Inhibition of nuclear factor κB by phenolic antioxidants: Interplay between antioxidant signaling and inflammatory cytokine expression

Molecular Pharmacology

Volumn 64, Issue 2, 2003, Pages 211-219

  Ma, Qiang ^a   Kinneer, Krista ^a   Ye, Jianping ^b   Chen, Bruce J ^a  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^b PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CYTOKINE; HYDROQUINONE; I KAPPA B ALPHA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; DNA SEQUENCE; DRUG MECHANISM; ENZYME ACTIVITY; GENE EXPRESSION; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPORTER GENE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIOXIDANTS; CELLS, CULTURED; CYTOKINES; DNA; MACROPHAGES; MICE; NF-KAPPA B; OXIDATION-REDUCTION; PHENOLS; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0041842588     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.64.2.211     Document Type: Article

References (40)

1. Adams J (2002) Proteasome inhibitors as new anticancer drugs. Curr Opin Oncol 14:628-634.
2. Aderem A and Ulevitch RJ (2000) Toll-like receptors in the induction of the innate immune response. Nature (Lond) 406:782-787.
3. Bjorkhem I, Henriksson-Freyschuss A, Breuer O, Diczfalusy U, Berglund L, and Henriksson P (1991) The antioxidant butylated hydroxytoluene protects against atherosclerosis. Arterioscler Thromb 11:15-22.
4. Chan K, Han XD, and Kan YW (2001) An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc Natl Acad Sci USA 98:4611-4616.
5. DiDonato JA (2000) Assaying for I kappa B kinase activity. Methods Enzymol 322:393-400.
6. Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y, Yamamoto M, and Talalay P (2002) Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci USA 99:11908-11913.
7. Feldmann M and Maini RN (2001) Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned? Annu Rev Immunol 19:163-196.
8. Futakuchi M, Hirose M, Miki T, Tanaka H, Ozaki M, and Shirai T (1998) Inhibition of DMBA-initiated rat mammary tumour development by 1-O-hexyl-2,3,5-trimethylhydroquinone, phenylethyl isothiocyanate and novel synthetic ascorbic acid derivatives. Eur J Cancer Prev 7:153-159.
9. Ghosh S and Karin M (2002) Missing pieces in the NF-kappaB puzzle. Cell 109 Suppl:S81-S96.
10. Hiramoto M, Shimizu N, Sugimoto K, Tang J, Kawakami Y, Ito M, Aizawa S, Tanaka H, Makino I, and Hands H (1998) Nuclear targeted suppression of NF-kappaB activity by the novel quinone derivative E3330. J Immunol 160:810-819.
11. Itoh K, Chiba T, Takahashi S, Ishii T, Igarashi K, Katoh Y, Oyake T, Hayashi N, Satoh K, Hatayama I, et al. (1997) An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun 236:313-322.
12. Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, and Yamamoto M (1999) Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 13:76-86.
13. Karin M and Lin A (2002) NF-kappaB at the crossroads of life and death. Nat Immunol 3:221-227.
14. Karin M, Takahashi T, Kapahi P, Delhase M, Chen Y, Makris C, Rothwarf D, Baud V, Natoli G, Guido F, et al. (2001) Oxidative stress and gene expression: the AP-1 and NF-kappaB connections. Biofactors 15:87-89.
15. Kwok BH, Koh B, Ndubuisi MI, Elofsson M, and Crews CM (2001) The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase. Chem Biol 8:759-766.
16. Laskin DL and Pendino KJ (1995) Macrophages and inflammatory mediators in tissue injury. Annu Rev Pharmacol Toxicol 35:655-677.
17. Li N and Karin M (1999) Is NF-kappaB the sensor of oxidative stress? FASEB J 13:1137-1143.
18. Locksley RM, Killeen N, and Lenardo MJ (2001) The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104:487-501.
19. Luster MI (1998) Inflammation, tumor necrosis factor and toxicology. Environ Health Perspect 106:A418-A419.
20. Luster MI, Simeonova PP, Gallucci R, and Matheson J (1999) Tumor necrosis factor alpha and toxicology. Crit Rev Toxicol 29:491-511.
21. Ma Q and Kinneer K (2002) Chemoprotection by phenolic antioxidants. Inhibition of tumor necrosis factor alpha induction in macrophages. J Biol Chem 277:2477-2484.
22. Nagakawa J, Hirota K, Hishinuma I, Miyamoto K, Sonoda J, Yamanaka T, Katayama K, and Yamatsu I (1993) Protective effect of E3330, a novel quinone derivative, in galactosamine-induced hepatitis in rats. J Pharmacol Exp Ther 264:496-500.
23. Nguyen T, Huang HC, and Pickett CB (2000) Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK. J Biol Chem 275:15466-73.
24. Nishi T, Shimizu N, Hiramoto M, Sato I, Yamaguchi Y, Hasegawa M, Aizawa S, Tanaka H, Kataoka K, Watanabe H, et al. (2002) Spatial redox regulation of a critical cysteine residue of NF-kappa B in vivo. J Biol Chem 277:44548-56.
25. Nishizono S, Hayami T, Ikeda I, and Imaizumi K (2000) Protection against the diabetogenic effect of feeding tert-butylhydroquinone to rats prior to the administration of streptozotocin. Biosci Biotechnol Biochem 64:1153-1158.
26. Novotny V, Prieschl EE, Csonga R, Fabjani G, and Baumruker T (1998) Nrfl in a complex with fosB, c-jun, junD and ATF2 forms the AP1 component at the TNF alpha promoter in stimulated mast cells. Nucleic Acids Res 26:5480-5485.
27. Nunn CJ (1991) Some comments on the dietary intake of butylated hydroxytoluene. Food Chem Toxicol 29:73-75.
28. Pomerantz JL and Baltimore D (2002) Two pathways to NF-kappaB. Mol Cell 10:693-695.
29. Prieschl EE, Novotny V, Csonga R, Jaksche D, Elbe-Burger A, Thumb W, Auer M, Stingl G, and Baumruker T (1998) A novel splice variant of the transcription factor Nrf1 interacts with the TNFalpha promoter and stimulates transcription. Nucleic Acids Res 26:2291-2297.
30. Prochaska HJ, De Long MJ, and Talalay P (1985) On the mechanisms of induction of cancer-protective enzymes: a unifying proposal. Proc Natl Acad Sci USA 82:8232-8236.
31. Ramos-Gomez M, Kwak MK, Dolan PM, Itoh K, Yamamoto M, Talalay P, and Kensler TW (2001) Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci USA 98:3410-3415.
32. Rushmore TH, Morton MR, and Pickett CB (1991) The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity. J Biol Chem 266:11632-9.
33. Shimizu N, Sugimoto K, Tang J, Nishi T, Sato I, Hiramoto M, Aizawa S, Hatakeyama M, Ohba R, Hatori H, et al. (2000) High-performance affinity beads for identifying drug receptors. Nat Biotechnol 18:877-881.
34. Sriram K, Matheson JM, Benkovic SA, Miller DB, Luster MI, and O'Callaghan JP (2002) Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: implications for Parkinson's disease. FASEB J 16:1474-1476.
35. Talalay P, De Long MJ, and Prochaska HJ (1988) Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis. Proc Natl Acad Sci USA 85:8261-8265.
36. Wattenberg LW, Coccia JB, and Lam LK (1980) Inhibitory effects of phenolic compounds on benzo(a)pyrene-induced neoplasia. Cancer Res 40:2820-2823.
37. Wills-Karp M (1999) Immunologic basis of antigen-induced airway hyperresponsiveness. Annu Rev Immunol 17:255-281.
38. Yang CS, Landau JM, Huang MT, and Newmark HL (2001) Inhibition of carcinoareinogenesis by dietary polyphenolic compounds. Annu Rev Nutr 21:381-406.
39. Ye J, Shi X, Jones W, Rojanasakul Y, Cheng N, Schwegler-Berry D, Baron P, Deye GJ, Li C and Castranova V (1999) Critical role of glass fiber length in TNF-alpha production and transcription factor activation in macrophages. Am J Physiol 276:L426-L434.
40. Zandi E, Rothwarf DM, Delhase M, Hayakawa M, and Karin M (1997) The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell 91:243-252.