Lactose as a carrier in dry powder formulations: The influence of surface characteristics on drug delivery

Journal of Pharmaceutical Sciences

Volumn 90, Issue 9, 2001, Pages 1424-1434

  Zeng, Xian Ming ^a   Martin, Gary P ^a   Marriott, Christopher ^a   Pritchard, John ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Albuterol sulfate; Crystal shape; Deposition; Dispersion; Dry powder inhalers; Lactose; Surface roughness

Indexed keywords

LACTOSE; SALBUTAMOL; SALBUTAMOL SULFATE;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG FORMULATION; DRY POWDER; PARTICLE SIZE; SURFACE PROPERTY;

EID: 0034827374     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.1094     Document Type: Article

References (13)

1. Dry powder inhalers
2. The influence of formulation on emission, deaggregation and deposition of dry powders for inhalation
3. In vitro evaluation of dry powder inhalers II: Influence of carrier particle size and concentrations on in vitro deposition
4. Protein deposition from dry powder inhalers: Fine particle multiplets as performance modifiers
5. The role of fine particle lactose on the dispersion and deaggregation of albuterol sulphate in an airstream in vitro
6. Assessment of disorder in crystalline solids
7. Process-induced crystallinity changes of albuterol sulphate and its effect on powder physical stability
8. The influence of carrier morphology on drug delivery by dry powder inhalers
9. Crystallization of lactose from Carbopol gels
10. Aerodynamic assessment of fine particles - Fine particle dose and particle size distribution
11. Studies on direct compression of tablets. 10. Measurements of tablet surface-area by permeametry-reply
12. Evaluation of a permeametry technique for surface area measurements of coarse particulate materials
13. Effects of particle morphology on emitted dose of fatty acid-treated disodium cromoglycate powder aerosols