Three different hepcidins from tilapia, Oreochromis mossambicus: Analysis of their expressions and biological functions

Molecular Immunology

Volumn 44, Issue 8, 2007, Pages 1922-1934

  Huang, Pao Hsian ^a   Chen, Jyh Yih ^a   Kuo, Ching Ming ^a  

^a INSTITUTE OF CELLULAR AND ORGANISMIC BIOLOGY   (Taiwan)

Author keywords

Antimicrobial peptide; cDNA; Gene expression; Hepcidin; Iron dextran; Lipopolysaccharide; Oreochromis mossambicus; Polyinosinic polycytidylic acid (poly I:poly C)

Indexed keywords

COMPLEMENTARY DNA; CYSTEINE; DISULFIDE; HEPCIDIN; IRON DEXTRAN; LIPOPOLYSACCHARIDE; MESSENGER RNA; POLYINOSINIC POLYCYTIDYLIC ACID; POLYPEPTIDE ANTIBIOTIC AGENT; ANTIMICROBIAL CATIONIC PEPTIDE;

AMINO ACID SEQUENCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; BASS; CODON; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISULFIDE BOND; DNA SEQUENCE; DNA TEMPLATE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; INFECTION RESISTANCE; KIDNEY; MOLECULAR WEIGHT; NONHUMAN; NUCLEOTIDE SEQUENCE; OREOCHROMIS MOSSAMBICUS; PEPTIDE ANALYSIS; PEPTIDE SYNTHESIS; PREDICTION; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SEA BREAM; SPLEEN; STRIPED BASS; TILAPIA; ANIMAL; ANTIBODY SPECIFICITY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; MOLECULAR GENETICS; PHYLOGENY; PROTEIN TERTIARY STRUCTURE;

MORONE CHRYSOPS; OREOCHROMIS MOSSAMBICUS; ORYCTOLAGUS CUNICULUS; PAGRUS MAJOR; PARALICHTHYS OLIVACEUS; TILAPIA;

AMINO ACID SEQUENCE; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; DNA, COMPLEMENTARY; GENE EXPRESSION REGULATION; LIPOPOLYSACCHARIDES; MOLECULAR SEQUENCE DATA; ORGAN SPECIFICITY; PHYLOGENY; POLY I-C; PROTEIN STRUCTURE, TERTIARY; RNA, MESSENGER; TILAPIA;

EID: 34250824283     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2006.09.031     Document Type: Article

References (35)

1. Andrews N.C. Anemia of inflammation: the cytokine-hepcidin link. J. Clin. Invest. 113 (2004) 1251-1253
2. Baez A., Cantor A., Fonseca S., Marcos-Martinez M., Mathews L.A., Muro-Cacho C.A., and Munoz-Antonia T. Differences in Smad4 expression in human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck squamous cell carcinoma. Clin. Cancer Res. 11 (2005) 3191-3197
3. Bao B., Peatman E., Xu P., Li P., Zeng H., He C., and Liu Z. The catfish liver-expressed antimicrobial peptide 2 (LEAP-2) gene is expressed in a wide range of tissues and developmentally regulated. Mol. Immunol. 43 (2006) 367-377
4. Bridle K.R., Frazer D.M., Wilkins S.J., Dixon J.L., Purdie D.M., Crawford D.H., Subramaniam V.N., Powell L.W., Anderson G.J., and Ramm G.A. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet 361 (2003) 669-673
5. Cole A.M., Weis P., and Diamond G. Isolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretions of winter flounder. J. Biol. Chem. 272 (1997) 12008-12013
6. Chen J.Y., Chen J.C., Huang W.T., Liu C.W., Hui C.F., Chen T.T., and Wu J.L. Molecular cloning and tissue-specific, developmental-stage-specific, and hormonal regulation of IGFBP3 gene in zebrafish. Mar Biotechnol. 6 (2004) 1-7
7. Detivaud L., Nemeth E., Boudjema K., Turlin B., Troadec M.B., Leroyer P., Ropert M., Jacquelinet S., Courselaud B., Ganz T., Brissot P., and Loreal O. Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function. Blood 106 (2005) 746-748
8. Douglas S.E., Gallant J.W., Liebscher R.S., Dacanay A., and Tsoi S.C. Identification and expression analysis of hepcidin-like antimicrobial peptides in bony fish. Dev. Comp. Immunol. 27 (2003) 589-601
9. Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 102 (2003) 783-788
10. Ganz T. Hepcidin-a regulator of intestinal iron absorption and iron recycling by macrophages. Best Pract. Res. Clin. Haematol. 18 (2005) 171-182
11. Hirono I., Hwang J.Y., Ono Y., Kurobe T., Ohira T., Nozaki R., and Aoki T. Two different types of hepcidins from the Japanese flounder Paralichthys olivaceus. FEBS J. 272 (2005) 5257-5264
12. Hunter H.N., Fulton D.B., Ganz T., and Vogel H.J. The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. J. Biol. Chem. 277 (2002) 37595-37603
13. Jensen I., Larsen R., and Robertsen B. An antiviral state induced in Chinook salmon embryo cells (CHSE-214) by transfection with the double-stranded RNA poly I:C. Fish. Shellfish Immunol. 13 (2002) 367-378
14. Krause A., Neitz S., Magert H.J., Schulz A., Forssmann W.G., Schulz-Knappe P., and Adermann K. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett. 480 (2000) 147-150
15. Lauth X., Shike H., Burns J.C., Westerman M.E., Ostland V.E., Carlberg J.M., Van Olst J.C., Nizet V., Taylor S.W., Shimizu C., and Bulet P. Discovery and characterization of two isoforms of moronecidin, a novel antimicrobial peptide from hybrid striped bass. J. Biol. Chem. 277 (2002) 5030-5039
16. Lauth X., Babon J.J., Stannard J.A., Singh S., Nizet V., Carlberg J.M., Ostland V.E., Pennington M.W., Norton R.S., and Westerman M.E. Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections. J. Biol. Chem. 280 (2005) 9272-9282
17. Lee P., Peng H., Gelbart T., and Beutler E. The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 9263-9265
18. Nemeth E., Valore E.V., Territo M., Schiller G., Lichtenstein A., and Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 101 (2003) 2461-2463
19. Nicolas G., Bennoun M., Devaux I., Beaumont C., Grandchamp B., Kahn A., and Vaulont S. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 8780-8785
20. Nygaard R., Husgard S., Sommer A.I., Leong J.A., and Robertsen B. Induction of Mx protein by interferon and double-stranded RNA in salmonid cells. Fish. Shellfish Immunol. 10 (2000) 435-450
21. Oren Z., and Shai Y. A class of highly potent antibacterial peptides derived from pardaxin, a pore-forming peptide isolated from Moses sole fish Pardachirus marmoratus. Eur. J. Biochem. 237 (1996) 303-310
22. Park C.B., Lee J.H., Park I.Y., Kim M.S., and Kim S.C. A novel antimicrobial peptide from the loach Misgurnus anguillicaudatus. FEBS Lett. 411 (1997) 173-178
23. Park C.H., Valore E.V., Waring A.J., and Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J. Biol. Chem. 276 (2001) 7806-7810
24. Park I.Y., Park C.B., Kim M.S., and Kim S.C. Parasin I, an antimicrobial peptide derived from histone H2A in the catfish Parasilurus asotus. FEBS Lett. 437 (1998) 258-262
25. Patrzykat A., Friedrich C.L., Zhang L., Mendoza V., and Hancock R.E. Sublethal concentrations of pleurocidin-derived antimicrobial peptides inhibit macromolecular synthesis in Escherichia coli. Antimicrob. Agents Chemother. 46 (2002) 605-614
26. Pigeon C., Ilyin G., Courselaud B., Leroyer P., Turlin B., Brissot P., and Loreal O. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J. Biol. Chem. 276 (2001) 7811-7819
27. Rodrigues P.N., Vazquez-Dorado S., Neves J.V., and Wilson J.M. Dual function of fish hepcidin: response to experimental iron overload and bacterial infection in sea bass (Dicentrarchus labrax). Dev. Comp. Immunol. 30 (2006) 1156-1167
28. Sang Y., Ramanathan B., Minton J.E., Ross C.R., and Blecha F. Porcine liver-expressed antimicrobial peptides, hepcidin and LEAP-2: cloning and induction by bacterial infection. Dev. Comp. Immunol. 30 (2006) 357-366
29. Shi J., and Camus A.C. Hepcidins in amphibians and fishes: antimicrobial peptides or iron-regulatory hormones?. Dev. Comp. Immunol. 30 (2006) 746-755
30. Shike H., Lauth X., Westerman M.E., Ostland V.E., Carlberg J.M., Van Olst J.C., Shimizu C., Bulet P., and Burns J.C. Bass hepcidin is a novel antimicrobial peptide induced by bacterial challenge. Eur. J. Biochem. 269 (2002) 2232-2237
31. Silphaduang U., and Noga E.J. Peptide antibiotics in mast cells of fish. Nature 414 (2001) 268-269
32. Verga Falzacappa M.V., and Muckenthaler M.U. Hepcidin: iron-hormone and anti-microbial peptide. Gene 364 (2005) 37-44
33. Vyoral D., and Petrak J. Hepcidin: a direct link between iron metabolism and immunity. Int. J. Biochem. Cell. Biol. 37 (2005) 1768-1773
34. Wang R.H., Li C., Xu X., Zheng Y., Xiao C., Zerfas P., Cooperman S., Eckhaus M., Rouault T., Mishra L., and Deng C.X. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab. 2 (2005) 399-409
35. Weinstein D.A., Roy C.N., Fleming M.D., Loda M.F., Wolfsdorf J.I., and Andrews N.C. Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood 100 (2002) 3776-3781