Nephropathy in human immunodeficiency virus-1 transgenic mice is due to renal transgene expression

Journal of Clinical Investigation

Volumn 100, Issue 1, 1997, Pages 84-92

  Bruggeman, Leslie A ^a,b   Dikman, Steven ^b   Meng, Charis ^a   Quaggin, Susan E ^c   Coffman, Thomas M ^d   Klotman, Paul E ^a  

^a MOUNT SINAI MEDICAL CENTER   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c YALE UNIVERSITY   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Chronic renal failure; Glomerulosclerosis; HIV associated nephropathy; Tubular interstitium

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CHRONIC KIDNEY FAILURE; GLOMERULOSCLEROSIS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; KIDNEY DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENE; TRANSGENIC MOUSE;

EID: 0030758075     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119525     Document Type: Article

References (47)

1. Rao, T.K. 1991. Human immunodeficiency virus (HIV) associated nephropathy. Annu. Rev. Med. 42:391-401.
2. Bourgoignie, J.J. 1990. Renal complications of human immunodeficiency virus type 1. Kidney Int. 37:1571-1584.
3. Humphreys, M.H. 1995. Human immunodeficiency virus-associated glomerulosclerosis. Kidney Int. 48:311-320.
4. Simon, D.B., A. Farhi, R. Mahnensmith, and R.P. Lifton. 1996. Inherited susceptibility to HIV nephropathy in African Americans. J. Am. Soc. Nephrol. 7:1343a. (Abstr.)
5. Bourgoignie, J.J., C. Ortiz-Interian, D.F. Green, and D. Roth. 1989. Race, a co-factor in HIV-1 associated nephropathy. Transplant. Proc. 21:3899-3901.
6. Kimmel, P.L., S.S. VedBrat, P.F. Pierce, W.O. Umana, L. Shepherd, D.A. Verme, R.P. Hirsch, and K.B. Hellman. 1995. Prevalence of viremia in human immunodeficiency virus-infected patients with renal disease. Arch. Intern. Med. 155:1578-1584.
7. Winston, J., P.E. Klotman, and M.E. Klotman. 1996. Plasma HIV-1 RNA in seropositive patients with renal disease. J. Am. Soc. Nephrol. 7:1345a. (Abstr.)
8. Cohen, A.H., N.C.J. Sun, P. Shapshak, and D.T. Imagawa. 1989. Demonstration of human immunodeficiency virus in renal epithelium in HIV-associated nephropathy. Mod. Pathol. 2:125-128.
9. Alpers, C.E., J. McClure, and S.L. Bursten. 1992. Human mesangial cells are resistant to productive infection by multiple strains of human immunodeficiency virus types 1 and 2. Am. J. Kid. Dis. 19:126-130.
10. Green, D.F., L. Resnick, and J.J. Bourgoignie. 1992. HIV infects glomerular endothelial and mesangial but not epithelial cells in vitro. Kidney Int. 41: 956-960.
11. di Belgiojoso, G.B., A. Genderini, L. Vago, C. Parravicini, S. Bertoli, and N. Landriani. 1990. Absence of HIV antigens in renal tissue from patients with HIV-associated nephropathy. Nephrol. Dial. Transplant. 5:489-492.
12. Ray, P.E., D. Henry, L. Xu, L. Dye, J.M. Orenstein, and T. Schuztbank. 1996. Infection and injury of human renal tubular epithelial cells (RETC) by HIV-1 derived from children with HIVAN. J Am. Soc. Nephrol. 7:13419a (Abstr.)
13. Kimmel, P.L., A. Ferreira-Centeno, T. Farkas-Szallasi, A.A. Abraham, and C.T. Garrett. 1993. Viral DNA in microdissected renal biopsy tissue from HIV infected patients with nephrotic syndrome. Kidney Int. 43:1347-1352.
14. Fauci, A.S., G. Pantaleo, S. Stanley, and D. Weissman. 1996. Immunopathogenic mechanisms of HIV infection. Ann. Intern. Med. 124:654-663.
15. Kopp, J.B., and P.E. Klotman. 1995. Transgenic animal models of renal development and pathogenesis. Am J. Physiol. 269:F601-F620.
16. Ketteler, M., W.A. Border, and N.A. Noble. 1994. Cytokines and L-arginine in renal injury and repair. Am. J. Physiol. 267:F197-F207.
17. Woo, D.D. 1995. Apoptosis and loss of renal tissue in polycystic kidney diseases. N. Engl. J. Med. 333:18-25.
18. Bonventre, J.V. 1993. Mechanisms of ischemic acute renal failure. Kidney Int. 43:1160-1178.
19. Shimizu, A., Y. Masuda, H. Kitamura, M. Ishizaki, Y. Sugisaki, and N. Yamanaka. 1996. Apoptosis in progressive crescentic glomerulonephritis. Lab. Invest. 74:941-951.
20. Gobe, G.C., R. Buttyan, K.R.L. Wyburn, M.R. Etheridge, and P.J. Smith. 1995. Clusterin expression and apoptosis in tissue remodeling associated with renal regeneration. Kidney Int. 47:411-420.
21. Coles, H.S., Burne, J.F., and M.C. Raff. 1993. Large-scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor. Development (Camb.). 118:777-784.
22. Savill, J. 1994. Apoptosis and the kidney. J. Am. Soc. Nephrol. 5:12-21.
23. Sorenson, C.M., S.A. Rogers, S.J. Korsmeyer, and M.R. Hammerman. 1995. Fulminant metanephric apoptosis and abnormal kidney development in bcl-2-deficient mice. Am. J. Physiol. 268:F73-F81.
24. Veis, D.J., C.M. Sorenson, J.R. Shutter, and S.J. Korsmeyer. 1993. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell. 75:229-240.
25. Laurnet-Crawford, A.G., K. Bernard, S. Muller, Y. Riviere, A.-M. Rey-Cuille, J.-M. Bechet, L. Montagnier, and A.G. Hovanessian. 1991. The cytopathic effect of HIV is associated with apoptosis. Virology. 185:829-839.
26. Bodi, I.S., A.A. Abraham, and P.L. Kimmel. 1995. Apoptosis in human immunodeficiency virus-associated nephropathy. Am. J. Kid. Dis. 26:286-291.
27. Dickie, P., J. Felser, M. Eckhaus, J. Bryant, J. Silver, N. Marinos, and A.L. Notkins. 1991. HIV-associated nephropathy in transgenic mice expressing HIV-1 genes. Virology. 185:109-119.
28. Kopp, J.B., M.E. Klotman, S.H. Adler, L.A. Bruggeman, P. Dickie, N.J. Marinos, M. Eckhaus, J.L. Bryant, A.L. Notkins, and P.E. Klotman. 1992. Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for HIV-1 genes. Proc. Natl. Acad. Sci. USA. 89:1577-1582.
29. Santoro, T., J.A. Bryant, J. Pellicoro, M.E. Klotman, J.B. Kopp, L.A. Bruggeman, R.R. Franks, A.L. Notkins, and P.E. Klotman. 1994. Growth failure and AIDS-like cachexia syndrome in HIV-transgenic mice. Virology. 201: 147-151.
30. Adler, S.H., L.A. Bruggeman, J.B. Kopp, N. Dorfman, J. Bryant, M. Eckhaus, A.L. Notkins, and P.E. Klotman. 1992. Transcription of HIV-1 genes in transgenic mice is associated with myopathy and myositis. AIDS (Phila.). 8:48a (Abstr.)
31. Kopp, J.B., J.F. Rooney, C. Wohlenberg, N. Dorfman, N.J. Marinos, J.L. Bryant, S.I. Katz, A.L. Notkins, and P. E. Klotman. 1993. Cutaneous disorders and viral gene expression in HIV-1 transgenic mice. AIDS Res. Hum. Retroviruses. 9:267-275.
32. Bruggeman, L.A., M.M. Thomson, P.J. Nelson, J.B. Kopp, J. Rappaport, P.E. Klotman, and M.E. Klotman. 1994. Evidence for tissue-specific regulation of viral expression and mRNA splicing in HIV-1 transgenic mice. Virology. 202:940-948.
33. Franks, R.R., P.E. Ray, C.C. Babbott, J.L. Bryant, A.L. Notkins, T.J. Santoro, and P.E. Klotman. 1995. Maternal-fetal interactions affect growth of human immunodeficiency virus type 1 transgenic mice. Pediatr. Res. 31:56-63.
34. Robert, B., D. Pinson Hyink, P.L. St. John and D.R. Abrahamson. Identification of endothelial precursors in embryonic mouse kidneys. J. Am. Soc. Nephrol. 6:708a. (Abstr.)
35. Schreck, S., J. Panozzo, J. Milton, C.R. Libertin, and G.E. Woloschak. 1995. The effects of multiple UV exposures on HIV-LTR expression. Photochem. Photobiol. 61:378-382.
36. Quaggin, S.E., H. Yeger, and P. Igarashi. 1997. Antisense oligonucleotides to cux-1, a cut-related homeobox gene, cause increased apoptosis in mouse embryonic kidney cultures. J. Clin. Invest. 99:718-724.
37. Coffman, T.M., S. Geier, S. Ibrahim, R. Griffiths, R. Spurney, O. Smithies. B. Koller, and F. Sanfilippo. 1993. Improved renal function in mouse kidney allografts lacking MHCclass I antigens. J. Immunol. 151:425-435.
38. Chang, Y., E. Cesarman, M.S. Pessin, F. Lee, J. Culpepper, D.M. Knowles, and P.S. Moore. 1994. Identification of new human herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science (Wash. DC). 266: 1865-1869.
39. Cauley, K., and I.M. Verma. 1994. Kappa B enhancer binding complexes that do not contain NF-kappa B are developmentally regulated in mammalian brain. Proc. Natl. Acad. Sci. USA. 91:390-394.
40. Buzy, J.M., L.M. Lindstrom, M.C. Zink, and J.E. Clements. 1995. HIV-1 in the developing CNS: Developmental differences in gene expression. Virology. 210:361-371.
41. Karlsson-Parra, A., E. Dimeny, B. Fellstrom, and L. Klareskog. 1989. HIV receptors (CD4 antigen) in normal human glomerular cells. N. Engl. J. Med. 320:741.
42. Rubin-Kelley, V.E., and A.M. Jevnikar. 1991. Antigen presentation by renal tubular epithelial cells. J. Am. Soc. Nephrol. 2:13-26.
43. Dragic, T., V. Litwin, G.P. Allaway, S.R. Martin, Y. Huang, K.A. Nagashima, C. Cayanan, P.J. Maddon, R.A Koup, J.P. Moore, and W.A. Paxton. 1996. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature (Lond.). 381:667-673.
44. Deng, H., R. Liu, W. Ellmeier, S. Choe, D. Unutmaz, M. Burkhart, P. DiMarzio, S. Marmon, R.E. Sutton, C.M. Hill, et al. 1996. Identification of a major co-receptor for primary isolates of HIV-1. Nature (Lond.). 381:661-666.
45. Feng, Y., C.C. Border, P.E. Kennedy, and E.A. Berger. 1996. HIV-1 entry cofactor: function cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science (Wash. DC). 272:872-877.
46. Liu, R, W.A. Paxton, S. Choe, D. Ceradini, S.R. Martin, R. Horuk, M.E. MacDonald, H. Stuhlmann, R.A. Koup, and N.R. Landau. 1996. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell. 86:367-377.
47. Dean, M., M. Carrington, C. Winkler, G.A. Huttley, M.W. Smith, R. Allikmets, J.J. Goedert, S.P. Buchbinder, E. Vittinghoff, E. Gomperts, et al. 1996. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science (Wash. DC). 273:1856-1862.