Induction of bulk and c-myc P2 promoter-specific DNA damage by an anti-topoisomerase II agent salvicine is an early event leading to apoptosis in HL-60 cells

FEBS Letters

Volumn 501, Issue 1, 2001, Pages 59-64

  Meng, Ling Hua ^a   Ding, Jian ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

c myc; DNA damage; DNA topoisomerase II inhibitor; P2 promoter; Salvicine

Indexed keywords

DNA TOPOISOMERASE INHIBITOR; MYC PROTEIN; PROTEIN C FOS; PROTEIN C JUN; SALVICINE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DNA FRAGMENT; DNA TOPOISOMERASE (ATP HYDROLYSING); ENZYME INHIBITOR; MESSENGER RNA; NAPHTHOQUINONE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; C JUN GENE; CANCER INHIBITION; CONTROLLED STUDY; DNA DAMAGE; GENE EXPRESSION REGULATION; GENE INDUCTION; HL 60 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; ONCOGENE; ONCOGENE C FOS; ONCOGENE C MYC; PRIORITY JOURNAL; PROMOTER REGION; PROMYELOCYTIC LEUKEMIA; PROTEIN EXPRESSION; CELL DIVISION; CELL STRAIN HL 60; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYME SPECIFICITY; GENETICS; METABOLISM; ONCOGENE MYC; RNA STABILITY;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL DIVISION; DNA DAMAGE; DNA FRAGMENTATION; DNA TOPOISOMERASES, TYPE II; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GENES, FOS; GENES, JUN; GENES, MYC; HL-60 CELLS; HUMANS; NAPHTHOQUINONES; PROMOTER REGIONS (GENETICS); RNA STABILITY; RNA, MESSENGER; SUBSTRATE SPECIFICITY;

EID: 0035854754     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/S0014-5793(01)02633-3     Document Type: Article

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