Distribution, proliferation, and function of paneth cells in uncomplicated and complicated adult celiac disease

American Journal of Clinical Pathology

Volumn 130, Issue 1, 2008, Pages 34-42

  Di Sabatino, Antonio ^a   Miceli, Emanuela ^a   Dhaliwal, Winnie ^b   Biancheri, Paolo ^a   Salerno, Raffaele ^d   Cantoro, Laura ^a   Vanoli, Alessandro ^a   De Vicenzi, Massima ^c   Del Vecchio Blanco, Camillo ^d   MacDonald, Thomas T ^b   Corazza, Gino R ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^d SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

defensin; Gliadin; Innate immunity; Ki 67; Refractory sprue

Indexed keywords

ALPHA DEFENSIN; ALPHA DEFENSIN 5; ALPHA DEFENSIN 6; GLIADIN;

ADULT; AGED; ARTICLE; CELIAC DISEASE; CELL COUNT; CELL FUNCTION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; ENTEROPATHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; INTESTINE BIOPSY; MALE; PANETH CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION; RNA TRANSCRIPTION; SMALL INTESTINE DISEASE; STATISTICAL SIGNIFICANCE; T CELL LYMPHOMA; ULCERATIVE JEJUNOILEITIS;

ADULT; AGED; ALPHA-DEFENSINS; CELIAC DISEASE; CELL PROLIFERATION; DUODENUM; FEMALE; HUMANS; INTESTINAL MUCOSA; KI-67 ANTIGEN; MALE; MIDDLE AGED; PANETH CELLS; RNA, MESSENGER;

EID: 48249138732     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/5ADNAR4VN11TTKQ6     Document Type: Article

References (36)

1. Porter EM, Bevins CL, Ghosh D, et al. The multifaceted Paneth cells. Cell Mol Life Sci. 2002;59:156-170.
2. Oulette AJ. Paneth cells and innate immunity in the crypt microenvironment. Gastroenterology. 1997;113:1779-1784.
3. Yang D, Chertov O, Bykovskaia SN, et al. β-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science. 1999;286:525-528.
4. Sollid LM. Coeliac disease: dissecting a complex inflammatory disorder. Nat Rev Immunol. 2002;2:647-655.
5. Stepniak D, Koning F. Celiac disease: sandwiched between innate and adaptive immunity. Hum Immunol. 2006;67:460-468.
6. Creamer B, Pink IJ. Paneth-cell deficiency. Lancet. 1967;1:304-306.
7. Ward A, Ferguson A, Eastwood MA. Jejunal lysozyme activity and the Paneth cell in coeliac disease. Gut. 1979;20:55-58.
8. Scott H, Brandtzaeg P. Enumeration of Paneth cells in coeliac disease: comparison of conventional light microscopy and immunofluorescence staining for lysozyme. Gut. 1981:22:812-816.
9. Elmes M, Jones JG, Stanton MR. Changes in the Paneth cell population of human small intestine assessed by image analysis of the secretory granule area. J Clin Pathol. 1983:36:867-872.
10. Kelly P, Feakins R, Domizio P, et al. Paneth cell granule depletion in the human small intestine under infective and nutritional stress. Clin Exp Immunol. 2004;135:303-309.
11. Forsberg G, Fahlgren A, Hörstedt P, et al. Presence of bacteria and innate immunity of intestinal epithelium in childhood celiac disease. Am J Gastroenterol. 2004;99:894-904.
12. Marsh MN. Gluten, major histocompatibility complex, and the small intestine: a molecular and immunobiologic approach to the spectrum of gluten sensitivity ("celiac sprue"). Gastroenterology. 1992;102:330-354.
13. Lendrum AC. The phloxine-tartrazine method as general histological stain and for the demonstration of inclusion bodies. J Pathol Bacteriol. 1947;59:399-404.
14. Möller P, Walczak H, Riedl S, et al. Paneth cells express high levels of CD ligand transcripts: a unique property among gastrointestinal epithelia. Am J Pathol. 1996;149:9-13.
15. Wong WM, Stamp GWH, Elia G, et al. Proliferative populations in intestinal metaplasia: evidence of deregulation in Paneth and goblet cells, but not endocrine cells. J Pathol. 2000;190:107-113.
16. Corazza GR, Frazzoni M, Dixon MF, et al. Quantitative assessment of the mucosal architecture of jejunal biopsy specimens: a comparison between linear measurement, stereology, and computer aided microscopy. J Clin Pathol. 1985;38:765-770.
17. Di Sabatino A, Pickard KM, Gordon JN, et al. Evidence for the role of interferon-alfa production by dendritic cells in the Th1 response in celiac disease. Gastroenterology. 2007;133:1175-1187.
18. Wehkamp J, Salzman NH, Porter E, et al. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A. 2005;102:18129-18134.
19. Gerdes J, Lemke H, Baisch H, et al. Cell cycle analysis of a cell proliferation associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol. 1984;133:1710-1715.
20. Savidge TC, Shmakov AN, Walker-Smith JA, et al. Epithelial cell proliferation in childhood enteropathies. Gut. 1996;39:185-193.
21. Moss SF, Attia L, Scholes JV, et al. Increased small intestinal apoptosis in coeliac disease. Gut. 1996;39:811-817.
22. Ayabe T, Satchell DP, Wilson CL, et al. Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol. 2000;1:113-118.
23. Schneider JJ, Unholzer A, Schaller M, et al. Human defensins. J Mol Med. 2005;83:587-595.
24. Bevins CL. Events at the host-microbial interface of the gastrointestinal tract, V: Paneth cell alpha-defensins in intestinal host defense. Am J Physiol Gastrointest Liver Physiol. 2005;289:G173-G176.
25. Ghosh D, Porter E, Shen B, et al. Paneth cell trypsin is the processing enzyme for human defensin-5. Nat Immunol. 2002;3:583-590.
26. Salzman NH, Ghosh D, Huttner KM, et al. Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature. 2003;422:522-526.
27. Cunliffe RN, Rose FR, Keyte J, et al. Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease. Gut. 2001;48:176-185.
28. Wehkamp J, Schwind B, Herrlinger KR, et al. Innate immunity and colonic inflammation: enhanced expression of epithelial alpha-defensins. Dig Dis Sci. 2002;47:1349-1355.
29. Lawrance IC, Fiocchi C, Chakravarti S. Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes. Hum Mol Genet. 2001;10:445-456.
30. Lala S, Ogura Y, Osborne C, et al. Crohn's disease and the NOD2 gene: a role for Paneth cells. Gastroenterology. 2003;125:47-57.
31. Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature. 2001;411:603-606.
32. Ogura Y, Lala S, Xin W, et al. Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis. Gut. 2003;52:1591-1597.
33. Wehkamp J, Harder J, Weichenthal M, et al. NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Gut. 2004;53:1658-1664.
34. Dvorak AM, Dickersin GR. Crohn's disease: transmission electron microscopic studies, I: barrier function: possible changes related to alterations of cell coat, mucous coat, epithelial cells, and Paneth cells. Hum Pathol. 1980;11:561-571.
35. Taha AS, Faccenda E, Angerson WJ, et al. Natural antibiotic expression in celiac disease: correlation with villous atrophy and response to a gluten-free diet. Dig Dis Sci. 2005;50:791-795.
36. Jahr H, Pfeiffer G, Hering BJ, et al. Endotoxin-mediated activation of cytokine production in human PBMCs by collagenase and Ficoll. J Mol Med. 1999;77:118-120.