Caffeic acid phenethyl ester protects mice from lethal endotoxin shock and inhibits lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW 264.7 macrophages via the p38/ERK and NF-κB pathways

International Journal of Biochemistry and Cell Biology

Volumn 40, Issue 11, 2008, Pages 2572-2582

  Jung, Won Kyo ^a   Choi, Inhak ^b   Lee, Da Young ^b   Yea, Sung Su ^c   Choi, Yung Hyun ^d   Kim, Moon Moo ^e   Park, Sae Gwang ^b   Seo, Su Kil ^b   Lee, Soo Woong ^b   Lee, Chang Min ^f   Park, Yeong Min ^f   Choi, Il Whan ^b  

^a Chosun University   (South Korea)

^b Department of Microbiology   (South Korea)

^c Inje University College of Medicine   (South Korea)

^d Dong Eui University   (South Korea)

^e Dong Eui University   (South Korea)

^f Pusan National University School of Medicine   (South Korea)

Author keywords

Caffeic acid phenethyl ester; Cyclooxygenase 2; Inducible nitric oxide synthase; Nuclear factor B; Septic shock

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CAFFEIC ACID PHENETHYL ESTER; CYCLOOXYGENASE 2; ENDOTOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PROSTAGLANDIN E2; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DRUG MECHANISM; DRUG SAFETY; ENDOTOXEMIA; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; INTRACELLULAR TRANSPORT; MACROPHAGE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROSTAGLANDIN SYNTHESIS; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; PROTEIN TRANSPORT; SEPTIC SHOCK; TREATMENT OUTCOME;

ANIMALS; CAFFEIC ACIDS; CELL LINE; CELL SURVIVAL; CYCLOOXYGENASE 2; DINOPROSTONE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MOLECULAR STRUCTURE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENYLETHYL ALCOHOL; SHOCK, SEPTIC; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 48349122162     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2008.05.005     Document Type: Article

References (40)

1. Baldwin Jr. A.S. The NF-kappaB and I-kappaB proteins: new discoveries and insights. Annual Review of Immunology 14 (1996) 649-683
2. Barnes P.J., and Karin M. Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. The New England Journal of Medicine 336 (1997) 1066-1071
3. Bone R.C., Balk R.A., Fein A.M., Perl T.M., Wenzel R.P., Reines H.D., et al. A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomized, controlled trial. Critical Care Medicine 23 (1995) 994-1006
4. Cario E., Rosenberg I.M., Brandwein S.L., Beck P.L., Reinecker H.C., and Podolsky D.K. Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors. Journal of Immunology 164 (2000) 966-972
5. Cho K.J., Yun C.H., Yoon D.Y., Cho Y.S., Rimbach G., Packer L., et al. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interleukin-1 production in lipopolysaccharide-stimulated RAW 264.7. Toxicology and Applied Pharmacology 168 (2000) 64-71
6. Coker R.K., and Laurent G.J. Pulmonary fibrosis: cytokines in the balance. The European Respiratory Journal 11 (1998) 1218-1221
7. Crespo A., Filla M.B., Russell S.W., and Murphy W.J. Indirect induction of suppressor of cytokine signalling-1 in macrophages stimulated with bacterial lipopolysaccharide: partial role of autocrine/paracrine interferon-alpha/beta. The Biochemical Journal 349 (2000) 99-104
8. De Nardin E. The role of inflammatory and immunological mediators in periodontitis and cardiovascular disease. Annals of Periodontology 6 (2001) 30-40
9. Dayer J.M. The pivotal role of interleukin-1 in the clinical manifestations of rheumatoid arthritis. Rheumatology (Oxford) 42 Suppl. 2 (2003) ii3-ii10
10. Erlich J., Fearns C., Mathison J., Ulevitch R.J., and Mackman N. Lipopolysaccharide induction of tissue factor expression in rabbits. Infection and Immunity 67 (1999) 2540-2546
11. Gautier G., Humbert M., Deauvieau F., Scuiller M., Hiscott J., Bates E.E., et al. A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells. The Journal of Experimental Medicine 201 (2005) 1435-1446
12. Gidday J.M., Park T.S., Shah A.R., and Gonzales E.R. Modulation of basal and postischemic leukocyte-endothelial adherence by nitric oxide. Stroke 29 (1998) 1423-1429
13. Giroi B.P., Quint P.A., Barton P., Kirsch E.A., Kitchen L., Goldstein B., et al. Preliminary evaluation of recombinant amino-terminal fragment of human bactericidal/permeability-increasing protein in children with severe meningococcal sepsis. Lancet 350 (1997) 1439-1443
14. Glauser M.P. The inflammatory cytokines. New developments in the pathophysiology and treatment of septic shock. Drugs 52 S2 (1996) 9-17
15. Hawkey C.J. Cox-2 inhibitors. Lancet 353 (1999) 307-314
16. Inoue K., Takano H., Shimada A., Yanagisawa R., Sakurai M., Yoshino S., et al. Urinary trypsin inhibitor protects against systemic inflammation induced by lipopolysaccharide. Molecular Pharmacology 67 (2005) 673-680
17. Isomaki P., and Punnonen J. Pro and anti-inflammatory cytokines in rheumatoid arthritis. Annals of Medicine 29 (1997) 499-507
18. Jin C.Y., Lee J.D., Park C., Choi Y.H., and Kim G.Y. Curcumin attenuates the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated BV2 microglia. Acta Pharmacologica Sinica 28 (2007) 1645-1651
19. Lawrence T., Gilroy D.W., Colville-Nash P.R., and Willoughby D.A. Possible new role for NF-κB in the resolution of inflammation. Nature Medicine 7 (2001) 1291-1297
20. Ma Q., Kinneer K., Ye J., and Chen B.J. Inhibition of nuclear factor κB by phenolic antioxidants: interplay between antioxidant signaling and inflammatory cytokine expression. Molecular Pharmacology 64 (2003) 211-219
21. MacMicking J., Xie Q.W., and Nathan C. Nitric oxide and macrophage function. Annual Review of Immunology 15 (1997) 323-330
22. Makarov S.S. NF-κB as a therapeutic target in chronic inflammation: recent advances. Molecular Medicine Today 6 (2000) 441-448
23. Mitchell J.A., Larkin S., and Williams T.J. Cyclooxygenase 2: regulation and relevance in inflammation. Biochemical Pharmacology 50 (1995) 1535-1542
24. Natarajan K., Singh S., Burke Jr. T.R., Grunberger D., and Aggarwal B.B. Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proceedings of the National Academy of Sciences of the United States of America 93 (1996) 9090-9095
25. Opal S.M. The host response to endotoxin, antilipopolysaccharide strategies, and the management of severe sepsis. International Journal of Medical Microbiology 297 (2007) 365-377
26. Orsolic N., Terzic S., Mihaljevic Z., Sver L., and Basic I. Effects of local administration of propolis and its polyphenolic compounds on tumor formation and growth. Biological & Pharmaceutical Bulletin 28 (2005) 1928-1933
27. Pergola C., Rossi A., Dugo P., Cuzzocrea S., and Sautebin L. Inhibition of nitric oxide biosynthesis by anthocyanin fraction of blackberry extract. Nitric Oxide 15 (2006) 30-39
28. Petros A., Bennett D., and valance P. Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet 338 (1991) 1557-1558
29. Picot D., Loll P.J., and Garavito R.M. The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1. Nature 367 (1994) 243-249
30. Renard P., and Raes M. The proinflammatory transcription factor NF-κB: a potential target for novel therapeutical strategies. Cell Biology and Toxicology 15 (1999) 341-344
31. Smith W.L., Garavito R.M., and Dewitt D.L. Prostaglandin endoperoxide H synthases (cyclooxygenase)-1 and -2. The Journal of Biological Chemistry 271 (1996) 33157-33160
32. Stoclet J.C., Muller B., Andriantsitohaina R., and Kleschyov A. Overproduction of nitric oxide in pathophysiology of blood vessels. Biochemistry 63 (1998) 826-832
33. Suh S.J., Chung T.W., Son M.J., Kim S.H., Moon T.C., Son K.H., Kim H.P., et al. The naturally occurring biflavonoid, ochnaflavone, inhibits LPS-induced iNOS expression, which is mediated by ERK1/2 via NF-kappaB regulation, in RAW264.7 cells. Archives of Biochemistry and Biophysics 447 (2006) 136-146
34. Surh Y.J., Chun K.S., Cha H.H., Han S.S., Keum Y.S., Park K.K., et al. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-κB activation. Mutation Research 480-481 (2001) 243-268
35. Thiemermann C. Nitric oxide and septic shock. General Pharmacology 29 (1997) 159-166
36. Tilg H., Wilmer A., Vogel W., Herold M., Nolchen B., Judmaier G., et al. Serum levels of cytokines in chronic liver diseases. Gastroenterology 103 (1992) 264-274
37. Tracey K.J., and Cerami A. Studies of cachexia in parasitic infection. Annals of the New York Academy of Sciences 569 (1989) 211-218
38. Won J.H., Im H.T., Kim Y.H., Yun K.J., Park H.J., Choi J.W., et al. Anti-inflammatory effect of buddlejasaponin IV through the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via the NF-kappaB inactivation. British Journal of Pharmacology 148 (2006) 216-225
39. Xie Q.W., Kashiwabara Y., and Nathan C. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. The Journal of Biological Chemistry 269 (1994) 4705-4708
40. Zhang F.X., Kirschning C.J., Mancinelli R., Xu X.P., Jin Y., Faure E., et al. Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes. The Journal of Biological Chemistry 274 (1999) 7611-7614