메뉴 건너뛰기




Volumn 244, Issue 2, 2006, Pages 176-184

Combined surgical and molecular therapy: The gastrointestinal stromal tumor model

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; DOXORUBICIN; EVEROLIMUS; IMATINIB; MIDOSTAURIN; N (3,3 DIMETHYL 6 INDOLINYL) 2 (4 PYRIDINYLMETHYLAMINO)NICOTINAMIDE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; STEM CELL FACTOR; SUNITINIB; UNCLASSIFIED DRUG;

EID: 33748101399     PISSN: 00034932     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.sla.0000218080.94145.cf     Document Type: Review
Times cited : (238)

References (61)
  • 1
    • 0035893766 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors with KIT mutations exhibit a remarkably homogeneous gene expression profile
    • Allander SV, Nupponen NN, Ringner M, et al. Gastrointestinal stromal tumors with KIT mutations exhibit a remarkably homogeneous gene expression profile. Cancer Res. 2001;61:8624-8628.
    • (2001) Cancer Res , vol.61 , pp. 8624-8628
    • Allander, S.V.1    Nupponen, N.N.2    Ringner, M.3
  • 2
    • 0037070754 scopus 로고    scopus 로고
    • Molecular characterisation of soft tissue tumours: A gene expression study
    • Nielsen TO, West RB, Linn SC, et al. Molecular characterisation of soft tissue tumours: a gene expression study. Lancet. 2002;359:1301-1307.
    • (2002) Lancet , vol.359 , pp. 1301-1307
    • Nielsen, T.O.1    West, R.B.2    Linn, S.C.3
  • 3
    • 0042345041 scopus 로고    scopus 로고
    • Classification and subtype prediction of adult soft tissue sarcoma by functional genomics
    • Segal NH, Pavlidis P, Antonescu CR, et al. Classification and subtype prediction of adult soft tissue sarcoma by functional genomics. Am J Pathol. 2003;163:691-700.
    • (2003) Am J Pathol , vol.163 , pp. 691-700
    • Segal, N.H.1    Pavlidis, P.2    Antonescu, C.R.3
  • 4
    • 0033984319 scopus 로고    scopus 로고
    • Two hundred gastrointestinal stromal tumors: Recurrence patterns and prognostic factors for survival
    • DeMatteo RP, Lewis JJ, Leung D, et al. Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival. Ann Surg. 2000;231:51-58.
    • (2000) Ann Surg , vol.231 , pp. 51-58
    • DeMatteo, R.P.1    Lewis, J.J.2    Leung, D.3
  • 5
    • 0035044154 scopus 로고    scopus 로고
    • The effect of surgery and grade on outcome of gastrointestinal stromal tumors
    • Pierie J-PEN, Choudry U, Muzikansky A, et al. The effect of surgery and grade on outcome of gastrointestinal stromal tumors. Arch Surg. 2001;136:383-389.
    • (2001) Arch Surg , vol.136 , pp. 383-389
    • Pierie, J-P.E.N.1    Choudry, U.2    Muzikansky, A.3
  • 6
    • 0037106370 scopus 로고    scopus 로고
    • Prognostic value of KIT mutation type, mitotic activity, and histologic subtype in gastrointestinal stromal tumors
    • Singer S, Rubin BP, Lux ML, et al. Prognostic value of KIT mutation type, mitotic activity, and histologic subtype in gastrointestinal stromal tumors. J Clin Oncol. 2002;20:3898-3905.
    • (2002) J Clin Oncol , vol.20 , pp. 3898-3905
    • Singer, S.1    Rubin, B.P.2    Lux, M.L.3
  • 7
    • 0037263582 scopus 로고    scopus 로고
    • Clinicopathologic study of primary malignant gastrointestinal stromal tumor of the stomach, with special reference to prognostic factors: Analysis of results in 140 surgically resected patients
    • Fujimoto Y, Nakanishi Y, Yoshimura K, et al. Clinicopathologic study of primary malignant gastrointestinal stromal tumor of the stomach, with special reference to prognostic factors: analysis of results in 140 surgically resected patients. Gastric Cancer. 2003;6:39-48.
    • (2003) Gastric Cancer , vol.6 , pp. 39-48
    • Fujimoto, Y.1    Nakanishi, Y.2    Yoshimura, K.3
  • 8
    • 0037342143 scopus 로고    scopus 로고
    • Prognostic factors influencing surgical management and outcome of gastrointestinal stromal tumours
    • Langer C, Gunawan B, Schuler P, et al. Prognostic factors influencing surgical management and outcome of gastrointestinal stromal tumours. Br J Surg. 2003;90:332-339.
    • (2003) Br J Surg , vol.90 , pp. 332-339
    • Langer, C.1    Gunawan, B.2    Schuler, P.3
  • 9
    • 0031848146 scopus 로고    scopus 로고
    • Familial gastrointestinal stromal tumours with germline mutation of the KIT gene
    • Nishida T, Hirota S, Taniguchi M, et al. Familial gastrointestinal stromal tumours with germline mutation of the KIT gene. Nat Genet. 1998;19:323-324.
    • (1998) Nat Genet , vol.19 , pp. 323-324
    • Nishida, T.1    Hirota, S.2    Taniguchi, M.3
  • 10
    • 0347361543 scopus 로고    scopus 로고
    • PDGFRA germline mutation in a family with multiple cases of gastrointestinal stromal tumor
    • Chompret A, Kannengiesser C, Barrois M, et al. PDGFRA germline mutation in a family with multiple cases of gastrointestinal stromal tumor. Gastroenterology. 2004;126:318-321.
    • (2004) Gastroenterology , vol.126 , pp. 318-321
    • Chompret, A.1    Kannengiesser, C.2    Barrois, M.3
  • 11
    • 0028890359 scopus 로고
    • Gastrointestinal cancer
    • Thomas RM, Sobin LH. Gastrointestinal cancer. Cancer. 1995;75(suppl 1):154-70.
    • (1995) Cancer , vol.75 , Issue.1 SUPPL. , pp. 154-170
    • Thomas, R.M.1    Sobin, L.H.2
  • 12
    • 33748112167 scopus 로고    scopus 로고
    • Gastrointestinal Stromal Tumors; Diagnosis, Epidemiology, Prognosis
    • Chicago
    • Kindblom LG. Gastrointestinal Stromal Tumors; Diagnosis, Epidemiology, Prognosis. ASCO Annual Meeting, Chicago, 2003.
    • (2003) ASCO Annual Meeting
    • Kindblom, L.G.1
  • 13
    • 0032955439 scopus 로고    scopus 로고
    • Prognosis of gastrointestinal smooth-muscle (stromal) tumors: Dependence on anatomic site
    • Emory TS, Sobin LH, Lukes L, et al. Prognosis of gastrointestinal smooth-muscle (stromal) tumors: dependence on anatomic site. Am J Surg Pathol. 1999;23:82-87.
    • (1999) Am J Surg Pathol , vol.23 , pp. 82-87
    • Emory, T.S.1    Sobin, L.H.2    Lukes, L.3
  • 14
    • 0037341737 scopus 로고    scopus 로고
    • Targeted molecular therapy for cancer: The application of STI571 to gastrointestinal stromal tumor
    • Dematteo RPRP, Maki RGRG, Antonescu CC, et al. Targeted molecular therapy for cancer: the application of STI571 to gastrointestinal stromal tumor. Curr Probl Surg. 2003;40:144-193.
    • (2003) Curr Probl Surg , vol.40 , pp. 144-193
    • Dematteo, R.P.R.P.1    Maki, R.G.R.G.2    Antonescu, C.C.3
  • 15
    • 0036301722 scopus 로고    scopus 로고
    • Diagnosis of gastrointestinal stromal tumors: A consensus approach
    • Fletcher CDM, Berman JJ, Corless C, et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol. 2002;33:459-465.
    • (2002) Hum Pathol , vol.33 , pp. 459-465
    • Fletcher, C.D.M.1    Berman, J.J.2    Corless, C.3
  • 16
    • 2142747025 scopus 로고    scopus 로고
    • KIT-negative gastrointestinal stromal tumors: Proof of concept and therapeutic implications
    • Medeiros F, Corless CL, Duensing A, et al. KIT-negative gastrointestinal stromal tumors: proof of concept and therapeutic implications. Am J Surg Pathol. 2004;28:889-894.
    • (2004) Am J Surg Pathol , vol.28 , pp. 889-894
    • Medeiros, F.1    Corless, C.L.2    Duensing, A.3
  • 17
    • 14844317303 scopus 로고    scopus 로고
    • Analysis of CD117-negative gastrointestinal stromal tumors
    • Tzen CY, Mau BL. Analysis of CD117-negative gastrointestinal stromal tumors. World J Gastroenterol. 2005;11:1052-1055.
    • (2005) World J Gastroenterol , vol.11 , pp. 1052-1055
    • Tzen, C.Y.1    Mau, B.L.2
  • 18
    • 0035122393 scopus 로고    scopus 로고
    • Malignant gastrointestinal stromal tumors of the small intestine: A review of 50 cases from a prospective database
    • Crosby JA, Catton CN, Davis A, et al. Malignant gastrointestinal stromal tumors of the small intestine: a review of 50 cases from a prospective database. Ann Surg Oncol. 2001;8:50-59.
    • (2001) Ann Surg Oncol , vol.8 , pp. 50-59
    • Crosby, J.A.1    Catton, C.N.2    Davis, A.3
  • 19
    • 0036301863 scopus 로고    scopus 로고
    • Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: A review
    • Miettinen M, El-Rifai WE, Leslie HS, et al. Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: a review. Hum Pathol. 2002;33:478-483.
    • (2002) Hum Pathol , vol.33 , pp. 478-483
    • Miettinen, M.1    El-Rifai, W.E.2    Leslie, H.S.3
  • 20
    • 7644242712 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors (GISTs) with KIT and PDGFRA mutations have distinct gene expression profiles
    • Subramanian S, West RB, Corless CL, et al. Gastrointestinal stromal tumors (GISTs) with KIT and PDGFRA mutations have distinct gene expression profiles. Oncogene. 2004;23:7780-7790.
    • (2004) Oncogene , vol.23 , pp. 7780-7790
    • Subramanian, S.1    West, R.B.2    Corless, C.L.3
  • 21
    • 3042646931 scopus 로고    scopus 로고
    • A great majority of GISTs with PDGFRA mutations represent gastric tumors of low or no malignant potential
    • Lasota J, Dansonka-Mieszkowska A, Sobin LH, et al. A great majority of GISTs with PDGFRA mutations represent gastric tumors of low or no malignant potential. Lab Invest. 2004;84:874-883.
    • (2004) Lab Invest , vol.84 , pp. 874-883
    • Lasota, J.1    Dansonka-Mieszkowska, A.2    Sobin, L.H.3
  • 22
    • 0033199890 scopus 로고    scopus 로고
    • Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors
    • Taniguchi M, Nishida T, Hirota S, et al. Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors. Cancer Res. 1999;59:4297-4300.
    • (1999) Cancer Res , vol.59 , pp. 4297-4300
    • Taniguchi, M.1    Nishida, T.2    Hirota, S.3
  • 23
    • 2442551759 scopus 로고    scopus 로고
    • Prognostic significance of c-kit mutation in localized gastrointestinal stromal tumors
    • Kim TW, Lee H, Kang Y-K, et al. Prognostic significance of c-kit mutation in localized gastrointestinal stromal tumors. Clin Cancer Res. 2004;10:3076-3081.
    • (2004) Clin Cancer Res , vol.10 , pp. 3076-3081
    • Kim, T.W.1    Lee, H.2    Kang, Y.-K.3
  • 24
    • 84879133032 scopus 로고    scopus 로고
    • Optimal management of patients with gastrointestinal stromal tumors (GIST): Expansion and update of NCCN Clinical Practice Guidelines
    • Demetri GD, Benjamin R, Blanke CD, et al. Optimal management of patients with gastrointestinal stromal tumors (GIST): expansion and update of NCCN Clinical Practice Guidelines. J Comprehensive Cancer Network. 2004;2(suppl 1):1-26.
    • (2004) J Comprehensive Cancer Network , vol.2 , Issue.1 SUPPL. , pp. 1-26
    • Demetri, G.D.1    Benjamin, R.2    Blanke, C.D.3
  • 25
    • 20944443259 scopus 로고    scopus 로고
    • Consensus meeting for the management of gastrointestinal stromal tumors: Report of the GIST Consensus Conference of 20-21 March 2004, under the auspices of ESMO
    • Blay JY, Bonvalot S, Casali P, et al. Consensus meeting for the management of gastrointestinal stromal tumors: Report of the GIST Consensus Conference of 20-21 March 2004, under the auspices of ESMO. Ann Oncol. 2005;16:566-578.
    • (2005) Ann Oncol , vol.16 , pp. 566-578
    • Blay, J.Y.1    Bonvalot, S.2    Casali, P.3
  • 26
    • 0034794797 scopus 로고    scopus 로고
    • Results of hepatic resection for sarcoma metastatic to liver
    • DeMatteo RP, Shah A, Fong Y, et al. Results of hepatic resection for sarcoma metastatic to liver. Ann Surg. 2001;234:540-547; discussion 547-548.
    • (2001) Ann Surg , vol.234 , pp. 540-547
    • DeMatteo, R.P.1    Shah, A.2    Fong, Y.3
  • 27
    • 15644363454 scopus 로고    scopus 로고
    • Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
    • Hirota S, Isozaki K, Moriyama Y, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science. 1998;279:577-580.
    • (1998) Science , vol.279 , pp. 577-580
    • Hirota, S.1    Isozaki, K.2    Moriyama, Y.3
  • 28
    • 2542462086 scopus 로고    scopus 로고
    • Gene expression in gastrointestinal stromal tumors is distinguished by KIT genotype and anatomic site
    • Antonescu CR, Viale A, Sarran L, et al. Gene expression in gastrointestinal stromal tumors is distinguished by KIT genotype and anatomic site. Clin Cancer Res. 2004;10:3282-3290.
    • (2004) Clin Cancer Res , vol.10 , pp. 3282-3290
    • Antonescu, C.R.1    Viale, A.2    Sarran, L.3
  • 29
    • 0642368571 scopus 로고    scopus 로고
    • Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
    • Heinrich MC, Corless CL, Demetri GD, et al. Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J Clin Oncol. 2003;21:4342-4349.
    • (2003) J Clin Oncol , vol.21 , pp. 4342-4349
    • Heinrich, M.C.1    Corless, C.L.2    Demetri, G.D.3
  • 30
    • 0038312141 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase
    • Sommer G, Agosti V, Ehlers I, et al. Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase. Proc Natl Acad Sci USA. 2003;100:6706-6711.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 6706-6711
    • Sommer, G.1    Agosti, V.2    Ehlers, I.3
  • 31
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker BJ, Tamura S, Buchdunger E, et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med. 1996;2:561-566.
    • (1996) Nat Med , vol.2 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3
  • 32
    • 0035810148 scopus 로고    scopus 로고
    • Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor
    • Joensuu H, Roberts PJ, Sarlomo-Rikala M, et al. Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. N Engl J Med. 2001;344:1052-1056.
    • (2001) N Engl J Med , vol.344 , pp. 1052-1056
    • Joensuu, H.1    Roberts, P.J.2    Sarlomo-Rikala, M.3
  • 33
    • 0035960428 scopus 로고    scopus 로고
    • Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: A phase I study
    • van Oosterom AT, Judson I, Verweij J, et al. Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study. Lancet. 2001;358:1421-1423.
    • (2001) Lancet , vol.358 , pp. 1421-1423
    • Van Oosterom, A.T.1    Judson, I.2    Verweij, J.3
  • 34
    • 0036303804 scopus 로고    scopus 로고
    • Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations
    • Heinrich MC, Rubin BP, Longley BJ, et al. Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations. Hum Pathol. 2002;33:484-495.
    • (2002) Hum Pathol , vol.33 , pp. 484-495
    • Heinrich, M.C.1    Rubin, B.P.2    Longley, B.J.3
  • 35
    • 0036769721 scopus 로고    scopus 로고
    • Update of phase I study of imatinib (STI571) in advanced soft tissue sarcomas and gastrointestinal stromal tumors: A report of the EORTC Soft Tissue and Bone Sarcoma Group
    • van Oosterom AT, Judson IR, Verweij J, et al. Update of phase I study of imatinib (STI571) in advanced soft tissue sarcomas and gastrointestinal stromal tumors: a report of the EORTC Soft Tissue and Bone Sarcoma Group. Eur J Cancer. 2002;38(suppl 5):83-87.
    • (2002) Eur J Cancer , vol.38 , Issue.5 SUPPL. , pp. 83-87
    • Van Oosterom, A.T.1    Judson, I.R.2    Verweij, J.3
  • 36
    • 0242691170 scopus 로고    scopus 로고
    • Phase III dose-randomized study of imatinib mesylate (STI571) for GIST: Intergroup S0033 early results
    • Abstr 3271
    • Benjamin RS, Rankin C, Fletcher C, et al. Phase III dose-randomized study of imatinib mesylate (STI571) for GIST: Intergroup S0033 early results [Abstr 3271]. Proc Am Soc Clin Oncol. 2003;22:814.
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 814
    • Benjamin, R.S.1    Rankin, C.2    Fletcher, C.3
  • 37
    • 20844433223 scopus 로고    scopus 로고
    • Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: Randomised trial
    • Verweij PJ, Casali PG, Zalcberg PJ, et al. Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial. Lancet. 2004;364:1127-1134.
    • (2004) Lancet , vol.364 , pp. 1127-1134
    • Verweij, P.J.1    Casali, P.G.2    Zalcberg, P.J.3
  • 38
    • 11244267661 scopus 로고    scopus 로고
    • Long-term follow up of advanced gastrointestinal stromal tumor (GIST) patients treated with imatinib mesylate
    • San Francisco
    • Blanke C, Joensuu H, Demetri G, et al. Long-term follow up of advanced gastrointestinal stromal tumor (GIST) patients treated with imatinib mesylate. 2004 Gastrointestinal Cancers Symposium, San Francisco, 2004.
    • (2004) 2004 Gastrointestinal Cancers Symposium
    • Blanke, C.1    Joensuu, H.2    Demetri, G.3
  • 39
    • 0033976051 scopus 로고    scopus 로고
    • Salvage surgery for patients with recurrent gastrointestinal sarcoma: Prognostic factors to guide patient selection
    • Mudan SS, Conlon KC, Woodruff JM, et al. Salvage surgery for patients with recurrent gastrointestinal sarcoma: prognostic factors to guide patient selection. Cancer. 2000;88:66-74.
    • (2000) Cancer , vol.88 , pp. 66-74
    • Mudan, S.S.1    Conlon, K.C.2    Woodruff, J.M.3
  • 40
    • 27244433314 scopus 로고    scopus 로고
    • Clinical benefit of Imatinib in patients (pts) with metastatic gastrointestinal stromal tumors (GIST) negative for the expression of CD117 in the S0033 trial
    • Blackstein ME, Rankin C, Fletcher C, et al. Clinical benefit of Imatinib in patients (pts) with metastatic gastrointestinal stromal tumors (GIST) negative for the expression of CD117 in the S0033 trial. J Clin Oncol. 2005;23(16 suppl):9010.
    • (2005) J Clin Oncol , vol.23 , Issue.16 SUPPL. , pp. 9010
    • Blackstein, M.E.1    Rankin, C.2    Fletcher, C.3
  • 41
    • 27244444216 scopus 로고    scopus 로고
    • Interruption of imatinib (IM) in GIST patients with advanced disease: Updated results of the prospective French Sarcoma Group randomized phase III trial on survival and quality of life
    • Le Cesne A, Perol D, Ray-Coquard I, et al. Interruption of imatinib (IM) in GIST patients with advanced disease: updated results of the prospective French Sarcoma Group randomized phase III trial on survival and quality of life. J Clin Oncol. 2005;23(16 suppl):9031.
    • (2005) J Clin Oncol , vol.23 , Issue.16 SUPPL. , pp. 9031
    • Le Cesne, A.1    Perol, D.2    Ray-Coquard, I.3
  • 42
    • 0019365237 scopus 로고
    • Reporting results of cancer treatment
    • Miller AB, Hoogstraten B, Staquet M, et al. Reporting results of cancer treatment. Cancer. 1981;47:207-214.
    • (1981) Cancer , vol.47 , pp. 207-214
    • Miller, A.B.1    Hoogstraten, B.2    Staquet, M.3
  • 43
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors: European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
    • Therasse P, Arbuck SG, Eisenhauer EA, et al. New guidelines to evaluate the response to treatment in solid tumors: European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst. 2000;92:205-216.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 205-216
    • Therasse, P.1    Arbuck, S.G.2    Eisenhauer, E.A.3
  • 44
    • 16644389881 scopus 로고    scopus 로고
    • CT evaluation of the response of gastrointestinal stromal tumors after imatinib mesylate treatment: A quantitative analysis correlated with FDG PET findings
    • Choi H, Charnsangavej C, de Castro Faria S, et al. CT evaluation of the response of gastrointestinal stromal tumors after imatinib mesylate treatment: a quantitative analysis correlated with FDG PET findings. AJR Am J Roentgenol. 2004;183:1619-1628.
    • (2004) AJR Am J Roentgenol , vol.183 , pp. 1619-1628
    • Choi, H.1    Charnsangavej, C.2    De Castro Faria, S.3
  • 45
    • 13844294023 scopus 로고    scopus 로고
    • The value of PET, CT and in-line PET/CT in patients with gastrointestinal stromal tumours: Long-term outcome of treatment with imatinib mesylate
    • Goerres GW, Stupp R, Barghouth G, et al. The value of PET, CT and in-line PET/CT in patients with gastrointestinal stromal tumours: long-term outcome of treatment with imatinib mesylate. Eur J Nucl Med Mol Imaging. 2005;32:153-162.
    • (2005) Eur J Nucl Med Mol Imaging , vol.32 , pp. 153-162
    • Goerres, G.W.1    Stupp, R.2    Barghouth, G.3
  • 46
    • 12144291080 scopus 로고    scopus 로고
    • Use of c-KIT/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumours entered on phase I and II studies of the EORTC Soft Tissue and Bone Sarcoma Group
    • Debiec-Rychter M, Dumez H, Judson I, et al. Use of c-KIT/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumours entered on phase I and II studies of the EORTC Soft Tissue and Bone Sarcoma Group. Eur J Cancer. 2004;40:689-695.
    • (2004) Eur J Cancer , vol.40 , pp. 689-695
    • Debiec-Rychter, M.1    Dumez, H.2    Judson, I.3
  • 47
    • 23844448447 scopus 로고    scopus 로고
    • Correlation of target kinase genotype with clinical activity of imatinib mesylate (IM) in patients with metastatic GI stromal tumors (GISTs) expressing KIT (KIT+)
    • Heinrich MC, Shoemaker JS, Corless CL, et al. Correlation of target kinase genotype with clinical activity of imatinib mesylate (IM) in patients with metastatic GI stromal tumors (GISTs) expressing KIT (KIT+). J Clin Oncol. 2005;23(16 suppl):7.
    • (2005) J Clin Oncol , vol.23 , Issue.16 SUPPL. , pp. 7
    • Heinrich, M.C.1    Shoemaker, J.S.2    Corless, C.L.3
  • 48
    • 0242670019 scopus 로고    scopus 로고
    • PDGFRA activating mutations in gastrointestinal stromal tumors
    • Heinrich MC, Corless CL, Duensing A, et al. PDGFRA activating mutations in gastrointestinal stromal tumors. Science. 2003;299:708-710.
    • (2003) Science , vol.299 , pp. 708-710
    • Heinrich, M.C.1    Corless, C.L.2    Duensing, A.3
  • 49
    • 0242691165 scopus 로고    scopus 로고
    • Mechanisms of resistance to imatinib mesylate (IM) in advanced gastrointestinal stromal tumor (GIST)
    • Abstr 3275
    • Fletcher JA, Corless CL, Dimitrijevic S, et al. Mechanisms of resistance to imatinib mesylate (IM) in advanced gastrointestinal stromal tumor (GIST) [Abstr 3275]. Proc Am Soc Clin Oncol. 2003;22:815.
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 815
    • Fletcher, J.A.1    Corless, C.L.2    Dimitrijevic, S.3
  • 50
    • 20844460619 scopus 로고    scopus 로고
    • A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors
    • Chen LL, Trent JC, Wu EF, et al. A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors. Cancer Res. 2004;64:5913-5919.
    • (2004) Cancer Res , vol.64 , pp. 5913-5919
    • Chen, L.L.1    Trent, J.C.2    Wu, E.F.3
  • 51
    • 14944352767 scopus 로고    scopus 로고
    • Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants
    • Debiec-Rychter M, Cools J, Dumez H, et al. Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants. Gastroenterology. 2005;128:270-279.
    • (2005) Gastroenterology , vol.128 , pp. 270-279
    • Debiec-Rychter, M.1    Cools, J.2    Dumez, H.3
  • 52
    • 20344393896 scopus 로고    scopus 로고
    • Acquired resistance to Imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation
    • Antonescu CR, Besmer P, Guo T, et al. Acquired resistance to Imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation. Clin Cancer Res. 2005;11:4182-4190.
    • (2005) Clin Cancer Res , vol.11 , pp. 4182-4190
    • Antonescu, C.R.1    Besmer, P.2    Guo, T.3
  • 53
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre ME, Mohammed M, Ellwood K, et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science. 2001;293:876-880.
    • (2001) Science , vol.293 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3
  • 54
    • 0001686739 scopus 로고    scopus 로고
    • Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
    • Shah NP, Nicoll JM, Nagar B, et al. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell. 2002;2:117-125.
    • (2002) Cancer Cell , vol.2 , pp. 117-125
    • Shah, N.P.1    Nicoll, J.M.2    Nagar, B.3
  • 55
    • 20844448396 scopus 로고    scopus 로고
    • A new mutation in the KIT ATP pocket causes acquired resistance to imatinib in a gastrointestinal stromal tumor patient
    • Tamborini E, Bonadiman L, Greco A, et al. A new mutation in the KIT ATP pocket causes acquired resistance to imatinib in a gastrointestinal stromal tumor patient. Gastroenterology. 2004;127:294-299.
    • (2004) Gastroenterology , vol.127 , pp. 294-299
    • Tamborini, E.1    Bonadiman, L.2    Greco, A.3
  • 56
    • 20144387198 scopus 로고    scopus 로고
    • Acquired resistance to imatinib in gastrointestinal stromal tumours caused by multiple KIT mutations
    • Wardelmann E, Thomas N, Merkelbach-Bruse S, et al. Acquired resistance to imatinib in gastrointestinal stromal tumours caused by multiple KIT mutations. Lancet Oncol. 2005;6:249-251.
    • (2005) Lancet Oncol , vol.6 , pp. 249-251
    • Wardelmann, E.1    Thomas, N.2    Merkelbach-Bruse, S.3
  • 57
    • 4644222221 scopus 로고    scopus 로고
    • SU11248, a multi-targeted tyrosine kinase inhibitor, can overcome imatinib (IM) resistance caused by diverse genomic mechanisms in patients with metastatic gastrointestinal stromal tumor (GIST)
    • Demetri GD, Desai J, Fletcher JA, et al. SU11248, a multi-targeted tyrosine kinase inhibitor, can overcome imatinib (IM) resistance caused by diverse genomic mechanisms in patients with metastatic gastrointestinal stromal tumor (GIST). J Clin Oncol. 2004;22(14 suppl):3001.
    • (2004) J Clin Oncol , vol.22 , Issue.14 SUPPL. , pp. 3001
    • Demetri, G.D.1    Desai, J.2    Fletcher, J.A.3
  • 58
    • 30344488355 scopus 로고    scopus 로고
    • Activity and tolerability of the multi-targeted tyrosine kinase inhibitor SU011248 in patients with metastatic gastrointestinal stromal tumor (GIST) refractory to imatinib mesylate
    • San Francisco
    • Desai J, Maki R, Heinrich MC, et al. Activity and tolerability of the multi-targeted tyrosine kinase inhibitor SU011248 in patients with metastatic gastrointestinal stromal tumor (GIST) refractory to imatinib mesylate. 2004 Gastrointestinal Cancers Symposium, San Francisco, 2004.
    • (2004) 2004 Gastrointestinal Cancers Symposium
    • Desai, J.1    Maki, R.2    Heinrich, M.C.3
  • 59
    • 23844531811 scopus 로고    scopus 로고
    • Results from a continuation trial of SU11248 in patients (pts) with imatinib (IM)-resistant gastrointestinal stromal tumor (GIST)
    • Maki RG, Fletcher JA, Heinrich MC, et al. Results from a continuation trial of SU11248 in patients (pts) with imatinib (IM)-resistant gastrointestinal stromal tumor (GIST). J Clin Oncol. 2005;23(16 suppl):9011.
    • (2005) J Clin Oncol , vol.23 , Issue.16 SUPPL. , pp. 9011
    • Maki, R.G.1    Fletcher, J.A.2    Heinrich, M.C.3
  • 60
    • 28044467635 scopus 로고    scopus 로고
    • Phase 3, multicenter, randomized, double-blind, placebo-controlled trial of SU11248 in patients following failure of imatinib for metastatic GIST
    • Demetri GD, van Oosterom AT, Blackstein M, et al. Phase 3, multicenter, randomized, double-blind, placebo-controlled trial of SU11248 in patients following failure of imatinib for metastatic GIST. J Clin Oncol. 2005;23(16 suppl):4000.
    • (2005) J Clin Oncol , vol.23 , Issue.16 SUPPL. , pp. 4000
    • Demetri, G.D.1    Van Oosterom, A.T.2    Blackstein, M.3
  • 61
    • 0037103424 scopus 로고    scopus 로고
    • Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
    • Demetri GD, von Mehren M, Blanke CD, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med. 2002;347:472-480.
    • (2002) N Engl J Med , vol.347 , pp. 472-480
    • Demetri, G.D.1    Von Mehren, M.2    Blanke, C.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.