and insulin for developing insulin resistance syndrome (syndrome X) in young adulthood: the Bogalusa Heart Study. Diabetes 2002;51:204-209.
2. Fischer-Posovszky P, Wabitsch M, Hochberg Z. Endocrinology of adipose tissue - an update. Horm Metab Res 2007;39:314-321.
3. Sethi JK, Vidal-Puig AJ. Targeting fat to prevent diabetes. Cell Metab 2007;5:323-325.
4. Matias I, Di Marzo V. Endocannabinoids and the control of energy balance. Trends Endocrinol Metab 2007;18:27-37.
5. Kunos G. Understanding metabolic homeostasis and imbalance: what is the role of the endocannabinoid system? Am J Med 2007;120:S18-S24; discussion S24.
6. Di Marzo V, Matias I. Endocannabinoid control of food intake and energy balance. Nat Neurosci 2005;8:585-589.
7. Jbilo O, Ravinet-Trillou C, Arnone M et al. The CB1 receptor antagonist rimonabant reverses the diet-induced obesity phenotype through the regulation of lipolysis and energy balance. Faseb J 2005;19:1567-1569.
8. Engeli S, Bohnke J, Feldpausch M et al. Activation of the peripheral endocannabinoid system in human obesity. Diabetes 2005;54:2838-2843.
9. Cota D, Marsicano G, Tschop M et al. The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. J Clin Invest 2003;112:423-431.
10. Pi-Sunyer FX, Aronne LJ, Heshmati HM, Devin J, Rosenstock J. Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. JAMA 2006;295:761-775.
11. Pagotto U, Marsicano G, Cota D, Lutz B, Pasquali R. The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Endocr Rev 2006;27:73-100.
12. Bensaid M, Gary-Bobo M, Esclangon A et al. The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells. Mol Pharmacol 2003;63:908-914.
13. Gary-Bobo M, Elachouri G, Gallas JF et al. Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats. Hepatology 2007;46:122-129.
14. Karylowski O, Zeigerer A, Cohen A, McGraw TE. GLUT4 is retained by an intracellular cycle of vesicle formation and fusion with endosomes. Mol Biol Cell 2004;15:870-882.
15. Zeigerer A, Lampson M, Karylowski O et al. GLUT4 retention in adipocytes requires two intracellular insulin-regulated transport steps. Mol Biol Cell 2002;13:2421-2435.
16. Martin OJ, Lee A, McGraw TE. GLUT4 distribution between the plasma membrane and the intracellular compartments is maintained by an insulin-modulated bipartite dynamic mechanism. J Biol Chem 2006;281:484-490.
17. Govers R, Coster AC, James DE. Insulin increases cell surface GLUT4 levels by dose dependently discharging GLUT4 into a cell surface recycling pathway. Mol Cell Biol 2004;24:6456-6466.
18. Eguez L, Lee A, Chavez JA et al. Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein. Cell Metab 2005;2:263-272.
19. Eyster CA, Duggins QS, Gorbsky GJ, Olson AL. Microtubule network is required for insulin signaling through activation of Akt/protein kinase B: evidence that insulin stimulates vesicle docking/fusion but not intracellular mobility. J Biol Chem 2006;281:39719-39727.
20. Lampson MA, Schmoranzer J, Zeigerer A, Simon SM, McGraw TE. Insulin-regulated release from the endosomal recycling compartment is regulated by budding of specialized vesicles. Mol Biol Cell 2001;12:3489-3501.
21. Huang S, Czech MP. The GLUT4 glucose transporter. Cell Metab 2007;5:237-252.
22. Taniguchi CM, Emanuelli B, Kahn CR. Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 2006;7:85-96.
23. Rockwell CE, Snider NT, Thompson JT, Vanden Heuvel JP, Kaminski NE. Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2. Mol Pharmacol 2006;70:101-111.
24. Gary-Bobo M, Elachouri G, Scatton B et al. The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits cell proliferation and increases markers of adipocyte maturation in cultured mouse 3T3 F442A preadipocytes. Mol Pharmacol 2006;69:471-478.
25. El-Jack AK, Kandror KV, Pilch PF. The formation of an insulin-responsive vesicular cargo compartment is an early event in 3T3-L1 adipocyte differentiation. Mol Biol Cell 1999;10:1581-1594.
26. Jiang ZY, Zhou QL, Coleman KA et al. Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing. Proc Natl Acad Sci USA 2003;100:7569-7574.
27. Gonzalez E, McGraw TE. Insulin Signaling Diverges into Akt-dependent and - independent signals to regulate the recruitment/docking and the fusion of GLUT4 vesicles to the plasma membrane. Mol Biol Cell 2006;17:4484-4493.
28. Pertwee RG. Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacol Ther 1997;74:129-180.
29. Gasperi V, Fezza F, Pasquariello N et al. Endocannabinoids in adipocytes during differentiation and their role in glucose uptake. Cell Mol Life Sci 2007;64:219-229.
30. Liao W, Nguyen MT, Imamura T et al. Lentiviral short hairpin ribonucleic acid-mediated knockdown of GLUT4 in 3T3-L1 adipocytes. Endocrinology 2006;147:2245-2252.
31. Hauner H, Rohrig K, Spelleken M, Liu LS, Eckel J. Development of insulin-responsive glucose uptake and GLUT4 expression in differentiating human adipocyte precursor cells. Int J Obes Relat Metab Disord 1998;22:448-453.
32. Pagano C, Pilon C, Calcagno A et al. The endogenous cannabinoid system stimulates glucose uptake in human fat cells via phosphatidylinositol 3-kinase and calcium-dependent mechanisms. J Clin Endocrinol Metab 2007;92:4810-4819.
33. Matias I, Gonthier MP, Orlando P et al. Regulation, function, and dysregulation of endocannabinoids in models of adipose and β-pancreatic cells and in obesity and hyperglycemia. J Clin Endocrinol Metab 2006;91:3171-3180.
34. Demuth DG, Molleman A. Cannabinoid signalling. Life Sci 2006;78:549-563.
35. Woods SC. The endocannabinoid system: mechanisms behind metabolic homeostasis and imbalance. Am J Med 2007;120:S9-S17; discussion S29-S32.
36. Gomez del Pulgar T, Velasco G, Guzman M. The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt. Biochem J 2000;347:369-373.
37. Galve-Roperh I, Rueda D, Gomez del Pulgar T, Velasco G, Guzman M. Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptor. Mol Pharmacol 2002;62:1385-1392.
38. Sanchez MG, Ruiz-Llorente L, Sanchez AM, Diaz-Laviada I. Activation of phosphoinositide 3-kinase/PKB pathway by CB(1) and CB(2) cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction. Cell Signal 2003;15:851-859.
39. Ozaita A, Puighermanal E, Maldonado R. Regulation of PI3K/Akt/GSK-3 pathway by cannabinoids in the brain. J Neurochem 2007;102:1105-1114.
40. Pertwee RG. Pharmacological actions of cannabinoids. Handb Exp Pharmacol 2005:1-51.
41. Bluher M, Engeli S, Kloting N et al. Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity. Diabetes 2006;55:3053-3060.
42. Matias I, Bisogno T, Di Marzo V. Endogenous cannabinoids in the brain and peripheral tissues: regulation of their levels and control of food intake. Int J Obes (Lond) 2006;30(Suppl 1):S7-S12.