Secondary mutations in the kinase domain of the KIT gene are predominant in imatinib-resistant gastrointestinal stromal tumor

Cancer Science

Volumn 99, Issue 4, 2008, Pages 799-804

  Nishida, Toshirou ^a   Kanda, Tatsuo ^b   Nishitani, Akiko ^a   Takahashi, Tsuyoshi ^a   Nakajima, Kiyokazu ^a   Ishikawa, Takashi ^b   Hirota, Seiichi ^c  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^c HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORODEOXYGLUCOSE F 18; IMATINIB; N (3,3 DIMETHYL 6 INDOLINYL) 2 (4 PYRIDINYLMETHYLAMINO)NICOTINAMIDE; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; SUNITINIB;

ADULT; AGED; ARTICLE; CHEMOEMBOLIZATION; CIS ISOMER; CLINICAL ARTICLE; DRUG DOSE INCREASE; FEMALE; GASTROINTESTINAL STROMAL TUMOR; GENE FUNCTION; GENE MUTATION; GENETIC SUSCEPTIBILITY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; JAPANESE; MALE; MISSENSE MUTATION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; RADIOFREQUENCY ABLATION;

AGED; ANTINEOPLASTIC AGENTS; ASIAN CONTINENTAL ANCESTRY GROUP; DRUG RESISTANCE, NEOPLASM; FEMALE; GASTROINTESTINAL STROMAL TUMORS; HUMANS; JAPAN; MALE; MIDDLE AGED; MUTATION, MISSENSE; PIPERAZINES; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-KIT; PYRIMIDINES;

EID: 41349109537     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2008.00727.x     Document Type: Article

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