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Volumn 24, Issue 8, 2007, Pages 1450-1456

Influence of mouthpiece geometry on the aerosol delivery performance of a dry powder inhaler

Author keywords

Computational fluid dynamics (CFD); Dry powder aerosols; Dry powder inhaler (DPI); Mouthpiece geometry; Pulmonary drug delivery

Indexed keywords

AEROLIZER; MANNITOL; UNCLASSIFIED DRUG;

EID: 34250840026     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-007-9262-z     Document Type: Article
Times cited : (105)

References (24)
  • 1
    • 0029030051 scopus 로고
    • Medical aerosol inhalers: Past, present, and future
    • A. R. Clark. Medical aerosol inhalers: past, present, and future. Aerosol Sci. Technol. 22:374-391 (1995).
    • (1995) Aerosol Sci. Technol. , vol.22 , pp. 374-391
    • Clark, A.R.1
  • 2
    • 0141740310 scopus 로고    scopus 로고
    • Inhalation drug delivery devices and emerging technologies
    • H.-K. Chan. Inhalation drug delivery devices and emerging technologies. Expert Opin. Ther. Pat. 13:1333-1343 (2003).
    • (2003) Expert Opin. Ther. Pat. , vol.13 , pp. 1333-1343
    • Chan, H.-K.1
  • 3
    • 0011489418 scopus 로고    scopus 로고
    • Dispersion and characterization of pharmaceutical dry powder aerosols
    • C. A. Dunbar, A. J. Hickey, and P. Holzner. Dispersion and characterization of pharmaceutical dry powder aerosols. KONA 16:7-44 (1998).
    • (1998) KONA , vol.16 , pp. 7-44
    • Dunbar, C.A.1    Hickey, A.J.2    Holzner, P.3
  • 5
    • 0034001190 scopus 로고    scopus 로고
    • Novel lipid-based hollow-porous microparticles as platform for immunoglobin delivery to the respiratory tract
    • A. I. Bot, T. E. Tarara, D. J. Smith, S. R. Bot, C. M. Woods, and J. G. Weers. Novel lipid-based hollow-porous microparticles as platform for immunoglobin delivery to the respiratory tract. Pharm. Res. 17:275-283 (2000).
    • (2000) Pharm. Res. , vol.17 , pp. 275-283
    • Bot, A.I.1    Tarara, T.E.2    Smith, D.J.3    Bot, S.R.4    Woods, C.M.5    Weers, J.G.6
  • 6
    • 0034750024 scopus 로고    scopus 로고
    • Use of solid corrugated particles to enhance powder aerosol performance
    • N. Y. K. Chew and H.-K. Chan. Use of solid corrugated particles to enhance powder aerosol performance. Pharm. Res. 18:1570-1577 (2001).
    • (2001) Pharm. Res. , vol.18 , pp. 1570-1577
    • Chew, N.Y.K.1    Chan, H.-K.2
  • 8
    • 0030200977 scopus 로고    scopus 로고
    • The influence of formulation on emission, deaggregation and deposition of dry powders for inhalation
    • D. L. French, D. A. Edwards, and R. W. Niven. The influence of formulation on emission, deaggregation and deposition of dry powders for inhalation. J. Aerosol Sci. 27:769-783 (1996).
    • (1996) J. Aerosol Sci. , vol.27 , pp. 769-783
    • French, D.L.1    Edwards, D.A.2    Niven, R.W.3
  • 9
    • 0032795651 scopus 로고    scopus 로고
    • Influence of particle size, air flow, and inhaler device on the dispersion of mannitol powders
    • N. Y. K. Chew and H.-K. Chan. Influence of particle size, air flow, and inhaler device on the dispersion of mannitol powders. Pharm. Res. 16:1098-1103 (1999).
    • (1999) Pharm. Res. , vol.16 , pp. 1098-1103
    • Chew, N.Y.K.1    Chan, H.-K.2
  • 10
    • 0028814516 scopus 로고
    • Dose emissions from marketed dry powder inhalers
    • M. Hindle and P. R. Byron. Dose emissions from marketed dry powder inhalers. Int. J. Pharm. 116:169-177 (1995).
    • (1995) Int. J. Pharm. , vol.116 , pp. 169-177
    • Hindle, M.1    Byron, P.R.2
  • 11
    • 0342940773 scopus 로고    scopus 로고
    • In vitro evaluation of dry powder inhalers I: Drug deposition of commonly used devices
    • H. Steckel and B. W. Müller. In vitro evaluation of dry powder inhalers I: drug deposition of commonly used devices. Int. J. Pharm. 154:19-29 (1997).
    • (1997) Int. J. Pharm. , vol.154 , pp. 19-29
    • Steckel, H.1    Müller, B.W.2
  • 12
    • 34250799516 scopus 로고    scopus 로고
    • Throat retention can explain the variability in lung deposition
    • L. Borgström, L. Asking, B. Olsson, and L. Thorsson. Throat retention can explain the variability in lung deposition. J. Aerosol Med. 18:99 (2005).
    • (2005) J. Aerosol Med. , vol.18 , pp. 99
    • Borgström, L.1    Asking, L.2    Olsson, B.3    Thorsson, L.4
  • 13
    • 1542291134 scopus 로고    scopus 로고
    • Predicting extrathoracic deposition from dry powder inhalers
    • W. H. DeHaan and W. H. Finlay. Predicting extrathoracic deposition from dry powder inhalers. J. Aerosol Sci. 35:309-331 (2004).
    • (2004) J. Aerosol Sci. , vol.35 , pp. 309-331
    • Dehaan, W.H.1    Finlay, W.H.2
  • 14
    • 3242722612 scopus 로고    scopus 로고
    • In vitro intersubject and intrasubject deposition measurements in realistic mouth-throat geometries
    • B. Grgic, W. H. Finlay, P. K. P. Burnell, and A. F. Heenen. In vitro intersubject and intrasubject deposition measurements in realistic mouth-throat geometries. J. Aerosol Sci. 35:1025-1040 (2004).
    • (2004) J. Aerosol Sci. , vol.35 , pp. 1025-1040
    • Grgic, B.1    Finlay, W.H.2    Burnell, P.K.P.3    Heenen, A.F.4
  • 15
    • 85010181389 scopus 로고
    • Intercomparison of experimental regional aerosol deposition data
    • W. Stahlhofen, G. Rudolf, and A. C. James. Intercomparison of experimental regional aerosol deposition data. J. Aerosol Med. 2:285-308 (1989).
    • (1989) J. Aerosol Med. , vol.2 , pp. 285-308
    • Stahlhofen, W.1    Rudolf, G.2    James, A.C.3
  • 16
    • 8644282632 scopus 로고    scopus 로고
    • Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 1: Grid structure and mouthpiece length
    • M. S. Coates, D. F. Fletcher, H.-K. Chan, and J. A. Raper. Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 1: grid structure and mouthpiece length. J. Pharm. Sci. 93:2863-2876 (2004).
    • (2004) J. Pharm. Sci. , vol.93 , pp. 2863-2876
    • Coates, M.S.1    Fletcher, D.F.2    Chan, H.-K.3    Raper, J.A.4
  • 17
    • 0345256446 scopus 로고    scopus 로고
    • Regional aerosol deposition and measurements in an idealized mouth and throat
    • B. Grgic, W. H. Finlay, and A. F. Heenen. Regional aerosol deposition and measurements in an idealized mouth and throat. J. Aerosol Sci. 35:21-32 (2004).
    • (2004) J. Aerosol Sci. , vol.35 , pp. 21-32
    • Grgic, B.1    Finlay, W.H.2    Heenen, A.F.3
  • 18
    • 8644271772 scopus 로고
    • Two-equation eddy-viscosity models for engineering applications
    • F. R. Menter. Two-equation eddy-viscosity models for engineering applications. AIAA J. 32:269-289 (1994).
    • (1994) AIAA J. , vol.32 , pp. 269-289
    • Menter, F.R.1
  • 19
    • 34250854901 scopus 로고    scopus 로고
    • (accessed 08/01/04)
    • ANSYS CFX, 2003. http://www.ansys.com/cfx. (accessed 08/01/04).
    • (2003)
  • 20
    • 21244438369 scopus 로고    scopus 로고
    • The role of capsule on the performance of a dry powder inhaler using computational and experimental analyses
    • M. S. Coates, H.-K. Chan, D. F. Fletcher, and J. A. Raper. The role of capsule on the performance of a dry powder inhaler using computational and experimental analyses. Pharm. Res. 22:923-932 (2005).
    • (2005) Pharm. Res. , vol.22 , pp. 923-932
    • Coates, M.S.1    Chan, H.-K.2    Fletcher, D.F.3    Raper, J.A.4
  • 21
    • 24044542653 scopus 로고    scopus 로고
    • Influence of air flow on the performance of a dry powder inhaler using computational and experimental analyses
    • M. S. Coates, H.-K. Chan, D. F. Fletcher, and J. A. Raper. Influence of air flow on the performance of a dry powder inhaler using computational and experimental analyses. Pharm. Res. 22:1445-1453 (2005).
    • (2005) Pharm. Res. , vol.22 , pp. 1445-1453
    • Coates, M.S.1    Chan, H.-K.2    Fletcher, D.F.3    Raper, J.A.4
  • 23
    • 3242684091 scopus 로고    scopus 로고
    • Particle deposition measurements and numerical simulation in a highly idealized mouth-throat
    • Y. Zhang, W. H. Finlay, and E. A. Matida. Particle deposition measurements and numerical simulation in a highly idealized mouth-throat. J. Aerosol Sci. 35:789-803 (2004).
    • (2004) J. Aerosol Sci. , vol.35 , pp. 789-803
    • Zhang, Y.1    Finlay, W.H.2    Matida, E.A.3
  • 24
    • 3342886225 scopus 로고    scopus 로고
    • An investigation of the relationship between the flow field and regional deposition in realistic extra-thoracic airways
    • A. F. Heenen, W. H. Finlay, B. Grgic, A. Pollard, and P. K. P. Burnell. An investigation of the relationship between the flow field and regional deposition in realistic extra-thoracic airways. J. Aerosol Sci. 35:1013-1023 (2004).
    • (2004) J. Aerosol Sci. , vol.35 , pp. 1013-1023
    • Heenen, A.F.1    Finlay, W.H.2    Grgic, B.3    Pollard, A.4    Burnell, P.K.P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.