Glucagon-like peptide-1 (GLP-1) diminishes neuronal degeneration and death caused by NGF deprivation by suppressing Bim induction

Neurochemical Research

Volumn 33, Issue 9, 2008, Pages 1845-1851

  Biswas, Subhas C ^a   Buteau, Jean ^b   Greene, Lloyd A ^a  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

^b UNIVERSITÉ LAVAL   (Canada)

Author keywords

Bim; GLP 1; Neuronal apoptosis; NGF

Indexed keywords

BIM PROTEIN; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; NERVE GROWTH FACTOR;

ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DIABETIC NEUROPATHY; NERVE CELL; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; CELL DEATH; CELLS, CULTURED; GLUCAGON-LIKE PEPTIDE 1; HUMANS; MEMBRANE PROTEINS; NERVE GROWTH FACTOR; NEURONS; NEUROPROTECTIVE AGENTS; PC12 CELLS; PROTO-ONCOGENE PROTEINS; RATS;

EID: 48349144982     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-008-9646-4     Document Type: Article

References (47)

1. DJ Drucker MA Nauck 2006 The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes Lancet 368 1696 1705
2. MA Nauck JJ Meier 2005 Glucagon-like peptide 1 and its derivatives in the treatment of diabetes Regul Pept 128 135 148
3. F Satoh SA Beak CJ Small 2000 Characterization of human and rat glucagon-like peptide-1 receptors in the neurointermediate lobe: lack of coupling to either stimulation or inhibition of adenylyl cyclase Endocrinology 141 1301 1309
4. VK Han MA Hynes C Jin 1986 Cellular localization of proglucagon/glucagon- like peptide I messenger RNAs in rat brain J Neurosci Res 16 97 107
5. R Goke PJ Larsen JD Mikkelsen 1995 Identification of specific binding sites for glucagon-like peptide-1 on the posterior lobe of the rat pituitary Neuroendocrinology 62 130 134
6. SL Jin VK Han JG Simmons 1988 Distribution of glucagonlike peptide I (GLP-I), glucagon, and glicentin in the rat brain: an immunocytochemical study J Comp Neurol 271 519 532
7. PJ Larsen M Tang-Christensen DS Jessop 1997 Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat Endocrinology 138 4445 4455
8. I Merchenthaler M Lane P Shughrue 1999 Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system J Comp Neurol 403 261 280
9. PJ Shughrue MV Lane I Merchenthaler 1996 Glucagon-like peptide-1 receptor (GLP1-R) mRNA in the rat hypothalamus Endocrinology 137 5159 5162
10. J Buteau R Roduit S Susini 1999 Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells Diabetologia 42 856 864
11. J Buteau S Foisy CJ Rhodes 2001 Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation Diabetes 50 2237 2243
12. J Buteau S Foisy E Joly 2003 Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor Diabetes 52 124 132
13. L Farilla H Hui C Bertolotto 2002 Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats Endocrinology 143 4397 4408
14. Y Li T Hansotia B Yusta 2003 Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis J Biol Chem 278 471 478
15. J Buteau W El-Assaad CJ Rhodes 2004 Glucagon-like peptide-1 prevents beta cell glucolipotoxicity Diabetologia 47 806 815
16. K Trumper A Trumper H Trusheim 2000 Integrative mitogenic role of protein kinase B/Akt in beta-cells Ann N Y Acad Sci 921 242 250
17. H Hui A Nourparvar X Zhao 2003 Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5′-adenosine monophosphate- dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway Endocrinology 144 1444 1455
18. Q Wang L Li E Xu 2004 Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells Diabetologia 47 478 487
19. T Perry NJ Haughey MP Mattson 2002 Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4 J Pharmacol Exp Ther 302 881 888
20. T Perry DK Lahiri K Sambamurti 2003 Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron J Neurosci Res 72 603 612
21. T Perry HW Holloway A Weerasuriya 2007 Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy Exp Neurol 203 293 301
22. MJ During L Cao DS Zuzga 2003 Glucagon-like peptide-1 receptor is involved in learning and neuroprotection Nat Med 9 1173 1179
23. T Perry DK Lahiri D Chen 2002 A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells J Pharmacol Exp Ther 300 958 966
24. MV Sofroniew CL Howe WC Mobley 2001 Nerve growth factor signaling, neuroprotection, and neural repair Annu Rev Neurosci 24 1217 1281
25. TL Spires BT Hyman 2004 Neuronal structure is altered by amyloid plaques Rev Neurosci 15 267 278
26. G Pittenger A Vinik 2003 Nerve growth factor and diabetic neuropathy Exp Diabesity Res 4 271 285
27. BJ Williams M Eriksdotter-Jonhagen AC Granholm 2006 Nerve growth factor in treatment and pathogenesis of Alzheimer's disease Prog Neurobiol 80 114 128
28. NH Greig MP Mattson T Perry 2004 New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists Ann N Y Acad Sci 1035 290 315
29. SN Willis JM Adams 2005 Life in the balance: how BH3-only proteins induce apoptosis Curr Opin Cell Biol 17 617 625
30. LA Greene DX Liu CM Troy 2007 Cell cycle molecules define a pathway required for neuron death in development and disease Biochim Biophys Acta 1772 392 401
31. GV Putcha KL Moulder JP Golden 2001 Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis Neuron 29 615 628
32. J Whitfield SJ Neame L Paquet 2001 Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release Neuron 29 629 643
33. DA Linseman RA Phelps RJ Bouchard 2002 Insulin-like growth factor-I blocks Bcl-2 interacting mediator of cell death (Bim) induction and intrinsic death signaling in cerebellar granule neurons J Neurosci 22 9287 9297
34. SC Biswas LA Greene 2002 Nerve growth factor (NGF) down-regulates the Bcl-2 homology 3 (BH3) domain-only protein Bim and suppresses its proapoptotic activity by phosphorylation J Biol Chem 277 49511 49516
35. SC Biswas Y Shi JP Vonsattel 2007 Bim is elevated in Alzheimer's disease neurons and is required for beta-amyloid-induced neuronal apoptosis J Neurosci 27 893 900
36. LA Greene AS Tischler 1976 Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor Proc Natl Acad Sci USA 73 2424 2428
37. DS Park EJ Morris L Stefanis 1998 Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation, and oxidative stress J Neurosci 18 830 840
38. A Rukenstein RE Rydel LA Greene 1991 Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms J Neurosci 11 2552 2563
39. Z Xu AC Maroney P Dobrzanski 2001 The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis Mol Cell Biol 21 4713 4724
40. J Ham A Eilers J Whitfield 2000 c-Jun and the transcriptional control of neuronal apoptosis Biochem Pharmacol 60 1015 1021
41. C Montrose-Rafizadeh P Avdonin MJ Garant 1999 Pancreatic glucagon-like peptide-1 receptor couples to multiple G proteins and activates mitogen-activated protein kinase pathways in Chinese hamster ovary cells Endocrinology 140 1132 1140
42. 2+ release in INS-1 pancreatic beta-cells J Physiol 536 375 385
43. J Gilley PJ Coffer J Ham 2003 FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons J Cell Biol 162 613 622
44. J Buteau ML Spatz D Accili 2006 Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass Diabetes 55 1190 1196
45. WJ Friedman LA Greene 1999 Neurotrophin signaling via Trks and p75 Exp Cell Res 253 131 142
46. GV Putcha M Deshmukh EM Johnson Jr 1999 BAX translocation is a critical event in neuronal apoptosis: regulation by neuroprotectants, BCL-2, and caspases J Neurosci 19 7476 7485
47. SC Biswas DX Liu LA Greene 2005 Bim is a direct target of a neuronal E2F-dependent apoptotic pathway J Neurosci 25 8349 8358