HIV-1 expression induces tubular cell G2/M arrest and apoptosis

Renal Failure

Volumn 30, Issue 6, 2008, Pages 655-664

  Vashistha, Himanshu ^b   Husain, Mohammad ^b   Kumar, Dileep ^b   Yadav, Anju ^b   Arora, Shitij ^b   Singhal, Pravin C ^a  

^a North Shore LIJ Health System ^*  (United States)

^b NONE

Author keywords

Apoptosis; Cell cycle; HIV 1; Tubular cells

Indexed keywords

PROTEIN P53;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL DAMAGE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; KIDNEY CELL; PRIORITY JOURNAL;

APOPTOSIS; CELL COMMUNICATION; CELL CYCLE; CELL DEATH; CELL DIVISION; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; FLOW CYTOMETRY; G2 PHASE; GENE EXPRESSION REGULATION, VIRAL; HIV-1; HUMANS; IN SITU NICK-END LABELING; KIDNEY TUBULES; TRANSDUCTION, GENETIC;

EID: 48149095513     PISSN: 0886022X     EISSN: 15256049     Source Type: Journal    
DOI: 10.1080/08860220802134672     Document Type: Article

References (35)

1. Bourgoignie JJ, Pardo V. The nephropathology in human immunodeficiency virus (HIV-1) infection. Kidney Int. 1991;40 (Suppl.): S19-S23.
2. Pardo V, Aldana M, Colton RM, Fischl MA, Jaffe D, Moskowitz L, Hensley GT, Bourgoignie JJ. Glomerular lesions in acquired immunodeficiency syndrome. Ann Intern Med. 1984;101:429-434.
3. Rao TKS, Filppone EJ, Nicastri AD, et al. Associated focal segmental glomerulosclerosis in the acquired immunodeficiency syndrome.N Engl J Med. 1984;310:664-673.
4. Kimmel PL, Phillips TM, Ferreira-Centeno A, Farkas-Szlallasi T, Abraham AA, Garrett CT. HIV-associated immune mediated renal disease. Kidney Int. 1993;44:1327-1340.
5. Winston JA, et al. Nephropathy and establishment of a renal reservoir of HIV type 1 during primary infection. N Engl J Med. 200001;344:1979-1984.
6. Bruggeman LA, Dikman S, Meng C, Quaggin SE, Coffman TM, Klotman PE. Nephropathy in human immunodeficiency virus-1 transgenic mice is due to renal transgene expression. J Clin Inv. 1997;100:84-92.
7. Cohen AH, Sun NCJ, Shapsak P, Imagawa DT. Demonstration of human immunodeficiency virus in renal epithelium in HIV-associated nephropathy. Mod Pathol. 1989;2:125-128.
8. Rappaport J, Kopp JB, Klotman PE. Host virus interactions and the molecular regulation of HIV-1: Role in the pathogenesis of HIV-associated nephropathy. Kidney Int. 1994; 46:16-27.
9. Conaldi PG, Biancone L, Bottelli A, Wade-Evans A, Racusen LC, Boccellino M, Orlandi V, Serra C, Camussi G, Toniolo A. HIV-1 kills tubular epithelial cells in vitro by triggering an apoptotic pathway involving caspase activation and Fas upregulation. J Clin Invest. 1998;102:2041-2049.
10. Marras D, Bruggman LA, Gao F, Tanji N, Mansukhani MM, Cara A, Ross MD, Gusella GL, Benson G, D'Agati VD, Hahn BH, Klotman ME, Klotman PE. Replication and compartalization of HIV-1 in kidney epithelium of patients with HIV-associated nephropathy. Nat Med. 2002;8:522-526.
11. Kapasi AA, Patel G, Franki N, Singhal PC. HIV-1 gp120-induced tubular epithelial cell apoptosis is mediated through p38-MAPK phosphorylation. Mol Med. 2002;8:676-685.
12. Eitner F, Cui Y, Hudkins KL, Stokes MB, Segerer S, Mack M, Lewis PL, Abraham AA, Schlöndorff D, Gallo G, Kimmel PL, Alpers CE. Chemokine receptor CCR5 and CXCR4 expression in HIV-associated kidney disease. J Am Soc Nephrol. 2000;11:856-867.
13. Hatsukari I, Singh P, Hitosugi N, Messmer D, Valderrama E, Teichberg S, Chaung W, Gross E, Schmidtmayerova H, Singhal PC. DEC-205-mediated internalization of HIV-1 results in the establishment of silent infection in renal tubular cells. J Am Soc Nephrol. 2007;18:780-787.
14. Ray PE, Liu XH, Henry D, Dye L, Xu L, Orenstein JM, Schuztbank TE. Infection of human primary renal epithelial cells with HIV-1 from children with HIV-associated nephropathy. Kidney Int. 1998;53:1217-1229.
15. Vogetseder A, Karadeniz A, Kaissling B, Le Hir M. Tubular cell proliferation in the healthy rat kidney. Histochem Cell Biol. 2005 Aug;124(2):97-104.
16. Fujigaki Y, Goto T, Sakakima M, Fukasawa H, Miyaji T, Yamamoto T, Hishida A. Kinetics and characterization of initially regenerating proximal tubules in S3 segment in response to various degrees of acute tubular injury. Nephrol Dial Transplant. 2006 Jan;21(1):41-50.
17. Nigg EA. Mitotic kinases as regulators of cell division and its checkpoints. Nat. Rev. Mol. Cell Biol. 2001;2(1):21-32.
18. Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR, Roberts JM. Formation and activation of a cyclinE-cdk2 complex during the G1 phase of the human cell cycle. Science. 1992;257:1689-1694.
19. Falck J, Mailand N, Syljuasen RG, Bartek J, Lukas J. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature. 2001;410:842-847.
20. Draetta G, Beach D. Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangement. Cell. 1988;54:17-26.
21. Draetta G, Luca F, Westendorf J, Brizuela L, Ruderman J, Beach D. Cdc2 protein kinase is complexed with both cyclin A and B: Evidence for proteolytic inactivation of MPF. Cell. 1989;56:829-838.
22. Ducommun B, Brambilla P, Felix MA, Franza BR Jr, Karsenti E, Draetta G. Cdc2 phosphorylation is required for its interaction with cyclin. EMBO J. 1991;10:3311-3319.
23. cdc2 on Thr-14 and Tyr-15 at the prophase/metaphase transition. J. Biol. Chem. 1996;271:27847-27854.
24. Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H. Mitotic and G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science. 1997;277:1501-1505.
25. Brown AL, Lee CH, Schwarz JK, Mitiku N, Piwnica-Worms H, Chung JH. A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage. Proc. Natl. Acad. Sci. (USA). 1999;96:3745-3750.
26. Aguda BD. A quantitative analysis of the kinetics of the G(2) DNA damage checkpoint system. Proc. Natl. Acad. Sci. (USA). 1999;96:11352-11357.
27. Hermeking H, Lengauer C, Polyak K, He T, Zhang L, Thiagalingam S.14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol. Cell. 1997;1:3-11.
28. Wang XW, Zhan QM, Coursen JD, Khan MA, Kontny HU, Yu L, Hollander MC, O'Connor PM, Fornace AJ Jr, Harris CC. GADD45 induction of a G(2)/M cell cycle checkpoint. Proc. Natl. Acad. Sci. (USA). 1999;96:3706-3711.
29. Miyashita T, Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell. 1995;80:293-299.
30. Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA, Hoffman B, Reed JC. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene. 1994;9:1799-1805.
31. Sax JK, Fei P, Murphy ME, Bernhard E, Korsmeyer SJ, El-Deiry WS. BID regulation by p53 contributes to chemosensitivity. Nat. Cell Biol. 2002;4:842-849.
32. Nakano K, Vousden KH. Puma, a novel proapoptotic gene, is induced by p53. Mol. Cell. 2001;7:683-694.
33. Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita Y, Tokino T, Taniguchi T, Tanaka N. Noxa, a BH3-only member of the bcl-2 family and candidate mediator of p53-induced apoptosis. Science. 2000; 288:1053-1058.
34. Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, Green DR. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science. 2004;303:1010-1014.
35. Dumont P, Leu JI, Della Pietra AC, George DL, Murphy M. The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat. Genet. 2003;33:357-365.