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Volumn 46, Issue 6, 2005, Pages 664-671

Molecular characterization of a neutralizing murine monoclonal antibody against Tityus serrulatus scorpion venom

Author keywords

Epitope; Immunization; Monoclonal antibody; Peptide; Tityus toxins

Indexed keywords

BOVINE SERUM ALBUMIN; EPITOPE; GLUTARALDEHYDE; HYBRID PROTEIN; LYSINE; LYSYLLYSYLGLYCYLSERYLSERYLGLYCYLTYROSYLSERYLALANYLTRYPTOPHYLPROLYLALANYL SERYLTYROSYLSERINE; LYSYLLYSYLSERYLLYSYLASPARTYLLYSYLLYSYLALANYLASPARTYLSERYLGLYCYLTYROSYL SERYLTYROSYLTRYPTOPHAN; MONOCLONAL ANTIBODY; NEUROTOXIN; NEUTRALIZING ANTIBODY; PROTEIN DERIVATIVE; SCORPION VENOM; SYNTHETIC PEPTIDE; TITYUS TOXIN; UNCLASSIFIED DRUG;

EID: 26444507281     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2005.07.014     Document Type: Article
Times cited : (25)

References (40)
  • 1
    • 1642452868 scopus 로고    scopus 로고
    • Production of monoclonal antibodies capable of neutralizing dermonecrotic activity of Loxosceles intermedia spider venom and their use in a specific immunometric assay
    • L.M. Alvarenga, M.S. Martins, J.F. Moura, E. Kalapothakis, J.C. Oliveira, O.C. Mangili, C. Granier, and C. Chavez-Olortegui Production of monoclonal antibodies capable of neutralizing dermonecrotic activity of Loxosceles intermedia spider venom and their use in a specific immunometric assay Toxicon 42 2003 725 731
    • (2003) Toxicon , vol.42 , pp. 725-731
    • Alvarenga, L.M.1    Martins, M.S.2    Moura, J.F.3    Kalapothakis, E.4    Oliveira, J.C.5    Mangili, O.C.6    Granier, C.7    Chavez-Olortegui, C.8
  • 3
    • 0022624191 scopus 로고
    • Specifity and neutralizing capacity of antibodies elicited by Synthetic peptide of scorpion toxin
    • E. Bahraoui, C. Granier, J. Van Riestchoten, H. Rochat, and M. El Ayeb Specifity and neutralizing capacity of antibodies elicited by Synthetic peptide of scorpion toxin J. Immunol. 136 1986 3371 3377
    • (1986) J. Immunol. , vol.136 , pp. 3371-3377
    • Bahraoui, E.1    Granier, C.2    Van Riestchoten, J.3    Rochat, H.4    El Ayeb, M.5
  • 4
    • 0033568324 scopus 로고    scopus 로고
    • Mapping of an epitope recognized by a neutralizing monoclonal antibody specific to toxin Cn2 from the scorpion Centruroides noxius, using discontinuous synthetic peptides
    • E.S. Calderon-Aranda, B. Selisko, E.J. York, G.B. Gurrola, J.M. Stewart, and L.D. Possani Mapping of an epitope recognized by a neutralizing monoclonal antibody specific to toxin Cn2 from the scorpion Centruroides noxius, using discontinuous synthetic peptides Eur. J. Biochem. 264 1999 746 755
    • (1999) Eur. J. Biochem. , vol.264 , pp. 746-755
    • Calderon-Aranda, E.S.1    Selisko, B.2    York, E.J.3    Gurrola, G.B.4    Stewart, J.M.5    Possani, L.D.6
  • 5
    • 0002009760 scopus 로고
    • Signs, symptoms and treatment of severe scorpion poisoning in children
    • D. Eaker T. Wadstrom Oxford Pergamon Press
    • J.A. Campos, S. Silva, M. Lopez, and L. Freire-Maia Signs, symptoms and treatment of severe scorpion poisoning in children D. Eaker T. Wadstrom Natural Toxins 1980 Oxford Pergamon Press 61 62 PressCardoso e cols., 1995
    • (1980) Natural Toxins , pp. 61-62
    • Campos, J.A.1    Silva, S.2    Lopez, M.3    Freire-Maia, L.4
  • 7
    • 0028670626 scopus 로고
    • ELISA for the detection of toxic antigens in experimental and clinical envenoming by Tityus serrulatus scorpion venom
    • C. Chavéz-Olórtegui, S.C.G. Fonseca, D. Campolina, C.F.S. Amaral, and C.R. Diniz ELISA for the detection of toxic antigens in experimental and clinical envenoming by Tityus serrulatus scorpion venom Toxicon 32 1994 1649 1656
    • (1994) Toxicon , vol.32 , pp. 1649-1656
    • Chavéz-Olórtegui, C.1    Fonseca, S.C.G.2    Campolina, D.3    Amaral, C.F.S.4    Diniz, C.R.5
  • 9
    • 0036196723 scopus 로고    scopus 로고
    • Molecular basis for the cross-reactive of antibodies elicited by a natural anatoxin with α- And β-toxins from the venom of Tityus serrulatus scorpion
    • C. Chávez-Olórtegui, F. Molina, and G. Granier Molecular basis for the cross-reactive of antibodies elicited by a natural anatoxin with α- and β-toxins from the venom of Tityus serrulatus scorpion Mol. Immunol. 38 2002 867 876
    • (2002) Mol. Immunol. , vol.38 , pp. 867-876
    • Chávez-Olórtegui, C.1    Molina, F.2    Granier, G.3
  • 10
    • 14244265321 scopus 로고    scopus 로고
    • Common features in the functional surface of scorpion beta-toxins and elements that confer specificity for insect and mammalian voltage-gated sodium channels
    • L. Cohen, I. Karbat, N. Gilles, N. Ilan, M. Benveniste, D. Gordon, and M. Gurevitz Common features in the functional surface of scorpion beta-toxins and elements that confer specificity for insect and mammalian voltage-gated sodium channels J. Biol. Chem. 280 2005 5045 5053
    • (2005) J. Biol. Chem. , vol.280 , pp. 5045-5053
    • Cohen, L.1    Karbat, I.2    Gilles, N.3    Ilan, N.4    Benveniste, M.5    Gordon, D.6    Gurevitz, M.7
  • 12
    • 0019864267 scopus 로고
    • Scorpion venoms and neurotoxins: An immunological study
    • P. Delori, J. van Rietschoten, and H. Rochet Scorpion venoms and neurotoxins: an immunological study Toxicon 19 1981 393 407
    • (1981) Toxicon , vol.19 , pp. 393-407
    • Delori, P.1    Van Rietschoten, J.2    Rochet, H.3
  • 13
    • 0030440412 scopus 로고    scopus 로고
    • A conserved region of scorpion toxins rendered immunogenic induces broadly cross-reactive, neutralizing antibodies
    • C. Devaux, P. Fourquet, and C. Granier A conserved region of scorpion toxins rendered immunogenic induces broadly cross-reactive, neutralizing antibodies Eur. J. Biochem. 242 1996 727 735
    • (1996) Eur. J. Biochem. , vol.242 , pp. 727-735
    • Devaux, C.1    Fourquet, P.2    Granier, C.3
  • 14
    • 0037146783 scopus 로고    scopus 로고
    • A strategy for inducing an immune response against Androctonus australis scorpion venom toxin I in mice. Production of high-affinity monoclonal antibodies and their use in a sensitive two-site immunometric assay
    • C. Devaux, O. Clot-Faybesse, M. Pugniere, J.c. Mani, H. Rochat, and C. Granier A strategy for inducing an immune response against Androctonus australis scorpion venom toxin I in mice. Production of high-affinity monoclonal antibodies and their use in a sensitive two-site immunometric assay J Immunol. Methods 271 2002 37 46
    • (2002) J Immunol. Methods , vol.271 , pp. 37-46
    • Devaux, C.1    Clot-Faybesse, O.2    Pugniere, M.3    Mani, J.C.4    Rochat, H.5    Granier, C.6
  • 15
    • 0000434269 scopus 로고
    • Chemical and pharmacological aspects of Tityinae venom
    • S. Bettini Springer-Verlag Berlin
    • C.R. Diniz, and C.R. Diniz Chemical and pharmacological aspects of Tityinae venom S. Bettini Arthropod Venoms 1978 Springer-Verlag Berlin 379 394
    • (1978) Arthropod Venoms , pp. 379-394
    • Diniz, C.R.1    Diniz, C.R.2
  • 16
    • 0026656122 scopus 로고
    • Spot-synthesis: An easy technique for the positionally addressable, parallel chemical synthesis on a membrane support
    • R. Frank Spot-synthesis: an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support Tetrahedron 48 1992 9217 9232
    • (1992) Tetrahedron , vol.48 , pp. 9217-9232
    • Frank, R.1
  • 17
    • 0345505300 scopus 로고    scopus 로고
    • Potential of peptides selected from random phage-displayed libraries to mimic conformational epitopes: A study on scorpion toxin Cn2 and the neutralizing monoclonal antibody BCF2
    • T.G. Gazarian, B. Selisko, G.B. Gurrola, R. Hernandez, L.D. Possani, and K.G. Gazarian Potential of peptides selected from random phage-displayed libraries to mimic conformational epitopes: a study on scorpion toxin Cn2 and the neutralizing monoclonal antibody BCF2 Comb. Chem. High Throughput Screen. 6 2003 119 132
    • (2003) Comb. Chem. High Throughput Screen. , vol.6 , pp. 119-132
    • Gazarian, T.G.1    Selisko, B.2    Gurrola, G.B.3    Hernandez, R.4    Possani, L.D.5    Gazarian, K.G.6
  • 18
    • 0020014262 scopus 로고
    • Epidemiological and clinical characteristics of the scorpion envenomation in Tunisia
    • M. Goyffon, M. Vachon, and N. Broglio Epidemiological and clinical characteristics of the scorpion envenomation in Tunisia Toxicon 20 1982 337 344
    • (1982) Toxicon , vol.20 , pp. 337-344
    • Goyffon, M.1    Vachon, M.2    Broglio, N.3
  • 20
    • 73049155988 scopus 로고
    • The isolation of nerve endings from brain: An electron microscope study of cell fragments derived by homogenization of centrifugation
    • E.G. Gray, and V.P. Whittaker The isolation of nerve endings from brain: an electron microscope study of cell fragments derived by homogenization of centrifugation J. Anat. 96 1962 79 87
    • (1962) J. Anat. , vol.96 , pp. 79-87
    • Gray, E.G.1    Whittaker, V.P.2
  • 21
    • 0019181273 scopus 로고
    • Two types of scorpion neurotoxins characterized by their binding to separate receptor sites on rat brain synaptossomes
    • E. Jover, F. Couraud, and H. Rochat Two types of scorpion neurotoxins characterized by their binding to separate receptor sites on rat brain synaptossomes Biochem. Biophys. Res. Commun. 95 1980 1607 1614
    • (1980) Biochem. Biophys. Res. Commun. , vol.95 , pp. 1607-1614
    • Jover, E.1    Couraud, F.2    Rochat, H.3
  • 22
    • 0020997912 scopus 로고
    • Dictionary of protein secondary structure: Pattern recognition of hydrogen-bonded and geometrical features
    • W. Kabsch, and C. Sander Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features Biopolymers 22 1983 2577 2637
    • (1983) Biopolymers , vol.22 , pp. 2577-2637
    • Kabsch, W.1    Sander, C.2
  • 24
    • 0031172734 scopus 로고    scopus 로고
    • Molecular characterization, antigenicity and immunogenicity of anatoxin polymeric forms conferring protection against scorpion venoms
    • R. Kharrat, I. Zemouaqi, Z.B. Lasfar, K. Miled, and Mohamed El Ayeb Molecular characterization, antigenicity and immunogenicity of anatoxin polymeric forms conferring protection against scorpion venoms Toxicon 35 1997 915 929
    • (1997) Toxicon , vol.35 , pp. 915-929
    • Kharrat, R.1    Zemouaqi, I.2    Lasfar, Z.B.3    Miled, K.4    El Ayeb Mohamed5
  • 25
    • 0030926906 scopus 로고    scopus 로고
    • Refined solution structure of the anti-mammal and anti-insect LqqIII scorpion toxin: Comparison with other scorpion toxins
    • C. Landon, P. Sodano, B. Cornet, J.M. Bonmatim, C. Kopeyan, H. Rochat, F. Vovelle, and M. Ptak Refined solution structure of the anti-mammal and anti-insect LqqIII scorpion toxin: comparison with other scorpion toxins Proteins 28 1997 360 374
    • (1997) Proteins , vol.28 , pp. 360-374
    • Landon, C.1    Sodano, P.2    Cornet, B.3    Bonmatim, J.M.4    Kopeyan, C.5    Rochat, H.6    Vovelle, F.7    Ptak, M.8
  • 26
    • 0036721676 scopus 로고    scopus 로고
    • Application of the Spot method to the identification of peptides and amino acids from the antibody paratope that contribute to antigen binding.
    • D. Laune, F. Molina, G. Ferrieres, S. Villard, C. Bes, F. Rieunier, T. Chardes, and C. Granier Application of the Spot method to the identification of peptides and amino acids from the antibody paratope that contribute to antigen binding. J. Immun. Methods 267 2002 53 70
    • (2002) J. Immun. Methods , vol.267 , pp. 53-70
    • Laune, D.1    Molina, F.2    Ferrieres, G.3    Villard, S.4    Bes, C.5    Rieunier, F.6    Chardes, T.7    Granier, C.8
  • 27
    • 4043081299 scopus 로고    scopus 로고
    • Molecular characterization of protective antibodies raised in mice by Tityus serrulatus scorpion venom toxins conjugated to bovine serum albumin
    • R.A. Machado de Avila, L.M. Alvarenga, C.A. Tavares, F. Molina, C. Granier, and C. Chavez-Olortegui Molecular characterization of protective antibodies raised in mice by Tityus serrulatus scorpion venom toxins conjugated to bovine serum albumin Toxicon 44 2004 233 241
    • (2004) Toxicon , vol.44 , pp. 233-241
    • MacHado De Avila, R.A.1    Alvarenga, L.M.2    Tavares, C.A.3    Molina, F.4    Granier, C.5    Chavez-Olortegui, C.6
  • 28
    • 0027028064 scopus 로고
    • The β-type toxin TsII from the scorpion Tityus serrulatus: Amino acid sequence determination and asessment of biological and antigenic properties
    • P. Mansuelle, M.F. Martin-Eauclaire, C. Chávez-Olórtegui, M.H. De Lima, M.H. Rochat, H. Rochat, and C. Granier The β-type toxin TsII from the scorpion Tityus serrulatus: amino acid sequence determination and asessment of biological and antigenic properties Natural Toxins 1 1992 119 125
    • (1992) Natural Toxins , vol.1 , pp. 119-125
    • Mansuelle, P.1    Martin-Eauclaire, M.F.2    Chávez-Olórtegui, C.3    De Lima, M.H.4    Rochat, M.H.5    Rochat, H.6    Granier, C.7
  • 29
    • 0028350972 scopus 로고
    • Biochemical, pharmacological an genomic characterization of TsIV, and α toxin from the venom of the South Amaricam scorpion Tityus serrulatus
    • M.F. Martin-Euclaire, B. Ceard, A.M. Ribeiro, C.R. Diniz, H. Rochat, and P.E. Bugis Biochemical, pharmacological an genomic characterization of TsIV, and α toxin from the venom of the South Amaricam scorpion Tityus serrulatus FEBS Lett. 342 1994 181 184
    • (1994) FEBS Lett. , vol.342 , pp. 181-184
    • Martin-Euclaire, M.F.1    Ceard, B.2    Ribeiro, A.M.3    Diniz, C.R.4    Rochat, H.5    Bugis, P.E.6
  • 30
    • 0014884098 scopus 로고
    • Purification of animal neurotoxins. Isolation and characterization of eleven neurotoxins from the venoms of scorpions Androctonus australis Hector, Buthus occitanus and Leiurus quinquestratus
    • F. Miranda, C. Kopeyan, H. Rochat, and S. Lissitzky Purification of animal neurotoxins. Isolation and characterization of eleven neurotoxins from the venoms of scorpions Androctonus australis Hector, Buthus occitanus and Leiurus quinquestratus Eur. J. Biochem. 16 1970 514 523
    • (1970) Eur. J. Biochem. , vol.16 , pp. 514-523
    • Miranda, F.1    Kopeyan, C.2    Rochat, H.3    Lissitzky, S.4
  • 31
    • 0030152613 scopus 로고    scopus 로고
    • Improved performances of spot multiple peptide synthesis
    • F. Molina, D. Laune, C. Gougat, B. Pau, and C. Granier Improved performances of spot multiple peptide synthesis Peptide Res. 9 1996 151 155
    • (1996) Peptide Res. , vol.9 , pp. 151-155
    • Molina, F.1    Laune, D.2    Gougat, C.3    Pau, B.4    Granier, C.5
  • 32
    • 0031981795 scopus 로고    scopus 로고
    • In vivo protection against Tityus serrulatus scorpion toxins by immunization of mice with a non-toxic protein
    • A.M. Moreira-Ferreira, E. Kalapothakis, C.R. Diniz, and C. Chavez-Olortegui In vivo protection against Tityus serrulatus scorpion toxins by immunization of mice with a non-toxic protein Toxicon 36 1998 333 339
    • (1998) Toxicon , vol.36 , pp. 333-339
    • Moreira-Ferreira, A.M.1    Kalapothakis, E.2    Diniz, C.R.3    Chavez-Olortegui, C.4
  • 33
    • 0344758340 scopus 로고    scopus 로고
    • Crystal structure of neurotoxin Ts1 from Tityus serrulatus provides insights into the specificity and toxicity of scorpion toxins
    • I. Polikarpov, M.S. Junior, S. Marangoni, M.H. Toyama, and A. Teplyakov Crystal structure of neurotoxin Ts1 from Tityus serrulatus provides insights into the specificity and toxicity of scorpion toxins J. Mol. Biol. 290 1999 175 184
    • (1999) J. Mol. Biol. , vol.290 , pp. 175-184
    • Polikarpov, I.1    Junior, M.S.2    Marangoni, S.3    Toyama, M.H.4    Teplyakov, A.5
  • 34
    • 0017390607 scopus 로고
    • Purification and properties of mammalian toxins from the venom of Brazilian Scorpion Tityus serrulatus Lutz and Mello
    • L.D. Possani, A.C. Alagon, P.L. Fletcher Jr, and B.W. Erickson Purification and properties of mammalian toxins from the venom of Brazilian Scorpion Tityus serrulatus Lutz and Mello Arch. Biochem. Biophys. 180 1977 394 403
    • (1977) Arch. Biochem. Biophys. , vol.180 , pp. 394-403
    • Possani, L.D.1    Alagon, A.C.2    Fletcher Jr., P.L.3    Erickson, B.W.4
  • 35
    • 0001551016 scopus 로고
    • Purification and chemical characterization of the major toxins from the venom of the Brazilian scorpion Tityus serrulatus
    • L.D. Possani, B.M. Martin, J. Mochca-Morales, and I. Svendsen Purification and chemical characterization of the major toxins from the venom of the Brazilian scorpion Tityus serrulatus Carlsberg Res. Commun. 46 1981 195 205
    • (1981) Carlsberg Res. Commun. , vol.46 , pp. 195-205
    • Possani, L.D.1    Martin, B.M.2    Mochca-Morales, J.3    Svendsen, I.4
  • 36
    • 0021970805 scopus 로고
    • Scorpion toxins from Centruroires noxius and Tityus serrulatus. Primary structures and sequence comparison by metric analysis
    • L.D. Possani, B.M. Martin, I. Svendsen, G.S. Rode, and B.W. Erickson Scorpion toxins from Centruroires noxius and Tityus serrulatus. Primary structures and sequence comparison by metric analysis Biochem J. 739 1985 750
    • (1985) Biochem J. , vol.739 , pp. 750
    • Possani, L.D.1    Martin, B.M.2    Svendsen, I.3    Rode, G.S.4    Erickson, B.W.5
  • 38
    • 0018400724 scopus 로고
    • Scorpion toxins: Chemistry and mode of action
    • B. Ceccarelli F. Clementi Raven Press New York
    • H. Rochat, P. Bernard, and F. Couraud Scorpion toxins: chemistry and mode of action B. Ceccarelli F. Clementi Advances in Cytopharmacology 1977 Raven Press New York 325 334
    • (1977) Advances in Cytopharmacology , pp. 325-334
    • Rochat, H.1    Bernard, P.2    Couraud, F.3
  • 39
    • 0027136282 scopus 로고
    • Comparative protein modelling by satisfaction of spatial restraints
    • A. Sali, and T.L. Blundell Comparative protein modelling by satisfaction of spatial restraints J. Mol. Biol. 234 1993 779 815
    • (1993) J. Mol. Biol. , vol.234 , pp. 779-815
    • Sali, A.1    Blundell, T.L.2
  • 40
    • 0017183482 scopus 로고
    • Purification and partial characterization of a second toxin from the scorpion Tityus serrulatus
    • D. Toledo, and A.G.A. Neves Purification and partial characterization of a second toxin from the scorpion Tityus serrulatus Comp. Biochem. Physiol. 55B 1976 249 253
    • (1976) Comp. Biochem. Physiol. , vol.55 , pp. 249-253
    • Toledo, D.1    Neves, A.G.A.2


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