A chimeric TCR-β chain confers increased susceptibility to EAE

Molecular Immunology

Volumn 44, Issue 14, 2007, Pages 3473-3481

  Petersen, Troels R ^a   Lata, Roleen ^a   Spittle, Evelyn ^a   Bäckström, B Thomas ^a,b  

^a MALAGHAN INSTITUTE OF MEDICAL RESEARCH   (New Zealand)

^b VICTORIA UNIVERSITY OF WELLINGTON   (New Zealand)

Author keywords

EAE; TCR; TH1 TH2

Indexed keywords

CHIMERIC PROTEIN; FAS ANTIGEN; FAS LIGAND; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL; TRANSGENIC MOUSE; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD95; CELL PROLIFERATION; CYTOTOXICITY, IMMUNOLOGIC; DISEASE SUSCEPTIBILITY; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FAS LIGAND PROTEIN; FEMALE; GLYCOPROTEINS; IMMUNIZATION; INTERFERON TYPE II; INTERLEUKIN-17; INTERLEUKIN-4; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ANTIGEN, T-CELL; RECOMBINANT PROTEINS; TH1 CELLS; TH2 CELLS;

MUS MUSCULUS;

EID: 34248571366     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2007.03.015     Document Type: Article

References (35)

1. Bäckström B.T., Milia E., Peter A., Jaureguiberry B., Baldari C.T., and Palmer E. A motif within the T cell receptor alpha chain constant region connecting peptide domain controls antigen responsiveness. Immunity 5 (1996) 437-447
2. Bäckström B.T., Muller U., Hausmann B., and Palmer E. Positive selection through a motif in the alphabeta T cell receptor. Science 281 (1998) 835-838
3. Balamuth F., Leitenberg D., Unternaehrer J., Mellman I., and Bottomly K. Distinct patterns of membrane microdomain partitioning in Th1 and th2 cells. Immunity 15 (2001) 729-738
4. Bettelli E., Pagany M., Weiner H.L., Linington C., Sobel R.A., and Kuchroo V.K. Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J. Exp. Med. 197 (2003) 1073-1081
5. Chen Y., Hancock W.W., Marks R., Gonnella P., and Weiner H.L. Mechanisms of recovery from experimental autoimmune encephalomyelitis: T cell deletion and immune deviation in myelin basic protein T cell receptor transgenic mice. J. Neuroimmunol. 82 (1998) 149-159
6. + T cell responses: the alternative approaches. Annu. Rev. Immunol. 15 (1997) 297-322
7. Dittel B.N., Merchant R.M., and Janeway Jr. C.A. Evidence for Fas-dependent and Fas-independent mechanisms in the pathogenesis of experimental autoimmune encephalomyelitis. J. Immunol. 162 (1999) 6392-6400
8. Dorado B., Portoles P., and Ballester S. NF-kappaB in Th2 cells: delayed and long-lasting induction through the TCR complex. Eur. J. Immunol. 28 (1998) 2234-2244
9. Gajewski T.F., Schell S.R., and Fitch F.W. Evidence implicating utilization of different T cell receptor-associated signaling pathways by TH1 and TH2 clones. J. Immunol. 144 (1990) 4110-4120
10. Hara H., Bakal C., Wada T., Bouchard D., Rottapel R., Saito T., and Penninger J.M. The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse. J. Exp. Med. 200 (2004) 1167-1177
11. + T cells. J. Exp. Med. 186 (1997) 757-766
12. Kawakami N., Lassmann S., Li Z., Odoardi F., Ritter T., Ziemssen T., Klinkert W.E., Ellwart J.W., Bradl M., Krivacic K., Lassmann H., Ransohoff R.M., Volk H.D., Wekerle H., Linington C., and Flugel A. The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis. J. Exp. Med. 199 (2004) 185-197
13. Kishimoto H., and Sprent J. A defect in central tolerance in NOD mice. Nat. Immunol. 2 (2001) 1025-1031
14. Kishimoto H., Surh C.D., and Sprent J. A role for Fas in negative selection of thymocytes in vivo. J. Exp. Med. 187 (1998) 1427-1438
15. Langrish C.L., Chen Y., Blumenschein W.M., Mattson J., Basham B., Sedgwick J.D., McClanahan T., Kastelein R.A., and Cua D.J. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201 (2005) 233-240
16. Lederer J.A., Liou J.S., Kim S., Rice N., and Lichtman A.H. Regulation of NF-kappa B activation in T helper 1 and T helper 2 cells. J. Immunol. 156 (1996) 56-63
17. Lumsden J.M., Roberts J.M., Harris N.L., Peach R.J., and Ronchese F. Differential requirement for CD80 and CD80/CD86-dependent co-stimulation in the lung immune response to an influenza virus infection. J. Immunol. 164 (2000) 79-85
18. Matsumoto R., Wang D., Blonska M., Li H., Kobayashi M., Pappu B., Chen Y., and Lin X. Phosphorylation of CARMA1 plays a critical role in T cell receptor-mediated NF-kappaB activation. Immunity 23 (2005) 575-585
19. Nicholson L.B., and Kuchroo V.K. Manipulation of the Th1/Th2 balance in autoimmune disease. Curr. Opin. Immunol. 8 (1996) 837-842
20. Okuda Y., Okuda M., and Bernard C.C. The suppression of T cell apoptosis influences the severity of disease during the chronic phase but not the recovery from the acute phase of experimental autoimmune encephalomyelitis in mice. J. Neuroimmunol. 131 (2002) 115-125
21. Park H., Li Z., Yang X.O., Chang S.H., Nurieva R., Wang Y.H., Wang Y., Hood L., Zhu Z., Tian Q., and Dong C. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 6 (2005) 1133-1141
22. Pender M.P. Activation-induced apoptosis of autoreactive and alloreactive T lymphocytes in the target organ as a major mechanism of tolerance. Immunol. Cell. Biol. 77 (1999) 216-223
23. Petersen T.R., Gulland S., Bettelli E., Kuchroo V., Palmer E., and Bäckström B.T. A chimeric T cell receptor with super-signaling properties. Int. Immunol. 16 (2004) 889-894
24. Ramsdell F., Seaman M.S., Miller R.E., Picha K.S., Kennedy M.K., and Lynch D.H. Differential ability of Th1 and Th2 T cells to express Fas ligand and to undergo activation-induced cell death. Int. Immunol. 6 (1994) 1545-1553
25. Ruedl C., Bachmann M.F., and Kopf M. The antigen dose determines T helper subset development by regulation of CD40 ligand. Eur. J. Immunol. 30 (2000) 2056-2064
26. Sabelko-Downes K.A., Cross A.H., and Russell J.H. Dual role for Fas ligand in the initiation of and recovery from experimental allergic encephalomyelitis. J. Exp. Med. 189 (1999) 1195-1205
27. Schmied M., Breitschopf H., Gold R., Zischler H., Rothe G., Wekerle H., and Lassmann H. Apoptosis of T lymphocytes in experimental autoimmune encephalomyelitis. Evidence for programmed cell death as a mechanism to control inflammation in the brain. Am. J. Pathol. 143 (1993) 446-452
28. Tamura T., Nakano H., Nagase H., Morokata T., Igarashi O., Oshimi Y., Miyazaki S., and Nariuchi H. Early activation signal transduction pathways of Th1 and Th2 cell clones stimulated with anti-CD3. Roles of protein tyrosine kinases in the signal for IL-2 and IL-4 production. J. Immunol. 155 (1995) 4692-4701
29. Teixeiro E., Daniels M.A., Hausmann B., Schrum A.G., Naeher D., Luescher I., Thome M., Bragado R., and Palmer E. T cell division and death are segregated by mutation of TCRbeta chain constant domains. Immunity 21 (2004) 515-526
30. Waldner H., Sobel R.A., Howard E., and Kuchroo V.K. Fas- and FasL-deficient mice are resistant to induction of autoimmune encephalomyelitis. J. Immunol. 159 (1997) 3100-3103
31. Walker L.S., and Abbas A.K. The enemy within: keeping self-reactive T cells at bay in the periphery. Nat. Rev. Immunol. 2 (2002) 11-19
32. Wang D., You Y., Case S.M., McAllister-Lucas L.M., Wang L., DiStefano P.S., Nunez G., Bertin J., and Lin X. A requirement for CARMA1 in TCR-induced NF-kappa B activation. Nat. Immunol. 3 (2002) 830-835
33. Weir C.R., Nicolson K., and Bäckström B.T. Experimental autoimmune encephalomyelitis induction in naive mice by dendritic cells presenting a self-peptide. Immunol. Cell. Biol. 80 (2002) 14-20
34. Williams K.C., Ulvestad E., and Hickey W.F. Immunology of multiple sclerosis. Clin. Neurosci. 2 (1994) 229-245
35. Zhang X., Brunner T., Carter L., Dutton R.W., Rogers P., Bradley L., Sato T., Reed J.C., Green D., and Swain S.L. Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis. J. Exp. Med. 185 (1997) 1837-1849