Drosophila Med6 is required for elevated expression of a large but distinct set of developmentally regulated genes

Molecular and Cellular Biology

Volumn 21, Issue 15, 2001, Pages 5242-5255

  Byung Soo Gim, ^a   Jin Mo Park, ^a   Jeong Ho Yoon, ^a   Kang, C ^a   Kim, Y J ^a  

^a Yonsei University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; COMPLEMENTARY DNA; MUTANT PROTEIN; PROTEIN MED6; UNCLASSIFIED DRUG;

ARTICLE; CELL METABOLISM; CELL PROLIFERATION; CELL VIABILITY; DNA MICROARRAY; DROSOPHILA MELANOGASTER; EVOLUTION; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ALLELES; ANIMALS; BLOTTING, NORTHERN; CELL DIVISION; CELL NUCLEUS; CELL SURVIVAL; CLONING, MOLECULAR; DNA NUCLEOTIDYLTRANSFERASES; DNA, COMPLEMENTARY; DROSOPHILA; DROSOPHILA PROTEINS; FUNGAL PROTEINS; GREEN FLUORESCENT PROTEINS; HOMOZYGOTE; LAC OPERON; LUMINESCENT PROTEINS; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SACCHAROMYCES CEREVISIAE PROTEINS; TIME FACTORS; TISSUE DISTRIBUTION; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

ARACHNIDA; DROSOPHILA MELANOGASTER; HEXAPODA; MELANOGASTER; METAZOA;

EID: 0034958920     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.15.5242-5255.2001     Document Type: Article

References (52)

1. IMP-L3, a 20-hydroxyecdysone-responsive gene, encodes Drosophila lactate dehydrogenase: Structural characterization and developmental studies
2. Activation of RNA polymerase II transcription
3. Global transcription regulators of eukaryotes
4. Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification
5. Mammalian Srb/mediator complex is targeted by adenovirus E1A protein
6. Functional interactions between the estrogen receptor and DRIP205, a subunit of the heteromeric DRIP coactivator complex
7. The roles of the homeobox genes aristaless and distal-less in patterning the legs and wings of Drosophila
8. The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development
9. The drosophila disembodied gene controls late embryonic morphogenesis and codes for a cytochrome P450 enzyme that regulates embryonic ecdysone levels
10. The autosomal FLP-DFS technique for generating germline mosaics in Drosophila melanogaster
11. Requirement for RGR1 and SIN4 in RME1-dependent repression in saccharomyces cerevisiae
12. Biological role of alcohol dehydrogenase in the tolerance of Drosophila melanogaster to aliphatic alcohols: Utilization of an ADH-null mutant
13. A nuclear GFP that marks nuclei in living Drosophila embryos; maternal supply overcomes a delay in the appearance of zygotic fluorescence
14. Genetic analysis of brahma: The Drosophila homolog of the yeast chromatin remodeling factor SWI2/SNF2
15. Thyroid hormone receptor-associated proteins and general positive cofactors mediate thyroid hormone receptor function in the absence of the TATA boxbinding protein-associated factors of TFIID
16. A maternal requirement for glutamine synthetase I for the mitotic cycles of syncytial Drosophila embryos
17. TBP-associated factors (TAFIIs): Multiple, selective transcriptional mediators in common complexes
18. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation
19. Activator-specific requirement of yeast mediator proteins for RNA polymerase II transcriptional activation
20. Cloning of the Schizosaccharomyces pombe TFIID gene reveals a strong conservation of functional domains present in Saccharomyces cerevisiae TFIID
21. Dissecting the regulatory circuitry of a eukaryotic genome
22. The mutability of the minute loci of Drosophila melanogastr with ethyl methanesulfonate
23. Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action
24. Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways
25. A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II
26. An RNA polymerase II holoenzyme responsive to activators
27. Caenorhabditis elegans mediator complexes are required for developmental-specific transcriptional activation
28. Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity
29. Requirement for a functional interaction between mediator components Med6 and Srb4 in RNA polymerase II transcription
30. A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans
31. An activator binding module of yeast RNA polymerase II holoenzyme
32. The Drosophila endocycle is controlled by cyclin E and lacks a checkpoint ensuring S-phase completion
33. Transcriptional regulation through mediator-like coactivators in yeast and metazoan cells
34. TBP-associated factors are not generally required for transcriptional activation in yeast
35. Mediator protein mutations that selectively abolish activated transcription
36. Composite co-activator ARC mediates chromatin-directed transcriptional activation
37. Drosophila mediator complex is broadly utilized by diverse gene-specific transcription factors at different types of core promoters
38. In vivo requirement of activator-specific binding targets of mediator
39. Diverse transcriptional functions of the multisubunit eukaryotic TFIID complex
40. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex
41. Specific structural motifs determine TRAP220 interactions with nuclear hormone receptors
42. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1
43. Structure and molecular analysis of RGR1, a gene required for glucose repression of Saccharomyces cerevisiae
44. The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes
45. Genetic analysis of the Drosophila cdc2 homolog
46. NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription
47. Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice
48. Transcription activation in cells lacking TAFIIS
49. Microarray analysis of Drosophila development during metamorphosis
50. Analysis of genetic mosaics in developing and adult Drosophila tissues
51. The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion
52. A C. elegans mediator protein confers regulatory selectivity on lineage-specific expression of a transcription factor gene