메뉴 건너뛰기




Volumn 43, Issue 7, 2008, Pages 499-508

Gastrointestinal stromal tumors: Past, present, and future

Author keywords

GIST; Imatinib mesylate; Interstitial cell of Cajal; KIT; Mast cell; PDGFR

Indexed keywords

BCR ABL PROTEIN; CD135 ANTIGEN; COLONY STIMULATING FACTOR RECEPTOR; COLONY STIMULATING FACTOR RECEPTOR 1; EVEROLIMUS; FLAVOPIRIDOL; IMATINIB; JANUS KINASE; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; PLACEBO; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; STEM CELL FACTOR; SUNITINIB; TANESPIMYCIN;

EID: 48449102939     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-008-2200-y     Document Type: Review
Times cited : (67)

References (100)
  • 1
    • 0020514752 scopus 로고
    • Gastric stromal tumors. Reappraisal of histogenesis
    • Mazur MT, Clark HB. Gastric stromal tumors. Reappraisal of histogenesis. Am J Surg Pathol 1983;7:507-519.
    • (1983) Am J Surg Pathol , vol.7 , pp. 507-519
    • Mazur, M.T.1    Clark, H.B.2
  • 4
    • 0038188644 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumor: A model for molecule-based diagnosis and treatment of solid tumors
    • Kitamura Y, Hirota S, Nishida T. Gastrointestinal stromal tumor: A model for molecule-based diagnosis and treatment of solid tumors. Cancer Sci 2003;94:315-320.
    • (2003) Cancer Sci , vol.94 , pp. 315-320
    • Kitamura, Y.1    Hirota, S.2    Nishida, T.3
  • 5
    • 1342321789 scopus 로고    scopus 로고
    • Targeting c-kit mutations: Basic science to novel therapies
    • Sattler M, Salgia R. Targeting c-kit mutations: Basic science to novel therapies. Leuk Res 2003;28S1:S11-20.
    • (2003) Leuk Res , vol.28 S1
    • Sattler, M.1    Salgia, R.2
  • 6
    • 25144443610 scopus 로고    scopus 로고
    • Pathophysiology, diagnosis, and treatment of gastrointestinal stromal tumors
    • Shinomura Y, Kinoshita K, Tsutsui S, Hirota S. Pathophysiology, diagnosis, and treatment of gastrointestinal stromal tumors. J Gastroenterol 2005;40:775-780.
    • (2005) J Gastroenterol , vol.40 , pp. 775-780
    • Shinomura, Y.1    Kinoshita, K.2    Tsutsui, S.3    Hirota, S.4
  • 7
    • 33749459756 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors: Review on morphology, molecular pathology, prognosis, and differential diagnosis
    • Miettinen M, Losota J. Gastrointestinal stromal tumors: Review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med 2006;130:1466-1478.
    • (2006) Arch Pathol Lab Med , vol.130 , pp. 1466-1478
    • Miettinen, M.1    Losota, J.2
  • 8
    • 33748101399 scopus 로고    scopus 로고
    • Combined surgical and molecular therapy: The gastrointestinal stromal tumor model
    • Gold JS, DeMatteo RP. Combined surgical and molecular therapy: The gastrointestinal stromal tumor model. Ann Surg 2006;244:176-184.
    • (2006) Ann Surg , vol.244 , pp. 176-184
    • Gold, J.S.1    DeMatteo, R.P.2
  • 9
    • 33846014993 scopus 로고    scopus 로고
    • Menetier disease and gastrointestinal stromal tumors: Hyperproliferative disorders of the stomach
    • Coffey RJ, Washington MK, Corless LC, Heinrich MC. Menetier disease and gastrointestinal stromal tumors: Hyperproliferative disorders of the stomach. J Clin Invest 2007;117:70-80.
    • (2007) J Clin Invest , vol.117 , pp. 70-80
    • Coffey, R.J.1    Washington, M.K.2    Corless, L.C.3    Heinrich, M.C.4
  • 10
    • 0017767169 scopus 로고
    • Development of mast cells from grafted bone marrow cells in irradiated mice
    • Kitamura Y, Shimada M, Hatanaka K, Miyano Y. Development of mast cells from grafted bone marrow cells in irradiated mice. Nature 1977;268:442-443.
    • (1977) Nature , vol.268 , pp. 442-443
    • Kitamura, Y.1    Shimada, M.2    Hatanaka, K.3    Miyano, Y.4
  • 11
    • 0019793469 scopus 로고
    • Spleen colony forming cell as common precursor for tissue mast cells and granulocytes
    • Kitamura Y, Yokoyama M, Matsuda H, Ohno T, Mori KJ. Spleen colony forming cell as common precursor for tissue mast cells and granulocytes. Nature 1981;291:159-160.
    • (1981) Nature , vol.291 , pp. 159-160
    • Kitamura, Y.1    Yokoyama, M.2    Matsuda, H.3    Ohno, T.4    Mori, K.J.5
  • 12
    • 0018096538 scopus 로고
    • v mice and their increase by bone marrow transplantation
    • v mice and their increase by bone marrow transplantation. Blood 1978;52:447-452.
    • (1978) Blood , vol.52 , pp. 447-452
    • Kitamura, Y.1    Go, S.2    Hatanaka, K.3
  • 13
  • 14
    • 0023694835 scopus 로고
    • The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus
    • Chabot B, Stephenson DA, Chapman VM, Besmer P, Bernstein A. The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature 1988;335:88-89.
    • (1988) Nature , vol.335 , pp. 88-89
    • Chabot, B.1    Stephenson, D.A.2    Chapman, V.M.3    Besmer, P.4    Bernstein, A.5
  • 15
    • 0024280901 scopus 로고
    • The dominant-white spotting (W) locus of the mouse encodes the c-kit protooncogene
    • Geissler EN, Ryan MA, Housman DE. The dominant-white spotting (W) locus of the mouse encodes the c-kit protooncogene. Cell 1988;55:185-192.
    • (1988) Cell , vol.55 , pp. 185-192
    • Geissler, E.N.1    Ryan, M.A.2    Housman, D.E.3
  • 16
    • 0025093247 scopus 로고
    • Steel locus defines new multipotent growth factor
    • Witte ON. Steel locus defines new multipotent growth factor. Cell 1990;63:5-6.
    • (1990) Cell , vol.63 , pp. 5-6
    • Witte, O.N.1
  • 17
    • 0024348298 scopus 로고
    • Heterogeneity of mast cells and phenotypic change between subpopulations
    • Kitamura Y. Heterogeneity of mast cells and phenotypic change between subpopulations. Annu Rev Immunol 1989;7:59-76.
    • (1989) Annu Rev Immunol , vol.7 , pp. 59-76
    • Kitamura, Y.1
  • 18
    • 0027359443 scopus 로고
    • Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product
    • Furitsu T, Tsujimura T, Tono T, Ikeda H, Kitayama H, Koshimizu U, et al. Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product. J Clin Invest 1992;92:1736-1744.
    • (1992) J Clin Invest , vol.92 , pp. 1736-1744
    • Furitsu, T.1    Tsujimura, T.2    Tono, T.3    Ikeda, H.4    Kitayama, H.5    Koshimizu, U.6
  • 20
  • 21
    • 15644363454 scopus 로고    scopus 로고
    • Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
    • Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 1998;279:577-580.
    • (1998) Science , vol.279 , pp. 577-580
    • Hirota, S.1    Isozaki, K.2    Moriyama, Y.3    Hashimoto, K.4    Nishida, T.5    Ishiguro, S.6
  • 22
    • 0031947592 scopus 로고    scopus 로고
    • Gastrointestinal pacemaker cell tumor (GIPACT): Gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal
    • Kindblom LG., Remotti HE, Aldenborg F, Meis-Kindblom JM. Gastrointestinal pacemaker cell tumor (GIPACT): Gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol 1998;152:1259-1269.
    • (1998) Am J Pathol , vol.152 , pp. 1259-1269
    • Kindblom, L.G.1    Remotti, H.E.2    Aldenborg, F.3    Meis-Kindblom, J.M.4
  • 23
    • 0018625422 scopus 로고
    • Hereditary anemias of the mouse: A review for geneticists
    • Russell ES. Hereditary anemias of the mouse: A review for geneticists. Adv Genet 1969;20:357-459.
    • (1969) Adv Genet , vol.20 , pp. 357-459
    • Russell, E.S.1
  • 25
    • 0026096497 scopus 로고
    • Exon skipping by mutation of an authentic splice site of c-kit gene in W/W mouse
    • Hayashi S, Kunisada T, Ogawa M, Yamaguchi K, Nishikawa S. Exon skipping by mutation of an authentic splice site of c-kit gene in W/W mouse. Nucl Acids Res 1991;19:1267-1271.
    • (1991) Nucl Acids Res , vol.19 , pp. 1267-1271
    • Hayashi, S.1    Kunisada, T.2    Ogawa, M.3    Yamaguchi, K.4    Nishikawa, S.5
  • 26
    • 0026038619 scopus 로고
    • Characterization of Ws mutant allele of rats: A 12-base deletion in tyrosine kinase domain of c-kit gene
    • Tsujimura T, Hirora S, Nomura S, Niwa Y, Yamazaki M, Tono T, et al. Characterization of Ws mutant allele of rats: A 12-base deletion in tyrosine kinase domain of c-kit gene. Blood 1991;78:1942-1946.
    • (1991) Blood , vol.78 , pp. 1942-1946
    • Tsujimura, T.1    Hirora, S.2    Nomura, S.3    Niwa, Y.4    Yamazaki, M.5    Tono, T.6
  • 27
    • 0025933325 scopus 로고
    • Anemia and mast cell depletion in mutant rats that are homozygous at "white spotting (Ws) " locus
    • Niwa Y, Kasugai T, Ohno K, Morimoto M, Yamazaki M, Dohmae K, et al. Anemia and mast cell depletion in mutant rats that are homozygous at "white spotting (Ws) " locus. Blood 1991;78:1936-1941.
    • (1991) Blood , vol.78 , pp. 1936-1941
    • Niwa, Y.1    Kasugai, T.2    Ohno, K.3    Morimoto, M.4    Yamazaki, M.5    Dohmae, K.6
  • 28
    • 0029200069 scopus 로고
    • Impaired development of interstitial cells and intestinal electrical rhythmicity in steel mutants
    • Ward SM, Burns AJ, Torihashi S, Harney SC, Sanders KM. Impaired development of interstitial cells and intestinal electrical rhythmicity in steel mutants. Am J Physiol 1995;269:1577-1585.
    • (1995) Am J Physiol , vol.269 , pp. 1577-1585
    • Ward, S.M.1    Burns, A.J.2    Torihashi, S.3    Harney, S.C.4    Sanders, K.M.5
  • 34
    • 0035796043 scopus 로고    scopus 로고
    • A loss-of-function mutation of c-kit results in depletion of mast cells and interstitial cells of Cajal, while its gain-of-function mutation results in their oncogenesis
    • Kitamura Y, Hirota S, Nishida T. A loss-of-function mutation of c-kit results in depletion of mast cells and interstitial cells of Cajal, while its gain-of-function mutation results in their oncogenesis. Mutation Res 2001;477:165-171.
    • (2001) Mutation Res , vol.477 , pp. 165-171
    • Kitamura, Y.1    Hirota, S.2    Nishida, T.3
  • 36
    • 0029101721 scopus 로고
    • Disturbed intestinal movement, bile reflux to the stomach, and deficiency of c-kit-expressing cells in Ws/Ws mutant rats
    • Isozaki K, Hirota S, Nakama A, Miyagawa JI, Shinomura Y, Xu Z, et al. Disturbed intestinal movement, bile reflux to the stomach, and deficiency of c-kit -expressing cells in Ws/Ws mutant rats. Gastroenterology 1995;109:456-464.
    • (1995) Gastroenterology , vol.109 , pp. 456-464
    • Isozaki, K.1    Hirota, S.2    Nakama, A.3    Miyagawa, J.I.4    Shinomura, Y.5    Xu, Z.6
  • 37
    • 0022626874 scopus 로고
    • A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family
    • Besmer P, Murphy JE, George PC, Qiu F, Bergold PJ, Lederman L, et al. A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family. Nature 1986;320:415-421.
    • (1986) Nature , vol.320 , pp. 415-421
    • Besmer, P.1    Murphy, J.E.2    George, P.C.3    Qiu, F.4    Bergold, P.J.5    Lederman, L.6
  • 38
    • 2742529418 scopus 로고
    • Human proto-oncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand
    • Yarden Y, Kuang WJ, Yang-Feng T, Coussens L, Munemitsu S, Dull TJ, et al. Human proto-oncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J 1987;6:3341-3351.
    • (1987) EMBO J , vol.6 , pp. 3341-3351
    • Yarden, Y.1    Kuang, W.J.2    Yang-Feng, T.3    Coussens, L.4    Munemitsu, S.5    Dull, T.J.6
  • 39
    • 0025870946 scopus 로고
    • Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family
    • Rosnet O, Marchetto S, deLapeyriere O, Birnbaum D. Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family. Oncogene 1991;6:1641-1650.
    • (1991) Oncogene , vol.6 , pp. 1641-1650
    • Rosnet, O.1    Marchetto, S.2    deLapeyriere, O.3    Birnbaum, D.4
  • 40
    • 0028856070 scopus 로고
    • Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder
    • Nagata H, Worobec AS, Oh CK, Chowdhury BA, Tannenbaum S, Suzuki Y, et al. Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder. Proc Natl Acad Sci USA 1995;92:10560-10564.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10560-10564
    • Nagata, H.1    Worobec, A.S.2    Oh, C.K.3    Chowdhury, B.A.4    Tannenbaum, S.5    Suzuki, Y.6
  • 41
    • 0009013631 scopus 로고    scopus 로고
    • Somatic c-kit activating mutation in urticaria pigmentosa and aggressive mastocytosis: Establishment of clonality in a human mast cell neoplasm
    • Longley BJ, Tyrrell L, Lu SZ, Ma YS, Langley K, Ding TG, et al. Somatic c-kit activating mutation in urticaria pigmentosa and aggressive mastocytosis: Establishment of clonality in a human mast cell neoplasm. Nat Genet 1996;12:312-314.
    • (1996) Nat Genet , vol.12 , pp. 312-314
    • Longley, B.J.1    Tyrrell, L.2    Lu, S.Z.3    Ma, Y.S.4    Langley, K.5    Ding, T.G.6
  • 43
    • 0042357240 scopus 로고    scopus 로고
    • Structure of a c-kit product complex reveals the basis for kinase transactivation
    • Mol CD, Lim KB, Sridhar V, Zou H, Chien EYT, Sang BC, et al. Structure of a c-kit product complex reveals the basis for kinase transactivation. J Biol Chem 2003;278:31461-31464.
    • (2003) J Biol Chem , vol.278 , pp. 31461-31464
    • Mol, C.D.1    Lim, K.B.2    Sridhar, V.3    Zou, H.4    Chien, E.Y.T.5    Sang, B.C.6
  • 44
    • 2942542387 scopus 로고    scopus 로고
    • Structure basis for the autoinhibition and STI-571 inhibition of c-kit tyrosine kinase
    • Mol CD, Dougan DR, Schneider TR, Skene RJ, Kraus ML, Scheibe DN, et al. Structure basis for the autoinhibition and STI-571 inhibition of c-kit tyrosine kinase. J Biol Chem 2004;279:31655-31663.
    • (2004) J Biol Chem , vol.279 , pp. 31655-31663
    • Mol, C.D.1    Dougan, D.R.2    Schneider, T.R.3    Skene, R.J.4    Kraus, M.L.5    Scheibe, D.N.6
  • 45
    • 0030889905 scopus 로고    scopus 로고
    • Kit receptor dimerization is driven by bivalent binding of stem cell factor
    • Lemmon MA, Pinchasi D, Zhou M, Lax I, Schlessinger J. Kit receptor dimerization is driven by bivalent binding of stem cell factor. J Biol Chem 1997;272:6311-6317.
    • (1997) J Biol Chem , vol.272 , pp. 6311-6317
    • Lemmon, M.A.1    Pinchasi, D.2    Zhou, M.3    Lax, I.4    Schlessinger, J.5
  • 46
    • 12144257058 scopus 로고    scopus 로고
    • Kit as a human oncogenic tyrosine kinase
    • Kitamura Y, Hirota S. Kit as a human oncogenic tyrosine kinase. Cell Mol Life Sci 2004;61;2924-2931.
    • (2004) Cell Mol Life Sci , vol.61 , pp. 2924-2931
    • Kitamura, Y.1    Hirota, S.2
  • 47
    • 13044305857 scopus 로고    scopus 로고
    • Activating and dominant inactivating c-kit catalytic domain mutations in distinct forms of human mastocytosis
    • Longley BJ Jr, Metcalfe DD, Tharp M, Wang X, Tyrrell L, Lu SZ, et al. Activating and dominant inactivating c-kit catalytic domain mutations in distinct forms of human mastocytosis. Proc Natl Acad Sci USA 1999;96:1609-1614.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 1609-1614
    • Longley Jr., B.J.1    Metcalfe, D.D.2    Tharp, M.3    Wang, X.4    Tyrrell, L.5    Lu, S.Z.6
  • 48
    • 0036210049 scopus 로고    scopus 로고
    • Spectrum of associated clonal hematologic non-mast cell lineage disorder occurring in patients with systemic mastocytosis
    • Wolfgang RS, Horny HS, Valent P. Spectrum of associated clonal hematologic non-mast cell lineage disorder occurring in patients with systemic mastocytosis. Int Arch Allergy Immunol 2002;127:140-142.
    • (2002) Int Arch Allergy Immunol , vol.127 , pp. 140-142
    • Wolfgang, R.S.1    Horny, H.S.2    Valent, P.3
  • 49
  • 50
    • 0028959163 scopus 로고
    • Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines
    • Kitayama H, Kanakura Y, Furitsu T, Tsujimura T, Oritani K, Ikeda H, et al. Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines. Blood 1995;85:790-798.
    • (1995) Blood , vol.85 , pp. 790-798
    • Kitayama, H.1    Kanakura, Y.2    Furitsu, T.3    Tsujimura, T.4    Oritani, K.5    Ikeda, H.6
  • 51
    • 0038640974 scopus 로고    scopus 로고
    • Alterations of the c-kit gene in testicular germ cell tumors
    • Sakuma Y, Sakurai S, Oguni S, Hironaka M, Saito K. Alterations of the c-kit gene in testicular germ cell tumors. Cancer Sci 2003;94:486-491.
    • (2003) Cancer Sci , vol.94 , pp. 486-491
    • Sakuma, Y.1    Sakurai, S.2    Oguni, S.3    Hironaka, M.4    Saito, K.5
  • 53
    • 0036092268 scopus 로고    scopus 로고
    • KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size
    • Corless CL, McGreevey L, Haley A, Town A, Heinrich MC. KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size. Am J Pathol 2002;160:1567-1572.
    • (2002) Am J Pathol , vol.160 , pp. 1567-1572
    • Corless, C.L.1    McGreevey, L.2    Haley, A.3    Town, A.4    Heinrich, M.C.5
  • 54
    • 0033883060 scopus 로고    scopus 로고
    • KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors
    • Lux ML, Rubin BP, Biase TL, Chen CJ, Maclure T, Demetri G, et al. KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors. Am J Pathol 2000;156:791-795.
    • (2000) Am J Pathol , vol.156 , pp. 791-795
    • Lux, M.L.1    Rubin, B.P.2    Biase, T.L.3    Chen, C.J.4    Maclure, T.5    Demetri, G.6
  • 55
    • 0033820064 scopus 로고    scopus 로고
    • Mutations in exons 9 and 13 of KIT gene are rare events in gastrointestinal stromal tumors
    • Lasota J, Wozniak A, Sarlomo-Rikala M, Rys J, Kordek R, Nassar A, et al. Mutations in exons 9 and 13 of KIT gene are rare events in gastrointestinal stromal tumors. Am J Pathol 2000;157:1091-1095.
    • (2000) Am J Pathol , vol.157 , pp. 1091-1095
    • Lasota, J.1    Wozniak, A.2    Sarlomo-Rikala, M.3    Rys, J.4    Kordek, R.5    Nassar, A.6
  • 56
    • 0035066051 scopus 로고    scopus 로고
    • Gain-of-function mutation at the extracellular domain of KIT in gastrointestinal stromal tumours
    • Hirota S, Nishida T, Isozaki K, Taniguchi M, Nakamura J, Okazaki T, et al. Gain-of-function mutation at the extracellular domain of KIT in gastrointestinal stromal tumours. J Pathol 2001;193:505-510.
    • (2001) J Pathol , vol.193 , pp. 505-510
    • Hirota, S.1    Nishida, T.2    Isozaki, K.3    Taniguchi, M.4    Nakamura, J.5    Okazaki, T.6
  • 57
    • 0035890740 scopus 로고    scopus 로고
    • KIT activation is a ubiquitous feature of gastrointestinal stromal tumors
    • Rubin BP, Singer S, Tsao C, Duensing A, Lux ML, Ruiz R, et al. KIT activation is a ubiquitous feature of gastrointestinal stromal tumors. Cancer Res 2001;61:8118-8121.
    • (2001) Cancer Res , vol.61 , pp. 8118-8121
    • Rubin, B.P.1    Singer, S.2    Tsao, C.3    Duensing, A.4    Lux, M.L.5    Ruiz, R.6
  • 59
    • 0041971080 scopus 로고    scopus 로고
    • Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors
    • Hirota S, Ohashi A, Nishida T, Isozaki K, Kinoshita K, Shinomura Y, et al. Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors. Gastroenterology 2003;125:660-667.
    • (2003) Gastroenterology , vol.125 , pp. 660-667
    • Hirota, S.1    Ohashi, A.2    Nishida, T.3    Isozaki, K.4    Kinoshita, K.5    Shinomura, Y.6
  • 60
  • 61
    • 0033971263 scopus 로고    scopus 로고
    • Cause of familial and multiple gastrointestinal autonomic nerve tumors with hyperplasia of interstitial cells of Cajal is germline mutation of the c-kit gene
    • Hirota S, Okazaki T, Kitamura Y, O'Brien P, Kapusta L, Dardick I. Cause of familial and multiple gastrointestinal autonomic nerve tumors with hyperplasia of interstitial cells of Cajal is germline mutation of the c-kit gene. Am J Surg Pathol 2000;24:326-327.
    • (2000) Am J Surg Pathol , vol.24 , pp. 326-327
    • Hirota, S.1    Okazaki, T.2    Kitamura, Y.3    O'Brien, P.4    Kapusta, L.5    Dardick, I.6
  • 62
    • 0036240932 scopus 로고    scopus 로고
    • Familial gastrointestinal stromal tumors associated with dysphagia and novel type germline mutation of KIT gene
    • Hirota S, Nishida T, Isozaki K, Taniguchi M, Nishikawa K, Ohashi A, et al. Familial gastrointestinal stromal tumors associated with dysphagia and novel type germline mutation of KIT gene. Gastroenterology 2002;122:1493-1499.
    • (2002) Gastroenterology , vol.122 , pp. 1493-1499
    • Hirota, S.1    Nishida, T.2    Isozaki, K.3    Taniguchi, M.4    Nishikawa, K.5    Ohashi, A.6
  • 63
    • 0033678402 scopus 로고    scopus 로고
    • Germline-activating mutation in the kinase domain of KIT gene in familial gastrointestinal stromal tumors
    • Isozaki K, Terris B, Belghiti J, Schiffmann S, Hirota S, Vanderwinden JM. Germline-activating mutation in the kinase domain of KIT gene in familial gastrointestinal stromal tumors. Am J Pathol 2000;157:1581-1585.
    • (2000) Am J Pathol , vol.157 , pp. 1581-1585
    • Isozaki, K.1    Terris, B.2    Belghiti, J.3    Schiffmann, S.4    Hirota, S.5    Vanderwinden, J.M.6
  • 64
    • 0035425217 scopus 로고    scopus 로고
    • Germline mutation in the juxtamembrane domain of the kit gene in a family with gastrointestinal stromal tumors and urticaria pigmentosa
    • Beghini A, Tibiletti MG, Roversi G, Chiaravalli AM, Serio G, Capella C, et al. Germline mutation in the juxtamembrane domain of the kit gene in a family with gastrointestinal stromal tumors and urticaria pigmentosa. Cancer 2001;92:657-662.
    • (2001) Cancer , vol.92 , pp. 657-662
    • Beghini, A.1    Tibiletti, M.G.2    Roversi, G.3    Chiaravalli, A.M.4    Serio, G.5    Capella, C.6
  • 65
    • 0035174752 scopus 로고    scopus 로고
    • Familial gastrointestinal stromal tumor with hyperpigmentation: Association with a germline mutation of the c-kit gene
    • Maeyama H, Hidaka E, Ota H, Minami S, Kajiyama M, Kuraishi A, et al. Familial gastrointestinal stromal tumor with hyperpigmentation: association with a germline mutation of the c-kit gene. Gastroenterology 2001;120:210-215.
    • (2001) Gastroenterology , vol.120 , pp. 210-215
    • Maeyama, H.1    Hidaka, E.2    Ota, H.3    Minami, S.4    Kajiyama, M.5    Kuraishi, A.6
  • 67
    • 0036895022 scopus 로고    scopus 로고
    • Polyclonal nature of diffuse proliferation of interstitial cells of Cajal in patients with familial and multiple gastrointestinal stromal tumours
    • Chen H, Hirota S, Isozaki K, Sun H, Ohashi A, Kinoshita K, et al. Polyclonal nature of diffuse proliferation of interstitial cells of Cajal in patients with familial and multiple gastrointestinal stromal tumours. Gut 2002;51:793-796.
    • (2002) Gut , vol.51 , pp. 793-796
    • Chen, H.1    Hirota, S.2    Isozaki, K.3    Sun, H.4    Ohashi, A.5    Kinoshita, K.6
  • 68
    • 0038312141 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors in a mouse model by target mutation of the Kit receptor tyrosine kinase
    • Sommer G, Agosti V, Ehlers I, Rossi F, Corbacioglu S, Farkas J, et al. Gastrointestinal stromal tumors in a mouse model by target mutation of the Kit receptor tyrosine kinase. Proc Natl Acad Sci USA 2003;100:6706-6711.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 6706-6711
    • Sommer, G.1    Agosti, V.2    Ehlers, I.3    Rossi, F.4    Corbacioglu, S.5    Farkas, J.6
  • 70
    • 38949125814 scopus 로고    scopus 로고
    • A mouse model of a human multiple GIST family with KIT-Asp820Tyr mutation generated by a knock-in strategy
    • Nakai N, Ishikawa T, Nishitani A, Liu NN, Shincho M, Hao H, et al. A mouse model of a human multiple GIST family with KIT-Asp820Tyr mutation generated by a knock-in strategy. J Pathol 2008;214:302-311.
    • (2008) J Pathol , vol.214 , pp. 302-311
    • Nakai, N.1    Ishikawa, T.2    Nishitani, A.3    Liu, N.N.4    Shincho, M.5    Hao, H.6
  • 71
    • 3042538269 scopus 로고    scopus 로고
    • Protein kinase C theta highly expressed in gastrointestinal stromal tumors but not in other mesenchymal neoplasms
    • Blay P, Astudillo A, Buesa JM, Campo E, Abad M, Garcia-Garcia J, et al. Protein kinase C theta highly expressed in gastrointestinal stromal tumors but not in other mesenchymal neoplasms. Clin Cancer Res 2004;10:4089-4095.
    • (2004) Clin Cancer Res , vol.10 , pp. 4089-4095
    • Blay, P.1    Astudillo, A.2    Buesa, J.M.3    Campo, E.4    Abad, M.5    Garcia-Garcia, J.6
  • 72
    • 16444380600 scopus 로고    scopus 로고
    • PKC theta, a novel immunohistochemical marker for gastrointestinal stromal tumor (GIST), especially useful for identifying KIT-negative tumors
    • Motegi A, Sakurai S, Nakayama H, Sano T, Oyama T, Nakajima T. PKC theta, a novel immunohistochemical marker for gastrointestinal stromal tumor (GIST), especially useful for identifying KIT-negative tumors. Pathol Int 2005;55:106-112.
    • (2005) Pathol Int , vol.55 , pp. 106-112
    • Motegi, A.1    Sakurai, S.2    Nakayama, H.3    Sano, T.4    Oyama, T.5    Nakajima, T.6
  • 73
    • 3042594995 scopus 로고    scopus 로고
    • The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status
    • West RB, Corless CL, Chen X, Rubin BP, Subramanian S, Montgomery K, et al. The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status. Am J Pathol 2004;165:107-113.
    • (2004) Am J Pathol , vol.165 , pp. 107-113
    • West, R.B.1    Corless, C.L.2    Chen, X.3    Rubin, B.P.4    Subramanian, S.5    Montgomery, K.6
  • 75
    • 0346025449 scopus 로고    scopus 로고
    • Absence of c-kit gene mutation in gastrointestinal tumors of neurofibromatosis type 1 patients
    • Kinoshita K, Hirota S, Isozaki K, Ohashi A, Nishida T, Kitamura Y, et al. Absence of c-kit gene mutation in gastrointestinal tumors of neurofibromatosis type 1 patients. J Pathol 2004;202:80-85.
    • (2004) J Pathol , vol.202 , pp. 80-85
    • Kinoshita, K.1    Hirota, S.2    Isozaki, K.3    Ohashi, A.4    Nishida, T.5    Kitamura, Y.6
  • 76
    • 33744809587 scopus 로고    scopus 로고
    • Novel NF1 gene mutation in a Japanese patient with neurofibromatosis type 1 and a gastrointestinal stromal tumor
    • Nemoto H, Tate G, Schirinzi A, Suzuki T, Sasaya S, Yoshikawa Y, et al. Novel NF1 gene mutation in a Japanese patient with neurofibromatosis type 1 and a gastrointestinal stromal tumor. J Gastroenterol 2006;41:378-382.
    • (2006) J Gastroenterol , vol.41 , pp. 378-382
    • Nemoto, H.1    Tate, G.2    Schirinzi, A.3    Suzuki, T.4    Sasaya, S.5    Yoshikawa, Y.6
  • 78
    • 34548051808 scopus 로고    scopus 로고
    • Epithelioid gastric stromal tumors of the antrum in young females with Carney triad: A report of three new cases with mutational analysis and comparative genomic hybridization
    • Agaimy A, Pelz AF, Corless CL, Wunsch PH, Heinrich MC, Hofstaedter F, et al. Epithelioid gastric stromal tumors of the antrum in young females with Carney triad: A report of three new cases with mutational analysis and comparative genomic hybridization. Oncol Rep 2007;18:9-15.
    • (2007) Oncol Rep , vol.18 , pp. 9-15
    • Agaimy, A.1    Pelz, A.F.2    Corless, C.L.3    Wunsch, P.H.4    Heinrich, M.C.5    Hofstaedter, F.6
  • 79
    • 35148813515 scopus 로고    scopus 로고
    • Pediatric KIT-wild-type and platelet-derived growth factor receptor alpha-wild-type gastrointestinal tumors share KIT activation but not mechanisms of genetic progression with adult gastrointestinal stromal tumors
    • Janeway KA, Liegl B, Harlow A, Le C, Perez-Atayde A, Kozakewich H, et al. Pediatric KIT-wild-type and platelet-derived growth factor receptor alpha-wild-type gastrointestinal tumors share KIT activation but not mechanisms of genetic progression with adult gastrointestinal stromal tumors. Cancer Res 2007;67:9084-9088.
    • (2007) Cancer Res , vol.67 , pp. 9084-9088
    • Janeway, K.A.1    Liegl, B.2    Harlow, A.3    Le, C.4    Perez-Atayde, A.5    Kozakewich, H.6
  • 80
    • 0034951384 scopus 로고    scopus 로고
    • STI571: Targeting BCR-ABL as therapy for CML
    • Mauro MJ, Druker BJ. STI571: Targeting BCR-ABL as therapy for CML. Oncologist 2001;6:233-238.
    • (2001) Oncologist , vol.6 , pp. 233-238
    • Mauro, M.J.1    Druker, B.J.2
  • 81
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker BJ, Tamura S, Buchdunger E, Ohno S, Segal GM, Fanning S, et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 1996;2:561-566.
    • (1996) Nat Med , vol.2 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3    Ohno, S.4    Segal, G.M.5    Fanning, S.6
  • 82
    • 0035810147 scopus 로고    scopus 로고
    • Efficiency and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdrunger E, Ford JM, et al. Efficiency and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001;344:1031-1037.
    • (2001) N Engl J Med , vol.344 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3    Peng, B.4    Buchdrunger, E.5    Ford, J.M.6
  • 83
    • 0033816156 scopus 로고    scopus 로고
    • Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors
    • Buchdunger E, Cioffi CL, Law N, Stover D, Ohno-Jones S, Druker BJ, et al. Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors. J Pharmacol Exp Ther 2000;295:139-145.
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 139-145
    • Buchdunger, E.1    Cioffi, C.L.2    Law, N.3    Stover, D.4    Ohno-Jones, S.5    Druker, B.J.6
  • 84
    • 0035899418 scopus 로고    scopus 로고
    • STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: Biological and clinical implications
    • Tuveson DA, Willis NA, Jacks T, Griffin JD, Singer S, Fletcher CD, et al. STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: Biological and clinical implications. Oncogene 2001;20:5054-5058.
    • (2001) Oncogene , vol.20 , pp. 5054-5058
    • Tuveson, D.A.1    Willis, N.A.2    Jacks, T.3    Griffin, J.D.4    Singer, S.5    Fletcher, C.D.6
  • 85
    • 0035810148 scopus 로고    scopus 로고
    • Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gas trointestinal stromal tumor
    • Joensuu H, Roberts PJ, Sarlomo-Rikala M, Andersson LC, Tervahartiala P, Tuveson D, et al. Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gas trointestinal stromal tumor. N Engl J Med 2001;344:1052-1056.
    • (2001) N Engl J Med , vol.344 , pp. 1052-1056
    • Joensuu, H.1    Roberts, P.J.2    Sarlomo-Rikala, M.3    Andersson, L.C.4    Tervahartiala, P.5    Tuveson, D.6
  • 87
    • 0642368571 scopus 로고    scopus 로고
    • Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
    • Heinrich MC, Corless CL, Demetri GD, Blanke CD, von Mehren M, Joensuu H, et al. Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J Clin Oncol 2003;21:4342-4349.
    • (2003) J Clin Oncol , vol.21 , pp. 4342-4349
    • Heinrich, M.C.1    Corless, C.L.2    Demetri, G.D.3    Blanke, C.D.4    von Mehren, M.5    Joensuu, H.6
  • 88
    • 20844460619 scopus 로고    scopus 로고
    • A missense mutation in KIT kinase domain I correlates with imatinib resistance in gastrointestinal stromal tumors
    • Chen LL, Trent JC, Wu EF, Fuller GN, Ramdas L, Zhang W, et al. A missense mutation in KIT kinase domain I correlates with imatinib resistance in gastrointestinal stromal tumors. Cancer Res 2004;64:5913-5919.
    • (2004) Cancer Res , vol.64 , pp. 5913-5919
    • Chen, L.L.1    Trent, J.C.2    Wu, E.F.3    Fuller, G.N.4    Ramdas, L.5    Zhang, W.6
  • 89
    • 20344393896 scopus 로고    scopus 로고
    • Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation
    • Antonescu CR, Besmer P, Guo T, Arkun K, Hom G, Koryotowski B, et al. Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation. Clin Cancer Res 2005;11:4182-4190.
    • (2005) Clin Cancer Res , vol.11 , pp. 4182-4190
    • Antonescu, C.R.1    Besmer, P.2    Guo, T.3    Arkun, K.4    Hom, G.5    Koryotowski, B.6
  • 90
    • 33645693156 scopus 로고    scopus 로고
    • Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal stromal tumors under treatment with imatinib mesylate
    • Wardelmann E, Merkelbach-Bruse S, Pauls K, Thomas N, Schildhous HU, Heinicke T, et al. Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal stromal tumors under treatment with imatinib mesylate. Clin Cancer Res 2006;12:1743-1749.
    • (2006) Clin Cancer Res , vol.12 , pp. 1743-1749
    • Wardelmann, E.1    Merkelbach-Bruse, S.2    Pauls, K.3    Thomas, N.4    Schildhous, H.U.5    Heinicke, T.6
  • 91
    • 41349109537 scopus 로고    scopus 로고
    • Secondary mutations in the kinase domain of the KIT gene are predominant in imatinib-resistant gastrointestinal stromal tumor
    • Nishida T, Kanda T, Nishitani A, Takahashi T, Nakajima K, Ishikawa T, et al. Secondary mutations in the kinase domain of the KIT gene are predominant in imatinib-resistant gastrointestinal stromal tumor. Cancer Sci 2008;99:799-804.
    • (2008) Cancer Sci , vol.99 , pp. 799-804
    • Nishida, T.1    Kanda, T.2    Nishitani, A.3    Takahashi, T.4    Nakajima, K.5    Ishikawa, T.6
  • 92
    • 18844457915 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumor: New nodule-within-a-mass pattern of recurrence after partial response to imatinib mesylate
    • Shanker S, vanSonnenberg E, Desai J, DiPiro PJ, Van Den Abbeele A, Demetri GD. Gastrointestinal stromal tumor: New nodule-within-a-mass pattern of recurrence after partial response to imatinib mesylate. Radiology 2005;235:892-898.
    • (2005) Radiology , vol.235 , pp. 892-898
    • Shanker, S.1    vanSonnenberg, E.2    Desai, J.3    DiPiro, P.J.4    Van Den Abbeele, A.5    Demetri, G.D.6
  • 93
    • 34848816032 scopus 로고    scopus 로고
    • Clonal evolution of resistance to imatinib in patients with metastatic gastrointestinal stromal tumors
    • Desai J, Shankar S, Heinrich MC, Fletcher JA, Fletcher CD, Manola J, et al. Clonal evolution of resistance to imatinib in patients with metastatic gastrointestinal stromal tumors. Clin Cancer Res 2007;13:5398-5405.
    • (2007) Clin Cancer Res , vol.13 , pp. 5398-5405
    • Desai, J.1    Shankar, S.2    Heinrich, M.C.3    Fletcher, J.A.4    Fletcher, C.D.5    Manola, J.6
  • 94
    • 33947423448 scopus 로고    scopus 로고
    • Approval summary: Sunitinib for treatment of imatinib refractory or intolerant gastrointestinal stromal tumors and advanced renal cell carcinoma
    • Goodman VL, Rock EP, Dagher R, Ramchandani RP, Abraham S, Gobburu JVS, et al. Approval summary: Sunitinib for treatment of imatinib refractory or intolerant gastrointestinal stromal tumors and advanced renal cell carcinoma. Clin Cancer Res 2007;13:1367-1373.
    • (2007) Clin Cancer Res , vol.13 , pp. 1367-1373
    • Goodman, V.L.1    Rock, E.P.2    Dagher, R.3    Ramchandani, R.P.4    Abraham, S.5    Gobburu, J.V.S.6
  • 95
    • 33748059560 scopus 로고    scopus 로고
    • Oncogenic Kit signaling and therapeutic intervention in a mouse model of gastrointestinal tumor
    • Rossi F, Ehlers I, Agosti V, Socci ND, Viale A, Sommer G, et al. Oncogenic Kit signaling and therapeutic intervention in a mouse model of gastrointestinal tumor. Proc Natl Acad Sci U S A 2006;103:12843-12848.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 12843-12848
    • Rossi, F.1    Ehlers, I.2    Agosti, V.3    Socci, N.D.4    Viale, A.5    Sommer, G.6
  • 96
    • 33749461709 scopus 로고    scopus 로고
    • Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal tumor
    • Bauer S, Yu LK, Demetri GD, Fletcher JA. Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal tumor. Cancer Res 2006;66:9153-61.
    • (2006) Cancer Res , vol.66 , pp. 9153-9161
    • Bauer, S.1    Yu, L.K.2    Demetri, G.D.3    Fletcher, J.A.4
  • 97
    • 33745259006 scopus 로고    scopus 로고
    • Flavopiridol targets c-Kit transcription and induces apoptosis in gastrointestinal stromal cells
    • Sambol EB, Ambrosini G, Geha RC, Kennealey PT, DeCarolis P, O'Conner R, et al. Flavopiridol targets c-Kit transcription and induces apoptosis in gastrointestinal stromal cells. Cancer Res 2006;66:5858-5866.
    • (2006) Cancer Res , vol.66 , pp. 5858-5866
    • Sambol, E.B.1    Ambrosini, G.2    Geha, R.C.3    Kennealey, P.T.4    DeCarolis, P.5    O'Conner, R.6
  • 99
    • 36448995057 scopus 로고    scopus 로고
    • Successful resection of an advanced duodenal gastrointestinal tumor after down-staging with imatinib: Report of a case
    • Ludvigsen L, Toxaerd A, Madhi B, Krarup-Hansen A, Bergenfeldt M. Successful resection of an advanced duodenal gastrointestinal tumor after down-staging with imatinib: Report of a case. Surg Today 2007;37:1105-1109.
    • (2007) Surg Today , vol.37 , pp. 1105-1109
    • Ludvigsen, L.1    Toxaerd, A.2    Madhi, B.3    Krarup-Hansen, A.4    Bergenfeldt, M.5
  • 100
    • 33846635001 scopus 로고    scopus 로고
    • Surgical management after neoadjuvant imatinib therapy in gastrointestinal stromal tumors (GISTs) with respect to imatinib resistance cued by secondary KIT mutations
    • Haller F, Detken S, Schulten HJ, Happel N, Gunawan B, Kuhlgatz J, et al. Surgical management after neoadjuvant imatinib therapy in gastrointestinal stromal tumors (GISTs) with respect to imatinib resistance cued by secondary KIT mutations. Ann Surg Oncol 2007;14:526-532.
    • (2007) Ann Surg Oncol , vol.14 , pp. 526-532
    • Haller, F.1    Detken, S.2    Schulten, H.J.3    Happel, N.4    Gunawan, B.5    Kuhlgatz, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.