Self-reactive memory-phenotype CD8 T cells exhibit both MHC-restricted and non-MHC-restricted cytotoxicity: A role for the T-cell receptor and natural killer cell receptors

Blood

Volumn 104, Issue 7, 2004, Pages 2116-2123

  Dhanji, Salim ^a   Teh, Soo Jeet ^a   Oble, Darryl ^a   Priatel, John J ^a   Teh, Hung Sia ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CD8 ANTIGEN; HY ANTIGEN; KILLER CELL ACTIVATING RECEPTOR ASSOCIATED PROTEIN; NATURAL KILLER CELL RECEPTOR NKG2D; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; BACTERIAL INFECTION; CELL FUNCTION; CELL KILLING; CELL MATURATION; CONTROLLED STUDY; CYTOTOXICITY; IN VITRO STUDY; IN VIVO STUDY; LYMPHOID TISSUE; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MEMORY CELL; MOUSE; NATURAL KILLER CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE ACTIVATION; TARGET CELL; TRANSGENIC MOUSE; TUMOR CELL;

EID: 4644221125     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2004-01-0150     Document Type: Article

References (37)

1. Teh HS, Kisielow P, Scott B, et al. Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells. Nature. 1988;335:229-233.
2. Kisielow P, Teh HS, Bluthmann H, von Boehmer H. Positive selection of antigen-specific T cells in thymus by restricting MHC molecules. Nature. 1988;335:730-733.
3. Kisielow P, Bluthmann H, Staerz UD, Steinmetz M, von Boehmer H. Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes. Nature. 1988;333:742-746.
4. Teh HS, Kishi H, Scott B, Von Boehmer H. Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules. J Exp Med. 1989;169:795-806.
5. von Boehmer H, Kirberg J, Rocha B. An unusual lineage of alpha/beta T cells that contains autoreactive cells. J Exp Med. 1991;174:1001-1008.
6. Yamada H, Ninomiya T, Hashimoto A, Tamada K, Takimoto H, Nomoto K. Positive selection of extrathymically developed T cells by self-antigens. J Exp Med. 1998;188:779-784.
7. Pihlgren M, Arpin C, Walzer T, et al. Memory CD44(int) CD8 T cells show increased proliferative responses and IFN-gamma production following antigenic challenge in vitro. Int Immunol. 1999;11:699-706.
8. Yamada H, Matsuzaki G, Chen Q, Iwamoto Y, Nomoto K. Reevaluation of the origin of CD44(high) "memory phenotype" CD8 T cells: comparison between memory CD8 T cells and thymus-independent CD8 T cells. Eur J Immunol. 2001;31:1917-1926.
9. Yamada H, Nakamura T, Matsuzaki G, Iwamoto Y, Nomoto K. TCR-independent activation of extrathymically developed, self antigen-specific T cells by IL-2/IL-15. J Immunol. 2000;164:1746-1752.
10. Harada M, Yamada H, Tatsugami K, Nomoto K. Evidence of the extrathymic development of tyrosinase-related protein-2-recognizing CD8+ T cells with low avidity. Immunology. 2001;104:67-74.
11. Opferman JT, Ober BT, Ashton-Rickardt PG. Linear differentiation of cytotoxic effectors into memory T lymphocytes. Science. 1999;283:1745-1748.
12. Yamada H, Matsuzaki G, Iwamoto Y, Nomoto K. Unusual cytotoxic activities of thymus-independent, self-antigen-specific CD8(+) T cells. Int Immunol. 2000;12:1677-1683.
13. Tsunobuchi H, Nishimura H, Goshima F, Daikoku T, Nishiyama Y, Yoshikai Y. Memory-type CD8+ T cells protect IL-2 receptor alpha-deficient mice from systemic infection with herpes simplex virus type 2. J Immunol. 2000;165:4552-4560.
14. Lertmemongkolchai G, Cai G, Hunter CA, Bancroft GJ. Bystander activation of CD8+ T cells contributes to the rapid production of IFN-gamma in response to bacterial pathogens. J Immunol. 2001;166:1097-1105.
15. high cells express both adaptive and innate immune system receptors and demonstrate specificity for syngeneic tumor cells. J Immunol. 2003;171:3442-3450.
16. Ho EL, Carayannopoulos LN, Poursine-Laurent J, et al. Costimulation of multiple NK cell activation receptors by NKG2D. J Immunol. 2002;169:3667-3675.
17. Cerwenka A, Baron JL, Lanier LL. Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class 1-bearing tumor in vivo. Proc Natl Acad Sci U S A. 2001;98:11521-11526.
18. Markiewicz M A, Girao C, Opferman JT, et al. Long-term T cell memory requires the surface expression of self-peptide/major histocompatibility complex molecules. Proc Natl Acad Sci U S A. 1998;95;3065-3070.
19. von Boehmer H, Teh HS, Kisielow P. The thymus selects the useful, neglects the useless and destroys the harmful. Immunol Today. 1989;10:57-61.
20. Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell. 1998;92:83-92.
21. Kersh EN, Kaech SM, Onami TM, et al. TCR signal transduction in antigen-specific memory CD8 T cells. J Immunol. 2002;170:5455-5463.
22. Kieper WC, Burghardt JT, Surh CD. A role for TCR affinity in regulating naive T cell homeostasis. J Immunol. 2004;172:40-44.
23. Tan JT, Ernst B, Kieper WC, LeRoy E, Sprent J, Surh CD. Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells. J Exp Med. 2002;195:1523-1532.
24. Tanchot C, Lemonnier FA, Perarnau B, Freitas AA, Rocha B. Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science. 1997;276:2057-2062.
25. Jiang J, Lau LL, Shen H. Selective depletion of nonspecific T cells during the early stage of immune responses to infection. J Immunol. 2003;171:4352-4358.
26. Diefenbach A, Jamieson AM, Liu SD, Shastri N, Raulet DH. Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages. Nat Immunol. 2000;1:119-126.
27. Gilfillan S, Ho EL, Cella M, Yokoyama WM, Colonna M. NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat Immunol. 2002;3:1150-1155.
28. Diefenbach A, Tomasello E, Lucas M, et al. Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. Nat Immunol. 2002;3:1142-1149.
29. Kronenberg M, Gapin L. The unconventional lifestyle of NKT cells. Nat Rev Immunol. 2002;2:557-568.
30. Brigl M, Bry L, Kent SC, Gumperz JE, Brenner MB. Mechanism of CD1d-restricted natural killer T cell activation during microbial infection. Nat Immunol. 2003;4:1230-1237.
31. Park SH, Benlagha K, Lee D, Balish E, Bendelac A. Unaltered phenotype, tissue distribution and function of Valpha14(+) NKT cells in germ-free mice. Eur J Immunol. 2000;30:620-625.
32. Ernst B, Lee DS, Chang JM, Sprent J, Surh CD. The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery. Immunity. 1999;11:173-181.
33. Taniguchi M, Nakayama T. Recognition and function of Valpha14 NKT cells. Semin Immunol. 2000;12:543-550.
34. Urdahl KB, Sun JC, Bevan MJ. Positive selection of MHC class Ib-restricted CD8(+) T cells on hematopoietic cells. Nat Immunol. 2002;3:772-779.
35. Kerksiek KM, Busch DH, Pilip IM, Allen SE, Pamer EG. H2-M3-restricted T cells in bacterial infection: rapid primary but diminished memory responses. J Exp Med. 1999;190:195-204.
36. Diefenbach A, Jensen ER, Jamieson AM, Raulet DH. Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity. Nature. 2001;413:165-171.
37. Murga M, Fernandez-Capetillo O, Field SJ, et al. Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity. Immunity. 2001;15:959-970.