Influence of process parameters in the ASES process on particle properties of budesonide for pulmonary delivery

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 57, Issue 3, 2004, Pages 507-512

  Steckel, Hartwig ^a   Pichert, Lars ^a   Müller, Bernd W ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Aerodynamic diameter; Aerosol solvent extraction system; Budesonide; Dry powder inhalation; Micronization; Supercritical fluid

Indexed keywords

BUDESONIDE;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG DELIVERY SYSTEM; DRY POWDER; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRECIPITATION;

ADMINISTRATION, INHALATION; BUDESONIDE; DRUG DELIVERY SYSTEMS; PARTICLE SIZE;

EID: 1842861700     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2004.01.002     Document Type: Article

References (16)

1. Ganderton D. Targeted delivery of inhaled drugs: current challenges and future trends. J. Aerosol Med. 12:(Suppl. 1):1999;3-8.
2. York P. Powdered raw materials: characterizing batch uniformity. Respir. Drug Del. IV:1994;83-91.
3. Parrott E.L. Comminution. Swarbrick J., Boylan J.C. Encyclopedia of Pharmaceutical Technology. vol. 3:1990;101-121 Marcel Decker, New York.
4. Ticehurst M.D., Basford P.A., Dallman C.I., Lukas T.M., Marshall P.V., Nichols G., Smith D. Characterisation of the influence of micronisation on the crystallinity and physical stability of revatropate hydrobromide. Int. J. Pharm. 193:2000;247-259.
5. Ward G.H., Schultz R.K. Process-induced crystallinity changes in albuterol sulfate and its effect on powder physical stability. Pharm. Res. 12:(5):1995;773-779.
6. Joshi V., Dwivedi S., Ward G.H. Increase in the specific surface area of budesonide during storage postmicronization. Pharm. Res. 19:2002;7-12.
7. Vidgrén M.T., Vidgrén P.A., Paronen T.P. Comparison of physical and inhalation properties of spray-dried and mechanically micronized disodium cromoglycate. Int. J. Pharm. 35:1987;139-144.
8. Chawla A., Taylor K.M.G., Newton J.M., Johnson M.C.R. Production of spray-dried salbutamol sulphate for use in dry powder aerosol formulations. Int. J. Pharm. 108:1994;233-240.
9. Rogers T.L., Nelsen A.C., Hu J., Brown J.N., Sarkari M., Young T.J., Johnston K.P., Williams R.O. III. A novel particle engineering technology to enhance dissolution of poorly water soluble drugs: spray-freezing into liquid. Eur. J. Pharm. Biopharm. 54:2002;271-280.
10. Kerc J., Srcic S., Knez Z., Sencar-Bozic P. Micronization of drugs using supercritical carbon dioxide. Int. J. Pharm. 182:1999;33-39.
11. Beach S., Latham D., Sidgwick C., Hanna M., York P. Control of the physical form of salmeterol xinafoate. Org. Proc. Res. Dev. 3:1999;370-376.
12. B.W. Müller, W. Fischer, German Patent No. DE 3744329, 1989.
13. 2 and cryogenic spray-freezing technologies. Drug Dev. Ind. Pharm. 27:(10):2001;1003-1015.
14. Steckel H., Thies J., Müller B.W. Micronizing of steroids for pulmonary delivery by supercritical carbon dioxide. Int. J. Pharm. 152:1997;99-110.
15. Stahl E., Glatz A. Extraction of natural substances with supercritical gases, 10th communication: qualitative and quantitative determination of solubilities of steroids in supercritical carbon dioxide. Seifen, Fette, Anstrichmittel. 1984;346-348.
16. Rasenack N., Steckel H., Müller B.W. Micronization of anti-inflammatory drugs for pulmonary delivery by a controlled crystallization process. J. Pharm. Sci. 92:2003;35-44.