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Volumn 20, Issue 8, 2008, Pages 981-991

Four novel ULBP splice variants are ligands for human NKG2D

Author keywords

MHC I like molecules; NK cells; Splice variants; Tumor immunity

Indexed keywords

BINDING PROTEIN; GAMMA INTERFERON; GLYCOPROTEIN; MONOCLONAL ANTIBODY; NATURAL KILLER CELL RECEPTOR NKG2D; RETINOIC ACID EARLY TRANSCRIPT 1 G3; UL16 BINDING PROTEIN; UL16 BINDING PROTEIN 4;

EID: 48249109843     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxn057     Document Type: Article
Times cited : (22)

References (49)
  • 1
    • 0142197631 scopus 로고    scopus 로고
    • Roles of the NKG2D immunoreceptor and its ligands
    • Raulet, D. H. 2003. Roles of the NKG2D immunoreceptor and its ligands. Nat. Rev. Immunol. 3:781.
    • (2003) Nat. Rev. Immunol , vol.3 , pp. 781
    • Raulet, D.H.1
  • 2
    • 5744233339 scopus 로고    scopus 로고
    • UL16 binding proteins
    • Cao, W. and He, W. 2004. UL16 binding proteins. Immunobiology 209:283.
    • (2004) Immunobiology , vol.209 , pp. 283
    • Cao, W.1    He, W.2
  • 3
    • 0035701536 scopus 로고    scopus 로고
    • A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3
    • Radosavljevic, M., Cuillerier, B., Wilson, M. J. et al. 2002. A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3. Genomics 79:114.
    • (2002) Genomics , vol.79 , pp. 114
    • Radosavljevic, M.1    Cuillerier, B.2    Wilson, M.J.3
  • 4
    • 0035695983 scopus 로고    scopus 로고
    • Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3
    • Radaev, S., Rostro, B., Brooks, A. G., Colonna, M. and Sun, P. D. 2001. Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3. Immunity 15:1039.
    • (2001) Immunity , vol.15 , pp. 1039
    • Radaev, S.1    Rostro, B.2    Brooks, A.G.3    Colonna, M.4    Sun, P.D.5
  • 5
    • 3142781416 scopus 로고    scopus 로고
    • Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D
    • Bacon, L., Eagle, R. A., Meyer, M., Easom, N., Young, N. T. and Trowsdale, J. 2004. Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D. J. Immunol. 173:1078.
    • (2004) J. Immunol , vol.173 , pp. 1078
    • Bacon, L.1    Eagle, R.A.2    Meyer, M.3    Easom, N.4    Young, N.T.5    Trowsdale, J.6
  • 6
    • 0037108353 scopus 로고    scopus 로고
    • Cutting edge: Murine UL16-bindinA protein-like transcript 1: a newly described transcript encoding a high-affinity ligand for murine NKG2D
    • Carayannopoulos, L. N., Naidenko, O. V., Fremont, D. H. and Yokoyama, W. M. 2002. Cutting edge: Murine UL16-bindinA protein-like transcript 1: a newly described transcript encoding a high-affinity ligand for murine NKG2D. J. Immunol. 169:4079.
    • (2002) J. Immunol , vol.169 , pp. 4079
    • Carayannopoulos, L.N.1    Naidenko, O.V.2    Fremont, D.H.3    Yokoyama, W.M.4
  • 7
    • 0037080348 scopus 로고    scopus 로고
    • UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells
    • Sutherland, C. L., Chalupny, N. J., Schooley, K., VandenBos, T., Kubin, M. and Cosman, D. 2002. UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells. J. Immunol. 168:671.
    • (2002) J. Immunol , vol.168 , pp. 671
    • Sutherland, C.L.1    Chalupny, N.J.2    Schooley, K.3    VandenBos, T.4    Kubin, M.5    Cosman, D.6
  • 8
    • 0035099068 scopus 로고    scopus 로고
    • ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor
    • Cosman, D., Mullberg, J., Sutherland, C. L. et al. 2001. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity 14:123.
    • (2001) Immunity , vol.14 , pp. 123
    • Cosman, D.1    Mullberg, J.2    Sutherland, C.L.3
  • 10
    • 0035286345 scopus 로고    scopus 로고
    • Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells
    • Groh, V., Rhinehart, R., Randolph-Habecker, J., Topp, M. S., Riddell, S. R. and Spies, T. 2001. Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells. Nat. Immunol. 2:255.
    • (2001) Nat. Immunol , vol.2 , pp. 255
    • Groh, V.1    Rhinehart, R.2    Randolph-Habecker, J.3    Topp, M.S.4    Riddell, S.R.5    Spies, T.6
  • 11
    • 0034897362 scopus 로고    scopus 로고
    • MICA engagement by human Vgamma2Vdelta2 T cells enhances their antigen-dependent effector function
    • Das, H., Groh, V., Kuijl, C. et al. 2001. MICA engagement by human Vgamma2Vdelta2 T cells enhances their antigen-dependent effector function. Immunity 15:83.
    • (2001) Immunity , vol.15 , pp. 83
    • Das, H.1    Groh, V.2    Kuijl, C.3
  • 12
    • 0036915968 scopus 로고    scopus 로고
    • Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D
    • Diefenbach, A., Tomasello, E., Lucas, M. et al. 2002. Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. Nat. Immunol. 3:1142.
    • (2002) Nat. Immunol , vol.3 , pp. 1142
    • Diefenbach, A.1    Tomasello, E.2    Lucas, M.3
  • 13
    • 0036910991 scopus 로고    scopus 로고
    • NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation
    • Gilfillan, S., Ho, E. L., Cella, M., Yokoyama, W. M. and Colonna, M. 2002. NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat. Immunol. 3:1150.
    • (2002) Nat. Immunol , vol.3 , pp. 1150
    • Gilfillan, S.1    Ho, E.L.2    Cella, M.3    Yokoyama, W.M.4    Colonna, M.5
  • 15
    • 23844500629 scopus 로고    scopus 로고
    • Costimulation through NKG2D enhances murine CD8+ CTL function: Similarities and differences between NKG2D and CD28 costimulation
    • Markiewicz, M. A., Carayannopoulos, L. N., Naidenko, O. V. et al. 2005. Costimulation through NKG2D enhances murine CD8+ CTL function: similarities and differences between NKG2D and CD28 costimulation. J. Immunol. 175:2825.
    • (2005) J. Immunol , vol.175 , pp. 2825
    • Markiewicz, M.A.1    Carayannopoulos, L.N.2    Naidenko, O.V.3
  • 17
    • 4444240035 scopus 로고    scopus 로고
    • Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease
    • Meresse, B., Chen, Z., Ciszewski, C. et al. 2004. Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity 21:357.
    • (2004) Immunity , vol.21 , pp. 357
    • Meresse, B.1    Chen, Z.2    Ciszewski, C.3
  • 18
    • 4644221125 scopus 로고    scopus 로고
    • Self-reactive memory-phenotype CD8 T cells exhibit both MHC-restricted and non-MHC-restricted cytotoxicity: A role for the T-cell receptor and natural killer cell receptors
    • Dhanji, S., Teh, S. J., Oble, D., Priatel, J. J. and Teh, H. S. 2004. Self-reactive memory-phenotype CD8 T cells exhibit both MHC-restricted and non-MHC-restricted cytotoxicity: A role for the T-cell receptor and natural killer cell receptors. Blood 104:2116.
    • (2004) Blood , vol.104 , pp. 2116
    • Dhanji, S.1    Teh, S.J.2    Oble, D.3    Priatel, J.J.4    Teh, H.S.5
  • 19
    • 1842526956 scopus 로고    scopus 로고
    • Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8+ T cells
    • Verneris, M. R., Karami, M., Baker, J., Jayaswal, A. and Negrin, R. S. 2004. Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8+ T cells. Blood 103:3065.
    • (2004) Blood , vol.103 , pp. 3065
    • Verneris, M.R.1    Karami, M.2    Baker, J.3    Jayaswal, A.4    Negrin, R.S.5
  • 20
    • 0042467770 scopus 로고    scopus 로고
    • NKG2D engagement of colorectal cancer-specific T cells strengthens TCR-mediated antigen stimulation and elicits TCR independent anti-tumor activity
    • Maccalli, C., Pende, D., Castelli, C., Mingari, M. C., Robbins, P. F. and Parmiani, G. 2003. NKG2D engagement of colorectal cancer-specific T cells strengthens TCR-mediated antigen stimulation and elicits TCR independent anti-tumor activity. Eur. J. Immunol. 33:2033.
    • (2003) Eur. J. Immunol , vol.33 , pp. 2033
    • Maccalli, C.1    Pende, D.2    Castelli, C.3    Mingari, M.C.4    Robbins, P.F.5    Parmiani, G.6
  • 21
    • 33646127371 scopus 로고    scopus 로고
    • NKG2D ligation without T cell receptor engagement triggers both cytotoxicity and cytokine production in dendritic epidermal T cells
    • Nitahara, A., Shimura, H., Ito, A., Tomiyama, K., Ito, M. and Kawai, K. 2006. NKG2D ligation without T cell receptor engagement triggers both cytotoxicity and cytokine production in dendritic epidermal T cells. J. Invest. Dermatol. 126:1052.
    • (2006) J. Invest. Dermatol , vol.126 , pp. 1052
    • Nitahara, A.1    Shimura, H.2    Ito, A.3    Tomiyama, K.4    Ito, M.5    Kawai, K.6
  • 22
    • 33747189760 scopus 로고    scopus 로고
    • ULBPs, human ligands of the NKG2D receptor, stimulate tumor immunity with enhancement by IL-15
    • Sutherland, C. L., Rabinovich, B., Chalupny, N. J., Brawand, P., Miller, R. and Cosman, D. 2006. ULBPs, human ligands of the NKG2D receptor, stimulate tumor immunity with enhancement by IL-15. Blood 108:1313.
    • (2006) Blood , vol.108 , pp. 1313
    • Sutherland, C.L.1    Rabinovich, B.2    Chalupny, N.J.3    Brawand, P.4    Miller, R.5    Cosman, D.6
  • 23
    • 0035855872 scopus 로고    scopus 로고
    • Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity
    • Diefenbach, A., Jensen, E. R., Jamieson, A. M. and Raulet, D. H. 2001. Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity. Nature 413:165.
    • (2001) Nature , vol.413 , pp. 165
    • Diefenbach, A.1    Jensen, E.R.2    Jamieson, A.M.3    Raulet, D.H.4
  • 24
    • 23344434099 scopus 로고    scopus 로고
    • DNA-based vaccines activate innate and adaptive antitumor immunity by engaging the NKG2D receptor
    • Zhou, H., Luo, Y., Lo, J. F. et al. 2005. DNA-based vaccines activate innate and adaptive antitumor immunity by engaging the NKG2D receptor. Proc. Natl Acad. Sci. USA 102:10846.
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 10846
    • Zhou, H.1    Luo, Y.2    Lo, J.F.3
  • 25
    • 33645747921 scopus 로고    scopus 로고
    • A DNA-based cancer vaccine enhances lymphocyte cross talk by engaging the NKG2D receptor
    • Zhou, H., Luo, Y., Kaplan, C. D. et al. 2006. A DNA-based cancer vaccine enhances lymphocyte cross talk by engaging the NKG2D receptor. Blood 107:3251.
    • (2006) Blood , vol.107 , pp. 3251
    • Zhou, H.1    Luo, Y.2    Kaplan, C.D.3
  • 26
    • 0037126310 scopus 로고    scopus 로고
    • Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation
    • Groh, V., Wu, J., Yee, C. and Spies, T. 2002. Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Nature 419:734.
    • (2002) Nature , vol.419 , pp. 734
    • Groh, V.1    Wu, J.2    Yee, C.3    Spies, T.4
  • 27
    • 0037108517 scopus 로고    scopus 로고
    • Cutting edge: Down-regulation of MICA on human tumors by proteolytic shedding
    • Salih, H. R., Rammensee, H. G. and Steinle, A. 2002. Cutting edge: down-regulation of MICA on human tumors by proteolytic shedding. J. Immunol 169:4098.
    • (2002) J. Immunol , vol.169 , pp. 4098
    • Salih, H.R.1    Rammensee, H.G.2    Steinle, A.3
  • 28
    • 0041737499 scopus 로고    scopus 로고
    • Functional expression and release of ligands for the activating immuno-receptor NKG2D in leukemia
    • Salih, H. R., Antropius, H., Gieseke, F. et al. 2003. Functional expression and release of ligands for the activating immuno-receptor NKG2D in leukemia. Blood 102:1389.
    • (2003) Blood , vol.102 , pp. 1389
    • Salih, H.R.1    Antropius, H.2    Gieseke, F.3
  • 29
    • 33645049837 scopus 로고    scopus 로고
    • Proteolytic release of soluble UL16-binding protein 2 from tumor cells
    • Waldhauer, I. and Steinle, A. 2006. Proteolytic release of soluble UL16-binding protein 2 from tumor cells. Cancer Res. 66:2520.
    • (2006) Cancer Res , vol.66 , pp. 2520
    • Waldhauer, I.1    Steinle, A.2
  • 30
    • 33745236078 scopus 로고    scopus 로고
    • Soluble ULBP suppresses natural killer cell activity via down-regulating NKG2D expression
    • Song, H., Kim, J., Cosman, D. and Choi, I. 2006. Soluble ULBP suppresses natural killer cell activity via down-regulating NKG2D expression. Cell Immunol. 239:22.
    • (2006) Cell Immunol , vol.239 , pp. 22
    • Song, H.1    Kim, J.2    Cosman, D.3    Choi, I.4
  • 31
    • 33748323243 scopus 로고    scopus 로고
    • Soluble MICB in malignant diseases: Analysis of diagnostic significance and correlation with soluble MICA
    • Holdenrieder, S., Stieber, P., Peterfi, A., Nagel, D., Steinle, A. and Salih, H. R. 2006. Soluble MICB in malignant diseases: Analysis of diagnostic significance and correlation with soluble MICA. Cancer Immunol. Immunother 55:1584.
    • (2006) Cancer Immunol. Immunother , vol.55 , pp. 1584
    • Holdenrieder, S.1    Stieber, P.2    Peterfi, A.3    Nagel, D.4    Steinle, A.5    Salih, H.R.6
  • 33
    • 33749593916 scopus 로고    scopus 로고
    • Soluble MIC is elevated in the serum of patients with pancreatic carcinoma diminishing gammadelta T cell cytotoxicity
    • Marten, A., von Lilienfeld-Toal, M., Buchler, M. W. and Schmidt, J. 2006. Soluble MIC is elevated in the serum of patients with pancreatic carcinoma diminishing gammadelta T cell cytotoxicity. Int. J. Cancer 119:2359.
    • (2006) Int. J. Cancer , vol.119 , pp. 2359
    • Marten, A.1    von Lilienfeld-Toal, M.2    Buchler, M.W.3    Schmidt, J.4
  • 34
    • 0037126312 scopus 로고    scopus 로고
    • Immunology: Catch us if you can
    • Yokoyama, W. M. 2002. Immunology: Catch us if you can. Nature 419:679.
    • (2002) Nature , vol.419 , pp. 679
    • Yokoyama, W.M.1
  • 35
    • 34547132338 scopus 로고    scopus 로고
    • RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity
    • Cao, W., Xi, X., Hao, Z. et al. 2007. RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity. J. Biol. Chem. 282:18922.
    • (2007) J. Biol. Chem , vol.282 , pp. 18922
    • Cao, W.1    Xi, X.2    Hao, Z.3
  • 36
    • 33344477900 scopus 로고    scopus 로고
    • A novel bispecific protein (ULBP2-BB4) targeting the NKG2D receptor on natural killer (NK) cells and CD138 activates NK cells and has potent antitumor activity against human multiple myeloma in vitro and in vivo
    • von Strandmann, E. P., Hansen, H. P., Reiners, K. S. et al. 2006. A novel bispecific protein (ULBP2-BB4) targeting the NKG2D receptor on natural killer (NK) cells and CD138 activates NK cells and has potent antitumor activity against human multiple myeloma in vitro and in vivo. Blood 107:1955.
    • (2006) Blood , vol.107 , pp. 1955
    • von Strandmann, E.P.1    Hansen, H.P.2    Reiners, K.S.3
  • 37
    • 1542433160 scopus 로고    scopus 로고
    • Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells
    • Conejo-Garcia, J. R., Benencia, F., Courreges, M. C. et al. 2003. Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells. Cancer Biol. Ther. 2:446.
    • (2003) Cancer Biol. Ther , vol.2 , pp. 446
    • Conejo-Garcia, J.R.1    Benencia, F.2    Courreges, M.C.3
  • 39
    • 0036829733 scopus 로고    scopus 로고
    • Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: Analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity
    • Pende, D., Rivera, P., Marcenaro, S. et al. 2002. Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: Analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity. Cancer Res. 62:6178.
    • (2002) Cancer Res , vol.62 , pp. 6178
    • Pende, D.1    Rivera, P.2    Marcenaro, S.3
  • 40
    • 0035347169 scopus 로고    scopus 로고
    • Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA
    • Li, P., Morris, D. L., Willcox, B. E., Steinle, A., Spies, T. and Strong, R. K. 2001. Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA. Nat. Immunol. 2:443.
    • (2001) Nat. Immunol , vol.2 , pp. 443
    • Li, P.1    Morris, D.L.2    Willcox, B.E.3    Steinle, A.4    Spies, T.5    Strong, R.K.6
  • 41
    • 0034567210 scopus 로고    scopus 로고
    • Comparative protein structure modeling. Introduction and practical examples with modeller
    • Sanchez, R. and Sali, A. 2000. Comparative protein structure modeling. Introduction and practical examples with modeller. Methods Mol. Biol. 143:97.
    • (2000) Methods Mol. Biol , vol.143 , pp. 97
    • Sanchez, R.1    Sali, A.2
  • 42
    • 0038526303 scopus 로고    scopus 로고
    • ZDOCK: An initial-stage protein-docking algorithm
    • Chen, R., Li, L. and Weng, Z. 2003. ZDOCK: An initial-stage protein-docking algorithm. Proteins 52:80.
    • (2003) Proteins , vol.52 , pp. 80
    • Chen, R.1    Li, L.2    Weng, Z.3
  • 43
    • 0031473847 scopus 로고    scopus 로고
    • SWISS-MODEL and the Swiss-PdbViewer: An environment for comparative protein modeling
    • Guex, N. and Peitsch, M. C. 1997. SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 18:2714.
    • (1997) Electrophoresis , vol.18 , pp. 2714
    • Guex, N.1    Peitsch, M.C.2
  • 45
    • 34548247599 scopus 로고    scopus 로고
    • Promiscuity and the single receptor: NKG2D
    • Eagle, R. A. and Trowsdale, J. 2007. Promiscuity and the single receptor: NKG2D. Nat. Rev. Immunol. 7:737.
    • (2007) Nat. Rev. Immunol , vol.7 , pp. 737
    • Eagle, R.A.1    Trowsdale, J.2
  • 46
    • 0037905745 scopus 로고    scopus 로고
    • Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity
    • Dunn, C., Chalupny, N. J., Sutherland, C. L. et al. 2003. Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity. J. Exp. Med. 197:1427.
    • (2003) J. Exp. Med , vol.197 , pp. 1427
    • Dunn, C.1    Chalupny, N.J.2    Sutherland, C.L.3
  • 47
    • 33744990829 scopus 로고    scopus 로고
    • Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142
    • Chalupny, N. J., Rein-Weston, A., Dosch, S. and Cosman, D. 2006. Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142. Biochem. Biophys. Res. Commun. 346:175.
    • (2006) Biochem. Biophys. Res. Commun , vol.346 , pp. 175
    • Chalupny, N.J.1    Rein-Weston, A.2    Dosch, S.3    Cosman, D.4
  • 48
    • 33846141778 scopus 로고    scopus 로고
    • Human immunodeficiency virus 1 Nef protein downmodulates the ligands of the activating receptor NKG2D and inhibits natural killer cell-mediated cytotoxicity
    • Cerboni, C., Neri, F., Casartelli, N. et al. 2007. Human immunodeficiency virus 1 Nef protein downmodulates the ligands of the activating receptor NKG2D and inhibits natural killer cell-mediated cytotoxicity. J. Gen. Virol. 88:242.
    • (2007) J. Gen. Virol , vol.88 , pp. 242
    • Cerboni, C.1    Neri, F.2    Casartelli, N.3
  • 49
    • 33749593916 scopus 로고    scopus 로고
    • Soluble MIC is elevated in the serum of patients with pancreatic carcinoma diminishing gammadelta T cell cytotoxicity
    • Marten, A., von Lilienfeld-Toal, M., Buchler, M. W. and Schmidt, J. 2006. Soluble MIC is elevated in the serum of patients with pancreatic carcinoma diminishing gammadelta T cell cytotoxicity. Int. J. Cancer 119:2359.
    • (2006) Int. J. Cancer , vol.119 , pp. 2359
    • Marten, A.1    von Lilienfeld-Toal, M.2    Buchler, M.W.3    Schmidt, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.