Generation of novel pikromycin antibiotic products through mutasynthesis

ChemBioChem

Volumn 9, Issue 10, 2008, Pages 1609-1616

  Gupta, Shuchi ^a   Lakshmanan, Venkatraman ^b,c   Kim, Beom Seok ^a,d   Fecik, Robert ^b   Reynolds, Kevin A ^a  

^a PORTLAND STATE UNIVERSITY   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c PharmaCore   (United States)

^d Korea University   (South Korea)

Author keywords

Biosynthesis; Natural products; Pikromycin; Polyketides; Triketides

Indexed keywords

BACTERIAL ENZYME; DELTA 15,16 DEHYDROPIKROMYCIN; NARBOMYCIN; NATURAL PRODUCT; PIKROMYCIN; PIKROMYCIN POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; MACROLIDE;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL GROWTH; BACTERIAL STRAIN; BIOSYNTHESIS; CONTROLLED STUDY; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STREPTOMYCES VENEZUELAE; WILD TYPE; BACTERIUM; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MICROBIOLOGICAL EXAMINATION; PROTEIN CONFORMATION; STREPTOMYCES; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-BACTERIAL AGENTS; BACTERIA; MACROLIDES; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PROTEIN CONFORMATION; STREPTOMYCES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 48649086914     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200700635     Document Type: Article

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