Human mediator kinase subunit CDK11 plays a negative role in viral activator VP16-dependent transcriptional regulation

Genes to Cells

Volumn 13, Issue 8, 2008, Pages 817-826

  Tsutsui, Taiki ^a   Umemura, Hiroyasu ^a   Tanaka, Aki ^a,b   Mizuki, Fumitaka ^a   Hirose, Yutaka ^a,b   Ohkuma, Yoshiaki ^a,b  

^a UNIVERSITY OF TOYAMA   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 11; CYCLIN DEPENDENT KINASE 8; EPITOPE; LUCIFERASE; PROTEIN SUBUNIT; PROTEIN VP16;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; HELA CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; REGULATORY MECHANISM; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; CYCLIN-DEPENDENT KINASES; HELA CELLS; HERPES SIMPLEX VIRUS PROTEIN VMW65; HUMANS; MOLECULAR SEQUENCE DATA;

EUKARYOTA; VERTEBRATA;

EID: 48649109121     PISSN: 13569597     EISSN: 13652443     Source Type: Journal    
DOI: 10.1111/j.1365-2443.2008.01208.x     Document Type: Article

References (38)

1. Akoulitchev, S., Chuikov, S. & Reinberg, D. (2000) TFIIH is negatively regulated by cdk8-containing mediator complexes. Nature 407, 102-106.
2. Andrau, J.C., van de Pasch, L., Lijnzaad, P., Bijma, T., Koerkamp, M.G., van de Peppel, J., Werner, M. & Holstege, F.C. (2006) Genome-wide location of the coactivator mediator: Binding without activation and transient Cdk8 interaction on DNA. Mol. Cell 22, 179-192.
3. Baek, H.J., Kang, Y.K. & Roeder, R.G. (2006) Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly. J. Biol. Chem. 281, 15172-15181.
4. Beyer, K.S., Beauchamp, R.L., Lee, M.F., Gusella, J.F., Naar, A.M. & Ramesh, V. (2007) Mediator subunit MED28 (Magicin) is a repressor of smooth muscle cell differentiation. J. Biol. Chem. 282, 32152-32157.
5. Bosveld, F., van Hoek, S. & Sibon, O.C. (2008) Establishment of cell fate during early Drosophila embryogenesis requires transcriptional Mediator subunit dMED31. Dev. Biol. 313, 802-813.
6. Chi, Y., Huddleston, M.J., Zhang, X., Young, R.A., Annan, R.S., Carr, S.A. & Deshaies, R.J. (2001) Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase. Genes Dev. 15, 1078-1092.
7. Chiang, C.M. & Roeder, R.G. (1993) Expression and purification of general transcription factors by FLAG epitope-tagging and peptide elution. Pept. Res. 6, 62-64.
8. Dignam, J.D., Lebovitz, R.M. & Roeder, R.G. (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11, 1475-1489.
9. Donner, A.J., Szostek, S., Hoover, J.M. & Espinosa, J.M. (2007) CDK8 is a stimulus-specific positive coregulator of p53 target genes. Mol. Cell 27, 121-133.
10. Fondell, J.D., Ge, H. & Roeder, R.G. (1996) Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex. Proc. Natl. Acad. Sci. USA 93, 8329-8333.
11. Fryer, C.J., White, J.B. & Jones, K.A. (2004) Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. Mol. Cell 16, 509-520.
12. Furumoto, T., Tanaka, A., Ito, M., Malik, S., Hirose, Y., Hanaoka, F. & Ohkuma, Y. (2007) A kinase subunit of the human mediator complex, CDK8, positively regulates transcriptional activation. Genes Cells 12, 119-132.
13. Gim, B.S., Park, J.M., Yoon, J.H., Kang, C. & Kim, Y.J. (2001) Drosophila Med6 is required for elevated expression of a large but distinct set of developmentally regulated genes. Mol. Cell. Biol. 21, 5242-5255.
14. Gu, W., Malik, S., Ito, M., Yuan, C.X., Fondell, J.D., Zhang, X., Martinez, E., Qin, J. & Roeder, R.G. (1999) A novel human SRB/ MED-containing cofactor complex, SMCC, involved in transcription regulation. Mol. Cell 3, 97-108.
15. Guglielmi, B., Soutourina, J., Esnault, C. & Werner, M. (2007) TFIIS elongation factor and Mediator act in conjunction during transcription initiation in vivo. Proc. Natl. Acad. Sci. USA 104, 16062-16067.
16. Hengartner, C.J., Myer, V.E., Liao, S.M., Wilson, C.J., Koh, S.S. & Young, R.A. (1998) Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases. Mol. Cell 2, 43-53.
17. Kelleher, R.J. 3rd., Flanagan, P.M. & Kornberg, R.D. (1990) A novel mediator between activator proteins and the RNA polymerase II transcription apparatus. Cell 61, 1209-1215.
18. Kim, Y.J., Bjorklund, S., Li, Y., Sayre, M.H. & Kornberg, R.D. (1994) A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell 77, 599-608.
19. Lin, X., Rinaldo, L., Fazly, A.F. & Xu, X. (2007) Depletion of Med10 enhances Wnt and suppresses Nodal signaling during zebrafish embryogenesis. Dev. Biol. 303, 536-548.
20. Liu, Y., Kung, C., Fishburn, J., Ansari, A.Z., Shokat, K.M. & Hahn, S. (2004) Two cyclin-dependent kinases promote RNA polymerase II transcription and formation of the scaffold complex. Mol. Cell. Biol. 24, 1721-1735.
21. Loncle, N., Boube, M., Joulia, L., Boschiero, C., Werner, M., Cribbs, D.L. & Bourbon, H.M. (2007) Distinct roles for Mediator Cdk8 module subunits in Drosophila development. EMBO J. 26, 1045-1054.
22. Malik, S. & Roeder, R.G. (2005) Dynamic regulation of pol II transcription by the mammalian Mediator complex. Trends Biochem. Sci. 30, 256-263.
23. Mo, X., Kowenz-Leutz, E., Xu, H. & Leutz, A. (2004) Ras induces mediator complex exchange on C/EBPβ. Mol. Cell 13, 241-250.
24. Muncke, N., Jung, C., Rudiger, H., Ulmer, H., Roeth, R., Hubert, A., Goldmuntz, E., Driscoll, D., Goodship, J., Schon, K. & Rappold, G. (2003) Missense mutations and gene interruption in PROSIT240, a novel TRAP240-like gene, in patients with congenital heart defect (transposition of the great arteries). Circulation 108, 2843-2850.
25. Myers, L.C. & Kornberg, R.D. (2000) Mediator of transcriptional regulation. Annu. Rev. Biochem. 69, 729-749.
26. Näär, A.M., Beaurang, P.A., Zhou, S., Abraham, S., Solomon, W. & Tjian, R. (1999) Composite co-activator ARC mediates chromatin-directed transcriptional activation. Nature 398, 828-832.
27. Nelson, C., Goto, S., Lund, K., Hung, W. & Sadowski, I. (2003) Srb10/ Cdk8 regulates yeast filamentous growth by phosphorylating the transcription factor Ste12. Nature 421, 187-190.
28. Nonet, M.L. & Young, R.A. (1989) Intragenic and extragenic suppressors of mutations in the heptapeptide repeat domain of Saccharomyces cerevisiae RNA polymerase II. Genetics 123, 715-724.
29. Ohkuma, Y., Hashimoto, S., Wang, C.K., Horikoshi, M. & Roeder, R.G. (1995) Analysis of the role of TFIIE in basal transcription and TFIIH-mediated carboxy-terminal domain phosphorylation through structure-function studies of TFIIE-α. Mol. Cell. Biol. 15, 4856-4866.
30. Osada, S., Matsubara, T., Daimon, S., Terazu, Y., Xu, M., Nishihara, T. & Imagawa, M. (1999) Expression, DNA-binding specificity and transcriptional regulation of nuclear factor 1 family proteins from rat. Biochem. J. 342, 189-198.
31. Rachez, C., Suldan, Z., Ward, J., Chang, C.P., Burakov, D., Erdjument-Bromage, H., Tempst, P. & Freedman, L.P. (1998) A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system. Genes Dev. 12, 1787-1800.
32. Roeder, R.G. (2005) Transcriptional regulation and the role of diverse coactivators in animal cells. FEBS Lett. 579, 909-915.
33. Sato, S., Tomomori-Sato, C., Parmely, T.J., Florens, L., Zybailov, B., Swanson, S.K., Banks, C.A., Jin, J., Cai, Y., Washburn, M.P., Conaway, J.W. & Conaway, R.C. (2004) A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. Mol. Cell 14, 685-691.
34. Sun, X., Zhang, Y., Cho, H., Rickert, P., Lees, E., Lane, W. & Reinberg, D. (1998) NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. Mol. Cell 2, 213-222.
35. Thompson, C.M., Koleske, A.J., Chao, D.M. & Young, R.A. (1993) A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast. Cell 73, 1361-1375.
36. Wang, X., Yang, N., Uno, E., Roeder, R.G. & Guo, S. (2006) A subunit of the mediator complex regulates vertebrate neuronal development. Proc. Natl. Acad. Sci. USA 103, 17284-17289.
37. Wery, M., Shematorova, E., Van Driessche, B., Vandenhaute, J., Thuriaux, P. & Van Mullem, V. (2004) Members of the SAGA and Mediator complexes are partners of the transcription elongation factor TFIIS. EMBO J. 23, 4232-4242.
38. Westerling, T., Kuuluvainen, E. & Mäkelä, T.P. (2007) Cdk8 is essential for preimplantation mouse development. Mol. Cell. Biol. 27, 6177-6182.