Immunostaining evidence for PI(4,5)P2 localization at the leading edge of chemoattractant-stimulated HL-60 cells

Journal of Leukocyte Biology

Volumn 84, Issue 2, 2008, Pages 440-447

  Sharma, Ved P ^a,d   DesMarais, Vera ^d   Sumners, Colin ^b   Shaw, Gerry ^c   Narang, Atul ^a  

^a University of Florida   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Chemotaxis; Gradient sensing; Phosphoinositides

Indexed keywords

CHEMOATTRACTANT; FORMYLMETHIONYLLEUCYLPHENYLALANINE; PHOSPHATIDYL INOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOLIPID DERIVATIVE;

ARTICLE; CELL POLARITY; CELL STIMULATION; CELL STRAIN HL 60; CELLULAR DISTRIBUTION; CHEMOTAXIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; NEUTROPHIL; PRIORITY JOURNAL;

BIOLOGICAL MARKERS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL MEMBRANE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HL-60 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHATIDYLINOSITOL PHOSPHATES;

EID: 48649090400     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0907636     Document Type: Article

References (42)

1. Ridley, A. J., Schwartz, M. A., Burridge, K., Firtel, R. A., Ginsberg, M. H., Borisy, G., Parsons, J. T., Horwitz, A. R. (2003) Cell migration: integrating signals from front to back. Science 302, 1704-1709.
2. Parent, C. A., Blacklock, B. J., Froehlich, W. M., Murphy, D. B., Devreotes, P. N. (1998) G protein signaling events are activated at the leading edge of cells. Cell 95, 81-91.
3. Meili, R., Ellsworth, C., Lee, S., Reddy, T. B. K., Ma, H., Firtel, R. A. (1999) Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium. EMBO J. 18, 2092-2105.
4. Haugh, J. M., Codazzi, F., Teruel, M., Meyer, T. (2000) Spatial sensing in fibroblasts mediated by 3′-phosphoinositides. J. Cell Biol. 151, 1269-1279.
5. Servant, G., Weiner, O. D., Herzmark, P., Balla, T., Sedat, J. W., Bourne, H. R. (2000) Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science 287, 1037-1040.
6. Servant, G., Weiner, O. D., Neptune, E. R., Sedat, J. W., Bourne, H. R. (1999) Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis. Mol. Biol. Cell 10, 1163-1178.
7. Janetopoulos, C., Jin, T., Devreotes, P. (2001) Receptor-mediated activation of heterotrimeric G-proteins in living cells. Science 291, 2408-2411.
8. Jin, T., Zhang, N., Long, Y., Parent, C. A., Devreotes, P. N. (2000) Localization of the G protein βγ complex in living cells during chemotaxis. Science 287, 1034-1036.
9. Li, Z., Jiang, H., Xie, W., Zhang, Z., Smrcka, A. V., Wu, D. (2000) Roles of PLC-β2 and -β3 and PI3Kγ in chemoattractant-mediated signal transduction. Science 287, 1046-1049.
10. Niggli, V., Keller, H. (1997) The phosphatidylinositol 3-kinase inhibitor wortmannin markedly reduces chemotactic peptide-induced locomotion and increases in cytoskeletal actin in human neutrophils. Eur. J. Pharmacol. 335, 43-52.
11. Devreotes, P., Janetopoulos, C. (2003) Eukaryotic chemotaxis: distinctions between directional sensing and polarization. J. Biol. Chem. 278, 20445-20448.
12. Iijima, M., Devreotes, P. N. (2002) Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell 109, 599-610.
13. Funamoto, S., Meili, R., Lee, S., Parry, L., Firtel, R. A. (2002) Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell 109, 611-623.
14. Li, Z., Dong, X., Wang, Z., Liu, W., Deng, N., Ding, Y., Tang, L., Hla, T., Zeng, R., Li, L., Wu, D. (2005) Regulation of PTEN by Rho small GTPases. Nat. Cell Biol. 7, 399-404.
15. Janetopoulos, C., Ma, L., Devreotes, P. N., Iglesias, P. A. (2004) Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton. Proc. Natl. Acad. Sci. USA 101, 8951-8956.
16. Stephens, L. R., Jackson, T. R., Hawkins, P. T. (1993) Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signaling system? Biochim. Biophys. Acta 1179, 27-75.
17. Vanhaesebroeck, B., Leevers, S. J., Ahmadi, K., Timms, J., Katso, R., Driscoll, P. C., Woscholski, R., Parker, P. J., Waterfield, M. D. (2001) Synthesis and function of 3-phosphorylated inositol lipids. Annu. Rev. Biochem. 70, 535-602.
18. Krishnan, J., Iglesias, P. A. (2004) A modeling framework describing the enzyme regulation of membrane lipids underlying gradient perception in Dictyostelium cells. J. Theor. Biol. 229, 85-99.
19. Hauert, A. B., Martinelli, S., Marone, C., Niggli, V. (2002) Differentiated HL-60 cells are a valid model system for the analysis of human neutrophil migration and chemotaxis. Int. J. Biochem. Cell Biol. 34, 838-854.
20. Nasuhoglu, C., Feng, S., Mao, J., Yamamoto, M., Yin, H. L., Earnest, S., Barylko, B., Albanesi, J. P., Hilgemann, D. W. (2002) Nonradioactive analysis of phosphatidylinositides and other anionic phospholipids by anion-exchange high-performance liquid chromatography with suppressed conductivity detection. Anal. Biochem. 301, 243-254.
21. Insall, R. H., Weiner, O. D. (2001) PIP3, PIP2, and cell movement - similar messages, different meanings? Dev. Cell 1, 743-747.
22. Rickert, P. W., Orion D., Wang, F., Bourne, H. R., Servant, G. (2000) Leukocytes navigate by compass: PI3K and its lipid products. Trends Cell Biol. 10, 466-473.
23. Fukami, K., Matsuoka, K., Nakanishi, O., Yamakawa, A., Kawai, S., Takenawa, T. (1988) Antibody to phosphatidylinositol 4,5-bisphosphate inhibits oncogene-induced mitogenesis. Proc. Natl. Acad. Sci. USA 85, 9057-9061.
24. Miyazawa, A., Umeda, M., Horikoshi, T., Yanagisawa, K., Yoshioka, T., Inoue, K. (1988) Production and characterization of monoclonal antibodies that bind to phosphatidylinositol 4,5-bisphosphate. Mol. Immunol. 25, 1025-1031.
25. Doughman, R. L., Firestone, A. J., Wojtasiak, M. L., Bunce, M. W., Anderson, R. A. (2003) Membrane ruffling requires coordination between type I phosphatidylinositol phosphate kinase and Rac signaling. J. Biol. Chem. 278, 23036-23045.
26. Laux, T., Fukami, K., Thelen, M., Golub, T., Frey, D., Caroni, P. (2000) GAP43, MARCKS, and CAP23 modulate PI(4,5)P(2) at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism. J. Cell Biol. 149, 1455-1472.
27. 2+ signaling. J. Cell Biol. 167, 1005-1010.
28. Chen, R., Kang, V. H., Chen, J., Shope, J. C., Torabinejad, J., DeWald, D. B., Prestwich, G. D. (2002) A monoclonal antibody to visualize PtdIns(3,4,5)P(3) in cells. J. Histochem. Cytochem. 50, 697-708.
29. Boronenkov, I. V., Loijens, J. C., Umeda, M., Anderson, R. A. (1998) Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors. Mol. Biol. Cell 9, 3547-3560.
30. Hannah, M. J., Weiss, U., Huttner, W. B. (1998) Differential extraction of proteins from paraformaldehyde-fixed cells: lessons from synaptophysin and other membrane proteins. Methods 16, 170-181.
31. Nakamura, F. (2001) Biochemical, electron microscopic and immunohistological observations of cationic detergent-extracted cells: detection and improved preservation of microextensions and ultramicroextensions. BMC Cell Biol. 2, 10.
32. Kiernan, J. A. (2000) Formaldehyde, formalin, paraformaldehyde and glutaraldehyde: what they are and what they do. Microscopy Today 8, 8-12.
33. 3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat. Cell Biol. 4, 509-513.
34. 2 hydrolysis inhibits cortical actin dynamics: regulation at a global but not at a micrometer scale. Mol. Biol. Cell 13, 3257-3267.
35. 2 in its place. J. Membr. Biol. 194, 77-89.
36. Stauffer, T. P., Ahn, S., Meyer, T. (1998) Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells. Curr. Biol. 8, 343-346.
37. 2+ mobilization patterns. Science 284, 1527-1530.
38. Xu, C., Watras, J., Loew, L. M. (2003) Kinetic analysis of receptor-mediated phosphoinositide turnover. J. Cell Biol. 161, 779-791.
39. Tall, E. G., Spector, I., Pentyala, S. N., Bitter, I., Rebecchi, M. J. (2000) Dynamics of phosphatidylinositol 4,5-biphosphate in actin-rich structures. Curr. Biol. 10, 743-746.
40. Watt, S. A., Kular, G., Fleming, I. N., Downes, P. C., Lucocq, J. M. (2002) Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C. Biochem. J. 363, 657-666.
41. Li, Z., Dong, X., Wang, Z., Liu, W., Deng, N., Ding, Y., Tang, L., Hla, T., Zeng, R., Li, L., Wu, D. (2005) Regulation of PTEN by Rho small GTPases. Nat. Cell Biol. 7, 399-404.
42. Subramanian, K. K., Narang, A. (2004) A mechanistic model for eukaryotic gradient sensing: spontaneous and induced phosphoinositide polarization. J. Theor. Biol. 231, 49-67.